The paper uses 15 national leading companies supported by new-generation artificial intelligence open innovation platforms as research samples, uses collected diversified data, and uses the fuzzy set qualitative comparative analysis method (fs QCA) to explore the impact path of artificial intelligence empowerment on innovation performance. The research found that the impact of AI empowerment on innovation performance is the result of a combination of factors at the technical level, data level, and enterprise level. According to the core factors of artificial intelligence empowerment, the influence paths of artificial intelligence empowerment on innovation performance can be summarized into five types: technology support type, data-driven type, organizational transformation type, service ecology type and marketing integration type, and further influence each path, the characteristics of the use are analyzed in detail. The research has theoretically enriched the related research on artificial intelligence empowerment and the impact path of innovation performance, and at the same time provided useful enlightenment for most Chinese enterprises to use artificial intelligence to accelerate the realization of digital and intelligent transformation and achieve high-quality development.