The cultivation of innovation and entrepreneurship ability is not only an important content of higher education talent cultivation under the new economic format, but also an urgent need for the implementation of the national innovation driven development strategy. Using blockchain distributed database, hash function, timestamp, consensus mechanism, asymmetric encryption and other technologies, this paper constructs a 1+n distributed maker space based on blockchain, so as to form a chain maker space talent training mechanism coordinated by college students, entrepreneurial mentors, schools, colleges and off campus cooperative enterprises, so as to solve the lack of individual innovation and entrepreneurship thinking of students Finally, take the 1+n distributed maker space of Y University as an example to verify the specific effect of collaborative innovation talent training practice under this mode.