Abstract: The shifting of modern science center is an unchanging research topic. In terms of time, there is a certain similarity between the establishment of patent system and the shifting of modern science center in the major countries in the modern world. In order to verify the existence of the phenomenon of the shifting of the patent center, to explore the economic, social and cultural background of it, and to reveal the correlation between the transfer of the world patent center and the scientific revolution, technological revolution and industrial revolution, a large number of historical data were collected by using the research method of the unification of history and logic. It is found that the world patent centers show the phenomenon of constant replacement and cross-coexistence of Britain, France, Germany and Japan, which not only accords with the wave transformation law of ideological liberation, social revolution,scientific center and industrial revolution, but also reflects the different characteristics of each country in promoting its own economic and social development. The research conclusion can provide historical experience and decision-making reference for the construction of China's intellectual property power and modern socialist country.