Using spatial statistical analysis software GeoDa and statistical software SPSS22, the framework of regional scientific and technological innovation capability evaluation index system in Hubei province, an analysis of the spatial and multivariate linear regression of regional innovation ability in Hubei province, the results show that the distribution of regional innovation ability of Hubei province in 2013 is not balanced, the center of the regional innovation, regional innovation center has obvious "shadow effect" and the location locking effect, knowledge spillover and diffusion of innovation of spatial agglomeration hindered the coordinated development of regional innovation, proposed the main path to further enhance the regional innovation ability of Hubei province.