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1.
Acute myocardial Infarction is one of the major causes of morbidity & mortality in world and atherosclerosis is the major
cause of ischemic heart disease. In order to determine the better clinical marker of atherosclerosis, we estimated serum low-density
lipoprotein (LDL-C) and high sensitivity C-reactive protein (hsCRP). Hundred patients of myocardial infarction and 100 controls
irrespective of age and sex were studied for these parameters over a period of 2 years. The statistical analysis showed that
the serum hsCRP was significantly raised in myocardial infarction cases than controls (P < 0.01) but LDL-C was not (P > 0.05). We conclude that the serum hsCRP has better predictive value for risk of atherosclerosis. 相似文献
2.
Carole A. Estabrooks Peter Norton Judy M. Birdsell Mandi S. Newton Adeniyi J. Adewale Richard Thornley 《Research Policy》2008,37(6-7):1066-1078
Defining knowledge translation activities using Gibbons and Nowotny's Mode I and II forms of knowledge production, health researcher (N = 240) characteristics are compared with their knowledge translation activities. Applied researchers (n = 168) engaged in more Mode II activity (p < .001), perceived their work as having more impact (p < .001), and reported higher levels of relational capital (p < .001) when compared to basic researchers (n = 72). Those from medical schools (n = 128) had more publications (p = .004) as did applied researchers in medical school compared to applied researchers from other faculties (p = .001). These findings provide early empirical insights into emerging tensions in environments where Mode I and Mode II activities co-exist; tensions that may extract unintended costs from researchers. Such costs may be paid in the currency not only of tenure and promotion, but also of successful grant and career scientist award acquisition. 相似文献
3.
Gacche RN Shaikh RU Chapole SM Jadhav AD Jadhav SG 《Indian journal of clinical biochemistry : IJCB》2011,26(3):303-308
The study was designed to evaluate the antioxidant activity and effect of Cymbopogon martinii (Roxb.) Wats. (Poaceae) leaves on the activity of monoamine oxidase and kinetics of enzyme inhibition. Ethanol extract of
C. martinii and rat brain mitochondrial monoamine oxidase preparation ware used to study the kinetics of enzyme inhibition using double
reciprocal Lineweaver–Burk plot. The DPPH was used as a source of free radical to evaluate antioxidant potential. It is observed
that, the ethanolic extract of C. martinii inhibits the monoamine oxidase activity with competitive mode of inhibition. The V
max (0.01 mM/min) remained constant while, K
m varied from 21.00 ± 1.1, 43.33 ± 1.5 and 83.33 ± 1.4 mM for 100–500 μg/ml concentration of C. martinii. The K
i values were calculated to be 90.00 ± 0.87, 75.00 ± 0.69, 68.18 ± 0.68 μg for 100–500 μg/ml concentration of C. martini. It also shows a significant DPPH (1,1-diphenyl-2-picryl hydrazine) radical scavenging (IC50 = 0.34 ± 0.05 mg/ml) and reducing activity (IC50 = 0.70 ± 0.22 mg/ml). The C. martini can be considered as a possible source of MAO inhibitor used in the treatment of depression and other neurological disorders. 相似文献
4.
Shilpa Reddy Ganasyam Talluri Bhaskar Rao Y. S. R. Murthy Akka Jyothy Madireddy Sujatha 《Indian journal of clinical biochemistry : IJCB》2012,27(1):69-73
Type 2 diabetes mellitus (DM) is a multifactorial disease where both genetic and environmental factors contribute to its pathogenesis.
Estrogen plays an important role in type 2 DM pathogenesis. A number of polymorphisms have been reported in the estrogen receptor
(ESR1), including the XbaI and PvuII restriction enzyme polymorphisms of ESR1,which may be involved in disease pathogenesis. Metallothioneins (MT) act as potent
antioxidants against various oxidative damages. Very few studies have indicated the association between Estrogen Receptor-α,
MT1 gene polymorphisms with type2 DM. A total of 100 type 2 diabetic women and 100 age, sex matched controls were recruited.
Using the PCR based RFLP method, the PvuII and XbaI polymorphisms of ESR1 and in MT1A (rs8052394 and rs11076161) gene polymorphisms were analysed. The genotype distribution and frequency of mutated allele showed no significant differences
between diabetic and non-diabetic groups in PvuII (χ2 = 2.443; P = 0.1181) or XbaI (χ2 = 1.789; P = 0.1812) and rs8052394 (χ2 = 1.154; P = 0.2840) or rs11076161 (χ2 = 0.4141; P = 0.5199), polymorphisms. This is the first Indian study to conclude that ESR1 and MT1 gene polymorphisms are not associated
with increased susceptibility to type 2 diabetes in Indian women. 相似文献
5.
Impact of Chronic Lead Exposure on Selected Biological Markers 总被引:1,自引:0,他引:1
Ambica P. Jangid P. J. John D. Yadav Sandhya Mishra Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2012,27(1):83-89
Lead poisoning remains a major problem in India due to the lack of awareness of its ill effects among the clinical community.
Blood lead, δ-aminolevulinic acid dehydratase (δ-ALAD) and zinc protoporphyrin (ZPP) concentrations are widely used as biomarkers
for lead toxicity The present study was designed to determine the impact of chronic lead exposure on selected biological markers.
A total of 250 subjects, of both sexes, ranging in age from 20 to 70 years, were recruited. On the basis of BLLs, the subjects
were categorized into four groups: Group A (BLL: 0–10 μg/dl), Group B (BLL: 10–20 μg/dl). Group C (BLL: 20–30 μg/dl) and Group
D (BLL: 30–40 μg/dl) having BLLs of 3.60 ± 2.71 μg/dl, 15.21 ± 2.65 μg/dl, 26.82 ± 2.53 μg/dl and 36.38 ± 2.83 μg/dl, respectively.
Significant changes in biological markers due to elevated BLLs were noted. The relation of BLL and biological markers to demographic
characteristics such as sex, habits, diet and substances abuse (smoking effect) were also studied in the present investigation.
Males, urban population, non-vegetarians, and smokers had higher blood lead levels. δ-ALAD activity was found to be significantly
lower with increased BLL (P < 0.001), while the ZPP level was significantly higher with increased BLL (P < 0.001). Further, BLL showed a negative correlation with δ-ALAD (r = −0.425, P < 0.001, N = 250) and a positive correlations with ZPP (r = 0.669, P < 0.001, N = 250). Chronic lead exposure affects the prooxidant-antioxidant equilibrium leading to cellular oxidative stress. 相似文献
6.
Zubieta-Calleja G Zubieta-Castillo G Zubieta-Calleja L Ardaya-Zubieta G Paulev PE 《Indian journal of clinical biochemistry : IJCB》2011,26(1):62-65
As the oxygen tension of inspired air falls with increasing altitude in normal subjects, hyperventilation ensues. This acute
respiratory alkalosis, induces increased renal excretion of bicarbonate, returning the pH back to normal, giving rise to compensated
respiratory alkalosis or chronic hypocapnia. It seems a contradiction that so many normal people at high altitude should permanently
live as chronic acid–base patients. Blood gas analyses of 1,865 subjects at 3,510 m, reported a P
aCO2 (arterial carbon dioxide tension ± SEM) = 29.4 ± 0.16 mmHg and pH = 7.40 ± 0.005. Base excess, calculated with the Van Slyke
sea level equation, is −5 mM (milliMolar or mmol/l) as an average, suggesting chronic hypocapnia. THID, a new term replacing
“Base Excess” is determined by titration to a pH of 7.40 at a P
aCO2 of 5.33 kPa (40 mmHg) at sea level, oxygen saturated and at 37°C blood temperature. Since our new modified Van Slyke equations
operate with normal values for P
aCO2 at the actual altitude, a calculation of THID will always result in normal values—that is, zero. 相似文献
7.
S. B. Sharma S. Dwivedi K. M. Prabhu Narendra Kumar M. C. Baruah 《Indian journal of clinical biochemistry : IJCB》1999,14(2):245-248
Serum lipid profile, apolipoprotein-B (apo-B), malondialdehyde levels(MDA) and superoxide dismutase (SOD) activity were assessed
in 12 cases of xanthelasma with and without coronary artery disease (CAD)/hypertension (HTN) and results are compared with
healthy controls. Dyslipidemia was found in 65% cases of xanthelasma as compared to 20% healthy controls. Xanthelasma patients
had significantly high malondialdehyde (MDA) levels (p<0.01) and significantly decreased (p<0.05) SOD activity as compared
to controls. Among xanthelasma patients, xanthelasma with CAD/HTN showed higher total cholesterol (236±32.7 vs 188±24.7 mg/dl),
low density lipoprotein cholesterol (157±35.5 vs 113±16 mg/dl) and Apo-B (120.5±9.4 vs 114±19.2 mg/dl) levels as compared
to xanthelasma without CAD/HTN. Results of our study indicate that xanthelasma patients with increased apo-B, MDA and decreased
SOD need cardiovascular monitoring. 相似文献
8.
Jafar T Agrawal S Mahdi AA Sharma RK Awasthi S Agarwal GG 《Indian journal of clinical biochemistry : IJCB》2011,26(3):296-302
The pathogenesis of idiopathic nephrotic syndrome is not completely understood. We postulate that cytokine gene polymorphisms
may influence susceptibility or clinical course in Idiopathic Nephrotic Syndrome. Polymorphisms of IL-4, IL-6, and TNF-α cytokines
were investigated in 150 children with Idiopathic Nephrotic Syndrome and 569 healthy controls by using polymerase chain reaction
and restriction fragment length polymorphism. On comparing patient with controls strong association were found for IL-6, TNF-α
and IL-4 at allelic level (IL-6-G174C (G vs. C): P = <0.001; OR = 6.33, TNF-α-G308A (G vs. A): P = <0.001; OR = 1.99, IL-4-C590T (C vs. T): P = 0.048; OR = 1.38). Further when SR group was compared with SS group significant association was found at genotypic level
in all the studied genetic polymorphisms. Studied cytokine gene polymorphisms may influence susceptibility to idiopathic nephrotic
syndrome and might affect steroid response in INS patients. 相似文献
9.
Madhusudhana Rao A Anand U Anand CV 《Indian journal of clinical biochemistry : IJCB》2011,26(1):28-31
Numerous lines of evidence implicate a role of myeloperoxidase (MPO) in the pathogenesis of cardiovascular disease (CVD).
It is a well accepted fact that patients with chronic kidney disease (CKD) are at an increased risk for CVD. MPO is a pro-oxidant
enzyme which could be involved in the increased susceptibility of these patients to CVD. Hence, the levels of plasma MPO was
determined in healthy controls as well as in patients with CKD [stratified with the level of their kidney failure as CKD stages
II–V (end stage renal disease)]. Plasma MPO was assayed by a spectrophotometric method. Serum urea and creatinine were estimated
on a clinical chemistry analyzer using standard laboratory procedures. The mean plasma MPO levels were significantly lower
with advancing stages of renal failure (P < 0.001). There was a positive correlation between MPO and GFR (r = +0.89, P < 0.001) and a negative correlation with urea (r = −0.85, P < 0.001) and creatinine (r = −0.82, P < 0.001). While an inverse association was observed between plasma MPO and urea in CKD patients, such an association was
not observed in control subjects (P = 0.43). In conclusion, the decline in plasma MPO levels may be due to the inhibitory effect of uraemic toxins on the enzyme. 相似文献
10.
M. Prasad D. Rajarajeswari P. Aruna K. Ramalingam R. Viswakumar Nusrath Fathima Sandeep Kumar Vishwakarma Aleem Ahmed Khan 《Indian journal of clinical biochemistry : IJCB》2022,37(3):335
Essential hypertension (EH) is a multifactorial and complex disease with high rate of incidence and associated co-morbidities. Previous studies do not provide unanimous results for the risk of hypertension and association with Fok I genotype frequency and serum vitamin D levels. Hence, this study was undertaken to determine the status of Fok I vitamin D receptor (VDR) gene polymorphism along with vitamin D levels and blood pressure in patients with EH. Four hundred (200 controls and 200 cases of essential hypertension) participants from general Indian population were enrolled in this study. Peripheral blood samples were collected for genotyping Fok I-VDR gene polymorphism using PCR–RFLP method whereas 25-OH vitamin D levels in serum were quantified using high performance liquid chromatography (HPLC). Significantly reduced 25-OH vitamin D levels were observed in patients with EH (24.04 ± 8.62 vs 50.46 ± 15.46) compared to control subjects (p = 0.0001). Homozygous recessive genotype ‘ff’ frequency was increased by 8.06 fold (CI: 3.71–17.47, p = 0.0001) in patients with EH compared to dominant ‘FF’ genotype frequency. In conclusion, recessive ‘ff’ genotype frequency correlates with reduced serum vitamin D levels and results in significantly increased systolic and diastolic blood pressures leading to predisposition of EH. 相似文献
11.
The anti oxidative effect of administration of 100 mg/kg bw and 200 mg/kg bw of the flower powder of Cassia auriculata (CFP) for 45 days to normoglycemic and diabetic rats (streptozotocin induced) was studied. Anti oxidative effect was not
observed in normoglycemic rats in the experiment. There was significant (P > 0.05) increase in the level of Thio Barbituric Acid Reactive Substances (TBARS), hydroperoxide and conjugated dienes and
significant (P > 0.05) decrease in the catalase, superoxide dismutase and glutathione peroxidase activities and in the level of ascorbic
acid, vitamin E and reduced glutathione in diabetic rats. The flower powder of Cassia auriculata significantly (P > 0.05) decreased the TBARS, hydroperoxide and conjugated dienes and increased the antioxidant enzymes (catalase, superoxide
dismutase and glutathione peroxidase) and non enzymic anti oxidants (ascorbic acid, vitamin E and reduced glutathione). The
antioxidatve effect of 200 mg/kg bw CFP was significantly (P > 0.05) better than 100 mg/kg bw CFP and the reference drugs (tolbutamide and metformin). The mode of action of CFP remains
to be elicited. 相似文献
12.
Adinortey MB Gyan BE Adjimani J Nyarko P Sarpong C Tsikata FY Nyarko AK 《Indian journal of clinical biochemistry : IJCB》2011,26(3):261-268
In this study, differences in lipid levels amongst diabetics with and without complications were assessed to determine lipid
disorders that are associated with diabetic complications other than cardiovascular diseases. A Cross sectional study design
was employed. The study included 288 diabetics and 108 non diabetics with different types of complications such as hypertension,
nephropathy, neuropathy, and retinopathy. The mean serum total cholesterol was higher in patients with complications compared
to those without complications and the non-diabetic controls. The normotensive diabetic patients had the lowest total cholesterol
among the diabetic patients’ groups (4.65 ± 0.17 mmol/l) compared to the diabetics with hypertension (6.051 ± 0.20 mmol/l),
retinopathy (6.26 ± 0.29 mmol/l), neuropathy (5.80 ± 0.17 mmol/l) and nephropathy patients 5.74 ± 0.26 mmol/l (P < 0.05). The prevalence of dyslipidaemia among diabetic subjects was between 19.2 and 84.0%. The study shows that, in addition
to macrovascular complications, dyslipidaemia is common in type 2 diabetes mellitus patients with microvascular complications. 相似文献
13.
We recruited 59 individuals of known HIV serostatus after informed consent however, 44 were serodiscordant heterosexual partners
[serodiscordant seronegative (SSN group) and serodiscordant seropositive (SSP group)] while 15 were seronegative healthy individuals
(SNH). In the case–control study we choose to determine Malondialdehyde (MDA) concentration as a marker of lipid peroxidation
index (oxidative stress) spectrophotometrically and quantify HIV mRNA by Real Time-nucleic acid sequence based amplification
assay (RT-NASBA). Here our result show for the first time a high concentration of lipid peroxidation product (MDA, 116.6%)
with a significant (P < 0.05) increase in HIV serodiscordant seropositive subjects over their seronegative partners. However, Spearman rank correlation
statistics of SSP group showed a positive correlation value (P < 0.01, r = 0.89) between MDA and mRNA and a negative correlation between MDA and T-cell ratio (P < 0.01, r = 0.96).The study may strongly indicate a possible lipid peroxidation product threshold for predicting HIV infection and
progression in serodiscordant heterosexual partners. 相似文献
14.
N. Unni C. Sumithra R. Lakshman Lakshmi N. Leela Menon K. N. Subhakumari V. S. Sheejamol 《Indian journal of clinical biochemistry : IJCB》2015,30(2):161-166
PCOS is a heterogeneous endocrine disorder with diverse clinical presentation. Oxidative stress plays a key role in the pathophysiology of this disease. Serumhigh sensitive C-reactive protein (hsCRP), a marker of chronic low grade inflammation, is indicative of future development of cardiovascular disease. Our aim is to evaluate the oxidant status and hsCRP levels in PCOS. The study involved 61 cases and 61 controls in the age group of 18–40 years diagnosed with PCOS. Erythrocyte malondialdehyde (MDA), superoxide dismutase (SOD), serum hsCRP, gonadotrophins, thyroid stimulating hormone, prolactin, glycemic status and lipid profile were estimated. Erythrocyte MDA (p < 0.001), SOD (p = 0.007) and serum hsCRP (p < 0.001) were significantly elevated in PCOS patients than controls. Oxidative stress is present in women with PCOS along with elevated hsCRP. 相似文献
15.
Bincy Verghese Sonu Bhatnagar Ramchander Tanwar Jayashree Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2011,26(4):373-377
Psoriasis is chronic autoimmune hyperproliferative skin disease with a population prevalence of 1.5–3%. The cause of psoriasis
is still not fully understood. It has been hypothesized to be an immune-mediated disorder in which the excessive reproduction
of keratinocytes is due to cytokines such as interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha, secreted by infiltrating
CD4+ and CD8+ T cells and natural killer cells. The aim of our study was to determine the serum levels of TNF-α, IL-4, IL-6 & IL-10 in
psoriasis patients and compare it with healthy controls. 30 clinically diagnosed psoriasis patients and 30 age and sex matched
healthy controls were included in the study. The serum cytokine levels were measured by solid phase sandwich ELISA (DIACLONE
Research, France). TNF-α and IL-6 levels were significantly raised in patients and the results were statistically significant
(P < 0.001). IL-4 levels were higher in patients than in controls (1.91 ± 4.7 pg/ml in cases & 0.9 ± 0.3 pg/ml in controls)
but were not statistically significant. Interestingly, IL-10 levels were found to be higher in controls than in patients but
again, it was not statistically significant. Pro-inflammatory cytokines play a pivotal role in the pathogenesis of psoriasis
and it is the type 1(TH1) cytokine pattern, i.e., IL-6 & TNF-α, which predominate in the psoriatic T cell response. Further
studies on IL-10 levels in psoriasis are recommended to establish their exact role in the pathogenesis of the disease. 相似文献
16.
Osteoporosis becomes a serious health threat for older postmenopausal women by predisposing them to an increased risk of fracture.
Osteoporosis and associated fractures are an important cause of morbidity and mortality. Special attention is being paid to
early detection, management, and treatment of postmenopausal osteoporosis in women. Biochemical markers can enable dynamic
and rapid measurement of total body skeletal metabolism and will be clinically useful in the management of postmenopausal
osteoporosis women (PMO) and also for assessing the effects of antiresorptive therapy. With this view, we planned to assess
osteoclastic activity by determining urinary hydroxyproline in osteoporotic women. The aim of this study is to measure urinary
hydroxyproline (expressed as mg of hydroxyproline/g of creatinine) and serum ascorbic acid in postmenopausal women with osteoporosis
and without osteoporosis. These biochemical parameters were determined 3 months post antiresorptive therapy (alendronate + calcium + vitamin
D) in postmenopausal osteoporosis patients. 60 postmenopausal women with osteoporosis in the age group 45–60 years and 60
healthy postmenopausal women (normal bone mineral density) in the same age group were included in the study. Urinary hydroxyproline
levels were significantly increased (P < 0.001) in PMO at baseline level as compared to control group. These levels were decreased significantly (P < 0.001) post therapy in PMO patients. Serum vitamin C levels were significantly decreased (P < 0.001) in PMO patients at baseline level as compared to controls. No significant change occurred of serum vitamin C level
post therapy. Raised excretion of hydroxyproline at the baseline level might be due to increased degradation of collagen type
I from the bone matrix in osteoporosis. Breakdown of collagen seems to be lowered as reflected by lowering of hydroxyproline
excretion post antiresorptive therapy. Alteration in the concentration of this marker can be very well utilized to monitor
the effectiveness of therapy. Thus simple, direct urinary assay to measure bone resorption is very useful in monitoring the
therapy in PMO and may become an integral part of the management of osteoporosis. 相似文献
17.
Reactive oxygen species (ROS) are cytotoxic at higher concentration resulting in cell death, mutations, chromosomal aberrations
or carcinogenesis. In this study DNA was modified by singlet oxygen and superoxide anion radicals generated by illumination
of riboflavin under 365 nm UV-light. The modified DNA induced high titre antibodies in experimental animals. In enzyme immunoassay,
serum antibodies from cancer patients (n = 34) showed a higher recognition of the modified DNA, as compared to the native form. This was further confirmed by the
gel-shift assay. Immune IgG were used as a probe to detect oxidative lesions in the DNA of cancer patients. DNA isolated from
lymphocytes of cancer patients proved to be an appreciable inhibitor of the experimentally induced antibodies against the
ROS-DNA. This indicates the presence of oxidative lesions in the DNA obtained from cancer patients. The results show that
ROS induced oxidative damage to DNA in cancer patients generate neo-epitopes that are alien for the immune system, resulting in autoantibody formation. 相似文献
18.
Benedicta D’Souza Rajeevalochana Parthasarathy Sreekantha Vivian D’Souza 《Indian journal of clinical biochemistry : IJCB》2011,26(4):396-399
The serum acid phosphatase (ACP) activity and Hemoglobin (Hb) levels were measured in malaria patients and nonmalarial fever
patients. The results were compared with normal healthy control subjects. ACP was significantly increased (P < 0.001) in all the malaria patients. ACP was significantly higher in Plasmodium falcifarum malaria and mixed malaria when compared to Plasmodium vivax malaria. Hb levels were significantly decreased in all the malaria patients which indicates that malaria parasite uses host
erythrocyte Hb as a major nutrient source. There is negative correlation(r = −0.478) between ACP and Hb in malaria patients, which is highly significant. These results suggest that the measurement
of ACP could be used as a marker for malaria. 相似文献
19.
India seems to have the highest prevalence of osteoporosis. With growing awareness of osteoporosis and its impact on life
span especially in India, special attention is being paid to early detection, management and treatment of postmenopausal osteoporosis
in women. Measurement of BMD and osteocalcin are of value in estimating bone turnover rates. The aim of this study is (1)
to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women
and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy
(alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Sixty clinically
diagnosed postmenopausal osteoporosis patients and 60 normal subjects (postmenopausal non-osteoporosis women) were recruited
as control. Mean bone mineral density T score and Z score was significantly decreased (P < 0.001) in postmenopausal osteoporosis patients as compared to controls. Highly significant increase in the mean score of
BMD—T score and Z score from baseline to post therapy of 3 months was observed in postmenopausal osteoporosis women. Serum osteocalcin levels
were significantly increased (P < 0.001) as compared to control group. Serum osteocalcin levels were decreased significantly (P < 0.001) from baseline to post therapy of 3 months in postmenopausal osteoporosis women. BMD is the best quantifiable predictor
of osteoporotic fracture and osteocalcin is specific, sensitive, promising, currently used marker for better prognosis of
osteoporosis and for monitoring responses to antiresorptive therapy. 相似文献
20.
P-selectin, a cell adhesion molecule is elevated in many inflammatory conditions including preeclampsia which is characterized
by generalized endothelial dysfunction and vasoconstriction presumably due to free radicals or mediators released by defective
placentation. Vitamin E has been documented to protect cell membranes from oxidative damage and also decrease platelet aggregation.
The role of vitamin E in pre-eclampsia is contradictory and hence the study was undertaken. Soluble P-selectin was measured
by ELISA and Vitamin-E levels in plasma was estimated spectrofluorometrically. In our study the effect of supplementation
of 400 IU/day of Vitamin E (a-tocopheryl acetate) to patients of pre-eclampsia showed significant decreased levels of soluble
P-selectin by 2nd week as compared to patients given placebo (P = 0.005). In this short period of study no direct correlations were observed between Vitamin E or P-selectin levels with
blood pressure as well as with proteinuria. Future studies may focus on the effect of a-tocopheryl acetate or the phosphate
form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli
of P-selectin release in pre-eclampsia. 相似文献