共查询到20条相似文献，搜索用时 31 毫秒
1.
Bcl-2家族是研究的最早与凋亡相关的因子,发挥抗凋亡或促凋亡的作用,是线粒体凋亡通路中最主要的调节因子。近年来对于Bcl-2家族的研究取得了很大的进展,个别Bcl-2家族成员不仅具有凋亡调节作用,与细胞增殖也密切相关,从而将细胞周期与细胞凋亡偶连。本文较全面地综述了Bcl-2家族中Bcl-2、Bax及Bid三个成员与细胞周期关系的研究新进展。 相似文献
2.
探讨He—Ne激光幅照诱导肿瘤细胞凋亡而抑制肿瘤的生长。采用He—Ne激光处理HL-60细胞,流式细胞仪检测DNA含量及细胞凋亡百分率。发现在57．24J／cm^2的He—Ne激光作用下,HL-60细胞的凋亡百分率为12．83％。同时细胞周期发生改变,G1期减少,S期降低,G2期增加。结果表明在一定剂量He—Ne激光照射下,导致细胞DNA断裂,诱导HL-60细胞凋亡并抑制肿瘤细胞生长。 相似文献
3.
The workplace, especially the academic department or division, provides an intriguing research site for study of correlates
of scholarly performance. The objective of this study was to estimate a correlate model of three-year scholarly performance
of clinical faculty in colleges of pharmacy. Two-hundred and ninety-six clinical faculty in pharmacy responded to an author-developed
questionnaire. The scholarly performance items factored into three dimensions: “Refereed Research,”, “Grants/Books Research,”
and “Nonresearch Scholarship.” A fourth single-item variable, “Contracts,” was also used as a dependent dimension. Eight correlates,
including two related to the departmental workplace, emerged as factors significantly explaining the variation in scholarly
performance. The two most significant were “Off-Campus Conversations” and “Department: Percent Time in Research.” These results
as well as others were contrasted with prior correlate studies and suggestions were made for future additional study. 相似文献
4.
端粒是由染色体末端的DN A重复序列组成的,其上有蛋白结合。可保护染色体免受伤害,与细胞周期过程中DN A末端片断的流失、细胞凋亡有关。端粒酶由hTERC和hTERT组成,可以维持端粒的稳定。造血干细胞有一定的端粒酶活性,目前已研究出多种因素影响其表达。端粒酶相关基因修饰干细胞可以达到建立永生化细胞系等目的,亦有很好的应用前景。最近,在研究端粒酶在人类造血系统的作用时,人们把目光集中到一种罕见的遗传病DCK上。治疗这种疾病可能需要进一步的研究来揭示hTERT的内在基因和外来因素的两种调节之间的关系。 相似文献
5.
This article received the “Implications of Research for Educational Practice” award at the 1995 meeting of the Association
for the Education of Teachers in Science. The award is made possible by Carolina Biological Supply. An adaptation of this
article, entitled “Don’t Compare, Complement: Making Best Use of Science Centres and Museums,” was published in the 1995 Set:
Research Information for Teachers, Number 1, Item 1, by the New Zealand and Australian Councils for Education Research. 相似文献
6.
Research concerning the supervisor role in separate educational programmes has been undertaken, but cross-professional studies
are few. The aim of this study was to explore the lived experience of supervising mentors in Sweden during the practice-based,
off-campus sections of the education in teaching, nursing, and social care. The study used a participatory phenomenological
approach in which four researchers and nineteen supervising mentors worked together in the research process which was accomplished
in four different phases. The data collecting method used was interview. The results constituted a main essence entitled “Struggle
of power and control of professional quality enhancement” built upon four themes: “Constitutes a motivating force”, “Feelings
of responsibility”, “Feelings of frustration” and “Wishes for alteration”. Conclusions from the study are that communication,
information and contact between the professionals in the fields and university teachers need to be strengthen to keep up supervising
mentors’ motivating force and to give them support. 相似文献
7.
Michael D. Petkovich Robert D. Tennyson 《Educational technology research and development : ETR & D》1985,33(2):146
In the Winter 1983 issue of Review of Educational Research, Richard Clark published the article “Reconsidering Research on
Learning from Media.” This article presented a particular point of view on media research that is of interest to educational
technologists and has aroused some debate. In the Winter 1984 issue of ECTJ, Petkovich and Tennyson took issue wfth some of
Clark’s points. Clark’s reply to that critique followed immediately after ft in the same publication (Volume 32, No.4. Winter
1984). Petkovich and Tennyson now add “A Few More Thoughts…” 相似文献
8.
This article is to summarize the molecular and functional analysis of the gene “suppression of tumorigenicity 13” (ST13). ST13 is in fact the gene encoding Hsp70 interacting protein (Hip), a co-factor (co-chaperone) of the 70-kDa heat shock proteins (Hsc/Hsp70). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), Hip facilitates may facilitate the chaperone function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis. Although the nomenclature of ST13 implies a role in the suppression of tumorigenicity (ST), to date available experimental data are not sufficient to support its role in cancer development, except for the possible down-regulation of ST13 in gastric and colorectal cancers. Further investigation of this gene at the physiological level would benefit our understanding of diseases such as endocrinological disorders, cancer, and neurodegeneration commonly associated with protein misfolding. 相似文献
9.
Summary The WKAR-TV Program Analyzer,an electric rating summaration device,was used to test a inescope of a composite television program
for farm men and homemakers entitledTown and Country. Additional phases of the experiment involved interviews with each group tested on the Analyzer and completion of a questionaire
by each subject. The subjects consisted of 20 farm men, 20 rural homemakers and 20 urban homemakers. The WKAR-TV Program Analyzer
tests included 10 subjects in each group.
Testing the hypothesis that “like-dislike” ratings of a TV kinescope shown as a film correlate negatively with “I am learning”
ratings, the author showed that the “liking” scale measured different attributes of the program than did the “learning” scale.
Irving R. Merrill is Director of Research at TV Station WKAR-TV, Michigan State University. 相似文献
10.
“New Basic Education” and me 总被引：1，自引：0，他引：1
Lan Ye 《Frontiers of Education in China》2009,4(4):558-609
Initiated in September 1994, “New Basic Education” first underwent a five-year Exploratory Research phase from September 1994
to May 1999, which was followed by a second five-year Developmental Research phase from September 1999 to May 2004. Thus during
the past ten years, “New Basic Education” has undergone a complete research process, including the presentation of the problem,
the formation of results, and finally the dissemination, application, perfection, and development of its research. This study
has preliminarily explored the transformation of schools, educational theories and educational research methods in China.
The author hopes to respond actively to educational changes caused by our transforming society through her professional research.
She presents in this paper the retrospective notes of her subjective state, such as her thought process, planning, actions
and experiences while conducting and developing “New Basic Education” research.
“New Basic Education” research originated from ten years of theoretical preparation (amassing basic educational theory, the
methodology for educational research, and meta-research of educational disciplines), as well as from the author’s personal
experiences conducting field research during the past three years and her profound reflections on the nature of the social
transformations taking place in late 20th century China. During the Exploratory Research phase, “New Basic Education” research—which consists of reconstructive research
on educational theory and practice—regards the rebuilding of educational aims as its theoretical starting point. Additionally,
“New Basic Education” research regards schools, which provide nine-year compulsory education as the entire unit of practical
research. The research also focused on classroom education, teaching reform, and school management for the experimentation
and reform of the schools. As for the core issue of methodology, the crux of the issue lies in how to deal with the relations
between theoretical research and practical research and the relationship between theoretical researchers and practical researchers. 相似文献
11.
A science teacher and her mentor reflect on their participation in the Learning Research Cycle, a professional learning model
that bridges research and practice in both university and public school contexts. Teachers do scientific research in scientists’
laboratories, then bridge their scientific experiences with the design of new classroom learning environments and teacher-driven
educational research projects. Science students do scientific research via their teachers’ lessons that bridge laboratory
research with classroom learning. Scientists and educational researchers bridge their research interests to create new questions
centered on teaching and learning in authentic science learning environments. The authors engaged in this qualitative inquiry
present their perspectives on “what goes on,” “what we have learned,” and “what it means to the larger community.” 相似文献
12.
Summary impressions In some ways, this report shows progress in audio-visual education. The work is being headed up by more widespread adoption
of central coordination, more classroom teachers are prepared to use audio-visual materials in their classes, and there is
more wide-spread use of the materials.
On the other hand, there are some urgent needs that become so evident from these data. “More time” is the need, “more central
coordination” is the need, “more adapted classrooms” is the need, and separately and behind all these is the need for “better
support.”
This article is a digest of a report given at the DAVI national convention in Los Angeles in April. The address was entitled
“A First Look at Findings of the NEA Survey of the Status of Audio-Visual Education in City and County School Systems.” Victor
Hornbostel is assistant director of the Research Division of the National Education Association and supervisor of the survey
which is reported. 相似文献
13.
France Frascarolo Chantal Zaouche-Gaudron Véronique Rouyer Nicolas Favez 《European Journal of Psychology of Education - EJPE》2005,20(2):185-199
The aim of this pilot study is to analyse the discourse of fathers of toddlers concerning fatherhood and the link between
some particularities in the discourse and family alliance. The sample consists of 13 Swiss first time fathers (5 fathers of
girls and 8 of boys). In order to evaluate the paternal discourse, the fathers were given a semistructured interview, which
was later analysed using the research package Alceste. The family alliance, i.e., the degree of coordination among the partners
when executing a task together, was assessed through the Lausanne Trilogue Play (Fivaz-Depeursinge & Corboz-Warnery, 1999).
The main results indicated an interesting link between classes of paternal discourse grouped around the following themes “affective
relationship”, “daily routine” and “educational goals”, and the family alliance (defined in two major categories; functional
and problematic alliances). Finally, clinical perspectives on links between paternal representations and family functioning
at an interactive level are discussed. 相似文献
14.
A new representation of the Maxwell relation for phase transformation is given, which is expressed in simpler form and has more direct physical meaning than the original Maxwell relation. It is shown that the physical conjecture for the so-called “lock-up” condition suggested by Jensen （1999） is correct, but the equation for the “lock-up” condition suggested by Jensen （1999） is not. Numerical examples also demonstrate that the application of the new representation of Maxwell relation gives exactly the same solutions as the ones with application of the original Maxwell relation and, however, application of the “lock-up” condition gives no real solutions. 相似文献
15.
Sylvia Rojas-Drummond Neil Mercer Ellen Dabrowski 《European Journal of Psychology of Education - EJPE》2001,16(2):179-196
Research in Mexican schools, drawing upon earlier research in the UK, has led to the development and use of a method for describing, comparing and evaluating the particular approaches and interactional strategies used by teachers and learners. Using this method, qualitative and quantitative comparisons are made to distinguish between teachers who use a conventional, formal, directive approach when teaching 5-year-old children mathematical skills (called the “Official” method) and those who use a more interactive, collaborative, supportive, “scaffolded” approach to teach similar classes of children (called the “High Scope” method). In an earlier study, we found more competent and independent problem-solving among High/Scope pupils than among their peers taught by the Official method. In the present study, discourse analysis and statistical analysis of the relative frequencies of types of teacher-pupil interaction in the classrooms of two “Official” teachers and two “High’ Scope” teachers are used to explain the improved problem-solving of the “High Scope” pupils. The findings support the view that by creating a more collaborative, scaffolded version of classroom education, teachers can more successfully enable children to develop their own problem-solving skills, learning strategies and curriculum-related understanding. The research also contributes to the development and implementation of methods for promoting a more effective style of teacher-learner interaction in the classroom. 相似文献
16.
Zhongping Hu 《Frontiers of Education in China》2007,2(2):201-213
One of the main reasons of the fact that Chinese moral education could hardly get out of its predicament is that “self-regard”
has been simply and unilaterally interpreted as the absolute opposite to morality, where “self-regard” is merely regarded
as the source of “everything evil”, and the fact that it is also the source of “everything good” is neglected. Actually, “self-regard”
is the nature of human beings who go for benefit and avoid harm, which is inevitable and reasonable. It is not naturally opposite
to altruism, for there is no problem concerning morality in self-regard itself, though there might be some in the means adopted.
Therefore, the aim of moral education is not to deprive a person of his/her intention of self-regard, but to normalize the
means he/she might adopt, so that he/she could suitably benefit himself/herself as he/she benefits others. It is proven by
the past experience and the present situation that the key premise for the Chinese moral education to get out of its predicament
is to set up a correct understanding over self-regard.
Translated from Xueshu Yanjiu 学术研究 (Academic Research), 2005, (6): 117–120 相似文献
17.
M K Chattopadhyay 《Resonance》2002,7(11):59-63
Cold-adapted organisms are known to accumulate cryoprotective substances inside their cells. Glycine betaine is a bacterial
cryoprotectant. It is believed to act by stabilizing cellular proteins and membranes at low temperature.
M K Chattopadhyay is working as a Scientist at the Centre for Cellular and Molecular Biology, Hyderabad, on cold adaptation
in Antarctic bacteria.
“There is for me powerful evidence that there is something going on behind it all… It seems as though somebody has fine-tuned
nature’s numbers to make the Universe… The impression of design is overwhelming.” 相似文献
18.
谈玲芳 《孝感职业技术学院学报》2003,6(2):77-79
目前已发现数个Bcl-2基因家族成员。主要有Bcl-2、Bax等，它们调节子宫内膜细胞的凋亡，与子宫内膜增生、癌变有密切联系。 相似文献
19.
Megumi Nakamura Agnes M. Watanabe-Muraoka 《International journal for the advancement of counseling》2006,28(3):213-226
This research was conducted with the aim of clarifying a concept of “global social responsibility.” A total sample of 395 senior high school students in Japan responded to a pool of items mostly adapted from a scale developed by Starrett (1996) and provided additional data concerning their social experiences. The data were used in the development of a Japanese version of the Global Social Responsibility (GSR) scale. It was found that “global altruism,” “active involvement with society,” and “understanding of interdependence” constituted a construct of global social responsibility. It was also found that females, those who discussed social problems with their family, those who revealed a high awareness of responsibility and those who had multiple experiences of volunteer activities for community service showed high GSR scores. The scale provides both an awareness of the concept and a measure for determining levels of global social responsibility. Counseling professionals are encouraged to consider their roles from a global and social perspective, with the notion of responsibility being seen as central to the concepts of freedom and personal development. 相似文献
20.
The 2009 Nobel Prize in Chemistry was awarded jointly to Venkatraman Ramakrishnan, Thomas Steitz and Ada Yonath “for studies
on the structure and function of the ribosome”. The ribosome is a massive molecular machine comprising proteins and RNA and
is responsible for the synthesis of proteins, often termed the workhorses of the cell. Proteins are key players in almost
all intracellular transactions and hence the importance of the ribosome. 相似文献