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慢性肾衰竭是由多种原因造成的肾脏慢性损伤以及进行性恶化的结果,其临床表现复杂,涉及到多个系统的损伤。其中,肾性贫血(RA)是慢性肾衰竭常见的严重并发症,也是导致慢性肾病进展和增加心血管并发症的重要危险因素,影响到患者的生活质量,并与预后密切相关。目前中医药在肾性贫血的治疗上疗效显著,在临床治疗上有其不可替代的作用,现对近年来中医药治疗肾性贫血的研究进展做一综述,以供临床参考。 相似文献
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尿毒症是慢性肾功能衰竭的终末期。此时,患者自身的肾脏功能几近丧失,必须依赖肾脏替代治疗才能维持生命。所谓肾脏替代治疗,就是用医疗手段来代替或弥补丧失的’肾功能。目前,这种替代手段包括透析（血液透析和腹膜透析）和肾移植两种,二者各有优劣。慢性肾功能衰竭患者应当在进入尿毒症之前,就对这两种治疗模式有充分的了解,以便做出恰当的选择。移植是公认首选肾移植是公认的尿毒症首选的治疗方式。首先,移植肾不仅能充分满足机体排除代谢废物的需要,而且对内环境稳态的调节和维持均可在一定程度上接近正常人水平。此外还有营养作用和内分泌作用（包括抗贫血和调节骨骼代谢）,故能够较全面地替代肾脏的功能。成功的肾移植能迅速纠正或改善尿毒症的症状及其并发症,如贫血、皮肤瘙痒、食欲不佳、不安腿综合征、高血压、肾性骨营养不良、周围神经病变、性功能障碍等。 相似文献
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肾脏疾病的发病率是非常高的,全国的病人数至少有几百万人,每年因肾病的恶化而丧失劳动力和危及生命者,为数也相当可观。因此,积极开展肾病的研究,做好肾病的防治工作,是一项保障大众健康的、非常重要的任务。常见肾病急性肾炎、慢性肾炎、慢性肾功能不全、尿路感染,都属肾脏的常见病。急性肾炎是青少年的常见病、多发病,常在溶血性链球菌感染后 相似文献
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随着人们生活质量的提高和休息时间的增多,健身运动由需要变为必要和可能,甚至已经成为一种时尚,人们越来越关注健身运动对身体的影响.健身运动能塑造强健的身体,提高身体的适应能力,增强心脑血管系统的功能,预防和诊治各种常见的慢性疾病.由此可见,健身运动对身体的影响正面影响是巨大的.但是一些不合理的健身运动也会对身体造成一些负面的影响.因此,我们在从事健身运动时一定要根据自身的身体状况,科学健身,安全健身. 相似文献
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目前状况下,我国经济发展迅速,在这一大环境之下各行各业都取得了一定程度的发展。就电力行业而言,近年来不断对新技术、新工艺进行有效的创新与引进,也取得了一定的成绩。其中DCS便具有一定的典型性,通过对DCS进行一定程度上的使用,可以对电厂生产管理水平的提升进行有效实现。但与此同时,它也对电厂机组运行的安全性造成了一定程度上的影响,最为常见的便是DCS故障,本文就主要结合桌一发电厂,针对DCS失电故障原因分析及其应对措施进行研究与分析。 相似文献
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随着社会的快速转型,城市道路桥梁的工程建设项目越来越受到普及和重视,特别是在当今科学技术不断发展的时代之下,我们对这些工程的质量安全水平提出了更高的要求。但值得特别注意的是,道路桥梁建设工程是一项极其复杂的系统性施工项目,如果在某一个环节出现问题,就必然会对其他各个环节产生一定的影响,特别是对于防水路基面的建设而言更是如此。接下来本文就针对这一问题进行详细的探讨,以提供给业内有关人士一些启发性的指导。 相似文献
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腹膜透析(简乐腹透)是维持和延长尿毒症患者生命的血液净化方法之一。我区尿毒症患者选择以腹膜透析作为替代治疗的患者也越来越多。我们的体会是对腹膜透析患者做好健康教育工作,对提高患者的生活质量,减少腹膜透析的不良事件,使患者减少各种并发症的发生,提高了患者的生活质量,对生活充满信心,具有非常重要的临床意义。 相似文献
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本文针对目前影响黑龙江省中学教师体育生活方式的现状进行调查研究。通过文献资料法、问卷调查法以及数理统计法对影响中学教师体育生活方式的主要因素进行了较为详细的分析,希望能为制定群众体育方针、政策、措施提供一定的参考。 相似文献
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Vivek B. Kute Aruna V. Vanikar Pankaj R. Shah Manoj R. Gumber Himanshu V. Patel Divyesh P. Engineer Umang G. Thakkar Hargovind L. Trivedi 《Indian journal of clinical biochemistry : IJCB》2013,28(4):429-432
Down syndrome is one of the most common genetic causes of learning disabilities in children. Although the incidence of renal and urological involvement in Down syndrome is not very common, monitoring of patients with Down syndrome for renal diseases should be done regularly as patient’s age into the second and third decades. With increased survival, it appears that a growing number of these patients present with chronic renal failure. Down syndrome patients are apparently not suited for peritoneal dialysis because of lacking cooperation. This procedure can be prone to failure, mainly because of an increased risk of peritonitis. Handling such patients especially those on peritoneal dialysis is challenging. Here we report a case of Down syndrome with end-stage renal disease treated with hemodialysis for 6 months. To the best of our knowledge and current literature review this is the first case report of a patient with Down syndrome undergoing hemodialysis. 相似文献
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目的：为了解慢性肾衰竭（ CRF）患者的心脏损害情况,并探讨这种心脏损害的影响因素。方法：选择2012年一月至2013年1月收治的慢性肾衰竭30例患者作为观察组,另选同一时间段未患慢性肾衰竭30例患者作为对照组。将超声心动图检查两组患者的LAD,LAPWs,LAPWd,IVSTd,IVSTs, SV,EF等数据进行评价,分析慢性肾衰竭后患者心功能受损的情况。结果：检查后的两组数据显示,肾衰竭组LAD,LAPWs,LAPWd,IVSTd,IVSTs较对照组显著增加,具有患者心脏彩超异常者占93.3%（28/30）,具有统计学意义（p〈0.05）,观察组SV,EF,A,E较对照组明显增高,异常者为96.6%（29/30）。对照组心脏超声主要表为左室扩大、左室肥厚、左房扩大、瓣膜反流及心功能不全,尤以左室舒张功能损害为主。这些心脏损害的主要影响因素有尿毒症毒素、高血压、贫血。尽早透析,积极控制高血压,纠正贫血是预防和治疗CRF患者心脏并发症的主要手段。结论：对于肾衰竭患者而言,心脏彩超是一种无创性的较准确地反心脏形态和心功能受损的辅助检查方法。 相似文献
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Pradeep Naik B. Premsagar M. Mallikarjuna 《Indian journal of clinical biochemistry : IJCB》2015,30(1):94-98
The acute renal failure is the frequent medical complication observed in liver transplant patients. The objective of this study was to determine the cause of acute renal failure in post liver transplant patients. A total of 70 patients who underwent (cadaveric 52, live 18) liver transplantation were categorized based on clinical presentation into two groups, namely hepatorenal failure (HRF, n = 29), and Hepatic failure (HF, n = 41). All the patients after the liver transplant had received tacrolimus, mycophenolate and steroids. We analyzed the modification of diet in renal disease, (MDRD) serum urea, creatinine and albumin before and after 5th and 30th day of liver transplant and data was categorized into survivors and non-survivors group. In HRF survivor group, serum creatinine, and urea levels were high and, albumin, MDRD were low in pre- transplant and reached to normal levels on 30th day of post transplant, and 79.3 % of patients in this group showed resumption of normal kidney function. On the contrary in HRF nonsurvivor group, we did not observed any significant difference and 20.7 % of patients showed irreversible changes after the liver transplant. In HF survivor group, 82.9 % of liver failure patients did not show any deviation in serum creatinine, urea, albumin and MDRD, whereas in HF non survivor group, 17.1 % of liver failure patients who had HCV positive before the transplant developed acute renal failure. The levels of creatinine, urea, albumin and MDRD were normal before the transplant and on day 30th, the levels of albumin and MDRD were significantly low whereas serum urea, creatinine levels were high. In conclusion, based on these observations, an diagnosis and treatment of Acute renal failure is important among the liver transplantation cases in the early postoperative period. 相似文献
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Vivek B. Kute Aruna V. Vanikar Manoj R. Gumber Himanshu V. Patel Pankaj R. Shah Sachin B. Patil Hargovind L. Trivedi 《Indian journal of clinical biochemistry : IJCB》2013,28(2):201-205
Bardet-Biedl syndrome (BBS) is a rare autosomal recessive condition characterized by retinitis pigmentosa, postaxial polydactyly, central obesity, and renal involvement. Renal failure is the commonest cause of death. We report a case of BBS with chronic kidney disease (CKD) at younger age (17 year) from India. This diagnosis should be considered in patients with renal disease and the characteristic phenotype of retinitis pigmentosa, postaxial polydactyly and central obesity. These patients should undergo regular monitoring of renal function test to early diagnosis and treatment of CKD to prevent morbidity and mortality. Renal transplantation is a viable option of renal replacement therapy in these patients. These findings are valuable for comparing phenotype of BBS patients with CKD from various national and international centers. 相似文献
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Murali Woodi Amit Kumar Mondal Balaram Padmanabhan Krishnaswamy Patnam Rajagopalan 《Indian journal of clinical biochemistry : IJCB》2009,24(1):23-29
Mass spectrometry provides a convenient platform for the study of different protein post translational modifications from
clinical specimen. Analysis of different post translational modifications of hemoglobin like glycation and glutathionylation
can provide useful information on the disease progression and the possible outcome of therapies. In the present study, we
have addressed post translational modifications of hemoglobin like glutathionylation and glycation in relation to diabetes
and chronic renal failure. We found that both alpha and beta chains of human hemoglobin are glycated irrespective of the extent
of glycemia as evidenced by a mass increment of 162 Da. The phenomenon of glutathionylation was observed with only the beta
globin chain of hemoglobin probably due to the presence of an accessible cysteine residue indicated by a mass increment of
305 Da. Also, the extent of gltuathionylation observed in the CRF patients could correlate with the severity of the oxidative
stress owing to renal replacement therapies like dialysis and transplantation. 相似文献
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Servin Yeşil Günal Bilal Üstündağ Ali İhsan Günal 《Indian journal of clinical biochemistry : IJCB》2013,28(4):390-395
The aim of this study is to evaluate the oxidative stress in predialysis, hemodialysis (HD) and peritoneal dialysis patients and to test the effects of antihypertensive drugs and volume control on oxidative stress parameters. The study was composed of five groups as follows: control group (n = 30), predialysis group (n = 30), peritoneal dialysis group (n = 30), hemodialysis group, (normotensive with strict volume control, n = 30), hemodialysis group (normotensive with medication, n = 30). Plasma malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) and routine biochemical parameters were studied in all patients. Hemodialysis patients with strict volume control (HDvc) had lower levels of MDA than other patient groups (p < 0.001), and CAT, SOD values had highest level other patient groups (p < 0.001). The treatment of hypertension with strict volume control in chronic renal failure patients causes less damage to the antioxidant capacity. 相似文献
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慢性心力衰竭(chronic hear failure,CHF)是一种极为复杂的临床综合征,是各种心脏病发展的最终阶段,严重危害患者及家属的生命安全和心理健康。生活质量能较全面评价生活优劣。近年来对影响心力衰竭患者生活质量的因素及干预措施不断涌现。文章结合循证医学证据和国内外最新研究,对慢性心力衰竭的生活质量及干预措施研究进展作一综述。 相似文献
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The estimated glomerular filtration rate (eGFR) is a parameter derived from the serum creatinine, patient age and gender and is used to ascertain renal function. It is subject to variation because of the analytical error of the creatinine measurement and biological variation. The widespread use of the eGFR to classify renal disease has led to the identification of more patients with marginal chronic kidney disease but because of the uncertainty of the eGFR it has also led to over-diagnosis of some kidney disease. There is a well described age relation with eGFR.The uncertainty of the eGFR at the critical decision level of 60 mL/min/1.73 m2 is calculated to be 11. Caution needs to be exercised when interpreting an eGFR between 49 and 71 mL/min/1.73 m2. 相似文献
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C. S. Parameswari B. Vijayageetha R. Vijayakumar 《Indian journal of clinical biochemistry : IJCB》2006,21(1):131-136
The oxidative modification of lipoprotein especially low density lipoprotein (LDL) plays a key role in the initiation and
progression of atherosclerosis. Serum apolipoproteinB (apoB) level is found to be an important marker for atherosclerosis.
The present paper focuses on the measurement of serum apoB levels and the effect of Vitamin E, Vitamin C and reduced glutathione
on the copper ion induced oxidation of LDL + VLDL (VLDL-Very Low Density Lipoprotein) lipoprotein fraction isolated from the
serum of chronic renal failure (CRF) and renal transplanted patients. The level of apoB is significantly higher in the serum
of transplanted patients when compared to CRF patients and normal subjects. The level of TBARS formed in oxidized LDL + VLDL
lipoprotein fraction of CRF and renal transplanted patients are significantly increased than normal even in the presence of
antioxidants but the level of TBARS produced, with antioxidants is comparatively lesser than that produced by oxidized lipoprotein
fraction without antioxidants. It may be concluded than that produced by oxidized lipoprotein fraction without antioxidants.
It may be concluded that oxidation of LDL can be prevented at an earlier stage by Vitamin E supplementation. The supplementation
with Glutathione serves as the best method of preventing the lipoprotein oxidation among the renal diseased patients. 相似文献