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1.
Abstract

This study examined associations between four health-related physical fitness measures and obesity in Taiwanese youth aged 10–18 years. Data from 13,500 school-aged youth were randomly selected from the “School Physical Fitness Database” of Taiwan by sex and age. Variables examined were height, body mass and performance on modified sit-and-reach (flexibility), bent-leg sit-up (abdominal muscular strength/endurance), standing long jump (lower body explosive strength) and distance run/walk (cardiorespiratory endurance). Adjusted logistic regression analyses were performed. Increased odds of being obese with decreased fitness levels were observed for lower body explosive strength and cardiorespiratory endurance in both sexes. The highest odds of being obese was found in the least fit quintile of cardiorespiratory endurance compared with the most fit quintile both in boys (Odds ratio, OR = 10.44; 95% confidence interval (CI), 7.94–13.73) and girls (OR = 5.40; 95% CI, 3.90–7.47). These findings suggest that in addition to cardiorespiratory fitness, lower body explosive strength is also associated with childhood and adolescent obesity.  相似文献   

2.
Abstract

The purpose of this project was to evaluate the utility of low- and high-repetition maximum (RM) strength tests used to assess rowers. Twenty elite heavyweight males (age 23.7 ± 4.0 years) performed four tests (5 RM, 30 RM, 60 RM and 120 RM) using leg press and seated arm pulling exercise on a dynamometer. Each test was repeated on two further occasions; 3 and 7 days from the initial trial. Per cent typical error (within-participant variation) and intraclass correlation coefficients (ICCs) were calculated using log-transformed repeated-measures data. High-repetition tests (30 RM, 60 RM and 120 RM), involving seated arm pulling exercise are not recommended to be included in an assessment battery, as they had unsatisfactory measurement precision (per cent typical error > 5% or ICC < 0.9). Conversely, low-repetition tests (5 RM) involving leg press and seated arm pulling exercises could be used to assess elite rowers (per cent typical error ≤ 5% and ICC ≥ 0.9); however, only 5 RM leg pressing met criteria (per cent typical error = 2.7%, ICC = 0.98) for research involving small samples (n = 20). In summary, low-repetition 5 RM strength testing offers greater utility as assessments of rowers, as they can be used to measure upper- and lower-body strength; however, only the leg press exercise is recommended for research involving small squads of elite rowers.  相似文献   

3.
The aim of this study was to determine if a potential relationship among physical activity (PA), fundamental movement skills and weight status exists amongst early adolescent youth. Participants were a sample of 85 students; 54 boys (mean age = 12.94 ± 0.33 years) and 31 girls (mean age = 12.75 ± 0.43 years). Data gathered during physical education class included PA (accelerometry), fundamental movement skills and anthropometric measurements. Standard multiple regression revealed that PA and total fundamental movement skill proficiency scores explained 16.5% (P < 0.001) of the variance in the prediction of body mass index. Chi-square tests for independence further indicated that compared with overweight or obese adolescents, a significantly higher proportion of adolescents classified as normal weight achieved mastery/near-mastery in fundamental movement skills. Results from the current investigation indicate that weight status is an important correlate of fundamental movement skill proficiency during adolescence. Aligned with most recent research, school- and community-based programmes that include developmentally structured learning experiences delivered by specialists can significantly improve fundamental movement skill proficiency in youth.  相似文献   

4.
The goal of this randomized, double-blind, cross-over study was to assess the acute effects of caffeine ingestion on muscular strength and power, muscular endurance, rate of perceived exertion (RPE), and pain perception (PP) in resistance-trained men. Seventeen volunteers (mean?±?SD: age?=?26?±?6 years, stature?=?182?±?9?cm, body mass?=?84?±?9?kg, resistance training experience?=?7?±?3 years) consumed placebo or 6?mg?kg?1 of anhydrous caffeine 1?h before testing. Muscular power was assessed with seated medicine ball throw and vertical jump exercises, muscular strength with one-repetition maximum (1RM) barbell back squat and bench press exercises, and muscular endurance with repetitions of back squat and bench press exercises (load corresponding to 60% of 1RM) to momentary muscular failure. RPE and PP were assessed immediately after the completion of the back squat and bench press exercises. Compared to placebo, caffeine intake enhanced 1RM back squat performance (+2.8%; effect size [ES]?=?0.19; p?=?.016), which was accompanied by a reduced RPE (+7%; ES?=?0.53; p?=?.037), and seated medicine ball throw performance (+4.3%, ES?=?0.32; p?=?.009). Improvements in 1RM bench press were not noted although there were significant (p?=?.029) decreases in PP related to this exercise when participants ingested caffeine. The results point to an acute benefit of caffeine intake in enhancing lower-body strength, likely due to a decrease in RPE; upper-, but not lower-body power; and no effects on muscular endurance, in resistance-trained men. Individuals competing in events in which strength and power are important performance-related factors may consider taking 6?mg?kg?1 of caffeine pre-training/competition for performance enhancement.  相似文献   

5.
Understanding how loading affects power production in resistance training is a key step in identifying the most optimal way of training muscular power – an essential trait in most sporting movements. Twelve elite male sailors with extensive strength-training experience participated in a comparison of kinematics and kinetics from the upper body musculature, with upper body push (bench press) and pull (bench pull) movements performed across loads of 10–100% of one repetition maximum (1RM). 1RM strength and force were shown to be greater in the bench press, while velocity and power outputs were greater for the bench pull across the range of loads. While power output was at a similar level for the two movements at a low load (10% 1RM), significantly greater power outputs were observed for the bench pull in comparison to the bench press with increased load. Power output (P max) was maximized at higher relative loads for both mean and peak power in the bench pull (78.6 ± 5.7% and 70.4 ± 5.4% of 1RM) compared to the bench press (53.3 ± 1.7% and 49.7 ± 4.4% of 1RM). Findings can most likely be attributed to differences in muscle architecture, which may have training implications for these muscles.  相似文献   

6.
Abstract

Untrained subjects can display diverse strength gain following an identical period of resistance exercise. In this investigation, 28 untrained males completed 16-weeks of resistance exercise, comprising 4-weeks familiarisation, and 12-weeks of heavy-load (80–85%) activity. High and low responders were identified by the Δ1RM (Δ one repetition maximum) observed following familiarisation (25.1 ± 1.4%, 9.5 ± 1.4%, P < 0.0001) and differences in electromyographic root mean square amplitude (ΔEMGRMS 29.5 ± 8.3%, 2.4 ± 6.0%, P = 0.0140), and habitual and occupational activity patterns were observed between these respective groups. The strength gain (P < 0.0001) observed within high (29.6 ± 1.7%) and low (31.4 ± 2.7%) responding groups was similar during the heavy-load phase, yet ΔEMGRMS increased (P = 0.0048) only in low responders (31.5 ± 9.3%). Retrospectively, differences (P < 0.0001) in baseline 1RM strength of high- (19.7 ± 0.9 kg) and low-responding (15.6 ± 0.7 kg) groups were identified, and a strong negative correlation with Δ1RM after 16-weeks (r 2 = ?0.85) was observed. As such, baseline 1RM strength provided a strong predicative measure of strength adaptation. The ΔEMGRMS suggests strength variability within high and low responders may be attributed to neural adaptation. However, differences in habitual endurance and occupational physical activity suggests one should consider screening not only recent resistance training, but also other modes of physical activity during participant recruitment.  相似文献   

7.
This study compared the functional and neural effects of two strength training programmes differing in set configuration. Thirteen participants performed 10 sessions, over a period of 5 weeks, of unilateral leg extensions with different set configurations but with identical work-to-rest ratios for each limb: a traditional configuration (4 sets of 8 repetitions, 10RM load, 3-min pause between sets) and an inter-repetition rest configuration (32 repetitions, 10RM load, 17.4 s of rest between each repetition). Mean propulsive velocity of the traditional sessions was lower than for inter-repetition rest sessions (0.48 ± 0.06 vs. 0.54 ± 0.06 m · s?1; P < 0.001), while perceived exertion was higher (8.3 ± 0.9 and 6.56 ± 1.6 for traditional training and IRT; P = 0.002). One repetition maximum (RM), work with 10RM load, maximum mean propulsive power, maximum voluntary contraction and time to failure with 50% of maximum isometric force improved similarly in both legs (time effect, P < 0.001; effect size range, 0.451–1.190). Time and set configuration did not show significant main effects or interactions for cortical adaptations (motor-evoked potentials, short-interval intracortical inhibition, intracortical facilitation). There were no significant correlations between changes in cortical and peripheral neural adaptations and strength improvement. In conclusion, inter-repetition rest configuration was as effective as traditional training in improving muscle performance.  相似文献   

8.
Participation in youth sport is assumed to promote and contribute towards more physically active lifestyles among children and adolescents. The aim of this study was to examine inter-participant variability in objectively measured habitual physical activity (PA) behaviours and sedentary time among youth sport participants and their implications for health. One-hundred-and-eighteen male youth sport footballers (Mean ± s = 11.72 ± 1.60) wore a GT3X accelerometer for 7 days. Average daily PA [min · day?1, in light (LPA), moderate (MPA), vigorous (VPA) and combined moderate-to-vigorous (MVPA)] and sedentary time were calculated. Participants’ body mass index adjusted for age and sex (BMI–standard deviation score), per cent body fat (BF%), waist circumference and cardiorespiratory fitness were assessed. Results revealed that variability in daily PA behaviours and sedentary time (min · day?1) was associated with BMI–standard deviation score [VPA (?), MVPA (?)], BF% [sedentary time (+), VPA (?), MVPA (?)], waist circumference [sedentary time (+), LPA (?)] and cardiorespiratory fitness [sedentary time (?), MPA (+), VPA (+), MVPA (+)]. Whilst sedentary time and MVPA were not related to health outcomes independent of one another, associations with markers of adiposity and cardiorespiratory fitness were stronger for sedentary time. Sedentary time was also significantly positively related to waist circumference independent of VPA. Results demonstrate inter-participant variability in habitual PA and sedentary time among youth sport participants which holds implications for their health. Thus, promoting PA and, in particular, reducing sedentary time may contribute towards the prevention of adverse health consequences associated with a physically inactive lifestyle for children and adolescents active in the youth sport context.  相似文献   

9.
This study aimed to determine the suitability of the load-velocity relationship to prescribe the relative load (%1RM) in women, as well as to compare the load-velocity profile between sexes and participants with different strength levels. The load-velocity relationship of 14 men (1RM: 1.17 ± 0.19) and 14 women (1RM: 0.66 ± 0.13) were evaluated in the bench press exercise. The main findings revealed that: (I) the load-velocity relationship was always strong and linear (R2 range: 0.987–0.993), (II) a steeper load-velocity profile was observed in men compared to women (Effect size [ES]: 1.09), with men showing higher velocities for light loads (ES: ? 0.81 and ? 0.40 for the y-intercept and 30%1RM, respectively), but women reporting higher velocities for the heavy loads (ES: 1.14 and 1.50 at 90%1RM and 100%1RM, respectively); and (III) while the slope of the load-velocity profile was moderately steeper for weak men compared to their strong counterpart (ES: 1.02), small differences were observed between strong and weak women (ES: ? 0.39). While these results support the use of the individual load-velocity relationship to prescribe the %1RM in the bench press exercise for women, they also highlight the large disparities in their load-velocity profile compared to men.  相似文献   

10.
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11.
We conducted a systematic literature review and meta-analysis to assess the chronic effects of the sequence of concurrent strength and endurance training on selected important physiological and performance parameters, namely lower body 1 repetition maximum (1RM) and maximal aerobic capacity (VO2max/peak). Based on predetermined eligibility criteria, chronic effect trials, comparing strength-endurance (SE) with endurance-strength (ES) training sequence in the same session were included. Data on effect sizes, sample size and SD as well other related study characteristics were extracted. The effect sizes were pooled using, Fixed or Random effect models as per level of heterogeneity between studies and a further sensitivity analyses was carried out using Inverse Variance Heterogeneity (IVHet) models to adjust for potential bias due to heterogeneity. Lower body 1RM was significantly higher when strength training preceded endurance with a pooled mean change of 3.96 kg (95%CI: 0.81 to 7.10 kg). However, the training sequence had no impact on aerobic capacity with a pooled mean difference of 0.39 ml.kg.min?1 (95%CI: ?1.03 to 1.81 ml.kg.min?1). Sequencing strength training prior to endurance in concurrent training appears to be beneficial for lower body strength adaptations, while the improvement of aerobic capacity is not affected by training order.  相似文献   

12.
The purpose of this study was to investigate the relationship between movement velocity and relative load in three lower limbs exercises commonly used to develop strength: leg press, full squat and half squat. The percentage of one repetition maximum (%1RM) has typically been used as the main parameter to control resistance training; however, more recent research has proposed movement velocity as an alternative. Fifteen participants performed a load progression with a range of loads until they reached their 1RM. Maximum instantaneous velocity (Vmax) and mean propulsive velocity (MPV) of the knee extension phase of each exercise were assessed. For all exercises, a strong relationship between Vmax and the %1RM was found: leg press (r2adj = 0.96; 95% CI for slope is [?0.0244, ?0.0258], P < 0.0001), full squat (r2adj = 0.94; 95% CI for slope is [?0.0144, ?0.0139], P < 0.0001) and half squat (r2adj = 0.97; 95% CI for slope is [?0.0135, ?0.00143], P < 0.0001); for MPV, leg press (r2adj = 0.96; 95% CI for slope is [?0.0169, ?0.0175], P < 0.0001, full squat (r2adj = 0.95; 95% CI for slope is [?0.0136, ?0.0128], P < 0.0001) and half squat (r2adj = 0.96; 95% CI for slope is [?0.0116, 0.0124], P < 0.0001). The 1RM was attained with a MPV and Vmax of 0.21 ± 0.06 m s?1 and 0.63 ± 0.15 m s?1, 0.29 ± 0.05 m s?1 and 0.89 ± 0.17 m s?1, 0.33 ± 0.05 m s?1 and 0.95 ± 0.13 m s?1 for leg press, full squat and half squat, respectively. Results indicate that it is possible to determine an exercise-specific %1RM by measuring movement velocity for that exercise.  相似文献   

13.
The purpose of this study was to determine whether the sequence of strength training before endurance training (ST/ET) is more or less effective than endurance training followed by strength training (ET/ST). Twenty‐three females and 11 males were assigned to one of three groups: ST/ET (n= 15), ET/ST (n= 15) or control (n = 4). The 7‐week training programme consisted of strength training using 10 exercises for two sets of 3–12 repetitions and running for 20–25 min at 60–90% of heart rate reserve. Maximal oxygen uptake (VO2 max) was measured during a graded treadmill test, and muscular strength was assessed using one‐repetition maximum tests for the bench press (BP), shoulder press (SP), arm curl (AC) and leg press (LP). The VO2 max significantly (P < 0.05) increased 6.7 and 6.2% for the ST/ET and ET/ST groups, respectively. There was no significant (P > 0.05) difference between the two experimental groups. Muscular strength significantly (P <0.05) improved by 15.2% (BP), 16.6% (SP), 17.2% (AC) and 11.9% (LP) for the ST/ET group and 19.9% (BP), 24.1% (SP), 20.9% (AC) and 14.0% (LP) for the ET/ST group. There were no significant (P > 0.05) differences between the two experimental groups for the BP, AC and LP; however, the ET/ST group increased (P < 0.05) SP strength more than the ST/ET group. In conclusion, adaptations to a combination of short‐term endurance and strength training as assessed by VO2 max and BP, AC and LP strength appear to be independent of whether endurance training occurs prior to or following strength training.  相似文献   

14.
Recently, there has been growing interest in high-intensity interval training (HIT) as a strategy to improve health. In this pilot study, we examined the feasibility of a 4-week low-volume HIT and its effects on cardiorespiratory fitness (CRF), blood pressure (BP) and enjoyment in overweight and obese youth. Twelve adolescents (body mass index (BMI): 34.8 ± 3.9 kg · m?2, 14.9 ± 1.5 years) participated in 12 sessions of HIT (10 × 60 s cycling bouts eliciting ~90% maximal heart rate, interspersed with 90 s recovery, 30 min/session, 3 sessions/week) over ~4 weeks. All the participants completed the study and exercise attendance averaged 92%. Despite no changes in body weight and total fat, HIT resulted in significant (P < 0.01) increases in CRF (pre: 20.1 versus post: 22.2 ml · kg?1 · min?1) and exercise time (pre: 425 versus post: 509 s) during peak oxygen uptake test, and a reduction in resting systolic BP (pre: 115.8 versus post: 107.6 mmHg). The majority of study participants (83%) enjoyed HIT and more than half of the participants (58%) reported that HIT is a more enjoyable form of exercise compared to other types of exercises. Low-volume HIT is a useful strategy to promote exercise participation and improve cardiovascular health in overweight and obese youth.  相似文献   

15.
Abstract

The purpose of this study was to assess the effects of heavy resistance, explosive resistance, and muscle endurance training on neuromuscular, endurance, and high-intensity running performance in recreational endurance runners. Twenty-seven male runners were divided into one of three groups: heavy resistance, explosive resistance or muscle endurance training. After 6 weeks of preparatory training, the groups underwent an 8-week resistance training programme as a supplement to endurance training. Before and after the 8-week training period, maximal strength (one-repetition maximum), electromyographic activity of the leg extensors, countermovement jump height, maximal speed in the maximal anaerobic running test, maximal endurance performance, maximal oxygen uptake ([Vdot]O2max), and running economy were assessed. Maximal strength improved in the heavy (P = 0.034, effect size ES = 0.38) and explosive resistance training groups (P = 0.003, ES = 0.67) with increases in leg muscle activation (heavy: P = 0.032, ES = 0.38; explosive: P = 0.002, ES = 0.77). Only the heavy resistance training group improved maximal running speed in the maximal anaerobic running test (P = 0.012, ES = 0.52) and jump height (P = 0.006, ES = 0.59). Maximal endurance running performance was improved in all groups (heavy: P = 0.005, ES = 0.56; explosive: P = 0.034, ES = 0.39; muscle endurance: P = 0.001, ES = 0.94), with small though not statistically significant improvements in [Vdot]O2max (heavy: ES = 0.08; explosive: ES = 0.29; muscle endurance: ES = 0.65) and running economy (ES in all groups < 0.08). All three modes of strength training used concurrently with endurance training were effective in improving treadmill running endurance performance. However, both heavy and explosive strength training were beneficial in improving neuromuscular characteristics, and heavy resistance training in particular contributed to improvements in high-intensity running characteristics. Thus, endurance runners should include heavy resistance training in their training programmes to enhance endurance performance, such as improving sprinting ability at the end of a race.  相似文献   

16.
ABSTRACT

The purpose of this study was to validate an alternative skinfold equation for women created from dual-energy x-ray absorptiometry (DXA). Anthropometrics and a whole-body DXA scan were completed on 77 women (mean age: 28.0 ± 10.2 years). Four Jackson-Pollack (JP) skinfold prediction equations and the DXA criterion (DC) equation were compared to DXA-derived body fat percentage (%BF). One-way repeated measures ANOVA revealed significant differences (p ≤ .001) in the %BF with post hoc-comparisons revealing significant differences among JP7 (21.3 ± 5.7), JP4 (21.4 ± 5.7), JP3a (22.2 ± 5.9), and JP3b (22.6 ± 5.7) when compared to the DXA-derived %BF; no significant difference existed between DC %BF (26.5 ± 5.6) and DXA-derived %BF (26.5 ± 5.4) (p = 1.0). The DC equation more accurately predicted %BF in women volunteers compared to Jackson-Pollack equations.  相似文献   

17.
The purpose of this study was to analyse the validity and reliability of a novel iPhone app (named: PowerLift) for the measurement of mean velocity on the bench-press exercise. Additionally, the accuracy of the estimation of the 1-Repetition maximum (1RM) using the load–velocity relationship was tested. To do this, 10 powerlifters (Mean (SD): age = 26.5 ± 6.5 years; bench press 1RM · kg?1 = 1.34 ± 0.25) completed an incremental test on the bench-press exercise with 5 different loads (75–100% 1RM), while the mean velocity of the barbell was registered using a linear transducer (LT) and Powerlift. Results showed a very high correlation between the LT and the app (r = 0.94, SEE = 0.028 m · s?1) for the measurement of mean velocity. Bland–Altman plots (R2 = 0.011) and intraclass correlation coefficient (ICC = 0.965) revealed a very high agreement between both devices. A systematic bias by which the app registered slightly higher values than the LT (P < 0.05; mean difference (SD) between instruments = 0.008 ± 0.03 m · s?1). Finally, actual and estimated 1RM using the app were highly correlated (r = 0.98, mean difference (SD) = 5.5 ± 9.6 kg, P < 0.05). The app was found to be highly valid and reliable in comparison with a LT. These findings could have valuable practical applications for strength and conditioning coaches who wish to measure barbell velocity in the bench-press exercise.  相似文献   

18.
This study compared knee angle-specific neuromuscular adaptations after two low-volume isometric leg press complex training programmes performed at different muscle lengths. Fifteen young males were divided into two groups and trained three times per week for 6 weeks. One group (n?=?8) performed 5–7 sets of 3 s maximum isometric leg press exercise, with 4?min recovery, with knee angle at 85°?±?2° (longer muscle-tendon unit length; L-MTU). The other group (n?=?7) performed the same isometric training at a knee angle of 145°?±?2° (180°?=?full extension; shorter muscle-tendon unit length; S-MTU). During the recovery after each set of isometric exercise, participants performed two CMJ every minute, as a form of complex training. Maximum isometric force (MIF) and rate of force development (RFD) were measured over a wide range of knee angles. Countermovement jump (CMJ) performance and maximum half-squat strength (1RM) were also assessed. Training at S-MTU induced a large increase of MIF (22–58%, p?p?p?=?0.001). In contrast, training at L-MTU, resulted in a moderate and similar (≈12.3%, p?=?0.028) improvement of force at all knee angles. CMJ performance and 1RM were equally increased in both groups after training by 10.4%?±?8.3% and 7.8%?±?4.7% (p?相似文献   

19.
This study developed and validated a vector magnitude (VM) two-regression model (2RM) for use with an ankle-worn ActiGraph accelerometer. For model development, 181 youth (mean ± SD; age, 12.0 ± 1.5 yr) completed 30 min of supine rest and 2–7 structured activities. For cross-validation, 42 youth (age, 12.6 ± 0.8 yr) completed approximately 2 hr of unstructured physical activity (PA). PA data were collected using an ActiGraph accelerometer, (non-dominant ankle) and the VM was expressed as counts/5-s. Measured energy expenditure (Cosmed K4b2) was converted to youth METs (METy; activity VO2 divided by resting VO2). A coefficient of variation (CV) was calculated for each activity to distinguish continuous walking/running from intermittent activity. The ankle VM sedentary behavior threshold was ≤10 counts/5-s, and a CV≤15 counts/5-s was used to identify walking/running. The ankle VM2RM was within 0.42 METy of measured METy during the unstructured PA (P > 0.05). The ankle VM2RM was within 5.7 min of measured time spent in sedentary, LPA, MPA, and VPA (P > 0.05). Compared to the K4b2, the ankle VM2RM provided similar estimates to measured values during unstructured play and provides a feasible wear location for future studies.  相似文献   

20.
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13?±?5.75, body mass index (BMI) 30.86?±?1.63) were randomly distributed in the CT group (n?=?12) and control group (CG n?=?10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks. Body composition, physical fitness, plasma FNDC5/irisin, biochemical markers and metabolic scores/index were evaluated. CT maintained FNDC5/irisin levels (µg/mL) (pre: 4.15?±?0.32, post: 4.21?±?0.32; p?=?.96) and improved body composition, metabolic and physical fitness markers. In the CG, decreased FNDC5/irisin (µg/mL) (pre: 4.36?±?0.23, post: 3.57?±?0.94; p?=?.01) and reduced strength (supine exercise/kg) (pre: 71?±?14.7, post: 60.1?±?14.05; p?<?.01) were observed, along with a trend to increase HOMA-IR (pre: 2.63?±?1.11, post: 3.14?±?1.27; p?=?.07) and other indicators of metabolic deterioration. An inverse correlation was found between the change (Δ%) in levels of FNDC5/irisin and Δ% glucose, Δ% total cholesterol, Δ% triglycerides and Δ% waist circumference, in addition to a positive relation with Δ% muscle strength. In conclusion, CT maintained FNDC5/irisin levels and provided metabolic and fitness benefits. The correlation between FNDC5/irisin changes and metabolic parameters, as well as the FNDC5/irisin reduction associated with fitness and metabolic worsening in the CG, suggests a relationship between FNDC5/irisin and a healthy metabolic status in humans.  相似文献   

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