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1.
Enterprise content management (ECM) systems are implemented in many organizations to deal with the complexity of the structured and unstructured organizational data. The little available ECM literature shows that many organizations using ECM focus on short-term benefits while strategic decision-making benefits are rarely considered. Although the relationship between the use of ECM and decision support (DS) is investigated recently, there is scarcity in research that investigates the categories of DS capabilities that ECM systems may have. The objective of this paper is to determine whether ECM systems can have the DS capabilities of four categories of decision support systems, namely classic decision support systems (DSS), executive information systems (EIS), expert systems (ES), and group decision support systems (GDSS). The findings indicate that ECM systems can have all decision support capabilities of classic DSS, EIS, and ES. However, ECM systems can have only a portion of decision support capabilities of GDSS. 相似文献
2.
Vitamin C in Disease Prevention and Cure: An Overview 总被引：1，自引：0，他引：1
Shailja Chambial Shailendra Dwivedi Kamla Kant Shukla Placheril J. John Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2013,28(4):314-328
The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management. 相似文献
3.
Rashmi Raghuvanshi M. Chandra P. C. Misra M. K. Misra 《Indian journal of clinical biochemistry : IJCB》2005,20(1):26-29
Platelets play important role in precipitating ischaemic myocardial syndromes in many ways. One of the consequences of ischaemic
diseases is excessive generation of oxygen derived free radicals that have numerous pathophysiological consequences. Platelet
pro-oxidant enzyme, xanthine oxidase is one of the sources of generation of free radicals. In the present paper, we report
the effect of administration of vitamin E along with aspirin on the levels of platelet xanthine oxidase and extent of free
radical mediated damage in the patients reperfused after myocardial infarction.
Our findings show that administration of 400 mg. vitamin E for six days along with 80 mg. aspirin has an excellent anti-oxidant
effect as evidenced by reduced platelet xanthine oxidase activity and lowering of malondialdehdye (MDA) levels which is an
index of the extent of free radical mediated damage. 相似文献
4.
基于和谐管理理论的企业危机管理研究 总被引：4，自引：0，他引：4
随着经营环境的复杂多变,企业危机已成为一种常态,危机管理已成为企业及理论界最关注的热门话题之一.现有的危机管理理论众多,从危机的预防到各职能危机的应对应有尽有,但这些理论关注的往往只是危机管理的某一方面,对企业危机管理的动态性和整体性把握不够,难以为复杂多变的实际问题提供系统可行的指导.针对这一现状,结合企业危机的基本特点,引入致力于多变环境下复杂管理问题求解的和谐管理理论,对企业危机管理的内在机理进行了深入系统的分析.在和谐管理理论系统指导的基础上,给出了解决企业危机问题的一般框架,为企业危机管理提供了一条新思路. 相似文献
5.
Pasalic D Marinkovic N Feher-Turkovic L 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):63-75
With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms. 相似文献
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Yousef Rezaei Chianeh Rashmi Manjunath Krishnananda Prabhu Donald Fernandes M. Vidyasagar Asha Kamath 《Indian journal of clinical biochemistry : IJCB》2014,29(2):238-241
Oral squamous cell carcinoma is one of the most common malignancies recognized. Biomarkers which can predict presence of cancer and its progression can help in better management of these disorders. Over production of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. Studies have shown a correlation of butyrylcholinesterase (BChE), with tumourigenesis, cell proliferation and cell differentiation. Earlier we have observed a significant elevation in plasma BChE and protein thiols in oral cancer patients which correlated well with stages of cancer. As it was not clear whether the above markers will be altered in saliva of oral cancer patients this study was undertaken. Institutional Ethics Committee gave permission to carry out this study. Total of 55 subjects comprising healthy controls (n = 30) and biopsy proven oral cancer patients (n = 25) consented to participate in this study. Salivary samples from cases were taken before any definitive treatment. Protein thiols and BChE were estimated in salivary samples using validated assay methods. Oral cancer patients had a significant increase in pre-treatment salivary BChE levels (p ≤ 0.001) and a significant decrease (p ≤ 0.001) in salivary thiols as compared to respective values in controls. Salivary protein thiols and BChE may have a role in pathophysiology of oral cancer. Saliva can be used as a potential non-invasive screening tool in oral cancer patients. 相似文献
8.
The living system on earth is largely using oxygen for burning metabolic fuel for energy. The toxicity of oxygen is largely due to the formation of free radicals in living systems. Stress is also responsible for the generation of free radicals. The evidence for the involvement of free radicals and oxidative injury in producing metabolic disturbance, maladjustment and many diseases has been accumulating since long. It is largely believed that the root cause of many chronic diseases is stress induced free radicals and resultant oxidative injury. 相似文献
9.
《International Journal of Information Management》2016,36(2):207-214
As academic institutions produce large amounts of information in their teaching/research and administrative activities and this information should flow smoothly between departments, there appears the need to organize and manage this information thoroughly. In order to avoid information overlapping, this should happen considering the other internal existing systems. Nevertheless, because not all institutions afford to spend a lot on various systems, open source software is an appropriate solution for both educational and administrative services. Our aim is to prove the utility of Enterprise Content Management (ECM) in context of academic organizations. The first part makes an introduction to the concepts of ECM and open source software, as means to enhance process management. The second part regards the components of ECM systems and makes an analysis of their potential use in academic institutions. A system architecture based on ECM, by means of which ECM is usefully connected to other systems operating in educational establishments is proposed. A case study, discussing the implementation of an open source ECM in a large Romanian university, showing its efficacy and focusing on features related to document workflow, is analyzed. 相似文献
10.
For over a decade, researchers have devoted much effort to construct theoretical models, such as the Technology Acceptance Model (TAM) and the Expectation Confirmation Model (ECM) for explaining and predicting user behavior in IS acceptance and continuance. Another model, the Cognitive Model (COG), was proposed for continuance behavior; it combines some of the variables used in both TAM and ECM. This study applied the technique of structured equation modeling with multiple group analysis to compare the TAM, ECM, and COG models. Results indicate that TAM, ECM, and COG have quite different assumptions about the underlying constructs that dictate user behavior and thus have different explanatory powers. The six constructs in the three models were synthesized to propose a new Technology Continuance Theory (TCT). A major contribution of TCT is that it combines two central constructs: attitude and satisfaction into one continuance model, and has applicability for users at different stages of the adoption life cycle, i.e., initial, short-term and long-term users. The TCT represents a substantial improvement over the TAM, ECM and COG models in terms of both breadth of applicability and explanatory power. 相似文献
11.
Extracellular matrix (ECM) proteins are required for cell culture. In this paper, we report the use of O(2) plasma bonding to fabricate a perfusion culture microchamber array chip with identical-size ECM spots in the isolated microchambers. The chip was fabricated by assembly of two poly(dimethylsiloxane) (PDMS) layers, a microfluidic network layer, and an ECM array layer, which were aligned and then bonded by O(2) plasma oxidation with protection of the ECM microarray with a physical mask made from PDMS. We successfully cultivated Chinese hamster ovary K1 cells in the microchambers with fibronectin. In the fibronectin microchambers, the cells adhered and extended after 12 h of static culture and then grew over the course of 1 d of perfusion culture. 相似文献
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Goreta SS Dabelic S Dumic J 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(2):156-170
Biochemical and biological properties of glycoconjugates are strongly determined by the specific structure of its glycan parts. Glycosylation, the covalent attachment of sugars to proteins and lipids, is very complex and highly-coordinated process involving > 250 gene products. Deficiency of glycosylation enzymes or transporters results in impaired glycosylation, and consequently pathological modulation of many physiological processes. Inborn defects of glycosylation enzymes, caused by the specific mutations, lead to the development of rare, but severe diseases - congenital disorders of glycosylation (CDGs). Up today, there are more than 45 known CDGs. Their clinical manifestations range from very mild to extremely severe (even lethal) and unfortunately, only three of them can be effectively treated nowadays. CDG symptoms highly vary, though some are common for several CDG types but also for other unrelated diseases, especially neurological ones, leaving the possibility that many CDGs cases are under- or misdiagnosed. Glycan analysis of serum transferrin (by isoelectric focusing or more sophisticated methods, such as HPLC (high-performance liquid chromatography) or MALDI (matrix-assisted laser desorption/ionization)) or serum N-glycans (by MS), enzyme activity assays and DNA sequence analysis are the most frequently used methods for CDG screening and identification, since no specific tests are available yet. In this review we summarize the current knowledge on the clinical, biochemical and genetic characteristic of distinct CDGs, as well as existing diagnostic and therapeutic procedures, aiming to contribute to the awareness on the existence of these rare diseases and encourage the efforts to elucidate its genetic background, improve diagnostics and develop new strategies for their treatment. 相似文献
14.
Seyed Ebrahim Alavi Maedeh Koohi Moftakhari Esfahani Fatemeh Alavi Fatemeh Movahedi Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2013,28(3):299-302
It is clear that cancer is one of the most mortal diseases in the world and the most prevalent among women is breast cancer. As hydroxyurea (HU)—a drug which is used in chemotherapy—has many adverse effects in long-term despite of its therapeutic properties, we made use of nano drug delivery technology in order to reduce adverse effects and increase therapeutic index. Thus, liposomation is a novel way in drug delivery systems. In this study a mixture of phosphatidylcholine and cholesterol was mixed and HU was added to the resultant mixture. The mean diameter of the nanoliposomal HU measured with the Zeta Sizer device (equal to 402.5 nm) and its encapsulation efficiency was 70.8 %. Besides, using dialysis, the pattern of drug release from nanoliposomes has been studied and the results showed that the drug release of nanoliposomal drug within 28 h was equal to 25.85 %. This study showed that the cytotoxicity effect of nanoliposomal drug is more than that of the standard drug. 相似文献
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Shashi Seth Bina Ravi H. S. Randhawa Neelam Chillar Harbans Lal 《Indian journal of clinical biochemistry : IJCB》1996,11(1):49-51
Gamma-glutamyl transpeptidase (gamma-GT) levels were estimated in the sera of patients with breast cancer and compared with those of benign breast diseases and healthy controls. Serum gamma-GT levels were found to be significantly increased in patients with breast cancer compared to the controls as well as benign breast diseases. The rise however, was nearly same in all the patients irrespective of histopathology of cancer but was directly related to tumour mass. After mastectomy the levels remained higher upto 3 months. In patients with cancer the rise in serum gamma-GT was significantly higher as compared to those with benign breast diseases. Although gamma-GT is an index of liver diseases, its high level in breast carcinoma suggests the release of the membrane bound constituents from different tissues even in carcinoma. 相似文献
17.
Giovanna Tomaiuolo 《Biomicrofluidics》2014,8(5)
Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to navigate
across various human microcirculation vessels, enabling them to pass through capillaries that are
smaller than their diameter and to carry out their role as gas carriers between blood and tissues.
Since there is growing evidence that red blood cell deformability is impaired in some pathological
conditions, measurement of RBC deformability has been the focus of numerous studies over the past
decades. Nevertheless, reports on healthy and pathological RBCs are currently limited and, in many
cases, are not expressed in terms of well-defined cell membrane parameters such as elasticity and
viscosity. Hence, it is often difficult to integrate these results into the basic understanding of
RBC behaviour, as well as into clinical applications. The aim of this review is to summarize
currently available reports on RBC deformability and to highlight its association with various human
diseases such as hereditary disorders (e.g., spherocytosis, elliptocytosis, ovalocytosis, and
stomatocytosis), metabolic disorders (e.g., diabetes, hypercholesterolemia, obesity), adenosine
triphosphate-induced membrane changes, oxidative stress, and paroxysmal nocturnal hemoglobinuria.
Microfluidic techniques have been identified as the key to develop state-of-the-art dynamic
experimental models for elucidating the significance of RBC membrane alterations in pathological
conditions and the role that such alterations play in the microvasculature flow dynamics. 相似文献
18.
Santosh Shinde Pawan Kumar Kaushala Mishra Neela Patil 《Indian journal of clinical biochemistry : IJCB》2006,21(2):156-160
Mitochondrial diseases are a heterogeneous group of disorders in which a primary mitochondrial dysfunction is proven by morphological,
biochemical, and genetic examinations. The mitral valve has important function in the regulation of blood flow from one chamber
to another. Often, the mitral valve becomes abnormal with age, in Rheumatic fever or it is abnormal from birth (Congenital)
or it can be destroyed by infection i.e. bacterial endocarditis and needs replacement. Myocardial function depends on energy
produced by mitochondria and in any of these disease conditions, mitochondrial functions and enzyme activities may be impaired.
With this in view, we analyzed the relationship between preoperative clinical conditions (as per New York heart Association)
and extent of mitochondrial enzyme activities in damaged Human mitral valve in two types of heart disease such as Rheumatic
Heart Disease (RHD) and Bacterial Endocarditis (BE). Thirty nine Patients undergoing cardiopulmonary bypass (CPB) for routine
valvular heart surgery were included in the study. Controls included 11 normal porcine mitral valve samples without any evidence
of heart disease. Mitochondrial enzymes like cytochrome oxidase (COX), succinate dehydrogenase (SDH), malate dehydrogenase
(MDH), citrate synthase (CS) and ATPase were determined. Mitochondrial COX, SDH, CS and Total ATPase activities were significantly
decreased in disease condition like BE and RHD when compared with control (P<0.001). On the other hand as per New York Heart
Association (NYHA) preoperative clinical classification, all the mitochondrial enzymes were significantly (p<0.05) impaired
in class IV as compared with NYHA class I, II and III. Present study shows that impairment in the mitochondrial enzymes activities
are more pronounced in bacterial endocarditis (BE). It also indicates that damage to mitochondrial enzymes are most pronounced
in NYHA class IV. 相似文献
19.
脑疾病是我国乃至全球人口健康领域正面临的重大挑战。尽快部署脑疾病研究的中长期战略具有重大意义,将显著提升我国在该领域的国际竞争力,促进相关学科的发展以及新技术和新治疗途径的开发,实现脑疾病的精准医疗。脑疾病的研究正在从分子细胞机理、介观网络机制、生物标记物与分子分型、影像诊断和治疗策略研发等多个层面推进,其中介观网络研究是当前脑科学研究的新焦点,将填补分子细胞机理和宏观疾病症状之间的鸿沟。基于脑疾病的复杂性,非人灵长类动物可能是研究人类脑疾病的最优模型,我国在该领域具有明显优势;而脑疾病的早期诊断和早期干预是脑疾病治疗的关键,我国有丰富的临床资源库,亟需建立国际规范化、全国统一化的采样、处理、分析标准和共享的规则。此外,单细胞和单分子技术是微观研究的新趋势,也是精准医疗的关键技术,在解析复杂脑疾病机理方面具有重要的价值。 相似文献
20.
K. Pratibha T. Seenappa K. Ranganath 《Indian journal of clinical biochemistry : IJCB》2007,22(2):158-161
Alkaptonuria, a metabolic disorder characterized by a triad of homogentisic aciduria, arthritis and ochronosis is one of the
first conditions in the charter of group of inborn errors of metabolism proposed to have Mendelian recessive inheritance.
It is due to the deficiency of the enzyme homogentisic acid oxidase which catalyzes the conversion of homogentisic acid to
maleylacetoacetic acid in the catabolism of tyrosine. Homogentisic acid thus accumulates in cells and body fluids and its
oxidized polymers bind to collagen, leading to progressive deposition of grey to bluish black pigment resulting in degenerative
changes in cartilage, intervertebral disc and other connective tissues, leading to arthritis which is the only disabling effect
in an affected older individual. However the diagnosis can be made in neonates when blackish stain is noticed in an unwashed
diaper. Alkaptonuria is treated symptomatically, surgical intervention necessitates in advanced stages, treatment with ascorbic
acid (Vitamin C) and dietary restrictions of food containing phenylalanine and tyrosine have proved to be successful in alleviating
the symptoms. 相似文献