共查询到20条相似文献,搜索用时 250 毫秒
1.
Caffeic acid is a well-known phenolic compound widely present in plant kingdom. The aim of this study was to investigate the
possible protective effect of caffeic acid (CA) against oxytetracycline (OXT) induced hepatotoxicity in male Albino Wistar
rats. A total of 30 rats weighing 150–170 g were randomly divided into five groups of six rats in each group. Oral administration
of OXT (200 mg/kg body weight/day) for 15 days produced hepatic damage as manifested by a significant increase in serum hepatic
markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase
(LDH), bilirubin and increased plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide). The present finding
shows that the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase
(GPx) were significantly decreased in OXT intoxicated rats. Upon oral administration of caffeic acid (40 mg/kg body weight/day)
there were decreased hepatic marker activities, bilirubin and lipid peroxidation and increased enzymatic antioxidants in OXT + Caffeic
acid group compared to Normal + OXT group(P < 0.05). Our study suggests that caffeic acid has antioxidant property and hepatoprotective ability against OXT induced toxicity. 相似文献
2.
Prasad P. Torkadi I. C. Apte A. K. Bhute 《Indian journal of clinical biochemistry : IJCB》2014,29(1):79-83
Alcoholic liver disease (ALD) is due to excessive alcohol intake for long duration. Distinguishing ALD from non-ALD (non-alcoholic steatohepatitis, hepatitis of viral origin) is difficult as patient may deny alcohol abuse. Clinical examination, histology and serology may not differentiate these conditions. Accurate diagnosis is important as management of ALD differs from non-ALD patients. The aim of our study was (1) To evaluate the patients of ALD and non-ALD by biochemical parameters compared to controls, (2) To assess whether these parameters can differentiate ALD from non-ALD. Study was carried out on 50 patients of ALD in group I and 35 patients of NASH (non-alcoholic steatohepatitis) and acute viral hepatitis each in group II. Age matched healthy controls n = 50. Selection criteria—history of alcohol intake (amount and duration), clinical examination, sonography of abdomen, serum alanine transaminase (ALT) and bilirubin levels. Blood samples were analyzed for bilirubin, aspartate transaminase (AST), ALT, alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) by kinetic method. Statistical analysis was done by Student unpaired ‘t’ test. Patients of ALD have raised AST/ALT ratio (De Ritis ratio) (>2), ALP and GGT compared to controls (P < 0.01).There is significant difference in AST/ALT ratio, serum GGT and ALP in ALD group compared to that in NASH and acute viral hepatitis (P < 0.05). This study suggests that De Ritis ratio >2 in ALD patients may be due to alcohol induced hepatic mitochondrial injury and pyridoxine deficiency. High GGT and ALP values may indicate enzyme induction by alcohol and mild cholestasis. Thus ALD patients have severe hepatic damage. De Ritis ratio <1 and normal to mild elevation in GGT level in NASH and acute viral hepatitis suggest mild hepatic injury of non-alcoholic origin. Our study concludes that ALD patients can be differentiated from NASH and acute viral hepatitis with certainty by measuring serum AST/ALT ratio, GGT and ALP. These biochemical parameters may help clinicians to support the diagnosis of ALD and non-ALD. 相似文献
3.
Jyotsna A. Patil Arun J. Patil Sanjay P. Govindwar 《Indian journal of clinical biochemistry : IJCB》2003,18(2):16-22
A total of 85 healthy male pesticide sprayers in grape garden exposed to different class of pesticides for 3 to 10 years were
compared with 75 controls matched for age with respect to serum cholinesterase, serum total protein, albumin, AST, ALT, hematological
parameters such as Hb, Hct, RBC and serum lipid peroxidation. Serum lipid peroxidation was estimated in the form of thiobarbituric
acid reactive substances (TBARS) produced. Significant decrease was observed in serum cholinesterase, serum total proteins,
albumin and hematological parameters viz. Hb, Hct and RBC. Significant increase in lipid peroxidation, AST, ALT, was observed
in exposed group when compared with control. These results suggest that the long term exposure of various pesticides on sprayers
of grape garden affect liver, heme biosynthesis and decrease serum cholinesterase. 相似文献
4.
Meena Verma Sanjeev Narang Ashish Moonat Akshra Verma 《Indian journal of clinical biochemistry : IJCB》2004,19(1):129-131
Tuberculosis has, in a short span of time, become a major health problem in the third world or developing countries like India.
In view of this, a retrospective study was conducted to study Adenosine deaminase activity in serum and pleural fluid in patients
affected with Pulmonary Tuberculosis and other common non-tubercular chronic respiratory diseases. The study was carried out
on 100 patients suffering from various pulmonary disorders, between January 2002 and August 2002. Thirty-five normal healthy
individuals were included as control subjects. ADA estimation was done by sensitive colorimetric method. The study revealed
that the serum ADA activity was higher in patients of tuberculous pulmonary and pleural diseases and non-tuberculous pulmonary
diseases than in control subjects. The mean serum ADA activity in the patients’ group was 35.5±6.93 u/l as compared to 16.20±2.85
u/l in control group, showing a highly significant (P≪0.001) difference. ADA activity was highest in tuberculous pleuropulmonary
diseases. The pleural fluid ADA activity was higher in pyogenic pleural effusion than in tuberculous pleural effusion. 相似文献
5.
Mascha Verma Rashmi Khadapkar Priyadarshi Soumyaranjan Sahu Bibhu Ranjan Das 《Indian journal of clinical biochemistry : IJCB》2006,21(2):90-94
An increase in the communication within the healthcare services, both nationally and internationally, has strengthened the
need for harmonization of measurements and reference intervals in laboratory medicine. In the present report, the calculated
reference interval for serum creatinine (sCr) levels of healthy normal individuals (n=1121) in different sex and age groups
are compared with the established interval. The calculated reference interval for sCr level was 0.4–1.3 mg/dL and 0.6 to 1.3
mg/dL in the age groups of 21–40 and 41–60 years respectively. The difference between the mean sCr values in total males and
total females (age range 21–60 years) was statistically significant (p<0.0001); When male and female subjects were analyzed
age-group wise, the data showed a significant difference in mean sCr values (p<0.0001) in three age groups (21–30, 31–40 and
41–50 years) however, in older age group (51–60 years), the difference was non-significant (p=0.07). The reference ranges
were 0.7–1.3 and 0.4–1.0 mg/dL for males and females respectively where the lower limit was 0.1–0.2 units less than that of
standard limits. An increase in the mean value of sCr was observed particularly in females with an increase in age. Hence
it is of interest to validate an age specific reference ranges for sCr in our population. 相似文献
6.
M. Shafi M. Zargar Z. A. Shah M. Salahuddin M. Siddiqi 《Indian journal of clinical biochemistry : IJCB》1998,13(2):106-110
Serum and urine samples from 513 patients clinically suspected of monoclonal gammopathies over a period of five years (1992–97)
were subjected to various immunological procedures viz, electrophoresis, immunoelectrophoresis and immunoglobulin estimations.
Laboratory investigations confirmed gammopathies in 10.33%. It was observed that overall age of incidence for monoclonal gammopathies
in both sexes was between 42–72 years with a male to female ratio of 1.4∶1. Predominant paraprotein detected was IgG type
(75.47%) followed by IgA (16.98%) and Bence Jones proteins (7.55%). Amongst positive patients, 64.16% were having kappa (k) type light chains and 35.84% lambda (δ) type light chains. 69.39% patients with serum M component (IgG and IgA) had Bence
Jones proteinuria. Densitometric scanning revealed that majority of IgG type paraprotein was found in the slow gamma globulin
region and majority of IgA type paraprotein was found equally distributed between beta and fast gamma globulin regions. Both
types had decreased albumin and alpha-2-globulin concentrations as compared to normal controls. Immunoglobulin levels in patients
with paraprotein had very high levels of serum IgG (6467.0 mg%) and IgA (2714.0 mg%) in respective types of monoclonal gammopathies;
the rest of immunoglobulin classes were either at normal or decreased levels. 相似文献
7.
K. Devika Rani N. Suneetha Shruti Mohanty Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2008,23(2):150-153
This study is conducted in chronic alcoholics to assess the association of an Individual’s level of serum homocysteine with
the success of achieving alcohol deaddiction in the patient. The patients’ nutrition status is also assessed. 50 chronic alcoholics
admitted to a deaddiction center were inducted into the study. Patients underwent an 8 weeks holistic program to promote rehabilitation
from alcoholism. All the patients were addicted to alcohol for 8 – 10 years. Of the 50 patients enrolled, 39 of them completed
the 8 weeks program including complete abstinence from alcohol during this period. Fasting blood samples were collected on
admission and again after 8 weeks of alcohol abstinence for analyses of serum homocysteine and serum prealbumin, transferrin,
total proteins and albumin, gammaglutamyl transferase (GGT) and alanine transaminase (ALT). Of the 50 patients enrolled in
the study, 39 completed the 8 weeks rehabilitation program. 11 patients discontinued within 2 weeks of admission. During the
8 weeks of complete alcohol abstinence, patients were given a balanced diet and multivitamin supplements. A significant improvement
in their nutritional status was noted by the elevation of serum levels of prealbumin, transferrin, total proteins and albumin.
Serum homocysteine levels decreased significantly (p<0.002) to normal levels from previous hyperhomocytenemia. This was accompanied
by decrease in serum GGT and ALT levels indicating improved liver functions. Serum estimation of homocysteine in chronic alcoholics
is important to assess whether the patient will have a successful rehabilitation. Normal homocysteine levels are achieved
after dietary changes and abstinence from alcohol. Timely correction of hyperhomocysteinemia also provides successful rehabilitation. 相似文献
8.
P. Pragathi P. V. Bharath Kumar P. Amar Kumar M. Ramakanth Reddy V. Sravani J. Neeraja Eapen Reeba Mary K. Gopalakrishna 《Indian journal of clinical biochemistry : IJCB》2005,20(2):195-197
Adenosine deaminase (ADA) and 5′-nucleotidase (5′-NT) activities were measured in sera of patients with ovarian cancer and
patients with benign ovarian tumour. The results were compared with that of a control group consisting of healthy women. ADA
levels were significantly increased (P<0.001) in the ovarian cancer group (n=50) but not in the benign group (n=28) when compared
to the controls (n=20). The results indicate that ADA and 5′-NT levels may help to differentiate malignant conditions from
benign tumours of the ovary in addition to the existing tests such as serum CA-125 levels and histopathological study. 相似文献
9.
Sandhya Mishra Dharamveer Yadav Monika Gupta Hemant Mishra Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2008,23(2):130-135
Metabolic syndrome contributes to pathogenesis of Type-2 diabetes and CAD. Insulin Resistance is the key factor of metabolic
syndrome implicated in development of Non Alcoholic Fatty Liver Disease (NAFLD). In present study we have investigated the
prevalence of NAFLD in metabolic syndrome and contribution of metabolic risk factors in causation of NAFLD in non-diabetic
North Indian male population. The study was conducted on 495 non-diabetic, nonalcoholic subjects (age 30–65 years). Metabolic
Syndrome was assessed by using ATP III and ADA (2005) criteria. Anthropometric factors-Waist circumference and blood pressure
were measured. Fasting serum samples were analyzed for Glucose, Triglycerides, Cholesterol and its fractions, Insulin, Alanine
transaminase, Aspartate transaminase, Gamma glutamyl transferase and free fatty acids. Insulin resistance was estimated by
Homeostasis Model and Insulin sensitivity by QUICKI Index. Liver ultrasonographic scanning was used for assessing fatty liver.
The prevalence of metabolic syndrome and NAFLD was 24% and 14.8% respectively in non-alcoholic population and 27% of metabolic
syndrome had NAFLD which was associated with hyperinsulinemia, insulin resistance, insulin insensitivity along with elevated
levels of waist circumference, blood pressure, triglyceride, FFA and decreased HDL-Cholesterol. The prevalence of NAFLD increased
with insulin resistance and clustering of metabolic risk factors. 相似文献
10.
D. Sreeramulu B. A. Ramalakshmi N. Balakrishna N. Raghuramulu 《Indian journal of clinical biochemistry : IJCB》2004,19(1):79-82
The objective of the present study was to evaluate the changes in serum dehydroepiandrosterone (DHEA) and lipid peroxide levels
during ageing in human subjects. Random blood samples were collected from a total of 128 apparently normal human volunteers
of both sexes, whose age ranged between 21–70 years. The subjects were divided into groups of a decade years of age difference.
Serum levels of dehydroepiandrosterone (DHEA), lipid peroxides as malondialdehyde (MDA), and insulin were analysed in all
the subjects recruited in the study. In the present study there was decrease in serum DHEA levels with age (11.30 to 7.99
ng/ml). However the differences were significant only after 50 years up to 70 years. Serum MDA levels of these subjects were
higher (3.91 to 4.74 ng/ml) as compared to the values reported earlier (2.64 to 3.94 ng/ml). The serum MDA levels also showed
an increasing trend with age but the increase was significant only in the 40–50 years age group and values plateaud off at
later ages. The MDA and DHEA levels in women in general were lower than in men and this could be due to female hormones, which
are known to protect lipid against peroxidation. There was a significant negative correlation between age and DHEA (r=−0.311
P<0.05) and positive correction between MDA and age (r=+0.405 P<0.01). No significant differences were seen in serum insulin,
albumin and total protein levels. These preliminary findings support the possible utility of DHEA and MDA as markers for chronological
ageing. 相似文献
11.
Medically diagnosed alcoholics can be differentiated reliably from non-alcoholics using clinically laboratory tests. In the
present study, patients with liver diseases either due to alcohol or without alcohol compared with a group of normal healthy
persons. Heavy drinkers showed significantly lower body weight and percent body fat, and low BMI compared with other groups.
The percentage of hemoglobin and total number of RBC were found to be significantly decreased, whereas mean corpuscular volume
(MCV) significantly increased in alcoholic liver disease (ALD). Hyperbilirubinemia, hyperuricemia and hypoalbuminemia correlate
with alcohol intake. Albumin/globulin ratio significantly decreased in ALD. In acute liver injury AST/ALT ratio is ≤1.0, whereas
in alcoholic hepatitis it is always >1.0. Moderately elevated level of ALP and high GGT values are good discriminator of alcoholic
patients. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased level of reduced glutathione
and ascorbic acid, and increased level of thiobarbituric acid reactive substances. 相似文献
12.
Itemobong S. Ekaidem Monday I. Akpanabiatu Friday E. Uboh Offiong U. Eka 《Indian journal of clinical biochemistry : IJCB》2007,22(2):36-40
Folic acid and vitamin B12 are very important vitamins needed for normal cellular metabolic activities. The effects of folic acid and vitamin B12 on liver integrity of growing Wistar albino rats following therapeutic dose of phenytoin administration were investigated.
The activities of serum AST, ALT, ALP were investigated. Serum total protein level and lipid profile were also measured as
indices of biochemical changes. The ingestion of phenytoin alone in rats significantly reduced serum protein while AST, ALT
activities incresed as compared to the control (P<0.05). Supplementation of phenytoin with oral administration of 70microgram/kg
body wt of folic acid resulted in a significant reversal in serum total protein and suppression in serum AST and ALT activities.
Vitamin B12 supplementation did not afford any significant protection against the effect of phenytoin ingestion but rather phenytoin
toxicity was exacerbated in this study. However, the combined effects of vitamin B12 and folic acid ameliorated the effects of phenytoin on serum enzymes of experimental rats. The effect of combination of phenytoin
with folic acid or folic acid and vitamin B12 is an interesting finding. Supplementation of phenytoin with folic acid or combination of these vitamins may be recommended
for the purpose of ameliorating the adverse biochemical changes which are associated with phenytoin therapy. Further work
is ongoing to help elucidate the effects of phenytoin and these vitamins on oxidative stress inducing mechanism. 相似文献
13.
Alka Singh Sheila Uthappa V. Govindaraju T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):25-28
The present study conducted on twenty-five uncomplicated cases of acute myocardial infarction diagnosed by clinical and electrocardiographic
findings indicated significantly increased level of cardiac Troponin-T and increased activities of the enzymes total creatine
kinase, creatine kinase-MB, aspartate transaminase and lactate dehydrogenase as compared to the twenty-five healthy control
subjects. The level of cardiac Troponin-T and the activities of the enzymes total creatine kinase, creatine kinase-MB, aspartate
transaminase and lactate dehydrogenase was found to be higher in “Q” wave myocardial infarction patients as compared to the
non-“Q” wave and the controls. Since cardiac Troponin-T has been shown to increase in unstable angina and renal failure without
cardiac disease and creatine kinase-MB activity has been found to be normal in patients with unstable angina and increase
very slightly in patients with renal failure, it was concluded that a combination of cardiac Troponin-T and creatine kinase-MB
activity was sufficient for the early diagnosis of acute myocardial infarction. 相似文献
14.
P. Faizal S. Suresh R. Satheesh Kumar K. T. Augusti 《Indian journal of clinical biochemistry : IJCB》2009,24(1):82-87
A study was undertaken for evaluating the hypoglycemic and hypolipidemic effects of an ayurvedic medicine “Rajanyamalakadi”
containing Curcuma longa, Emblica officinalis and Salacia oblonga in type II diabetic patients over a period of 3 months.
Ethical committee consent for the study was given by the Director, Indian Systems of Medicine, Kerala. A total of 43 patients
with established diabetes mellitus as adjudged from clinical features and FBS values, appeared for the camp (Age group 35–75
yrs). An informed consent for the study was obtained from each patient. The clinical proforma was given to each patient to
collect data such as height, weight, diet pattern, previous history of illness etc. The ongoing antidiabetic medications were
stopped under medical supervision and the patients were provided with ‘Rajanyamalakadi’ tablets (dose 1–2 tablets each weighing
500mg). The dosage of the drug was decided by the supervising medical officer on a case to case basis, taking note of the
clinical conditions and responsiveness of the patients. The patients were monitored for three months, who were divided into
6 groups based on their age and again into two groups, 5 & 6, based on their mean FBS values. ie; Normal Persons, Diabetics
of age groups 35–45yrs, 46–55yrs, >55yrs and those with FBS < 145.9 mg% and > 145.9 mg%. The Ayurvedic medicine “Rajanyamalakadi”
has showed significant antidiabetic, hypolipidemic and antioxidant effects. In addition to that significant ameliorating effects
on the elevated serum AST and ALT activities were also demonstrated by the treatment. The nutraceuticals present in the drug
like Terpenoids, Polyphenols, Curcumin etc are responsible for the medicinal effects. 相似文献
15.
The serum PSA is universally accepted as the useful and clinically relevant tumor marker for monitoring therapy and identifying
early recurrence in patients of carcinoma prostate throughout the world. However, application of serum PSA is limited to screening
for early adenocarcinoma prostate among males above fifty years of age.
Serum PSA concentration varies from one population to another in different parts of the world. Many groups of workers have
selected 4 ng/ml of serum PSA as upper limit of normal range without giving due consideration for age specific increase in
serum PSA. There is no single report available on normal decade wise age specific reference intervals for serum PSA in Indian
males.
The present study is undertaken to establish age specific reference intervals in healthy Indian males from 20–89 years belonging
to subpopulation of Andhra Pradesh from South India. Our results revealed lowest concentration of 95 percentile serum PSA
in Indian males compared to other populations globally. Contrary to this, healthy Afro Americans were found to have highest
concentration of serum PSA compared to all other populations. 相似文献
16.
L. Hema Bindu P. Usha Rani P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2007,22(2):32-35
Calcineurin, a Ca2+—Calmodulin dependent protein phosphatase, is important for Ca2+ mediated signal transduction. The main objective of this study was to examine the potential role of calcineurin in idiopathic
mental handicap. Calcineurin levels were estimated in 20 children in the age group of 5–16 years with idiopathic mental handicap
attending the Special. Education Centre for the Mentally Handicapped in Hyderabad. The results of the present study showed
decreased activity of serum calcineurin in children with idiopathic mental handicap compared to those of normal subjects in
the same age group. The observations thus suggest impaired calcineurin activity in children with mental handicap. Calcineurin
that is involved in biosynthesis and release of neurotransmitters at the synaptic terminal brain is affected thereby causing
brain damage and leading to mental handicap. Impaired calcineurin activity was already indicated in many human diseases such
as Down's syndrome, Alzheimers, Brain ischemia, cardiac hypertrophy etc. It is therefore necessary to check the calcineurin
levels in children with mental handicap to understand the role of calcineurin in the causation of Mental handicap. 相似文献
17.
M. S. Ghadge A. V. Sirsat M. S. Bhansali L. J. Desouza P Jagannath 《Indian journal of clinical biochemistry : IJCB》2001,16(1):60-64
Serum levels of leucine amino peptidase (LAP) was studied along with bilirubin, aspartate transaminase (AST), alanine transaminase
(ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and the ratio of AST/ALT and GGT/AST in 25 healthy
subjects and 52 patients with hepatobiliary malignancies of which 12 were with hepatocellular carcinoma, 12 with liver metastasis,
6 with obstructive jaundice, 9 with carcinoma of gall bladder, 6 with carcinoma of pancreas and 7 with periampullary carcinoma.
24 Of the 52 patients studied had jaundice and 28 were without jaundice.
LAP as compared to the other enzymes AST, ALT, GGT, ALP and AST/ALT ratio and GGT/AST ratio showed 100% elevation in obstructive
jaundice, carcinoma of gall bladder and pancreas and periampullary carcinoma, 91.7% elevation in hepatocellular carcinoma
and 83.3% elevation in liver metastasis. On comparing the levels of these enzymes in non jaundiced and jaundiced groups, LAP
was elevated in both jaundiced and non jaundiced groups in 95.8% and 92.9% cases respectively whereas the other enzymes AST
showed increase from 67.9% to 100%, ALT from 21.4% to 83.3%, GGT from 71.4% to 95.4% and ALP from 82.1% to 100% in non jaundiced
and jaundiced groups respectively indicating that LAP rises in hepatic dysfunction due to hepatobiliary malignancy whereas
the other liver function enzymes showed increased hepatic dysfunction due to hepatobiliary malignancy with the onset of jaundice
thereby indicating that LAP is a better indicator of hepatobiliary malignancy as compared to other enzymes.
The quantitative methods used for determination are reliable, accurate, simple, rapid and cost effective and therefore have
better application in a clinical setting. 相似文献
18.
Anjali C. Warrier Narasimha Y. Rao Devdutta S. Kulpati Tarun K. Mishra Bhaskar C. Kabi 《Indian journal of clinical biochemistry : IJCB》1995,10(1):9-13
There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white
blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus
(IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared
with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were
also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant
positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is
suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia
and lipid peroxidation in diabetes mellitus. 相似文献
19.
Shalini N. Maksane Sucheta P. Dandekar Akash Shukla Shobna Bhatia 《Indian journal of clinical biochemistry : IJCB》2016,31(1):108-116
The reference intervals (RIs) of serum aminotransferases and Gamma-glutamyl transferase (GGT) have been established many years ago. Recent RIs are not available. The prospective study was conducted to re-evaluate the RIs of liver enzymes and the effect of demographic and anthropometric variables on them in western Indian population. A total of 1059 blood donors comprised the study population. Anthropometry and serum liver enzymes levels were measured. Subjects were categorized into normal weight and overweight by using body mass index (BMI) and waist circumference (WC). For RI determination, non-parametric methodology recommended by IFCC/CLSI was adopted. Mann–Whitney test and Spearman’s rank correlation were used for statistical analysis. Upper limit of normal reference value of liver enzymes were lower in female compared to male. (ALT—23.55 F vs 36.00 M, GGT—34.58 F vs 36.20 M) When RI of liver enzymes were calculated according to body mass index, the upper limit of normal of ALT and GGT were higher in overweight group compared to normal weight group. (ALT—38.00 vs 27.00 IU/L and GGT—37.59 vs 35.26 IU/L). In both male and female, liver enzymes correlated significantly with age. WC and BMI were positively correlated with AST, ALT and GGT in both subgroups and the correlation was stronger in male. Demographic factors should be considered for making liver enzyme tests more clinically relevant. Gender based partitioning should be adopted for serum alanine aminotransferase (ALT) and GGT reference values for Western Indian population. 相似文献
20.
The level of serum cholesterol (Ch), serum-high density lipoprotein cholesterol (HDLc), serum-low density lipoprotein cholesterol
(LDLc), serum very low density lipoprotein cholesterol (VLDLc), Triglyceride (Tg), Apolipoprotein A-1, B and ratio of Apolipoprotein
A1/B were observed in 151 survivors of myocardial infarction in different age groups. A significant increase was found in
the level of triglyceride, LDLc, apolipoprotein-B and a significant decrease in apolipoprotein-A1 and the ratio of apolipoprotein
A1/B. No significant alteration was found in serum cholesterol, HDLc except in the age group of 31–40 years and 41–50 years
and VLDLc. Thus, serum Apo A-1 and Apo-B may be considerably better markers for coronary artery disease than traditional lipid
parameters. 相似文献