共查询到20条相似文献，搜索用时 15 毫秒
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Nilima N. Dongre Adinath N. Suryakar Arun J. Patil Indira A. Hundekari Basavaraj B. Devarnavadagi 《Indian journal of clinical biochemistry : IJCB》2013,28(1):65-70
Lead is one of the most widely scattered toxic metals in the environment and used by mankind for over 9,000 years. Lead in the environment may be derived from natural or anthropogenic sources. In humans, lead can cause a wide range of biological effects depending upon the level and duration of exposure. The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, serum calcium, ionized calcium, phosphorus, parathyroid hormone and vitamin D and examine the overall effect of all these parameters on the bone mineral density of battery manufacture workers. For this study ninety battery manufacture workers were selected and divided in three groups depending upon duration of lead exposure. Group I—workers with duration of lead exposure 1–5 years, Group II—workers with duration of lead exposure 6–10 years and Group III—workers with duration of lead exposure more than 10 years. Each group consisted of thirty workers. Thirty age matched healthy control subjects were taken for comparison. Demographic, occupational and clinical data were collected by using questionnaire and interview. The venous blood samples were collected from the study groups and normal healthy control group. At the time of blood collection random urine samples were collected in amber coloured bottles. The biochemical parameters were estimated by using standard assay procedures. Statistical analysis of the data was done using independent student‘t’ test for parametric variables. Values were expressed as mean ± standard deviation (SD). P values of 0.05 or less were considered to be statistically significant. The blood lead levels and urinary lead levels of all workers were significantly increased (P < 0.001) in proportion to the duration of lead exposure as compared to controls. Systolic and diastolic blood pressure were significantly raised (P < 0.001) in all three study groups of battery manufacture workers as compared to controls. Serum Calcium, Ionized calcium, phosphorus were significantly decreased (P < 0.001) in all the three study groups. Serum vitamin D levels were lowered (P < 0.01) and serum PTH was increased (P < 0.01) in workers as compared to controls. The results of this study clearly indicate that the absorption of lead is more in these workers which adversely affects blood pressure, disturbs calcium and phosphorus metabolism which further impairs mineralization of bone resulting in decreased bone mineral density observed in these workers. Lead toxicity is still persistent in battery manufacture workers though they are using sophisticated techniques in these industries. There is a need to protect the workers from the health hazards of occupational lead exposure. 相似文献
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Saira Hanif Soroya Ali Farooq Khalid Mahmood Jouni Isoaho Shan-e Zara 《Information processing & management》2021,58(2):102440
Individuals seek information for informed decision-making, and they consult a variety of information sources nowadays. However, studies show that information from multiple sources can lead to information overload, which then creates negative psychological and behavioral responses. Drawing on the Stimulus-Organism-Response (S-O-R) framework, we propose a model to understand the effect of information seeking, information sources, and information overload (Stimuli) on information anxiety (psychological organism), and consequent behavioral response, information avoidance during the global health crisis (COVID-19). The proposed model was tested using partial least square structural equation modeling (PLS-SEM) for which data were collected from 321 Finnish adults using an online survey. People found to seek information from traditional sources such as mass media, print media, and online sources such as official websites and websites of newspapers and forums. Social media and personal networks were not the preferred sources. On the other hand, among different information sources, social media exposure has a significant relationship with information overload as well as information anxiety. Besides, information overload also predicted information anxiety, which further resulted in information avoidance. 相似文献
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Herman S. Dsouza Geraldine Menezes T Venkatesh M.Sc. Ph.D. FACBI. FINASS 《Indian journal of clinical biochemistry : IJCB》2002,17(1):9-11
It is well known that lead exposure in the early period of pre pregnancy and antenatal life leads to serious health complications. In this case report, a five month old child who was suffering from encephalopathy was finally confirmed a victim of lead exposure, the source being the environment and the family. We report this case with complete clinical investigation including blood lead analysis. This case report highlights the various ways in which lead may accumulate in the body. It is also aimed at increasing awareness regarding the pathogenesis and clinical manifestations of lead toxicity. The literature survey done reveals that this is the youngest age at which lead toxicity has been documented in India. 相似文献
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Shailja Chambial Kamla Kant Shukla Shailendra Dwivedi Pankaj Bhardwaj Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2015,30(3):357-359
Lead interferes with a variety of body processes and is toxic to many organs and tissues including the heart, bones, intestines, kidneys, and reproductive and nervous systems. Routes of exposure to lead include contaminated air, water, soil, food, and consumer products. The possibility of lead exposure in humans is therefore of great significance from health point of view. Occupational exposure is a common known cause of lead poisoning in adults but current status of adults exposed otherwise is not known. School teachers representing wide local population were selected and asked to furnish information regarding possible lead exposure. Blood lead level (BLL) was estimated using anodic stripping voltammetry. The mean BLL was 6.89 ± 9.5 μg/dl (<3.5–>65 μg/dl) in representative adult population. Out of the total 16 % were found to be having BLL >10 μg/dl which has significantly decreased from leaded gasoline era. Those with increased BLL (>10 μg/dl) were found to have common determinants like usage of old metallic pipes for plumbing, water consumption without any purification system, usage of cosmetics and Ayurvedic/herbal medicines. 相似文献
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Shailja Chambial Pankaj Bhardwaj Abbas Ali Mahdi Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2017,32(2):246-247
Lead ranks as one of the most serious environmental poisons all over the world amongst toxic heavy metals with no known biological function useful for the human body. A case of lead toxicity due to consumption of herbal medicine is being discussed. The case presented with gastrointestinal complaints and history of intake of herbal medicines for diabetes control for past 8 months. The analysis of the powdered herbal medicine procured from ayurveda practitioner was found to have high content of lead responsible for the lead toxicity. The patient is under regular followup. He has improved symptomatically on chelating therapy and blood lead levels have gradually improved. Regular awareness programs should be conducted in the population regarding possible exposure through home made herbal remedies so that general public can be made aware of the dangerous side effects of lead and other heavy metals on health. 相似文献
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It is well known that chronic exposure of lead leads to adverse health effects. Workers for plastic industry are generally exposed to high concentration of lead as fume, dust, and additive that protect PVC. This study was done on them to find out the detrimental effects of chronic lead exposure on hepatic and hematological toxicity. Blood and 24 h urine sample was collected from 47 plastic industry workers and matched against 42 controls for various parameters. The study group shows significant increase in blood (p < 0.0001) and urinary level of lead (p < 0.0001). Hemoglobin levels were significantly decreased (p < 0.0001), and the liver enzymes like ALP, ALT, AST and y-GT were significantly increased (p < 0.0001) in all cases exposed for >10 years. Serum lipid peroxide by quantitative assay of thiobarbituric acid reactive substances was also found increased in the study group (p < 0.0001). The observations point towards the acute health risk faced by plastic industry workers, in whom chronic exposure to lead increases the absorption and accumulation, over a period of time, of this highly toxic element in their body. This increases oxidative stress, causes metabolic damage to RBC and cell membranes, and also suggests necrosis of liver cell, hepatocellular injury and presence of space occupying lesions. Considering the data immediate health and hygiene monitoring and proper rehabilitation for the suffering population seem to be of paramount need in plastic industry to minimize occupational hazards. 相似文献
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There is a body of research that highlights the role of data management to improve the quality of data, which in return improves organizational performance. The literature in data management has indicated the five theoretical constructs used to understand the factors influencing data quality, including top management support, capability on the regulation and process management, business-IT alignment, staff participation, and integration of information systems. However, it is unclear how these theoretical constructs can be utilized to understand the antecedents of data completeness as a dimension of data quality. Following that stream of research, the current paper examines the factors influencing data completeness in electronic medical records (EMR). The scope of this study is by only surveying medical professionals at healthcare settings in northern Nevada. The empirical results reveal that resources should be added as one of the antecedents of data completeness in EMR. 相似文献
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Ram Mudambi 《Research Policy》2009,38(5):736-745
Scientific research is a crucial success factor for knowledge intensive firms and is often a joint effort of scientists and managers. However, scientists and managers belong to different “professional guilds,” subscribing to different belief systems and valuing different types of incentives. These differences give rise to tension between scientists and managers. We integrate a large body of literature from knowledge management to develop a new theoretical model predicting that this organizational tension is affected by environmental factors such as the degree of industry munificence, firm-specific factors like knowledge-management policies, and the individual roles of boundary spanners within the firm. Further, we argue that this tension can lead to positive or negative outcomes. 相似文献
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Herman Sunil D'Souza Geraldine Menezes T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2003,18(2):154-160
Heavy metals are important toxicants known to exert adverse effects in humans and animals, given sufficient exposure and accumulation
in the body. This has a great concern both at personal and public health risk. Heavy metals are also known to interact with
the essential trace minerals at the level of absorption and also during the metabolism. The adverse effects of the absorbed
and accumulated heavy metals include neurological, reproductive, renal and hematological systems. Children are more sensitive
than adults to the effects of lead. Efforts are made to understand the mechanism of the interactions of heavy metals with
essential trace minerals at the level of absorption. With available sensitive and specific methodologies like Anodic Stripping
Voltammetry for the evaluation of the levels of toxic heavy metals such as lead, cadmium, mercury etc., better understanding
of heavy metal absorption is made possible.
Due to the poor nutritional standards, risk of heavy metal exposure is still a major concern in developing countries. Studies
carried out by the author have provided evidence towards the understanding of the prevailing mechanisms of metal-metal interaction
at the intestinal level. During growth and development the demand for the essential minerals being at higher level, differentiation
of various essential metals and heavy metals pose an inherent problem due to certain common properties shared by them. With
this approach to the problem of heavy metal toxicity, it is preventable not only with environmental intervention but also
by the nutritional management. 相似文献
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通过构建一套既能充分体现服务公众的公益性要求,实现良好的社会效益,又能增强自身的功能,拓展多方面的资金来源的运营管理系统,从而寻求一条促进科技馆可持续发展的路径。我们探讨广东科学中心的运营管理系统,就是为了探讨市场经济条件下大型公共设施运行管理的规律,为我国建立公共设施运营管理理论体系做出贡献。 相似文献
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矿产资源开采的管理有效性——探明储量、私有信息与过度开采 总被引：1，自引：0，他引：1
本文建立了一个简约的两期模型,结合我国资源管理的现实,分析了不可再生资源开采问题。本文认为,在资源短缺的情况下,即使政府想实现跨期福利的最大化,但由于开采企业拥有探明储量的私有信息,代际靠前的企业会夸大探明储量,从而导致过度开采,使得最优开采计划无法实现。本文讨论了过度开采对不同经济主体的福利效应,并提出了相应的应对思路。 相似文献
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用户参与创新:国外相关理论文献综述 总被引：2，自引：0，他引：2
以von Hippel为主要代表的国外创新专家通过长期深入细致的调查、观察和研究，在创新源理论和用户创新研究方面取得了丰富的成果，对他们在用户创新、领先用户和用户创新工具箱等方面的研究进行了梳理和评述，指出进一步发展和完善的研究方向。 相似文献
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Vesile Altinyazar Fevziye Burcu Sirin Recep Sutcu Ibrahim Eren Imran Kurt Omurlu 《Indian journal of clinical biochemistry : IJCB》2016,31(4):473-479
Long-term exposure to organophosphate pesticides (OPs) without acute poisoning can lead to various OPs. Environmental exposure to organophosphate pesticides may be associated with depression and suicide attempts in a population living in a rural agricultural area. Patients (n = 149) suffering from major depressive disorder (with and without attempted suicide) and a control group of healthy individuals (n = 64) who had been living in the same rural district for at least 1 year were selected. Red blood cell acetylcholine esterase (RBC-AChE) activity was examined as the basis of evaluating the degree of chronic environmental exposure to OPs residues. There were negative association between RBC-AChE activity levels and suicide attempts, the number of past suicide attempts and hopelessness levels in the depressive patients. The results of the study may support the idea that environmental exposure to OPs may be associated with mental health in individuals living in agricultural districts who are not farmers or working in occupations with access to OPs. 相似文献
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Quinlan S 《Endeavour》2010,34(4):142-150
During the French Revolution, there appeared a striking and far-ranging medical literature on heredity, reproduction and biological 'perfectibility'. In some ways anticipating ideas associated with modern eugenics, these writings emerged from radical revolutionary projects for 'physical and moral regeneration' and incarnated deep-seated desires to transform French society and make a 'new man' in mind and body. But by breaking down boundaries between public and private life, doctors did more than just try to regulate intimate sexual behaviour. Instead, they proffered a more intimate vision of civic volunteerism, in which sexual hygiene and domestic practices allowed their patients to imagine new forms of society and gave them ways to attain these socio-political dreams. Moreover, they were responding to powerful new worries about heredity and sought to counsel their patients in the ways of family panning. By the end of revolutionary period, then, medical and lay thinkers had transformed the marriage bed and household into a specially controlled environment - a kind of affective laboratory - in which conscientious parents could make healthy children and raise them in the context of specific political and social values. 相似文献
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赵嫣红 《科技成果管理与研究》2010,(8):85-86
为了解老龄人抗生素使用情况,加强抗生素使用管理,本文对2009年1～12月年龄在65岁以上的125位老龄门诊患者进行抗生素使用调查分析。调查发现,老龄患者因缺乏抗生素相关知识,自行购药或经验购药行为较多,极易出现联合用药和不良反应。因此,合理使用抗生素尤为重要,需要医疗监督管理部门、医疗机构、医师和患者共同努力。 相似文献
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Christian Köhler 《Research Policy》2012,41(8):1344-1356
The shift toward more open and interconnected innovation activities has been a major topic in recent academic and practitioner discussions. Firms must connect their in-house R&D activities with external partners, such as leading customers or universities, to increase the effectiveness of their innovation activities. Hence, management needs to define where to search for valuable knowledge in its environment. In this paper we argue that knowledge search has to reflect the heterogeneity of various knowledge sources with regard to the knowledge they can provide and how these sources can be activated. We hypothesize that search strategies driven by science, suppliers and the product market will contribute differently to innovation success with new-to-market versus imitated products. Moreover, we explore the effect of these types of knowledge search within different sectoral patterns of innovation. Our empirical analysis rests on a sample of almost 5000 firms from five Western European countries. The results support our hypotheses and highlight the potentials and shortcomings of different types of knowledge search. 相似文献
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通过从使命、愿景和价值观、外部管理体制、内部治理结构、经费来源、人员管理、设施共享等6个方面分析美国阿贡国家实验室的管理模式现状,可以发现其管理模式呈现以国家需求作为核心旨归、以合同管理理顺外部关系、以矩阵结构优化内部治理、以政府拨款保障高质运行、以灵活多样提升人力资源、以高度开放促进资源共享等特点。结合阿贡管理模式的现状与特点,提出对我国大学国家实验室管理模式有益的启示。 相似文献