共查询到18条相似文献，搜索用时 187 毫秒
1.
目的：为探讨经导管射频消融术对心脏和心脏自主神经的急性期损伤。方法：选择接受射频消融术的阵发性室上性心动过速病人120例，在术前，术后进行超氧化物歧化酶测定和心率变异性分析。结果：射频消融术后超氧化物歧化酶较术前明显增高（P＜0．01）；术后心率变异性的各项频域和时域指标均降低，但与超氧化物歧化酶变化无明显相关，结论：射频消融术对心脏和心脏自主神经的急性期损伤是存在的，但术后心率变异性的降低是由于射频电流损伤心脏迷走神经所致，与手术引起的心肌应激性损伤无关。 相似文献
2.
目的:分析强负荷运动量同心率变异的关系。方法:将某学院40男子健美操运动员,按照强负荷运动量从小到大划分成,短时间、中时间以及长时间运动三组实验组,每组10名运动员,普通运动员10名,设为安静组。对实验组以及安静组的运动员心率变异性机进行心率变化、时域、频域以分析,对强负荷运动员的运动量与心率变异关系进行分析。结果:随着运动员运动负荷量的逐渐增加,长时间运动结束后的心率下降最为显著,运动员的平均RR、SDNN、SDNN/HR都不断降低,长时间运动员的平均RR、SDNN/HR明显低于安静组,SDNN值略低于安静组,不具备显著性(p0.05)。结论:随着强负荷运动量的逐渐增加,运动员心率变异性逐渐降低,总体自主神经调控功能增强,交感神经张力在运动中持续升高,迷走神经对交感神经的抑制逐渐降低。 相似文献
3.
老年高血压病左室肥厚与神经体液因素及室性早搏的相关性 总被引：1，自引：0，他引：1
为探讨老年高血压病左室肥厚（LVH）与部分神经体液因素之间的关系及与室性早搏，心肌缺血的相关性，老年高血压病伴左室肥厚60例为A组，单纯老年高;血压病60例为B组，对比观察心率变异，肾素（Ren)，血管紧张素（AT－II），醛固酮（Ald)，胰岛素峰值（Ins),24h动态心电图和血压等指标，结果显示：1）A组病人交感神经张力明显增高，迷走神经活性下降不明显，室性早搏的发生与交感神经张力增高有关；室性早搏与心肌缺血具有相关性；2）A组病人与Ald及Ins水平有关，与Ren和AT－II无明显相关；3）A组病人与室性早搏和心肌缺血明显相关，结论表明，老年高血压病在室肥厚患者交感神经张力增高，Ald及Ins水平升高，与室性早搏，心肌缺血具有正相关。 相似文献
4.
目的 探讨西藏山南地区干部不同年龄、性别、民族、体重指数（BMI）、血脂与脂肪肝之间的相关关系。方法 2006年山南地区干部健康体检人群2168例。测定空腹血清总胆固醇（TC）、血清甘油三酯（TG），并空腹作肝脏B超检查，测体重、身高等：分析不同性别、年龄、民族、体重指数（BMI）、血脂异常与脂肪肝检出率的差异。结果 脂肪肝发生率中，藏族高于汉族，男性高于女性，老年组高于青年组。随着体重指数（BMI）的增高及血脂异常的检出率增高，脂肪肝患病率增高。结论 脂肪肝与性别、年龄、民族、体重指数（BMI）、血脂水平等因素密切相关。 相似文献
5.
目的 调查西藏高海拔世居藏族居民体质指数(BMI)的分布情况及超重和肥胖的检出率,并进一步探讨BMI与血脂的相关性。方法 随机选取西藏自治区昌都市八宿县郭庆乡(海拔4500m,179人)、芒康县纳西乡(海拔2516m,252人)合计世居藏族居民431人。对受试者进行身高、体重测量,并留取血样标本进行血脂检测。结果 两组不同海拔人群的BMI水平差异无统计学意义(P>0.05)。整合两组不同海拔人群进行超重和肥胖检出率分析,体重过低占3.5%、体重正常47.6%、超重30.6%、肥胖18.3%.与正常体重相比,超重和肥胖组的TG(甘油三酯)、TC(血清总胆固醇)、LDL-C(低密度脂蛋白胆固醇)显著较高,而HDL-C(高密度脂蛋白胆固醇)较低,差异有统计学意义(P<0.05)。血脂各项指标均与BMI有关,尤其海拔在2516米的人群TG与BMI呈显著正相关(R=0.67,P<0.001)。多元线性回归分析结果提示：经海拔、性别、年龄校正后BMI和血脂仍有相关性,血脂异常人群的BMI均值比血脂正常人群高2.207kg/m2(P<0.001)。结论 ... 相似文献
6.
目的：探讨广西某地区八家机关单位体检人员脂肪肝跟高血压、血脂异常及高尿酸血症的相关性。方法：随机抽取目标地区2017年到广西医科大学体检中心开展代谢健康体检的826名机关单位体检人员作为研究对象，测量血压、采集空腹静脉血液，检测血脂、血尿酸、胆固醇等生化指标，以及肝脏B超，分析讨论体检结果。结果：根据脂肪肝检出结果，脂肪肝组高血压、血脂异常、高尿酸血症的检出率（18.28%、21.31%、18.28%）均高于非脂肪肝组（17.80%、16.71%、12.59%），两组对比具有统计学意义（P<0.05）；经Logistic回归分析，血脂异常、高血压、高尿酸血症与脂肪肝之间存在正相关；合并患病种类越多，脂肪肝发生比例越高。结论：该地区人群脂肪肝与高血压、血脂异常、高尿酸血症疾病密切相关，合并患病比例越高，发生脂肪肝的几率也越高。因此，有必要对该地区开展健康宣教工作，预防和控制这些相关疾病，以降低脂肪肝发生概率。 相似文献
7.
目的：探究阿托伐他汀钙辅助治疗脑梗死后认知功能障碍的临床药学分析。方法：选取2021年1月到2021年12月于广西岑溪市人民医院接受治疗的210例脑梗死后认知功能障碍患者，随机分为观察组和对照组，105例/组。对照组给予常规治疗，观察组给予常规治疗+阿托伐他汀钙辅助治疗。结果：观察组治疗总有效率为95.24%，高于对照组的80%(P<0.05)。治疗后，观察组Barthel指数（Barthel指数评定量表）、MMSE（简易智能精神状态检查量表）各维度评分均高于对照组，NIHSS（美国国立卫生院卒中评分量表）评分均低于对照组（P<0.05）。治疗后，观察组患者TC（总胆固醇）、TG（甘油三酯）、LDL-C（低密度脂蛋白胆固醇）水平低于对照组，HDL-C（高密度脂蛋白胆固醇）水平高于对照组（P<0.05）。治疗后，观察组PAdT（血小板黏附率）、PAgT（血小板聚集率）、CD62P（血小板膜糖蛋白）水平均低于对照组（P<0.05）。观察组患者不良反应发生率为4.00%，低于对照组的20.00%(P<0.05)。结论：对脑梗死后认知功能障碍患者采用阿托伐他汀钙辅... 相似文献
8.
对１４０例老年高血压类型、年龄、合并缺血性脑血管病的例数及血脂、载脂蛋白、血液流变学进行统计学处理,分析它们之间的关系。结果表明：随增龄,（Ⅰ型）收缩期型高血压的比例增多,（Ⅱ型）混合型高血压次之,（Ⅲ型）舒张期型高血压随增龄减少。缺血性脑血管病占高血压病的３０％,脑梗塞居多,其中腔隙性脑梗塞占５２．６３％,脑出血占９％。缺血性脑血管病的高发年龄在６５～７５岁,以Ⅰ、Ⅱ型高血压为主。高血压组和脑血管病组的血脂、血粘滞度增高与对照组比较Ｐ＜０．０１。载脂蛋白ＡＰＯＡ１／ＡＰＯＢ比值下降。脑出血患者的载脂蛋白无明显变化。提示老年高血压是缺血性脑血管病重要危险因素之一,其类型、年龄、血脂、血液流变学及脑血管病之间关系密切。 相似文献
9.
报告１０８例病毒性肝炎患者血清总补体（ＣＨ＿（５０））和Ｃ＿３值的检测结果：急性肝炎的ＣＨ＿（５０）为６８．４±６．１３单位／ｍｌ，Ｃ＿３为１３０．２±６．６７ｍｇ％，均高于正常组（ＣＨ＿（５０）为４８．５±５．７５单位／ｍｌ，Ｃ＿３为１０２±５ｍｇ％），Ｐ＜０．０１；其他类型的肝炎患者组的补体均低于正常组，Ｐ＜０．０１．补体的含量与Ｔ细胞花环（Ｅｔ花环）呈中度相关，与ＧＰＴ呈高度相关，因此测定ＣＨ＿（５０）和Ｃ＿３可作为衡量患者机体免疫功能和判断病毒性肝炎预后的指标之一。 相似文献
10.
用盐析－双缩脲法对９７例健康人和７９例冠心病患者进行了血浆纤维蛋白原含量的测定，结果表明：冠心病患者血浆纤维蛋白原含量显著高于健康人（Ｐ＜０．０１），提示纤维蛋白原含量升高是冠心病、中风、血栓形成的一种重要的危险因素．对血浆纤维蛋白原进行检测，将为冠心病的临床诊断及预防提供依据 相似文献
11.
D. Rajasekhar K. S. S. Saibaba P. V. L. N. Srinivasa Rao S. A. A. Latheef G. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2004,19(2):53-59
In an attempt to search for risk factors which can explain the increasing prevalence of coronary heart disease (CHD) in Indian
population, we conducted a case-control study to assess the association of Lipoprotein (a)(Lp(a)) with CHD. One hundred and
fifty one consecutive patients with clinical and angiographic evidence of CHD and forty-nine healthy controls were drawn for
the study. Triglycerides, very low density cholesterol (VLDL-C), total cholesterol (total-C)/high density cholesterol (HDL-C)
ratio, low density cholesterol (LDL-C)/HDL cholesterol ratio and Lp(a) were found to be higher in patients than controls.
In female sex and in those with family history of CHD, higher total and LDL cholesterol levels were observed to be associated
with higher Lp(a) levels. Lp(a) levels were also found to be higher in triple vessel disease than other vessel disease patients.
Significant difference in Lp(a) levels were observed between normal coronaries vs. single and triple vessel disease(P<0.05)
and also between single vs. double and triple vessel disease (P<0.01).Lp(a) levels correlated positively with vessel severity(P<0.005).
Lp(a) levels >25 mg/dl were associated with coronary heart disease (Odds ratio 1.98 P<0.05 95% CI 0.007–1.18). Our findings
suggest a cut-off level of 25mg/dl for determination of risk of CHD. Studies from different areas involving larger sample
size are needed to confirm the findings of the present study. 相似文献
12.
Manisha Mavai Yogendra Raj Singh R. C. Gupta Sandeep K. Mathur Bharti Bhandari 《Indian journal of clinical biochemistry : IJCB》2018,33(2):222-228
Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. This study was designed to investigate the correlation of CK and its isoform CK-MB with thyroid profile and linear parameters of heart rate variability (HRV). The study was conducted on 35 hypothyroid and hyperthyroid patients each, and 25 age-matched healthy controls. Autonomic activity was assessed by simple short term 5-min HRV. Biochemical evaluation of serum thyroid profile, CK-NAC and CK-MB were estimated in all the subjects. Our results demonstrated low HRV in hypo- as well as hyperthyroid patients. We observed significantly higher serum CK levels in hypothyroid patients when compared to hyperthyroids and controls. However, no significant differences were observed in CK-MB levels in the three groups. Significant positive correlation of CK with TSH and negative correlation with some HRV parameters (LF power, HF power, total power, SDNN, RMSSD) was observed in hypothyroid patients. Whereas correlation of CK-MB with thyroid profile as well as HRV parameters was non-significant in all the groups. Based on the CK and CK-MB findings and their correlation, we conclude that the cardiovascular changes seen in thyroid dysfunctions may primarily be due to autonomic imbalance without apparent cardiac muscle involvement. Whereas, raised CK levels indicate predominantly skeletal muscle involvement in hypothyroid patients. 相似文献
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14.
Sanjeev Shruthi Molly Mary Thabah Bobby Zachariah Vir Singh Negi 《Indian journal of clinical biochemistry : IJCB》2021,36(2):185
To study oxidative stress in systemic lupus erythematosus (SLE) by estimating serum oxidised LDL (OxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total anti-oxidant status and to correlate with SLE disease activity and disease damage. Eighty SLE patients satisfying the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) 2012 criteria and 80 healthy controls were studied. Exclusion criteria were infections, renal insufficiency, other connective tissue diseases, drug-induced lupus, smoking, alcohol consumption. Disease activity was measured by SLE disease activity index-2 K (SLEDAI), disease damage was quantified by SLICC-Damage Index (SDI). Sera was tested for OxLDL, 8-OHdG, and total antioxidant status (TAS) by double-antibody sandwich ELISA; MDA measured by Colorimetric assay. Oxidative stress markers were compared between group1- controls, group 2-mildly active SLE (SLEDAI ≤ 5), group 3- moderate to highly active SLE (SLEDAI ≥ 6). SLE patients had significantly higher MDA, 8-OHdG and lower TAS when compared to healthy controls, while OxLDL was similar in the three groups. MDA, 8-OHdG were significantly higher, TAS lower in group 3 compared to group 2. MDA had positive correlation with SLEDAI, TAS negatively correlated with SLEDAI. SLE with neuropsychiatric manifestations, vasculitis, anti-sdDNA antibodies had higher MDA, MDA/TAS ratio. SLE patients with thrombocytopenia, and vasculitis had higher OxLDL. Only OxLDL was significantly higher in those patients who have SDI > 1. SLE patients have increased oxidative stress measured by increases in MDA, 8-OHdG, and lower total antioxidant status that was associated with disease activity and some disease manifestations. However only OxLDL was associated with damage. 相似文献
15.
T. Angeline RitaMary Aruna K. Ramadevi G. Mohan Nirmala Jeyaraj 《Indian journal of clinical biochemistry : IJCB》2003,18(1):103-106
Coronary artery disease is now a major health problem in India. In past few decades the battle to reduce the incidence of
coronary artery disease has led the researchers to look for various clinical markers, which would help early diagnosis of
the diseases. The present study was undertaken to assess the level of lipoprotein (a) [Lp(a)] and few other lipids in selected
myocardial infarction (MI) patients below 45 years without having any traditional risk factors but with positive family history.
Fasting blood samples were taken from 65 patients and their total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol,
triglycerides and serum Lp(a) were determined. The control group consisted of 50 age matched healthy individuals. The mean
Lp(a) level was 58.6±3.20 mg/dl in patients and 19.70±0.18 mg/dl in controls. Thus Lp(a) levels were found significantly higher
in patients with MI (p<0.05 for patients versus control) as compared to the controls. There was no significant difference
in the levels of total cholesterol (TC), LDL, VLDL HDL, TGL as compared to controls but there was an increase in TC/HDL cholesterol
ratio. The results of this study suggest that high level of Lp(a) and TC/HDL ratio has a distinctive association with MI,
independent of other common coronary risk factors. Hence, Lp(a) level in serum emerges to be a promising marker for diagnosis
of coronary artery diseases. 相似文献
16.
观察了力平脂对高脂血症者的治疗作用和安全性．确诊高脂血症者６８例，力平脂，０．１，Ｔｉｄ，服一个月为一疗程后，血清总胆固醇（ＴＣ）平均降低２０．９８％，甘油三酯平均降低５１．８８％，ＨＤＬ－Ｃ平均升高１０．２６％，ＬＤＬ－Ｃ平均降低１２．５７％，ＡｐｏＡ１平均升高２．２４％，ＡｐｏＢ平均降低２１．１０％，从调血脂的个体疗效分析，力平脂降低ＴＣ的总有效率８４．６１％，降低ＴＧ的总有效率９５．２４％，升高ＨＤＬ－Ｃ的总有效率６１．７７％，降低ＬＤＬ－Ｃ的总有效率为５５．８８％，升高ＡｐｏＡ１的总有效率３８．２４％，降低ＡｐｏＢ的总有效率７７．９４％．提示：力平脂治疗高脂血症者，对降低ＴＣ，ＴＧ，ＬＤＬ－Ｃ，ＡｐｏＢ和升高ＨＤＬ－Ｃ，ＡｐｏＡ１均有明显效果，其中降低ＴＧ的疗效尤为突出，副作用轻微．临床实践表明：力平脂是一个疗效高、安全、服用方便的调血脂新药 相似文献
17.
选择46岁以上的高血压(HBP)、冠心病(CHD)、卒中及其它内科住院病人共140名进行了血浆纤维蛋白原(FG)、血压、甘油三酯(TG)和吸烟等因素的观察.结果表明高血压、冠心病和车中患者FG值升高,逐步回归分析看出吸烟,HBP和TG水平升高明显影响FG的含量,提示FG水平升高同HBP,CHD和年中存在着紧密的联系。 相似文献
18.
Sana Parveen Rachel Jacob Liza Rajasekhar C. Srinivasa Iyyapu Krishna Mohan 《Indian journal of clinical biochemistry : IJCB》2017,32(1):26-32
Dyslipidaemia is a major CVD risk factor in the general population. Current evidence suggests that lipid metabolism is altered in RA due to inflammation, and that use of anti-inflammatory therapy may reverse some of these changes. The objective of our study is to compare the effect of treatment with DMARD on lipid fractions after 6 months of therapy. Forty patients who met the American College of Rheumatology, ACR/EULAR criteria for rheumatoid arthritis, with disease duration of less than 1 year and no prior treatment were included in the study. Thirty healthy volunteers were included as controls. The mean DAS-28 at disease onset was 5.15 ± 1.3. Early Rheumatoid Arthritis (ERA) patients exhibited higher serum levels of total cholesterol (TC) and lowdensity lipoprotein cholesterol (LDL-C) and lower serum high-density lipoprotein cholesterol (HDL-C) levels compared to controls. As a consequence, the atherogenic index of plasma [log (TG/HDL-C)], the atherogenic indices: TC/HDL-C as well as LDLC/HDL-C was significantly higher in ERA patients compared to controls. After 6 months of treatment, there was significant reduction of the DAS 28, HDL-C and Apo A-I improved and Lp(a) decreased significantly. All lipid ratios improved, a phenomenon primarily due to the increase in serum HDL-C levels. These changes were inversely correlated with CRP and ESR. In conclusion, ERA patients are characterized by an atherogenic lipid profile, which improves with DMARD therapy. 相似文献