共查询到20条相似文献，搜索用时 296 毫秒
1.
Xian-bao LIU Ju-bo JIANG Qi-jing ZHOU Zhao-xia PU Wei HE Ai-qiang DONG Yan FENG Jun JIANG Yong SUN Mei-xiang XIANG Yu-xin HE You-qi FAN Liang DONG Jian-an WANG 《Journal of Zhejiang University. Science. B》2015,16(3):208-214
目的:评估经导管主动脉瓣置入术在中国人群二叶式主动脉瓣重度狭窄中的安全性和有效性。创新点:首次在中国人群比较经导管主动脉瓣置入术在二叶式和三叶式主动脉瓣重度狭窄中的安全性和有效性。方法:选取2013年3月至2014年9月行经导管主动脉瓣置入术的40位主动脉瓣狭窄的患者,分二叶式和三叶式主动脉瓣两组,比较基线水平、手术以及随访1月结果的差别。结论:经导管主动脉瓣置入术在中国人群中二叶式主动脉瓣重度狭窄中的应用是安全有效的。 相似文献
2.
目的 观察骨化三醇对尿毒症维持性血透(MHD)患者继发性甲状旁腺功能亢进症(SHPT)的远期疗效。方法 血透的26例尿毒症合并SHPT患者随机分成冲击治疗组和常规治疗组,各13例。常规治疗组给予骨化三醇0.25~0.50μg治疗;冲击治疗组根据i PTH水平给予不同剂量的骨化三醇治疗。观察两组患者治疗前、后甲状旁腺激素、血钙、血磷及钙磷乘积和患者临床症状的变化。结果 两组总有效率无明显差别(P>0.05);治疗后两组患者i PTH均明显下降(P<0.05);常规治疗组Ca、P及Ca×P水平与治疗前比较无明显差别(P>0.05);冲击治疗组Ca、Ca×P水平与治疗前比较升高(P<0.05),血P水平无明显变化(P>0.05);冲击治疗组患者i PTH、P与常规治疗组比较无明显差别(P>0.05),而血Ca、Ca×P水平比常规治疗组明显升高(P<0.05)。结论 维持性血透伴继发性甲状旁腺功能亢进症的尿毒症患者应用骨化三醇治疗,无论应用常规剂量持续给药或是冲击治疗方案,36个月后少数患者无效,大部分患者效果明显,两种治疗方法长期疗效无明显区别,但冲击治疗组患者血钙及钙磷乘积高于常规剂量治疗组。 相似文献
3.
磷营养不足能引起牛的乳肉生产率、乳脂率和血磷水平降低,矿物质代谢紊乱,骨营养不良,不孕症,並诱发产后疾病(阴道或子宫脱、子宫内膜炎、乳房炎、产后轻痪)与角化过度症。由这样母牛所生的犢牛,易患胃肠病和肺病等。 然而,对于用含磷的补充料预防母牛及其胎儿发生骨营养不良和产后疾病,目前研究得仍不够。作者的研究,对利用含氮、磷的补充料预防上述疾病,提供了可靠的效果。 化学工业正生产含钙、磷和含磷的补充料,作为反刍动物日粮的添加剂。第一类包括 相似文献
4.
孙亦兵 《河北北方学院学报(医学版)》2007,24(4):13-15
目的：探讨血液灌流加血液透析对慢性肾衰患者血清中瘦素（Leptin）、同型半胱氨酸（tHcy）及甲状旁腺素（iPTH）的清除作用,并与单纯血液透析清除Leptint、Hcy、iPTH的效果比较。方法：在25例慢性肾衰患者常规血液透析中增加一次血液透析加灌流治疗,在透析及透析加灌流前后分别检测其Leptint、Hcy、iPTH血清水平,结果表明血透加灌流治疗后较治疗前明显降低（P〈0.01）,且较单纯血液透析明显降低（P〈0.05）,而单纯血液透析前后血清Leptint、Hcyi、PTH水平没有改变（P〉0.05）。结论：血液灌流可以明显降低慢性肾衰患者血清中的Leptin、tHcyi、PTH水平,从而改善透析患者的生活质量,减少营养不良、心血管疾病和肾性骨病和异位钙化并发症的发生。 相似文献
5.
川芎嗪对糖尿病大鼠骨质疏松的保护作用 总被引：2，自引：0，他引：2
探讨川芎嗪对糖尿病大鼠骨质疏松的保护作用.选择健康SD大鼠,随机分为正常对照组、糖尿病(DM)模型组和治疗组.一次性腹腔注射链脲佐菌素60mg/kg诱发糖尿病.HE染色观察股骨头结构变化;VanGieson氏染色法观察骨胶原纤维;紫外分光光度法测定醛糖还原酶(AR)、骨羟脯氨酸(B-HYP)和甲状旁腺激素(PTH)的含量.结果,DM模型组大鼠AR和PTH含量显著增高(P<0.01).B-HYP含量显著降低(P<0.01).胶原纤维减少,川芎嗪可逆转上述改变(P<0.01).结果表明,川芎嗪对糖尿病大鼠骨质疏松有一定的治疗作用. 相似文献
6.
《赤峰学院学报(自然科学版)》2008,(Z1)
目的:讨论颈动脉支架成形术治疗症状性颈动脉狭窄的短期疗效和安全性。方法:25例症状性颈动脉狭窄病人(狭窄率>70%)采用颈动脉支架治疗,随访1至12个月。结果:25例患者手术操作完全成功,术后残余狭窄小于20%。1~12个月后TCD及颈动脉彩超未显示再狭窄。结论:颈动脉支架成形术治疗症状性颈动脉狭窄是一种安全可行的方法,短期疗效肯定。 相似文献
7.
目的:他汀类药物在治疗骨质疏松症时会加重肌肉损伤。本实验研究左卡尼汀和辅酶Q10对阿托伐他汀在切除卵巢的老鼠的抗骨质疏松作用的影响。创新点:研究新的治疗骨质疏松症及其并发症的方法。方法:选取48只雌性SD大鼠,40只大鼠切除卵巢,8只为假手术组。切除卵巢8周后,大鼠被分成去卵巢非治疗组和4个去卵巢治疗组(每组8只),通过灌胃法给药(单位为mg/(kg·d),为期8周):雌二醇(0.1)、阿托伐他汀(50)、阿托伐他汀(50)+左卡尼汀(100)或阿托伐他汀(50)+辅酶Q10(20)。在治疗结束时,测量骨矿物质密度、骨矿物质含量及骨代谢标志物和肌酸激酶的血清水平,利用股骨研究抗断强度和组织病理学变化。结论:相比辅酶Q10,合并给药左卡尼汀可在提高阿托伐他汀对切除卵巢的老鼠的抗骨质疏松作用的同时避免肌肉损伤。 相似文献
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9.
糖尿病是临床常见的内分泌代谢性疾病,是由于胰岛素分泌绝对或相对不足,从而引起糖、蛋白质和脂肪的紊乱,高渗性非酮症糖尿病昏迷(简称高渗性昏迷)是糖尿病急性代谢紊乱的另一临床类型,其临床特征:先有多尿、多饮,可有发热,多食不明显,甚至食欲减退、恶心、呕吐、失水逐渐加重,随后出现精神症状,最后陷入昏迷,由于病情的严重性,决定了它有可能发生诸多的合并症,高渗性昏迷合并上消化道出血多年来较为罕见,现介绍一例病人的护理。 相似文献
10.
组合型人工肾对慢性肾衰患者血清多胎类毒素清除效果观察 总被引：5，自引：0，他引：5
孙亦兵 《河北北方学院学报(医学版)》2007,24(6):21-23
目的:探讨血液灌流加血液透析对慢性肾衰患者血清中多胎类毒素:β2微球蛋白(β2-MG)、全段甲状旁腺素(iPTH)的清除作用,并与单纯血液透析清除β2-MGi、PTH的效果比较。方法:在28例慢性肾衰患者常规血液透析中增加一次血液透析加灌流治疗,在透析及透析加灌流前后分别检测其β2-MG、iPTH血清水平。结果:血液透析加灌流治疗后较治疗前血清β2-MG、iPTH水平明显降低(P<0.01),单纯血液透析前后血清β2-MG、iPTH水平没有明显改变(P>0.05)。结论:血液灌流加透析可以明显降低慢性肾衰患者血清中β2-MGi、PTH水平,从而改善透析患者的生活质量,减少血液透析相关并发症的发生。 相似文献
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Guang-yong Ye Ke-yi Wang Qiao-di Gui Min Wang 《Journal of Zhejiang University. Science. B》2018,19(8):654-661
Objective
The purpose of this study was to determine the role of Ureaplasma urealyticum-derived lipidassociated membrane proteins (LAMPs) in the host innate immune system, specifically their effect on Toll-like receptors (TLRs).Methods
LAMPs were derived from U. urealyticum strains, and human amniotic epithelial cells (HAECs) were isolated from healthy full-term placentas. Cytokine concentrations were determined by enzyme-linked immunosorbent assay (ELISA) and TLR2 mRNA by real-time PCR. Expression of TLR2 was confirmed by Western blotting and immunohistochemistry.Results
LAMPs induced HAECs to produce inflammatory cytokines interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α. Cytokine production was reduced after blocking TLR2 using TLR2 inhibitor (anti-hTLR2-IgA).Conclusions
LAMPs isolated from U. urealyticum induced TLR2-dependent up-regulation of inflammatory genes and cytokines in HAECs.13.
题目：复方西洋参和红枣制剂对小鼠免疫功能影响的研究 总被引：1，自引：0，他引：1
Zhuo-ping Yu Dong-dong Xu Lai-feng Lu Xiao-dong Zheng Wei Chen 《Journal of Zhejiang University. Science. B》2016,17(2):147-157
14.
Wojciech Szczęsny Magdalena Kuligowska-Prusińska Stanisław Dąbrowiecki Jakub Szmytkowski Adrian Reśliński Maciej Słupski 《Journal of Zhejiang University. Science. B》2018,19(1):65-70
Purpose
Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls.Materials and methods
The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).Results
A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.Conclusions
The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.15.
Pan Xu Shu-ping Xu Ke-zhu Wang Cong Lu Hong-xia Zhang Rui-le Pan Chang Qi Yan-yan Yang Ying-hui Li Xin-min Liu 《Journal of Zhejiang University. Science. B》2016,17(7):503-514
Objectives
The aim of the study is to evaluate the cognitive-enhancing effects of hydrolysate of polygalasaponin (HPS) on senescence accelerate mouse P8 (SAMP8) mice, an effective Alzheimer’s disease (AD) model, and to research the relevant mechanisms.Methods
The cognitive-enhancing effects of HPS on SAMP8 mice were assessed using Morris water maze (MWM) and step-through passive avoidance tests. Then N-methyl-d-aspartate (NMDA) receptor subunit expression for both the cortex and hippocampus of mice was observed using Western blotting.Results
HPS (25 and 50 mg/kg) improved the escape rate and decreased the escape latency and time spent in the target quadrant for the SAMP8 mice in the MWM after oral administration of HPS for 10 d. Moreover, it decreased error times in the passive avoidance tests. Western blotting showed that HPS was able to reverse the levels of NMDAR1 and NMDAR2B expression in the cortex or hippocampus of model mice.Conclusions
The present study suggested that HPS can improve cognitive deficits in SAMP8 mice, and this mechanism might be associated with NMDA receptor (NMDAR)-related pathways.16.
Jing ZHAO Hui-min YAN Ya LI Jia WANG Lu HAN Zhi-hao WANG Meng-xiong TANG Wei ZHANG Yun ZHANG Ming ZHONG 《Journal of Zhejiang University. Science. B》2015,16(5):380-387
目的:观察匹伐他汀钙对高胆固醇血症患者外周血管的影响。创新点:首次在国内发现匹伐他汀钙能够改善高胆固醇血症患者肱动脉和颈动脉血管内皮功能而且延缓其动脉粥样硬化发展,并首次证实改善内皮功能是匹伐他汀钙延缓其动脉粥样硬化发展的重要原因。方法:按照入选排除标准,选取本院高胆固醇血症患者(HC),完成超声心动图检查的40例。根据剂量不同,分为两个剂量组:1 mg剂量组20例(男性5例,女性15例,平均年龄(55.20±8.35)岁),2 mg剂量组20例(男性9例,女性11例,平均年龄(57.56±6.09)岁)。访视结束后完成超声心动图检查的HC组36例,两个剂量组分别有2人失访。治疗后1 mg剂量组18例(男性3例,女性15例,平均年龄(56.00±7.85)岁),2 mg剂量组18例(男性7例,女性11例,平均年龄(57.79±6.46)岁)。选择本院同期体检中心30例正常人作为对照(年龄和性别均与病例组匹配,男性14例,女性16例,平均年龄(54.94±6.90)岁)。所有研究对象,均经隔夜禁食12~14小时,次日清晨抽取空腹肘静脉血,测定临床生化指标。采用Sequia512彩色多普勒超声诊断仪,应用高分辩率外周血管超声技术,检测HC治疗前后肱动脉血流介导性舒张功能(FMD)、颈动脉结构和功能。结论:经匹伐他汀钙治疗8周后,高胆固醇血症患者血管功能明显改善,表现为FMD升高,僵硬度减小;颈动脉僵硬度和内中膜厚度(IMT)延缓进展与其内皮功能改善密切相关。 相似文献
17.
Jian-fang Zhu Lian-hui Chen Ke Yuan Li Liang Chun-lin Wang 《Journal of Zhejiang University. Science. B》2018,19(10):807-814
Objective
The aim of this study was to explore the association of dopamine receptor D2 (DRD2) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up.Methods
This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and DRD2 polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance.Results
One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30?8.58).Conclusions
The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.18.
Ping Li Xuan Li Qing Gu Xiu-yu Lou Xiao-mei Zhang Da-feng Song Chen Zhang 《Journal of Zhejiang University. Science. B》2016,17(8):569-579
Objective
In previous studies, Lactobacillus plantarum ZJ316 showed probiotic properties, such as antimicrobial activity against various pathogens and the capacity to significantly improve pig growth and pork quality. The purpose of this study was to reveal the genes potentially related to its genetic adaptation and probiotic profiles based on comparative genomic analysis.Methods
The genome sequence of L. plantarum ZJ316 was compared with those of eight L. plantarum strains deposited in GenBank. BLASTN, Mauve, and MUMmer programs were used for genome alignment and comparison. CRISPRFinder was applied for searching the clustered regularly interspaced short palindromic repeats (CRISPRs).Results
We identified genes that encode proteins related to genetic adaptation and probiotic profiles, including carbohydrate transport and metabolism, proteolytic enzyme systems and amino acid biosynthesis, CRISPR adaptive immunity, stress responses, bile salt resistance, ability to adhere to the host intestinal wall, exopolysaccharide (EPS) biosynthesis, and bacteriocin biosynthesis.Conclusions
Comparative characterization of the L. plantarum ZJ316 genome provided the genetic basis for further elucidating the functional mechanisms of its probiotic properties. ZJ316 could be considered a potential probiotic candidate.19.
Jun Zhu Rong-jun Gao Qiang Liu Ru-hong Jiang Lu Yu Ya-xun Sun Pei Zhang Jian-wei Lin Yang Ye Zu-wen Zhang Shi-quan Chen Hui Cheng Xia Sheng Chen-yang Jiang 《Journal of Zhejiang University. Science. B》2017,18(11):946-954
Background and objective
Rivaroxaban is a new oral anticoagulant for stroke prevention in patients with non-valvular atrial fibrillation (NVAF), which has less drug–food interaction than warfarin. We conducted this prospective randomized study to evaluate the metabolic benefits as well as the safety and efficacy with rivaroxaban versus warfarin in patients with NVAF following radiofrequency catheter ablation (RFCA).Methods
From April to July 2014, 60 patients with NVAF undergoing RFCA were prospectively enrolled in our study. Following RFCA, all patients were randomly assigned to receive rivaroxaban (Group R, n=30) or warfarin (Group W, n=30). Metabolic indices including serum total protein, albumin, globulin, and high-density lipoprotein (HDL) as well as bleeding, stroke, and systemic thromboembolism events were evaluated and compared during follow-up after 15, 30, 60, and 90 d of RFCA procedure.Results
Serum total protein, albumin, globulin, and HDL levels were all significantly elevated at each follow-up stage in Group R when compared to the baseline (P<0.05 respectively). In Group W, the metabolic indices decreased at first and then had an increasing trend. There were no deaths or thromboembolic complications in each group. The prevalence of total bleeding complications was similar between Group R and Group W (11/30, 36.7% vs. 10/30, 33.3%, P=0.79).Conclusions
Patients with NVAF receiving rivaroxaban after RFCA procedures appear to benefit from a metabolic perspective compared with warfarin, providing practical clinical reference for the choice of the anticoagulant. Rivaroxaban seems to be as safe and effective in preventing thromboembolic events as warfarin for these patients.20.
Christian Mehl Matthias Kern Friederike Neumann Telse Bähr Jörg Wiltfang Volker Gassling 《Journal of Zhejiang University. Science. B》2018,19(7):525-534