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1.
In prehistoric times carbon wasknown in the form of soot andcharcoal. Ever since AntoineLavoisier in 1792 and Smithson Te-net in 1797 demonstrated that dia-mond and graphite are allotropicforms of carbon[1], people have beeninterested in converting the relativelyabundant carbon materials into muchrarer diamond. It is found that dia-mond burnt in oxygen yields exactlythe same amount of carbon dioxideas that produced by burning the sameweight of carbon, proving diamondconsists of pure carbon.S… 相似文献
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Saba Khan Gorantla V. Raghuram Neelam Pathak Subodh K. Jain Dolly H. Chandra Pradyumna K. Mishra 《Indian journal of clinical biochemistry : IJCB》2014,29(1):38-44
Increased leukocyte apoptosis is intrinsically linked to disease patho-physiology, susceptibility to and severity of infections in type 2 diabetes mellitus (T2DM) patients. A consistent defect in neutrophil function is considered central to this increased risk for infections. Although redox imbalance is considered a potential mediator of these associated complications, detailed molecular evidence in clinical samples remains largely undetected. The study consisted of three groups (n = 50 each) of Asian Indians: early diagnosed diabetic patients, cases with late-onset diabetic complications and age and gender-matched healthy controls. We evaluated mitochondrial oxidative stress, levels of nuclear DNA damage and apoptosis in peripheral blood neutrophils isolated from T2DM patients. We observed that in both early and late diabetic subjects, the HbA1c levels in neutrophils were altered considerably with respect to healthy controls. Increased oxidative stress observed in both early and late diabetics imply the disentanglement of fine equilibrium of mitochondria-nuclear cross talk which eventually effected the augmentation of downstream nuclear γH2AX activation and caspase-3 expression. It would be overly naïve to refute the fact that mitochondrial deregulation in neutrophils perturbs immunological balance in type 2 diabetic conditions. By virtue of our data, we posit that maneuvering mitochondrial function might offer a prospective and viable method to modulate neutrophil function in T2DM. Nevertheless, similar investigations from other ethnic groups in conjunction with experimental evidences would be a preeminent need. Obviously, our study might aid to comprehend this complex interplay between mitochondrial dysfunction and neutrophil homeostasis in T2DM. 相似文献
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《中国科学院院刊(英文版)》2006,(4)
Division of Life & Medical Sciences CHANG Wenru CHANG Wenrui, a structural biologist, now serves as research professor at the CAS Insti- tute of Biophysics. He was born in Jinzhou City, Liaoning Province in 1940 and graduated from Nankai University as a major in chemistry in 1964. At the end of the 1960s, he participated in the whole process of determining the crystal structure of the por- cine insulin as a backbone member of the Beijing Insu-lin Research Team assigned to the resea… 相似文献
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《中国科学院院刊(英文版)》2005,(1)
Fei Weiyang, expert of chemical engineering,now serves as a professor at the Department of Chemical Engineering of Tsinghua University.He was born in Shanghai in 1939 and graduated fromTsinghua as a major in engineering chemistry in 1963.He is a veteran scholar specializing in modern S&T forseparation such as liquid-liquid extraction. By using advanced technology of measurement and CFD simulation, he probed mathematic models of the sepa- ration equipment and their strengthening approaches… 相似文献
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《中国科学院院刊(英文版)》2005,19(1):34-41
Fei Weiyang, expert of chemical engineering, now serves as a professor at the Department of Chemical Engineering of Tsinghua University. He was born in Shanghai in 1939 and graduated from Tsinghua as a major in engineering chemistry in 1963. He is a veteran scholar specializing in modern S&T for separation such as liquid-liquid extraction. 相似文献
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N. Maithili Karpaga Selvi M. G. Sridhar R. P. Swaminathan R. Sripradha 《Indian journal of clinical biochemistry : IJCB》2015,30(2):180-186
It is known that there is a significant interplay of insulin resistance, oxidative stress, dyslipidemia, and inflammation in type 2 diabetes mellitus (T2DM). The study was undertaken to investigate the effect of turmeric as an adjuvant to anti-diabetic therapy. Sixty diabetic subjects on metformin therapy were recruited and randomized into two groups (30 each). Group I received standard metformin treatment while group II was on standard metformin therapy with turmeric (2 g) supplements for 4 weeks. The biochemical parameters were assessed at the time of recruitment for study and after 4 weeks of treatment. Turmeric supplementation in metformin treated type 2 diabetic patient significantly decreased fasting glucose (95 ± 11.4 mg/dl, P < 0.001) and HbA1c levels (7.4 ± 0.9 %, P < 0.05). Turmeric administered group showed reduction in lipid peroxidation, MDA (0.51 ± 0.11 µmol/l, P < 0.05) and enhanced total antioxidant status (511 ± 70 µmol/l, P < 0.05). Turmeric also exhibited beneficial effects on dyslipidemia LDL cholesterol (113.2 ± 15.3 mg/dl, P < 0.01), non HDL cholesterol (138.3 ± 12.1 mg/dl, P < 0.05) and LDL/HDL ratio (3.01 ± 0.61, P < 0.01) and reduced inflammatory marker, hsCRP (3.4 ± 2.0 mg/dl, P < 0.05). Turmeric supplementation as an adjuvant to T2DM on metformin treatment had a beneficial effect on blood glucose, oxidative stress and inflammation. 相似文献
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Shilpa Reddy Ganasyam Talluri Bhaskar Rao Y. S. R. Murthy Akka Jyothy Madireddy Sujatha 《Indian journal of clinical biochemistry : IJCB》2012,27(1):69-73
Type 2 diabetes mellitus (DM) is a multifactorial disease where both genetic and environmental factors contribute to its pathogenesis.
Estrogen plays an important role in type 2 DM pathogenesis. A number of polymorphisms have been reported in the estrogen receptor
(ESR1), including the XbaI and PvuII restriction enzyme polymorphisms of ESR1,which may be involved in disease pathogenesis. Metallothioneins (MT) act as potent
antioxidants against various oxidative damages. Very few studies have indicated the association between Estrogen Receptor-α,
MT1 gene polymorphisms with type2 DM. A total of 100 type 2 diabetic women and 100 age, sex matched controls were recruited.
Using the PCR based RFLP method, the PvuII and XbaI polymorphisms of ESR1 and in MT1A (rs8052394 and rs11076161) gene polymorphisms were analysed. The genotype distribution and frequency of mutated allele showed no significant differences
between diabetic and non-diabetic groups in PvuII (χ2 = 2.443; P = 0.1181) or XbaI (χ2 = 1.789; P = 0.1812) and rs8052394 (χ2 = 1.154; P = 0.2840) or rs11076161 (χ2 = 0.4141; P = 0.5199), polymorphisms. This is the first Indian study to conclude that ESR1 and MT1 gene polymorphisms are not associated
with increased susceptibility to type 2 diabetes in Indian women. 相似文献
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《中国科学院院刊(英文版)》2006,20(4):235-245
CHANG Wenrui, a structural biologist, now serves as research professor at the CAS Institute of Biophysics. He was born in Jinzhou City, Liaoning Province in 1940 and graduated from Nankai University as a major in chemistry in 1964. 相似文献
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《Information processing & management》2023,60(3):103259
B2B livestreaming has become increasingly popular, but few studies have investigated the role of streamers in these B2B livestreaming events. In contrast to the existing studies that explored the appearance and professionalism of streamers and focused on the B2C livestreaming commerce, this study analyzes how streamers’ linguistic characteristics relate to the livestreaming sales performance in online B2B marketplaces by conducting a streamer-level analysis. By combining deep learning and econometric analysis on a livestreaming dataset consisting of 915 livestreaming events across 14 industry categories from a B2B commerce platform, this study specifically examines the impact of three speech acts (i.e., assertive, expressive, and directive speech acts) on sales performance. We first extract three speech acts by combining Word2Vec and Bi-GRU network with Attention Mechanism (WBA), then use econometric models to examine the effect of the streamer's speech acts on sales performance, and finally explore the moderating roles of product-level factors (i.e., product novelty and product category). The results show that the assertive and directive acts have a positive effect on sales performance, but the expressive acts have a negative effect on the sales performance. In addition, this study also provides strong evidence that the effects of these speech acts on sales performance are highly dependent on the novelty of the live product. This moderating effect is particularly significant for sensory products. 相似文献
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《中国专利与商标》2006,(4)
On 27 October 2001, the Standing Committee of the People's Congress reviewed and passed the Amendment to the Copyright Law of the People's Republic of China. In Article 10 of the amended Copyright Law as of 2001 has been incorporated a new subject matter under the copyright protection: the right of communication through information network, that is, the right to make a work available to the public by wire or by wireless means, so that people may have access to the work from a place and at a time individually chosen by them. This is the first time to have put the right of communication through information network in place in the law in China. But, the legislators did not make any specific provisions concerning this right in the Copyright Law. 相似文献
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《中国科学院院刊(英文版)》2005,(3)
The Standard Model (SM) is the basic theory of particle physics. Almost all of its predictions agree with the experimental results within measurement precision. However, the Higgs particle predicted by the SM, which is closely connected with the origin of mass, has not been found yet. In theoretical calculation of the SM that underlies major research areas of high energy physics, the R values, namely the hadronic production cross sections,are necessary as basic input quantities. Unfortunat… 相似文献
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《中国专利与商标》2007,(3)
In recent years,along with the rapid increase in the number of applications for patent received,examined and granted by the State Intellectual Property Office(SIPQ),the number of the cases of dispute arising from patent infringe- ment has been on the rise.In hearing cases of infringement of patent limited or defined by a functional feature,construc- 相似文献
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《中国专利与商标》2007,(2)
Article 8 of the Trademark Law of the People's Republic of China provides that any visual sign capable of distinguish- ing the goods or service of one natural person,legal person or any other entity from those of others,including words,de- vices,letters,numerals,three-dimensional symbols,combi- nations of colours or any combination of the above elements, may be applied for the registration of a trademark.It may be seen from the provision on the components of a registered trademark that any visual sign comprising three-dimensional symbols or three-dimensional symbol containing other ele- 相似文献
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《中国科学院院刊(英文版)》2006,(1)
(Adopted by the Presidium of the Chinese Academy of Sciences onDecember 4, 1992, and amended by the Presidium on December 16,1994, November 6, 1996, December 14, 1998, September 29, 2000,December 19, 2002 and October 18, 2004)Article I. General RulesSecti… 相似文献
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《中国科学院院刊(英文版)》2003,17(2):71-71
Entanglement purificationholds the promise for quan-tum communication overlarge distances. Now Pan Jianwei (J.W. Pan), a CAS scholar working atthe University of Vienna, and hiscolleagues have obtained the firstever experimental verification of pu-rification of entangled quantumstates. Scientists believe their workcould be an important step towardslong-distance quantumcommunication.Distribution of entangled statesbetween distant locations is essen-tial for quantum communication overlarge di… 相似文献
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This exploratory study investigates value co-destruction in the Business-to-Business (B2B) context and examines the impact of actors’ opportunistic behaviour on value co-creation. The research undertakes an in-depth case study based approach. It uses data triangulation, where multiple sources of evidence (interviews, conference audio recordings and documents) are collected from the case organisation (a vendor) and its service ecosystem partners in the ICT sector. The partners included in the study are distributors, channel partners, competitors, and customers. B2B alliances are driven by the motivations to maximise strategic value and minimise transaction cost. Thus, using the ecosystem lens, we find that actors’ capabilities (resources and perceived value), vendor's approach to achieving strategic benefit and the channel governance mechanism enable value co-creation. However, using the transaction cost theory lens, we report that actors’ opportunistic behaviour, technological disruptions and new business model challenges lead to value co-destruction (in the form of termination of relationship, conflict and business liquidation). Alliance partners need to evaluate the strategic benefits of collaboration, knowledge sharing, learning, trust building, market expansion and technology sharing, considering partners’ self-serving behaviour driven by transaction cost economies. All ecosystem actors are seeking to develop capabilities, exhibit knowledge differentiators, demonstrate technology leadership, reduce uncertainty and respond to new business model challenges thus causing value co-destruction. Thus, this research is more encompassing because it explores factors that lead to both value co-creation and co-destruction. 相似文献
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《中国专利与商标》2007,(1)
In today's society where science and technology are undergoing rapid development,and enterprises competing each other primarily with advanced technologies in which they enjoy their own intellectual property right,a major part of an enterprise's business activities is that patented technolo- gy and technical secret(or known-how)are taken as goods of technical trade and that R&D of hi-tech achievements are undertaken by way of conclusion of contracts.It is worth at- taching importance to how to ensure the legitimacy and va- 相似文献