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1.
Most of the literature on university–industry (U–I) linkages assumes that these linkages are beneficial per se. We question this assumption, suggesting that not all such linkages are equally helpful. In this paper, we explore the factors driving the formation of ‘valuable U–I linkages’, conceived as those linkages between universities and firms that have a higher potential to diffuse knowledge to other firms in their regional economy. Our empirical strategy combines case-study methodology with econometric techniques using data from two wine clusters in Chile and in Italy. The firm's knowledge base is found to be a key driver of ‘valuable’ U–I linkages. We conclude that selectivity should be encouraged among policy makers endeavouring to promote U–I linkages. 相似文献
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In this paper, He's variational iteration method (VIM) is applied to solve the Emden–Fowler type equations in the second-order ordinary differential equations (ODEs). In this method, general Lagrange multipliers are introduced to construct correction functionals for the problems. The Lagrange multipliers in the functionals can be identified optimally via variational theory. This technique provides a sequence of functions which convergence to the exact solutions of the Emden–Fowler equations. Comparison with the exact solutions and the solutions by the Adomian decomposition method (ADM) show efficiency of VIM in solving equations with singularity. 相似文献
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Lack of a close ‘Information systems (IS)–business relationship’ has been described as a potential inhibitor to improving the contribution that information systems (IS) make to business performance. Yet the value of specific attributes of an enduring relationship between IS and business remains to be demonstrated by empirically confirming their link to IS performance. Using data collected from 167 South African and Australian companies, this study examined the effect of three relational attributes, namely commitment, mutual understanding and shared vision, on the contribution of IS to business performance. The study also examines the interrelationship amongst the relational attributes. Results revealed that a strong IS–business relationship is a significant determinant of IS performance. Organisations more successful in their use of IS are characterised by strong commitment on the part of the business to IS efforts, higher levels of IS understanding of the business, and a long-term agreement, between business and IS executives, on IS priorities. Results have important implications for organisations looking to improve the contribution of IS to organisational performance. 相似文献
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Keith Bauer 《Ethics and Information Technology》2004,6(2):83-91
Some critiques of cybermedicine claim that it is problematic because it fails to create physician–patient relationships. But, electronically mediated encounters do create such relationships. The issue is the nature and quality of those relationships and whether they are conducive to good patient care and meet the ethical ideals and standards of medicine. In this paper, I argue that effective communication and compassion are, in most cases, necessary for the establishment of trusting and morally appropriate physician–patient relationships. The creation of these relationships requires patients and physicians to take psychological and emotional risks and to make commitments to each other. The problem is that by altering the form and content of verbal and non-verbal behaviors and by limiting the kinds of interactions that can take place, cybermedicine makes risk-free interactions easier and more commonplace and retards the development of physician compassion and patient trust. In doing so, cybermedicine encourages morally inappropriate physician–patient relationships. I argue that Merleau-Ponty's notion of embodiment and Kierkegaard's criticisms of disinterested reflection help us to understand how cybermedicine can undermine patient health and well being and why it should be seen as a possible threat to the moral integrity of physician–patient relationships. 相似文献
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Universities and industrially relevant science: Towards measurement models and indicators of entrepreneurial orientation 总被引：3，自引：0，他引：3
Which university departments engaged in industrially relevant science are likely candidates to become entrepreneurial? At present, there are neither measurement models nor leading indicators that can answer such questions at an international comparative level. This paper introduces concepts, theory, and a measurement model for identifying (the early stages of) a university's enterpreneurial orientation within a quantitative analytical framework. This approach focuses specifically on university–industry interactions, in which the connectivity between academic science and industrial research is captured and measured empirically in terms of (1) public–private co-authored research articles, and (2) references (‘citations’) within corporate research articles to university research articles.The paper examines a range of country-level and institutional determinants of industrially relevant science, across 18 research areas of significant industrial interest, and at two different levels of analysis: research systems of OECD countries, and large sets of research universities within those countries. The results of these large-scale analyses, along with those of a case study dealing with European universities active in the field of immunology research, suggest that many structural factors determine university–industry interactions and (the potential for) entrepreneurial orientation. The two connectivity indicators appear to be of minor significance compared to a university's country of location and the magnitude of its research activities in industrially relevant fields of science. 相似文献
7.
A predator–prey model with prey-dependent functional response is considered. The set of all points in the positive quadrant of the state plane that can be made equilibrium points by means of an affine state-feedback control law is determined, and the values of the control parameters ensuring the desired equilibria are provided. It is shown how the asymptotic stability of the equilibrium points depends on simple geometric conditions. The problem of stabilizing unstable equilibrium points is also briefly discussed. 相似文献
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This paper studies the problem of the stochastic stability and H∞ disturbance attenuation for linear continuous-time time-delay systems that possess randomly Markovian jumping parameters. A delay-dependent sufficient condition on the stochastic stability with given H∞ performance is proposed using the stochastic Lyapunov–Krasovskii stability theory. The conditions are formulated as a set of coupled linear matrix inequalities. 相似文献
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Zouhaïer M&#x;Chirgui 《Research Policy》2009,38(9):1453-1467
This paper analyzes how the structure and the evolution of inter-firm agreements have shaped the development of the smart card industry. The aim is to establish a closer connection between the evolution of inter-firm agreements in the smart card industry and the patterns of change of technology and demand in this new high-tech industry. Based on a proprietary database covering both collaborative agreements and mergers and acquisitions (M&As) occurring in this industry over the period 1992–2006, we find that the evolution of technology and market demand shapes the dynamics of R&D networks and M&As are likely to change the industry structure. We also find that a small group of producers – first-movers – still control the industry and technological trajectories. Their position arises not for oligopolistic reasons of market structure, but for technological and organizational reasons. 相似文献
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Sourcing technological knowledge through corporate acquisition: Evidence from an international sample of high technology firms 总被引：2，自引：0，他引：2
We investigate the prevalence of the motive to source technological knowledge externally through corporate acquisition. Drawing on make-or-buy and organizational learning theories, we infer the implications of this explanation for the acquirers' pre-acquisition innovative characteristics. Using an international sample of 6106 high technology acquisitions during 1984–2000, we assess the contribution of innovative characteristics to the acquisition likelihood. For firms acquiring small private firms and former subsidiaries—but not public targets—the evidence is consistent with three propositions: (1) A firm's commitment to internal R&D is negatively affected by the decision to acquire; (2) Low R&D productivity increases the likelihood of acquisition; (3) A large knowledge stock predisposes firms to acquire because they perceive they are capable of selecting and absorbing targets. We conclude that acquisitions of small private firms and former subsidiaries are a viable R&D strategy to explore a range of potential future innovation trajectories for large public firms. 相似文献
11.
This paper investigates the causal effect of foreign acquisitions on the research and development (R&D) activities of domestic target firms over the period 1994–2004. Using accounting data on French innovative manufacturing firms, we implement appropriate difference-in-difference estimation techniques associated with a matching propensity score procedure. We find that the acquisitions of French firms by foreign companies boost R&D spending. There is a simultaneous rise in the external and in-house R&D expenditures of French acquired firms. R&D is more contracted out to local research providers, in particular to local public laboratories and universities. The increase in internal R&D spending benefits to development, but also basic and applied research. Finally, the growth of the R&D budget is not only financed by internal resources but also receives financing from external partners, especially parent companies. Thus, our results call into question the idea that foreign takeovers hamper the R&D development of target firms and are detrimental to the national innovation system of the host country. First, acquisitions appear to bring efficiency gains enough to counterbalance the various costs of integration and market power effects, pushing firms to invest more in R&D. Acquisitions do not seem to incite managers to take shorter term and more financial driven decisions at the expense of R&D. Second, when motivated by technology sourcing and overseas R&D development, acquisitions might be used to access the specific know-how of target firms and to tap into the knowledge of the national innovation system. Then, purchaser firms could be more likely to develop the innovative capability of target firms and to strengthen their linkages with local partners than to reduce them and relocate R&D abroad. 相似文献
12.
We analyse the impact of R&D cooperation on firm performance differentiating between four types of R&D partners (competitors, suppliers, customers, and universities and research institutes), and considering two performance measures: labour productivity and productivity in innovative (new to the market) sales. Using data on a large sample of Dutch innovating firms in two waves of the Community Innovation Survey (1996, 1998), we examine the impact of R&D cooperation in 1996 on subsequent productivity growth in 1996–1998. The results confirm a major heterogeneity in the rationales and goals of R&D cooperation. Competitor and supplier cooperation focus on incremental innovations, improving the productivity performance of firms. University cooperation and again competitor cooperation are instrumental in creating innovations generating sales of products that are novel to the market, improving the growth performance of firms. Furthermore, customers and universities are important sources of knowledge for firms pursuing radical innovations, which facilitate growth in innovative sales in the absence of formal R&D cooperation. 相似文献
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Cooper H. Langford Jeremy Hall Peter Josty Stelvia Matos Astrid Jacobson 《Research Policy》2006,35(10):1586-1598
This paper analyzes Canadian Government attempts to encourage and measure commercialization of university knowledge for socio-economic improvement. Universities are regarded as major, insufficiently exploited, repositories of knowledge. Here, paths by which knowledge can be transferred across institutional boundaries, and various input and output/outcome measures are identified. Available Canadian data are evaluated and a detailed quantitative and qualitative study of one institution is presented. Three key issues emerge: (1) current proxies focus on licensing and spin-off, and do not measure several important paths of knowledge flow; (2) most readily available proxies are derived from aggregate data and are inadequate to fully reflect the idiosyncratic and path-dependent nature of innovation; (3) if the goals and incentives of the actors in the ‘triple helix’ are skewed or misinterpreted by indicators, universities and firms may engage in counterproductive activities. We propose additional indicators that might help to prevent one measurable dimension from becoming the policy driver to the detriment of the overall goals. 相似文献
14.
This paper examines the relationship between the economic growth of European regions and their knowledge and human capital endowments. The share of adult population with tertiary education and the intensity of R&D expenditures in value-added emerge as the most effective factors enhancing the growth of GDP per capita recorded, during 1995–2002, by the regions belonging to twelve countries of the former EU15. However, while the educational variable is effective for the whole regional set, the impact of R&D is significant only for the regions that are above a given threshold of per capita GDP. Moreover, remarkable disparities arise among the regions of different countries. In particular, only within North European countries there is a significant relationship between regional growth and the intensity of R&D and higher education. The policy implications of both findings are discussed. 相似文献
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Many regions of the European Union with a high degree of autonomy have elected very clearly to stimulate scientific research and technological development (R&D) as a specific means of promoting economic growth and the welfare of their citizens. In Spain, several autonomous regions have organised their efforts in science and technology by means of the adoption of regional R&D plans. In some cases, particular concern is taken to link the scope of scientific research with that of technology, but even in these few cases, it is acknowledged that little is known of the mechanisms by which the results of scientific research are translated into technological development, and how this latter in turn influences the objectives of scientific research. Our aim in this article is to study in greater depth the relationship between science and technological development in the various regions of Spain. The methodology that we apply to investigate the links between science and technology is based on an analysis of scientific citations in patent documents (non-patent citation (NPC)). The results obtained from this study provide some relevant data on the interconnection between the scientific and technological systems from a regional perspective. 相似文献
17.
This paper analyses the effects of the deregulation policy introduced in India in the mid-1980s on the relationship between technology imports and in-house R&D efforts. Using appropriate statistical techniques, it examines the interactions between policy regime, economic environment and the determinants of inter-industry variation in technology imports in Indian manufacturing. In doing so, it introduces R&D efforts as one of the main determinants. Literature suggests that there is simultaneity in the relationship between technology imports and R&D efforts. To tackle this problem, lagged R&D expenditure intensity is adopted as a proxy for in-house R&D efforts. The empirical results reveal that technology imports were only weakly related with the past in-house R&D efforts in the protective regime. Deregulation promoted complementarity between technology imports and R&D efforts significantly. The results also suggest that after deregulation, the impact of product differentiation, demand conditions and technology-related factors increased significantly in determining the inter-industry patterns of technology imports. Thus, unlike in a regulated regime where technology imports are viewed important for filling gaps in domestic technological capabilities, in a deregulated regime technology upgradation seems to be the major role of technology imports. 相似文献
18.
Kritsada Singha Goonnapa Fucharoen Supan Fucharoen 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(1):167-174
Hemoglobin (Hb) Grey Lynn is a Hb variant caused by a substitution of Phe for Leu at position 91 of α1-globin chain, originally described in individual of unknown ethnic background. This article addresses the interaction of Hb Grey Lynn with a non-deletional α+-thalassemia found in Thailand, a hitherto un-described condition. The proband was adult Thai woman referred for investigation of mild anemia with Hb 90 g/L. Hb analyses using low pressure liquid chromatography raised a suspicion of abnormal Hb presence, which was failed to demonstrate by cellulose acetate electrophoresis and capillary electrophoresis. DNA sequencing identified a CTT (Leu) to TTT (Phe) mutation at codon 91 corresponding to the Hb Grey Lynn (Vientiane) [α91(FG3)Leu>Phe (α1) on α1-globin gene and a C deletion between codons 36 and 37 on α2-globin gene causing α+-thalassemia. As compared to those observed in a compound heterozygote for Hb Grey Lynn / α0-thalassemia reported previously, higher MCV (81.7 fL) and MCH (26.3 pg) values with a lower level of Hb Grey Lynn (19.7%) were observed in the proband. The normochromic normocytic anemia observed could be due to the interaction of Hb Grey Lynn with α+-thalassemia. The two mutations could be identified using PCR-RFLP and allele-specific PCR assays developed. 相似文献
19.
The centrality of firms vis-à-vis regions underlines a general contrast between two models of producing innovations. This paper uses a new database composed of 4262 European chemical patents applied by 693 firms during 1987–1996 to compare the relative effect of firm and regional characteristics on the production of technological “hits” (highly cited patents). By using extensive controls, the main finding of the paper is that technological hits in the “traditional” chemical sectors are explained only by R&D intensity at the firm level and the scale of the research projects. Firm competencies, particularly technological specialisation, are still important in biotechnology. However, the distinct feature of the biotechnology model is that localised knowledge spillovers also matter. 相似文献
20.
This study examines the organizational knowledge creation processes in two highly virtual teams involved in new product development projects in the automotive industry. Using Nonaka's model of knowledge creation, we explore how the virtualization of knowledge-based processes, i.e. the intensive exploitation of information and communication technologies (ICTs), has led to new forms of knowledge creation at both the individual and organizational levels. In contrast to previous studies that identify knowledge codification as the main contribution of ICTs, this study provides detailed micro-level evidence about the ability of virtual technologies to support the transfer and the creation of new knowledge – both explicit and tacit – and offers some implications for scholars and practitioners. 相似文献