共查询到20条相似文献，搜索用时 234 毫秒
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为了在蛋白质相互作用网络上预测蛋白质复合物和功能模块,文章提出了WCFM聚类算法,提高了在人类PPI网络上预测蛋白质复合物准确率,并且将D3可视化技术应用到PPI网络可视化领域,为生物网络模块的挖掘和分析提供了有益的参考。 相似文献
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后基因组时代,如何从大量的蛋白质相互作用(PPI)数据中寻找特定信息并以图形方式显示是迫切需要解决的问题.为此,本文提出了一种基于极大团扩展的蛋白质复合物聚类算法,该算法通过一种基于极大团扩展的蛋白质符合物识别算法构造功能模块,对PPI网络中的功能模块进行聚类,通过将功能模块用抽象节点代替的方法将PPI网络层次化,这样不但降低了复杂性而且提高了PPI网络中信息的可阅读性.同时采用增加、删除、修改数据的方法对算法进行稳定性分析.结果表明,该算法具有较好稳定性.对于其他具有相似结构的网络,该方法也具有借鉴意义. 相似文献
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资源库是实现网络教学的基础。本文介绍了基于web的网络教学资源建设的现状,提出了平台的设计目标,给出了系统的体系结构,并介绍了系统的主要功能模块。 相似文献
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《科学中国人》2023,(6):40-40
时空可分辨全局性解析蛋白质-DNA相互作用新方法中国科学院上海药物研究所陈小华课题组和谭敏佳课题组合作,实现了对蛋白质-DNA动态互作、包括弱相互作用的转录因子-DNA的时空动态性深度解析。相关成果发表于《自然·化学》（Nature Chemistry）。蛋白质与DNA的相互作用在生物学过程中发挥着关键作用。精确解析蛋白质-DNA相互作用能够揭示二者相互识别机制和动态变化,对于深入理解生理和病理条件下基因的调控机制至关重要。这项研究为全局性深度解析蛋白质-DNA的时空动态互作提供了一种新方法,以目标DNA序列为探针的互作蛋白质结合活性分析策略,有望用于解析目标DNA序列中不同的碱基修饰与蛋白质相互作用的研究。 相似文献
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生物信息学是在生命科学研究中独具活力的新兴前沿学科之一。它利用计算机硬件、软件和计算机网络,采用信息学、计算机科学和数学的手段,主要研究蛋白质、核酸等生物大分子数据。本文着重介绍了两种智能化算法,分别讨论了人工神经网络方法在蛋白质二级结构预测中的应用及遗传算法在蛋白质二维晶格中的应用。 相似文献
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基于ArcGIS Server的数字物流系统研究 总被引：1，自引：0，他引：1
GIS以其空间查询分析和决策等功能在物流中发挥着越来越重要的作用。目前随着网络技术的发展,物流需要整合公共信息同时减轻终端用户负担,因此网络版的数字物流系统的研发迫在眉睫。文章首先介绍了数字物流和ArcGIS Server技术,同时分析了B／S结构物流系统的优势,提出了系统集成框架,讲述了系统各功能模块,并分析了主要的Web GIS技术。 相似文献
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《Information processing & management》2020,57(6):102357
Finding side effects of drugs, before reaching the animal and clinical test, can decrease the cost and time of developing new drugs. Also, a lot of side effects are reported after going to market and using it by patients (post-marketing). There are some systems to report these events but most of the time, side effects stay hidden. Thus, a lot of computational methods have been developed to predict the side effects of drugs before reaching the clinical test or going to market. These methods are based on different features of drugs like chemical or biological features. Most of these methods can just complete the side effect list of approved drugs or require a great deal of biological information about the drugs. So, it is impossible to find the side effects of a new drug candidate very early. In this paper, we propose a network and domain-based algorithm (NDDSA) that can predict the side effects of new drug candidates by assigning a score to each side effect. Unlike other methods, it needs just the chemical formula of the new drug. We show that NDDSA performs better than the best present method in case of predicting ADRs for a new drug and has acceptable results in case of predicting potential side effects for approved drugs, while it is much faster than the other methods. 相似文献
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虽然多数的现有监控工具可以提供关于系统整体性能的宏观信息,但是这样的数据并不能帮助用户理解系统内部的运行状况.为了揭示内部行为,提出了一种基于监控元数据的方法来收集系统执行过程中的内部组件状态和通信.新方法能应用于许多网络通讯协议和应用程序类型,通过信息跟踪机制记录系统内部发生的关键性能事件,并捕获它们之间的时序和因果关系,为系统诊断提供支持. 相似文献
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利用Hadamard变换的去相关性能和3D小波视频编码的帧结构特性,提出了一种新的面向空间通信视频编码算法的业务流模型。实验结果表明,新模型产生的仿真数据能够匹配视频源数据的概率密度函数,能够模拟空间通信视频源数据的短时相关性和长时相关性,在漏桶评估实验中,模型仿真数据与视频源数据的排队性能匹配效果好,可以作为空间通信系统研究的视频源模型。 相似文献
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《Journal of The Franklin Institute》2022,359(9):4468-4488
The conjugate gradient (CG) method exhibits fast convergence speed than the steepest descent, which has received considerable attention. In this work, we propose two CG-based methods for nonlinear active noise control (NLANC). The proposed filtered-s Bessel CG (FsBCG)-I algorithm implements the functional link artificial neural network (FLANN) as a controller, and it is derived from the Matérn kernel to achieve enhanced performance in various environments. On the basis of the FsBCG-I algorithm, we further develop the FsBCG-II algorithm, which utilizes the Bessel function of the first kind to constrain outliers. As an alternative, the FsBCG-II algorithm has reduced computational complexity and similar performance as compared to the FsBCG-I algorithm. Moreover, the convergence property of the algorithms is analyzed. The proposed algorithms are compared with some highly cited previous works. Extensive simulation results demonstrate that the proposed algorithms can achieve robust performance when the noise source is impulsive, Gaussian, logistic, and time-varying. 相似文献
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《The Journal of High Technology Management Research》2004,15(1):73-89
The developments in the biological microelectromechanical systems (BioMEMS) industry have gone largely unnoticed by pharmaceutical and health care firms. We propose that the lack of linkages between the pharmaceutical and BioMEMS industries is based on the disruptive nature of BioMEMS technology. Using resource dependence and network theories, we present a model of the development of linkages based on resource interdependence and the nature of technology. We discuss the implications for increased innovation output. 相似文献
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《Information processing & management》2023,60(3):103282
Detecting collusive spammers who collaboratively post fake reviews is extremely important to guarantee the reliability of review information on e-commerce platforms. In this research, we formulate the collusive spammer detection as an anomaly detection problem and propose a novel detection approach based on heterogeneous graph attention network. First, we analyze the review dataset from different perspectives and use the statistical distribution to model each user's review behavior. By introducing the Bhattacharyya distance, we calculate the user-user and product-product correlation degrees to construct a multi-relation heterogeneous graph. Second, we combine the biased random walk strategy and multi-head self-attention mechanism to propose a model of heterogeneous graph attention network to learn the node embeddings from the multi-relation heterogeneous graph. Finally, we propose an improved community detection algorithm to acquire candidate spamming groups and employ an anomaly detection model based on the autoencoder to identify collusive spammers. Experiments show that the average improvements of precision@k and recall@k of the proposed approach over the best baseline method on the Amazon, Yelp_Miami, Yelp_New York, Yelp_San Francisco, and YelpChi datasets are [13%, 3%], [32%, 12%], [37%, 7%], [42%, 10%], and [18%, 1%], respectively. 相似文献
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计算机应急响应系统体系研究 总被引：6，自引：0，他引：6
应急响应是维护计算机和网络系统动态安全性的关键问题 .提出了基于层次化模型的计算机应急响应系统体系结构 ,从安全服务层、系统模块层、安全研究层的角度对系统的功能需求、模块划分和相应的技术支持给出了明确的定义 ,针对计算机应急响应系统所关注的事件响应、安全监控、入侵追踪、灾难恢复等问题 ,结合向用户提供的安全咨询、安全公告、安全状况分析等服务功能 ,进行了详细的阐述 . 相似文献
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《Journal of The Franklin Institute》2023,360(2):1036-1057
This paper investigates the event-based asynchronous finite-time control for a class of cyber-physical switched systems under Denial-of-Service (DoS) attacks. Considering the attack’s characteristics, we put forward a novel attack-instant-constrained hybrid event-triggered scheme (HETS), which can not only contribute to reducing the network transmission overload, but also well descibe the network denial service behavior under attack interference. An asynchronous and ZOH-based controller is delicately constructed to mitigate the influence of DoS attacks and network-induced delay. A double-mode dependent Lyapunov–Krasovskii functional (LKF) is developed to set up some sufficient finite-time stability criteria for the concerned systems in view of the asynchronous switching effect. Finally, an application example of the urban railway system is offered to verify the proposed control algorithm. 相似文献
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We herein report a study on the intelligent control of microfluidic systems using reinforcement learning. Integrated microvalves are utilized to realize a variety of microfluidic functional modules, such as switching of flow pass, micropumping, and micromixing. The application of artificial intelligence to control microvalves can potentially contribute to the expansion of the versatility of microfluidic systems. As a preliminary attempt toward this motivation, we investigated the application of a reinforcement learning algorithm to microperistaltic pumps. First, we assumed a Markov property for the operation of diaphragms in the microperistaltic pump. Thereafter, components of the Markov decision process were defined for adaptation to the micropump. To acquire the pumping sequence, which maximizes the flow rate, the reward was defined as the obtained flow rate in a state transition of the microvalves. The present system successfully empirically determines the optimal sequence, which considers the physical characteristics of the components of the system that the authors did not recognize. Therefore, it was proved that reinforcement learning could be applied to microperistaltic pumps and is promising for the operation of larger and more complex microsystems. 相似文献
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无线传感器中路由协议的选择制约着网络寿命,选择一个好的路由协议可以有效地延长网络的生存时间.根据层次型拓扑控制的分簇机制所提出的LEACH协议有效地延长了网络的生存时间,但是它在能量均衡上还存在问题.目前学术界也提出了许多的改进方法,本文是基于LEACH协议所存在的不足.在选簇上做了改进.提出新的N-LEACH协议,优... 相似文献