共查询到20条相似文献,搜索用时 687 毫秒
1.
A. N. Kalia H. Lal D. K. Agrawal V. Shankar A. S. Saini 《Indian journal of clinical biochemistry : IJCB》1994,9(2):79-81
Hypoglycaemic effects of caraway seeds, and the aqueous extract, petroleum ether extract and methanolic extract of the defatted
marc were studied on normoglycaemic as well as hyperglycaemic rats. Further the effect of caraway seeds was also studied on
serum insulin level. A significant decrease in blood glucose with corresponding increase in insulin was observed with 3 g/kg
of the seeds powder in normoglycaemic rats. It also improved glucose tolerance of the animal by increasing insulin secretion
response to glucose load. The aqueous and methanolic extracts did not show any effect. The dose dependent decrease in blood
glucose was observed with petroleum ether extract (caraway seed oil) in normoglycaemic rats. Moreover, the oil also improved
glucose tolerance in the animal. The effects were similar to those observed with tolbutamide (0.5 g/kg) but of longer duration.
It is suggested that the hypoglycaemic effect of caraway seeds is through pancreas and the active principle is in oily fraction
only. 相似文献
2.
4-氯-2,6-双吡啶双氧钒化合物降低1型糖尿病大鼠血糖的生物学作用 总被引:1,自引:0,他引:1
通过1型和2型糖尿病动物模型的研究发现过渡金属元素钒(V)具有降糖作用。有机钒化合物与无机钒相比,其副作用低、体内吸收率和生物利用度高。本文主要探讨了四价有机钒化合物4-氯-2,6-双吡啶双氧钒化合物(4-chloro-2,6-dipicolinatodioxovanadium(Ⅳ),V4dipic-Cl)对链脲佐菌素(STZ,55 mg/kg)诱导的1型糖尿病大鼠的生物学作用。大鼠通过自由饮水的方式口服V4dipic-Cl(0.5 mg/ml)8天。结果表明,V4dipic-Cl组的大鼠血糖和血清碱性磷酸酶(ALP)活性显著低于糖尿病对照组,并且其葡萄糖耐量水平得到明显改善。但有机配体H2dipic-Cl对糖尿病大鼠的血糖和血清ALP活性的影响不显著。结果提示V4dipic-Cl具有降低糖尿病大鼠的血糖,提高葡萄糖耐量和改善肝功能的作用。 相似文献
3.
Dolly Jaiswal Prashant Kumar Rai Amit Kumar Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2008,23(2):167-170
The present study deals with the evaluation of glycemic profile of aqueous extract of Cajanus cajan leaves in streptozotocin induced type 2 diabetic rats. Single oral administration of graded doses of aqueous extract of Cajanus
cajan leaves showed significant increment of 14.3 % in fasting blood glucose levels of normal rats. The sub diabetic and mild diabetic
models have also shown hyperglycemic effect from the same variable doses of the extract. The dose of 1000 mg/kg showed the
maximum rise of 17.1, 71.2 and 50.7 % in Blood glucose levels of normal, sub and mild diabetic rats respectively during glucose
tolerance test. The study of leaves was taken into consideration on the basis of earlier reported hypoglycemic activity of
Cajanus cajan seeds. However the results observed were found just opposite and therefore it may be useful in controlling hypoglycemia,
occasionally caused due to excess of insulin and other hypoglycemic drugs. 相似文献
4.
Y. K. Murali Ramesh Chandra P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2004,19(2):202-204
Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of
reduction in the peak blood glucose at 2nd hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting
blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood
glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia
chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats. 相似文献
5.
Santosh Kumar Singh Achyut Narayan Kesari Prashant Kumar Rai Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2007,22(2):48-52
The present study reveals the effect of Musa paradisiaca stem juice on blood glucose level (BGL) of normal & diabetic rats.
The dose of 500 mg/kg bodyweight produces a significant rise of 28.3% in blood glucose level after 6h of oral administration
in normal rats. Whereas, in sub diabetic rats the same dose produces a rise of 16.4% in blood glucose levels within 1h during
glucose tolerance test (GTT) and a rise of 16% after 4 h in fasting blood glucose levels of severe diabetic cases. These results
were unexpected and important to report as other species of Musa like Musa sapientum has been reported for its hypoglycemic
effect. 相似文献
6.
J. O. Olanlokun 《Indian journal of clinical biochemistry : IJCB》2008,23(1):62-66
The effect of oral administration of vitamin E for twenty-eight consecutive days on blood glucose, reduced glutathione levels,
antioxidant enzymes (superoxide dismutase and catalase activities), and levels of malondialdehyde (as an index of free radical-mediated
lipid peroxidation) was observed in the whole blood and liver of normal and alloxan-induced diabetic rats. It was found that
oral administration of vitamin E significantly (p<0.05) lowered the blood glucose level and increased the body weight of the
diabetic rats. The activities of superoxide dismutase and levels of reduced glutathione increased significantly (p<0.05) while
the level of lipid peroxidation decreased. 相似文献
7.
Halim Eshrat M. Ali Hussain Kaiser Jamil Mala Rao 《Indian journal of clinical biochemistry : IJCB》2001,16(1):77-80
The hypoglycemic effect of the aqueous extract ofAbroma augusta (Family: Steculiceae) was studied in normal as well as alloxan diabetic rats. Treatement of diabetic rats with 4 ml (4gm
dry weight) of agueous extract ofA. augusta for 16 weeks resulted in gradual but significant fall in fasting blood glucose and improvement in glucose tolerance. Serum
total and LDL cholesterol and triacylglycerol which increased in diabetic rats showed improvement. These results show that
the water extract ofA. augusta has both hypoglycemic and hypocholesterolemic effects. 相似文献
8.
Amar B. Singh J. P. Chaturvedi T. Narender Arvind K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2008,23(4):391-393
Peganum harmala L. (Zygophyllaceae) is a traditional medicine used for the treatment of variety of human ailments, including
antidepression, hallucination, antileishmaniasis etc. We report for first time the hypoglycemic activity of the ethanolic
extract of this plant at two dose levels of 150 and 250mg/kg bw in sucrose challenged normal as well as in rats with streptozotocin
induced diabetes. The oral administration of ethanolic extract causes maximum fall of blood glucose level to 22.9% (p<0.05)
and 29.4% (p<0.01) respectively with the two doses in normal and 30.3% (p<0.01) and 48.4% (p<0.001) in diabetic rats. The
standard drug metformin treated group showed 28.0% (p<0.01) and 45.5% (p<0.001) respectively in normal and diabetic rats.
The above results show that the ethanolic extract of P. harmala is as effective as metformin in reducing the blood glucose
levels of normoglycemic and streptozotocin-induced diabetic rats. 相似文献
9.
Mahalingam Gayathri Krishnan Kannabiran 《Indian journal of clinical biochemistry : IJCB》2008,23(4):394-400
The aim of the present study was to evaluate the antidiabetic and ameliorative potential of aqueous extract of Ficus bengalensis
bark in streptozotocin induced diabetic rats. The effect of oral administration of aqueous extract of F. bengalensis bark
on blood glucose, serum electrolytes, serum glycolytic enzymes, liver microsomal protein, hepatic cytochrome P-450 dependent
monooxygenase enzymes and lipid peroxidation in liver and kidney of streptozotocin -induced diabetic rats was studied. Oral
administration of Ficus bengalensis to fed, fasted and glucose loaded diabetic rats significantly [F > 0.05 (ANOVA) and P<
0.05 (DMRT)] decreased the blood glucose level at 5 hrs and restored the levels of serum electrolytes, glycolytic enzymes
and hepatic cytochrome P-450 dependent enzyme systems and decreased the formation of liver and kidney lipid peroxides at the
end of 12 weeks. Further, the aqueous extract of Ficus bengalensis at a dose of 500mg/kg/day exhibits significant antidiabetic
and ameliorative activity as evidenced by histological studies in normal and Ficus bengalensis treated streptozotocin induced
diabetic rats. On the basis of our findings, it could be used as an antidiabetic and ameliorative agent for better management
of diabetes mellitus. 相似文献
10.
Dolly Jaiswal Prashant Kumar Rai Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2009,24(1):88-93
The present study defines the systematic evaluation and the role of minerals in glycemic potential of aqueous extract of Withania
coagulans fruits in order to develop an effective and safe alternative treatment for diabetes mellitus. Laser Induced Breakdown
Spectroscopy was used for glycemic element detection. The study is based on the results of lowering in blood glucose levels
of normal, sub, mild and severely diabetic rats assessed during fasting blood glucose, glucose tolerance test and post prandial
glucose studies. The dose of 1000mg/ kg was identified as the most effective dose, which reduces the Fasting Blood Glucose
level maximum by 33.2% at 4h in normal rats during fasting blood glucose studies. Glucose tolerance test studies of normal,
sub and mild diabetic rats showed the maximum reduction of 15.7, 28.9 and 37.8% at 3h respectively. Long-term study in case
of severely diabetic rats showed reduction of 52.9 and 54.1% in Fasting Blood Glucose and Post Prandial Glucose levels respectively
after 30 days of treatment. The present study, besides confirming hypoglycemic and antidiabetic activities of aqueous extract
of W. coagulans, helps in identifying the role of trace minerals like Mg & Ca responsible for antidiabetic potential of this
potent indigenous shrub. 相似文献
11.
Alireza Nakhaee Mohammad Bokaeian Mohsen Saravani Ali Farhangi Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2009,24(4):419-425
In traditional medicine, Eucalyptus globulus (eucalyptus) was used for the treatment of diabetes mellitus. Hyperglycemia in
diabetes has been associated with increased formation of reactive oxygen species (ROS) and oxidative damage to tissue compounds.
The aim of this study was to evaluate the effects of eucalyptus in the diet (20 g/Kg) and drinking water (2.5 g/L) on lipid
peroxidation, protein oxidation and antioxidant power in plasma and liver homogenate, as well as glycated-Hb (HbA1C) of blood in streptozotocin-induced diabetic rats for a period of 4 weeks. Diabetes induced in rats by a single intraperitoneal
injection of streptozotocin (STZ, 65 mg/Kg). At the end of the treatment period, the level of plasma glucose, plasma and liver
malondialdehyde (MDA, the main product of lipid peroxidation), protein carbonyl (PC, one of the protein oxidation products)
and HbA1C increased and ferric reducing antioxidant power (FRAP) decreased in diabetic rats compared to normal rats. Eucalyptus administration
for 4 weeks caused a significant decrease in the plasma glucose levels, plasma and liver MDA, PC and HbA1C, also a concomitant increase in the levels of FRAP in diabetic treated rats. In conclusion, the present study showed that
eucalyptus posses antioxidant activities. Eucalyptus probably restores antioxidant power, due to the improved hyperglycemia
in streptozotocin-induced diabetic rats. 相似文献
12.
Mst. Marium Begum Zakia Sultana Md. Ershad Ali Md. Safkath Ibne Jami Proma Khondkar Md. Masuduzzaman Khan Md. Mominul Haque 《Indian journal of clinical biochemistry : IJCB》2014,29(4):452-461
High blood glucose level, elevated level of liver enzyme, necrosis and shrinkage of islets of Langerhans has been implicated in the pathogenesis of type 2 diabetes. High blood glucose cause oxidative stress, production of free radical as well as elevated SGPT and SGOT level. Both glibenclamide and simvastatin in fixed dose used as antihyperglycemic antidyslipidemic and antioxidative agents for type 2 diabetes treatment. This study therefore aimed to evaluate the antihyperglycemic, antidyslipidemic and antioxidative effect of fixed dose combination of glibenclamide (0.6 mg/70 kg body weight) and simvastatin (5 mg/70 kg body weight) on long term alloxan induced diabetic rats with cardiovascular disease using various diagnostic kits as a parameter of phamacotherapeutic and pharmacological effect. The study was carried out using 96 Swiss Albino male rats weighing about 200–220 g. Combination therapy induced a significant decrease in blood glucose level in alloxan induced diabetic rats, from 33.75 ± 1.65 to 5.80 ± 0.07 mmol/l 2 h after last dose administration, after 4 weeks treatment. In case of dyslipidemic effect, combination therapy reduced total cholesterol (45 %), triglyceride (36 %) and low density lipoprotein-cholesterol (32 %) levels significantly and increased high density lipoprotein-cholesterol level (57 %) in comparison with their respective diabetic control groups. Results of this study showed that combination therapy effectively decreased SGPT (ALAT) (55 %) and SGOT (ASAT) (51 %) in comparison with diabetic control group. It was also observed that catalase and superoxide dismutase enzyme activity was increased by 58 and 91 % respectively in comparison with diabetic control group after 4 weeks treatment with combination of both drugs. In conclusion, these findings of combination therapy (glibenclamide and simvastatin) on alloxan induced diabetes in rats are significantly better than monotherapy using single drug. The results of the present study suggest that, combination of the fixed dose of glibenclamide and simvastatin might be efficacious in patients with diabetic dyslipidemia and increased oxidative stress. Furthermore, this combination therapy offer dosage convenience to the patients and by virtue of its dual mode of action might be a useful addition to the therapeutic armamentarium for patients with diabetic dyslipidemia and oxidative stress. 相似文献
13.
口服富铬啤酒酵母对链脲佐霉素诱导糖尿病大鼠的生物效应 总被引:1,自引:0,他引:1
研究富铬啤酒酵母和普通啤酒酵母以及醋酸铬对链脲佐霉素(STZ)诱导的糖尿病大鼠的生物效应。富铬酵母的制备是以普通啤酒酵母作为微量元素载体,酵母细胞在含铬(Cr)的介质中驯化生长,吸收并同化无机铬化合物,使之转化成富集铬元素的啤酒酵母,普通啤酒酵母和富铬啤酒酵母均来自于相同的单克隆细胞系。以普通酵母为对照,分别每天灌胃给予链脲佐霉素诱导的糖尿病大鼠含铬量为300 μg/kg.bw的富铬酵母和醋酸铬,实验周期为32天。结果表明,富铬酵母组和普通酵母组大鼠的体重明显高于糖尿病大鼠(p < 0.01),醋酸铬对糖尿病大鼠的体重影响不显著。与普通酵母和醋酸铬相比,富铬酵母明显改善糖尿病大鼠的口服糖耐量(OGTT)水平。与糖尿病组相比,富铬酵母组大鼠的血清甘油三酯(TG)、肌苷、血清谷丙转氨酶(ALT)和谷草转氨酶(AST)水平下降。结果提示富铬酵母能够改善糖尿病大鼠的糖尿病症状及其肝肾功能。 相似文献
14.
Aim is to study the antidiabetic effect of a compound GII purified earlier from the water extract of fenugreek (Trigonella foenum graecum) seeds by Murthy and his colleagues (patented in India and USA) in diabetic rabbits. Diabetes was induced in rabbits by injecting
80 mg/kg bw of alloxan intravenously into rabiits. Rabbits were subdivided into subdiabetic [fasting blood sugar (FBG) up
to 120 mg/dl with abnormal glucose tolerance in glucose tolerance test (GTT)], moderately diabetic (FBG below 250 mg/dl) and
severely diabetic (FBG above 250 mg/dl). Blood glucose and glycosylated hemoglobin (HbA1C) were estimated by procedures in
the kits of Stangen Immunodiagnostics, Mumbai using, respectively, glucose oxidase method and absorbance at 415 nm. Serum
insulin was estimated by the ELISA method as described in the kit of Boehringer Mannheim Immunodiagnostics, Mumbai, India.
GII was found to improve blood glucose utilization in GTT and reduced FBG and HbA1C. In the present communication detailed
studies were carried out with GII in the subdiabetic, moderately diabetic and severely diabetic rabbits. GII at a dose of
50 mg/kg bw per day brought down the elevated FBG levels in the untreated subdiabetic (FBG 96.6 ± 7 mg/dl), moderately diabetic
(150.1 ± 14 mg/dl) and severely diabetic rabbits (427 ± 46 mg/dl) to normal in 12, 15 and 28 days of treatment. It improved
serum HbA1C and insulin levels also in these rabbits. Intermittent therapy once a week for 6 weeks with GII at the same dose
brought down the FBG values to normal in the subdiabetic (FBG 96.0 ± 2 mg/dl) and in the moderately diabetic rabbits to 133.0 ± 12 mg/dl.
After stopping therapy of the subdiabetic and moderately diabetic rabbits whose FBG values came to normal after treatment
with GII 50 mg/kg bw, the values remained normal for 1 week and showed a tendency to increase only after 15 days. If these
animal studies are applicable to humans these results indicate that a diabetic person need not take GII daily when once the
FBG value comes to normal or near to normal. Patients might be able to take GII only when the FBG value shows tendency to
increase. So, intermittent therapy is possible with the potent product GII of the fenugreek seeds which is of a great advantage. 相似文献
15.
Induction of diabetes by Streptozotocin in rats 总被引:1,自引:0,他引:1
A. Akbarzadeh D. Norouzian M. R. Mehrabi Sh. Jamshidi A. Farhangi A. Allah Verdi S. M. A. Mofidian B. Lame Rad 《Indian journal of clinical biochemistry : IJCB》2007,22(2):60-64
The objective of this study is to induce experimental diabetes mellitus by Streptozotocin in normal adult Wistar rats via
comparison of changes in body weight, consumption of food and water, volume of urine and levels of glucose, insulin and C-peptide
in serum, between normal and diabetic rats. Intra-venous injection of 60mg/kg dose of Streptozotocin in adult wistar rats,
makes pancreas swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes mellitus
in the 2–4 days. Induction of experimental diabetes mellitus is indeed the first step in the plan of purification of pancreatic
Langerhans islet cells of normal rats for transplanting under the testis subcutaneous of experimentally induced diabetic rats.
Streptozotocin induces one type of diabetes which is similar to diabetes mellitus with non-ketosis hyperglycemia in some animal
species. For induction of experimental diabetes in male adult rats weighted 250–300 grams (75–90 days), 60mg/kg of Streptozotocin
was injected intravenously. Three days after degeneration of beta cells, diabetes was induced in all animals. The diabetic
and normal animals were kept in the metabolic cages separately and their body weight, consumption of food and water, urine
volume, the levels of serum glucose, insulin and C-peptide quantities in all animals were measured and then these quantities
were compared. For a microscopic study of degeneration of Langerhans islet beta cells of diabetic rats, sampling from pancreas
tissue of diabetic and normal rats, staining and comparison between them, were done. Induction of diabetes with Streptozotocin
decreases Nicotinamide-adenine dinucleotide (NAD) in pancreas islet beta cells and causes histopathological effects in beta
cells which probably intermediates induction of diabetes. In this study, we used Streptozotocin for our experiments in induction
of experimental diabetes mellitus. After Induction of diabetes, consumption of food and water, volume of urine and glucose
increased in the diabetic animals in comparison with normal animals, but the weight of body and the volume of insulin and
C-peptide decreased in the diabetic animals. Sampling and staining of pancreas tissue of diabetic and normal rats showed that
the Langerhans islet beta cells of diabetic rats have been clearly degenerated. In three days, Streptozotocin makes pancreas
swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes. It also changes normal
metabolism in diabetic rats in comparison with normal rats. Consumption of water and food, volume of urine, serum glucose
increases in diabetic animals in comparison with normal rats but the levels of serum insulin, C-peptide and body weight decreases. 相似文献
16.
Abolfazl Nasiri Nasrin Ziamajidi Roghayeh Abbasalipourkabir Mohammad Taghi Goodarzi Massoud Saidijam Hamid Behrouj Sara Solemani Asl 《Indian journal of clinical biochemistry : IJCB》2017,32(3):329-336
One of the most important complications of diabetes is nephropathy. This study investigates the effects of aqueous garlic extract on inflammation and oxidative stress status in the kidneys of diabetic rats. Male rats were divided into four groups- control rats, diabetic rats, garlic extract-treated diabetic rats, garlic extract-treated normal rats. The glucose, urea, uric acid, and creatinine levels were measured in sera using colorimetric methods. To determine the oxidative stress condition in the kidney tissues, total antioxidant capacity (TAC), malondialdehyde (MDA), and total oxidant status (TOS) were measured using colorimetric methods. Inflammation status was evaluated by the determination of tumor necrosis factor-alpha (TNF-α) gene and protein expression using qRT-PCR and ELISA respectively, while nitric oxide (NO) level in these tissues was measured using the Griess method. Histological examination of Kidneys was carried out by H&E staining. The levels of glucose, urea, and uric acid were found to increase in the serum of diabetic rats and decrease in that of diabetic rats after treatment with garlic. Measurement of MDA, TOS, and TAC revealed oxidative stress in diabetic rats, which improved after receiving the extract. The NO and TNF-α protein levels in diabetic rats were higher than those in control rats. After treatment with garlic, the levels of TNF-α protein and NO became close to the normal levels. Histological results confirmed certain other data as well. Garlic has antioxidant properties; therefore, it can reduce oxidative stress, which plays an important role in the development of diabetic nephropathy. Reduction in oxidative stress has beneficial effects on inflammation because it leads to a decrease in the level of TNF-α. 相似文献
17.
M. Bokaeian A. Nakhaee Bita Moodi A. Farhangi Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2010,25(2):182-187
The anti-candidial effect of garlic extract (Allium sativum L.) was investigated in normal and streptozotocin-induced diabetic
rats. Diabetes was induced after a single intraperitoneal injection of streptozotocin (60 mg/kg). Rats were divided into six
groups with fifteen rats in each group: (1) Normal control rats (2) Control rats + C. albicans (3) Control rats + garlic extract
+ C. albicans (4) Diabetic control rats (5) Diabetic rats + C. albicans (6) Diabetic rats + garlic extract + C. albicans.
The concerned groups were inoculated with C.albicans on the 15 th day. At the end of one month experiment, fasted rats were
killed by cervical decapitation. Blood was collected for estimation of glucose and C. albicans concentrations were estimated
in liver and kidneys homogenates. A significant increase was observed in serum glucose levels in diabetic rats. A loss of
bodyweight, polydipsia and polyphagia were observed in diabetic rats. Administration of alcoholic extract of garlic (0.25
g/kg body weight) reduced the hyperglycemia, polydipsia, polyphagia and associated weight loss of streptozotocin-treated rats.
Administration of garlic extract significantly reduced C. albicans concentrations in liver and kidneys homogenates in infected
control and diabetic rats. It is concluded that garlic extract improves candidia infection in diabetic rats. 相似文献
18.
Vijay Navghare Shashikant Dhawale 《Indian journal of clinical biochemistry : IJCB》2016,31(4):380-389
Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks. Changes in plasma glucose, lipid profile along with kidney function before and after treatment with EMC were recorded. The ethanolic extract of peels of Musa cavendish reduced blood glucose, serum triglyceride, cholesterol, LDL cholesterol and creatinine levels and improvement in body weight, liver glycogen, serum HDL cholesterol, serum albumin and total protein level when compared with untreated rats. Musa cavendish has lipid lowering, nephroprotective and antidiabetic property by regulating glucose uptake in the liver and muscles by restoring the intracellular energy balance. 相似文献
19.
Vishnu Kumar Ranjana Singh Farzana Mahdi Abbas Ali Mahdi Raj Kumar Singh 《Indian journal of clinical biochemistry : IJCB》2017,32(3):323-328
The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cassia tora (C. tora) seeds extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes. Ethanolic extract of C. tora seeds extract and standard drug (glibenclamide) prepared in aqueous gum acacia (2 %, w/v) suspension and fed orally to streptozotocin induced male adult diabetic rats of Charles Foster strain for 15 days. Biochemical parameters in normal, diabetic control, standard (600 μg/kg bw p.o.) and treated (500 mg/kg bw p.o.) animal groups were quantified and compared. Treatment of streptozotocin induced diabetic rats with ethanolic seeds extract caused significant (p < 0.001) reduction in blood glucose (270–220 mg/dl), total cholesterol (140–104 mg/dl), triglyceride (149–99 mg/dl), phospholipids (100–74 mg/dl), free fatty acid (2.39–2.00 μmol/l), lipid peroxide (9–5.63 nmol MDA/dl) and significantly increased post heparin lipolytic activity (11–14 nmol FFA released/h/l plasma) (p < 0.001). Furthermore, the seeds extract (100–400 μg) when tested for its antioxidant activity in vitro, showed significant (p < 0.001) inhibition in the generation of super oxide anions in enzymic system a (46–37, 33, 23, 21 nmol uric acid formed/min), in enzymic system b (113–91, 77, 60, 51 nmol formazon formed/min), non-enzymic system (324–230, 211, 161, 141 nmol uric acid formed/min) and hydroxyl radicals in enzymic system (544–501, 411, 319, 291 nmol 2,3-dihydroxybenzoate formed/h) and non-enzymic system (28–21, 17, 14, 12). The results of the present study demonstrated antidiabetic, antidyslipidemic and antioxidant activities of C. tora seeds which could help in prevention of diabeticdyslipidemia and related complications. 相似文献
20.
Halim Eshrat M. Ali Hussain 《Indian journal of clinical biochemistry : IJCB》2002,17(2):115-123
This study was carried out to investigate the effect of oral feeding of water extract of fresh leaves ofAzadirachta indica (Fam:Meliaceae) in streptozotocin induced diabetes and its associated retinopathy in rats. Treatment of the diabetic rats with aqueous extract of leaves ofA. indica at a dose of 250 mg/kg body weight for 16 weeks resulted in gradual but significant fall in blood glucose and improvement in serum total, LDL and HDL cholesterol and triacylglycerol which increased in diabetic rats. It also showed improvement in body weight and reversed retinopathy. 相似文献