共查询到20条相似文献，搜索用时 93 毫秒
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为了梳理近10年知识服务的发展,对万方数据提供的海量文献数据库进行检索,从文献总体产出统计、中文期刊论文与学位论文统计、中外文会议论文数据、专利、共词分析、主题学科渗透等角度进行统计分析,得出了知识服务的研究主要集中在图书馆学、情报学研究领域,在工业技术领域、医学和卫生领域有一定的研究和应用和2006年是知识服务从研究向应用转移的结论。 相似文献
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医学图书馆知识服务的定位、特征与实施探讨 总被引：4，自引：0，他引：4
探讨了新时期知识服务在医学图书馆的角色定位,结合解放军医学图书馆知识服务探索的有关情况,归纳分析了医学图书馆知识服务的特征,并对如何实施医学图书馆知识服务提出了建议。 相似文献
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为满足大数据时代科技创新对知识的需求,科技期刊应该从信息服务向知识服务转型。面向知识服务的需求梳理科技期刊编辑应具备的信息素养,分别从信息分析和管理能力、信息获取和检索能力、信息挖掘和组织能力3个层面阐析科技期刊编辑面向知识服务的信息能力。信息分析和管理能力指通过分析稿件多维度信息生成立体、网状、互相关联的信息管理集约化平台;信息获取和检索能力指能够高效获取政策方针、相关基金等信息,并能够识别信息源、选择检索词、取舍检索工具、构建高级检索策略以及评价检索结果;信息挖掘和组织能力指能够从科技期刊文献的外部特征进行统计和分析,紧随国内外科研前沿和热点,获得所在研究领域的热点、开展富有地域特色的知识服务、前瞻性地提供相应的知识服务。 相似文献
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一种基于本体论的知识检索原型系统 总被引：6，自引：0，他引：6
构建了一个基于本体论知识检索原型系统，探讨了它的设计思路、体系结构和工作流程。该系统利用本体论方法对Internet信息资源进行自动领域分类与重组、规范与完善用户的信息需求、指导和优化检索过程，从而提供信息检索和知识检索功能，并提高检索效率和检索结果的质量。 相似文献
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医学文献检索服务,实质上属于医学情报咨询服务,是通过医学文献检索工具,查找有关医学文献,向用户提供题录、文摘和原始文献,以了解某一课题的发展动向及国内外相关的情报资料,从而为医、教、研人员的知识开拓,科研定题,成县鉴定等提供信息。我所图书情报室从1986年开始,对市属各医疗卫生单位的科研开题和成果鉴定进行了查新检索服务,受到基层单位的好评。普遍反映,通过查新检索,使用户们开扩了视野,避免了重复,加快了科研工作的进度。同时也受到了上级主管部门的重视,于1987 相似文献
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因特网上免费医学信息检索及相关问题 总被引：1，自引：0，他引：1
通过对Internet上免费医学检索站的介绍和分析,着重探讨了当前Internet上医学信息检索的特点,医学信息检索领域中关于医学信息资源、医学信息检索技术及网络检索与光盘检索问题。 相似文献
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There are a plethora of approaches to construct microtissues as building blocks for the repair and regeneration of larger and complex tissues. Here we focus on various physical and chemical trapping methods for engineering three-dimensional microtissue constructs in microfluidic systems that recapitulate the in vivo tissue microstructures and functions. Advances in these in vitro tissue models have enabled various applications, including drug screening, disease or injury models, and cell-based biosensors. The future would see strides toward the mesoscale control of even finer tissue microstructures and the scaling of various designs for high throughput applications. These tools and knowledge will establish the foundation for precision engineering of complex tissues of the internal organs for biomedical applications. 相似文献
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通过网络整体性分析、个体网络分析、网络中心性以及网络结构洞分析,对江苏省生物医药产业的专利引用和创新知识流动进行研究。研究结果显示,江苏省生物医药专利的引用表现出较为明显的子群特征,高校在生物医药专利技术中占有重要地位,并承担着重要的知识流动桥梁作用,特别是中国药科大学表现出明显的结构洞特征。 相似文献
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＂数字图像处理＂是生物医学工程专业一门重要的专业课,让学生学会将理论知识转化为解决本专业实际问题的能力是这门课的重点。我们对理论和实践教学两个方面的教学方法和经验进行了探讨,经过几年的教学实施,这些方法取得了良好的教学效果。 相似文献
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Generating gene summaries from biomedical literature: A study of semi-structured summarization 总被引：3，自引：0，他引：3
Xu Ling Jing Jiang Xin He Qiaozhu Mei Chengxiang Zhai Bruce Schatz 《Information processing & management》2007,43(6):1777
Most knowledge accumulated through scientific discoveries in genomics and related biomedical disciplines is buried in the vast amount of biomedical literature. Since understanding gene regulations is fundamental to biomedical research, summarizing all the existing knowledge about a gene based on literature is highly desirable to help biologists digest the literature. In this paper, we present a study of methods for automatically generating gene summaries from biomedical literature. Unlike most existing work on automatic text summarization, in which the generated summary is often a list of extracted sentences, we propose to generate a semi-structured summary which consists of sentences covering specific semantic aspects of a gene. Such a semi-structured summary is more appropriate for describing genes and poses special challenges for automatic text summarization. We propose a two-stage approach to generate such a summary for a given gene – first retrieving articles about a gene and then extracting sentences for each specified semantic aspect. We address the issue of gene name variation in the first stage and propose several different methods for sentence extraction in the second stage. We evaluate the proposed methods using a test set with 20 genes. Experiment results show that the proposed methods can generate useful semi-structured gene summaries automatically from biomedical literature, and our proposed methods outperform general purpose summarization methods. Among all the proposed methods for sentence extraction, a probabilistic language modeling approach that models gene context performs the best. 相似文献
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Large animals (non-human primates, livestock and dogs) are playing important roles in biomedical research, and large livestock animals serve as important sources of meat and milk. The recently developed programmable DNA nucleases have revolutionized the generation of gene-modified large animals that are used for biological and biomedical research. In this review, we briefly introduce the recent advances in nuclease-meditated gene editing tools, and we outline these editing tools’ applications in human disease modeling, regenerative medicine and agriculture. Additionally, we provide perspectives regarding the challenges and prospects of the new genome editing technology. 相似文献
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Yi-Feng Wang Chunqiu Zhang Keni Yang Yufei Wang Shaobo Shan Yan Yan Kenneth A Dawson Chen Wang Xing-Jie Liang 《国家科学评论(英文版)》2021,8(6)
Liposomes, especially cationic liposomes, are the most common and well-investigated nanocarriers for biomedical applications, such as drug and gene delivery. Like other types of nanomaterials, once liposomes are incubated in a biological milieu, their surface can be immediately cloaked by biological components to form a protein corona, which confers a new ‘biological identity’ and modulates downstream interactions with cells. However, it remains unclear how the protein corona affects the transportation mechanism after liposomes interact with cells. Here, we employed home-made aggregation-induced-emission-visualized nanoliposomes TR4@Lipo as a model to investigate transportation with or without the protein corona by optical imaging techniques. The results show that the protein corona can change the cellular transportation mechanism of TR4@Lipo from energy-independent membrane fusion to energy-dependent endocytosis. The protein corona also modulates the intracellular distribution of loaded cargoes. This knowledge furthers our understanding of bio-nano interactions and is important for the efficient use of cationic liposomes. 相似文献
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Jayasinghe SN 《Biomicrofluidics》2011,5(1):13301
In this special issue of Biomicrofluidics, many manifestations of biological microfluidics have been highlighted that have significance to regenerative biology and medicine. The collated articles demonstrate the applicability of these biological microfluidics for studying a wide range of biomedical problems most useful for understanding and shining light on basic biology to those applications relevant to clinical medicine. 相似文献
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研究我国生物医药产业创新集群演化动力机制,为促进我国生物医药产业创新能力提升提供决策依据。运用复杂适应系统理论模型,分析生物医药创新集群的聚集、非线性、流、多样性特征与标识机制、内部模型机制和积木机制。在此基础上建立生物医药创新集群演化机制的回声模型,运用不完全信息下的重复静态博弈分析主体互动作用,并运用涌现模型分析系统涌现机制。生物医药产业创新集群是复杂适应系统,具备其所有特征;创新集群主体通过流空间网络实现交互学习并适应性调整自身行为;通过交互学习,创新集群主体产生了与其他主体合作创新的可能性,但是否真正实现合作创新取决于主体间竞争合作博弈的结果;涌现推动生物医药产业创新集群演化发展。涌现包括知识涌现和创新网络的涌现,通过涌现创新集群产生新的更优的系统功能和结构,可实现生物医药产业创新集群的可持续发展。 相似文献
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Yi D 《Isis; an international review devoted to the history of science and its cultural influences》2011,102(3):446-474
This essay analyzes how academic institutions, government agencies, and the nascent biotech industry contested the legal ownership of recombinant DNA technology in the name of the public interest. It reconstructs the way a small but influential group of government officials and university research administrators introduced a new framework for the commercialization of academic research in the context of a national debate over scientific research's contributions to American economic prosperity and public health. They claimed that private ownership of inventions arising from public support would provide a powerful means to liberate biomedical discoveries for public benefit. This articulation of the causal link between private ownership and the public interest, it is argued, justified a new set of expectations about the use of research results arising from government or public support, in which commercialization became a new public obligation for academic researchers. By highlighting the broader economic and legal shifts that prompted the reconfiguration of the ownership of public knowledge in late twentieth-century American capitalism, the essay examines the threads of policy-informed legal ideas that came together to affirm private ownership of biomedical knowledge as germane to the public interest in the coming of age of biotechnology and genetic medicine. 相似文献
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本文介绍了在生物学英文文本纷繁芜杂的当今．面对中英文本的文化差异,生物医学自然语言处理fNatu一0aILanguageProcesS{ngforB10]ogy,B1ONLP）的基本概念和方法。归纳总结了B1oNLP在挖掘生物医学文献信息中的重要方面。通过研究实例分析了常见的以“词”、“句”、“篇”为语言单位的分析方法并指出这些方法的局限性,最后展望了生物医学计篮语言堂研窜抬撼 相似文献