共查询到20条相似文献，搜索用时 46 毫秒
1.
Mamatha Kunder V. Lakshmaiah A. V. Moideen Kutty 《Indian journal of clinical biochemistry : IJCB》2018,33(2):218-221
Dengue fever (DF) is characterized by systemic inflammatory response including neutrophil activation leading to uncontrolled elastase activity. This study was aimed to measure the activity of plasma neutrophil elastase (NE), its endogenous inhibitors α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-MG) and elastase in complex with α1-AT (NE–α1-AT complex) in DF. 50 dengue patients [39 DF and 11 dengue hemorrhagic fever (DHF)] and 52 healthy subjects were included in the study. NE was measured using N-succinyl-tri-alanine-p-nitroanilide as substrate. α1-AT, α2-MG and NE–α1-AT complex were estimated by ELISA. The result analysis indicated that the dengue patients had significantly higher elastase activity with significantly reduced inhibitor levels compared to controls. Between DF and DHF patients, DHF group had significantly higher elastase activity. In conclusion, significantly elevated NE and reduced inhibitors level in dengue fever indicate these parameters could be of significance in DF particularly for the assessment of progression of inflammatory processes. 相似文献
2.
A. K. Sayyed K. H. Despande A. N. Suryakar R. D. Ankush R. V. Katkam 《Indian journal of clinical biochemistry : IJCB》2008,23(4):375-377
The present study was undertaken to evaluate the levels of serum lipid peroxide, nitric oxide end poducts, erythrocytic superoxide
dismutase activity and serum α
1-antitrypsin in smokers. Total 90 active cigarette smokers were subdivided into Group I (subjects with smoking habit of less
than 10 cigarettes per day) and Group II (with smoking habit of more than 10 cigarettes per day). In both groups lipid peroxide
and nitric oxide end products were significantly increased with significantly decrease in erythrocytic superoxide dismutase
activity and serum α
1-antitrypsin as compared to controls. Our findings show enhanced oxidative stress and reduced α
1-antitrypsin in cigarette smokers. Further increase in number of cigarettes per day exacerbates the oxidative stress with
decrease in α
1-antitrypsin. 相似文献
3.
Hajar Eftekhari Maryam Pilehchian Langroudi Ali Banihashemi Mandana Azizi Reza Youssefi Kamangar Haleh Akhavan-Niaki 《Indian journal of clinical biochemistry : IJCB》2018,33(2):231-234
α-Thalassemia (α-thal) is considered as the most common inherited hemoglobin disorder worldwide. The present study describes the first observation of a combination of rare α-chain variants, and β-globin gene cluster deletion. A 21-year-old woman with thalassemia trait, marked microcytosis, mild anemia, and normal range of Hb F was referred to Amirkola genetic center in the North of Iran for routine molecular test of thalassemia in the context of carrier detection and prevention of thalassemia major birth. Nucleotide sequencing revealed a novel compound heterozygosity status for two non-deletional mutations on HBA2, Hb O Indonesia (α116(GH4)Glu → Lys), and Hb Matsue–Oki (α75 (EF4) Asp → Asn), together with heterozygosity for the sicilian (δβ)0-thal mutation. This finding highlights the necessity of deep molecular investigation of thalassemia in regions where thalassemia is abundant, and present highly heterogeneous population. 相似文献
4.
B. Antony M. Benny T. N. B. Kaimal 《Indian journal of clinical biochemistry : IJCB》2008,23(4):378-381
Emblica officinalis Gaertn., commonly known as the Indian gooseberry or “Amla”, has been used as health food for centuries
in India and other Asian countries. The biological effects of amla have been attributed to the antioxidant properties of the
low-molecular weight hydrolysable tannins present in the fruit. Amlamax™ is a purified, standardized, dried extract of amla
containing about 35% galloellagi tannins along with other hydrolysable tannins. Our earlier studies on rabbits showed significant
reduction in total cholesterol and triglycerides as well as increase in HDL. The present study extends these results to human
volunteers. Two doses of the extract were evaluated — 500 mg and 1000 mg per day for 6 months. Blood samples were collected
at the 3rd and 6th months showed reduction in total and LDL cholesterols and enhancement of beneficial HDL cholesterol. In
addition, blood CRP levels, a marker for inflammation, were also significantly reduced. Since dyslipidemia and inflammation
are the two major components of cardiovascular diseases, the present results must be considered encouraging and indicate the
potential of Amlamax™ in the management of heart diseases. 相似文献
5.
Nabarun Mandal Debojyoti Bhattacharjee Jayanta Kumar Rout Anindya Dasgupta Gorachand Bhattacharya Chandan Sarkar Prasanta Kumar Gangopadhyaya 《Indian journal of clinical biochemistry : IJCB》2016,31(4):468-472
Wilson’s disease is a disease of abnormal copper metabolism in which free serum copper level is raised. The objective of the study was to determine, whether in Wilson disease, l-cysteine/l-cystine influx into RBC was decreased or not and the specific amino acid transporter affected by copper in normal human RBC. For l-cysteine/l-cystine influx, ten untreated cases, ten treated cases and ten age and sex matched healthy controls were recruited. To study the effect of copper on l-cysteine/l-cystine influx in RBC, 15 healthy subjects were selected. RBC GSH and l-cysteine/l-cystine influx were estimated by Beautler’s and Yildiz’s method respectively. In untreated cases, l-cysteine/l-cystine influx and erythrocyte GSH level were decreased showing that elevated level of free copper in serum or media decreased l-cysteine/l-cystine influx in human RBC. Copper treatment inhibited L amino acid transporter in normal RBC specifically. 相似文献
6.
联盟企业技术创新的推动是专利联盟的基本职能之一。我国专利联盟出现的时间较短、经验不足,尚未产生深层次的作用。联盟特质对联盟企业技术创新存在着重要的影响。实证性的检验揭示了专利联盟中联盟企业技术创新的成长机理,发现了各项联盟特质对技术创新的影响路径,提出联盟企业技术创新的改进策略,从而进一步提高专利联盟的市场价值。研究结论对我国专利联盟与联盟企业的发展均存在着现实的借鉴意义。 相似文献
7.
8.
9.
10.
本文分析了“一带一路”背景下西部地区军民融合发展的客观必然性,并在此基础上,提出西部地区军民融合发展的战略构想目标,同时通过传统的AHP方法对战略目标进行了量化,并最终确定西部地区军民融合发展的战略构想,主要内容为全方位推进军民融合深度发展、驱动军工行业创新发展、打造军民融合示范区等,具体包括：培育具有全球竞争力的军工企业,探索“军工+ ”融合发展模式,发挥科技创新和金融创新的力量,建立全要素资源融合渠道等。 相似文献
11.
Luciano Floridi argues that every existing entity is deserving of at least minimal moral respect in virtue of having intrinsic value qua information object. In this essay, I attempt a comprehensive assessment of this important view as well as the arguments Floridi offers in support of it. I conclude both that the arguments are insufficient and that the thesis itself is substantively implausible from the standpoint of ordinary intuitions. 相似文献
12.
本研究利用系统动力学方法,从知识流动的角度描述、量化、模拟企业创新网络与企业技术创新动态能力协同演进的过程。模型分析结果表明当前企业创新绩效取决于技术创新动态能力与创新网络协同演进路径：技术创新动态能力→创新网络构建与演化→外部知识内化→创新绩效→技术创新动态能力。在协同演进的过程中随着企业技术创新的发展,在创新绩效驱动三要素中,动态能力以及创新网络知识内化对创新绩效提升具有边际递增的效应,同时创新战略、产业政策平台和管理平台对企业技术创新都存在显著影响,但这种影响作用存在较大差异。 相似文献
13.
Nasrin Ziamajidi Hamid Behrouj Roghayeh Abbasalipourkabir Fatemeh Lotfi 《Indian journal of clinical biochemistry : IJCB》2018,33(2):147-153
Diabetes mellitus (DM) is one of the most prevalent diseases in the world, which is strongly associated with liver dysfunction. Hyperglycemia, through an oxidative stress pathway, damages various tissues. Herbal medicine is a good candidate to ameliorate hyperglycemia and oxidative stress. In this study, the effects of aqueous Allium sativum (garlic) extract (AGE) on gene expression of inducible nitric oxide synthases (iNOS) and production of nitric oxide (NO) were evaluated in the liver tissue of diabetic rats. Four groups of rats contained normal control rats, garlic control rats (AGE), Streptozotocin (STZ) + nicotinamide-induced diabetic rats (DM), and diabetic rats treated with garlic (DM + AGE). Glucose levels and liver enzymes activities were determined by colorimetric assay in the serum. Gene expression of iNOS by real-time PCR, NO levels by Griess method, oxidative stress parameters by spectrophotometric method and histopathological examination by hematoxylin and eosin staining method were evaluated in the liver tissues. Glucose levels, activities of liver enzymes, oxidative stress markers, iNOS gene expression, and NO production increased significantly in diabetic rats in comparison with control rats, whereas after oral administration of garlic, these parameters decreased significantly, close to the normal levels. Hence, the beneficial effects of garlic on the liver injury of diabetes could be included in the hypoglycaemic and antioxidant properties of garlic via a decrease in gene expression of iNOS and subsequent NO production. 相似文献
14.
《中国科学院院刊(英文版)》2007,(2)
While constantly revealing the laws of the objective world and of mankind itself, science, and technology, whose development is based on the former, have greatly advanced the productive forces of society and brought about 相似文献
15.
《中国科学院院刊(英文版)》2005,(1)
Launched in 1994, the Bairen Program is a major initiative of CAS to speed up its cultivation of disciplinary pacesetters and bridge the gen- erationgap of scientific personnel. Asa pioneering move of its kind in this country, the Program is noted for its ambitious goals, high standards and strong support. The term “bairen” means “one hundred people” in Chinese. The original goal of the CAS Bairen Program wastoearmarkatotal of200millionyuan(US$24 million) to bring in 100 young talent… 相似文献
16.
17.
18.
It is often argued that small–medium enterprises (SMEs) do not manage knowledge the same way as large firms, but may need appropriate approaches to capture and exploit external knowledge effectively. This paper compares two opposite approaches to knowledge management (KM): one is called ‘deliberate’ or ‘planned’, and the other ‘emergent’. These approaches are analysed with reference to the management of knowledge pertaining to client–supplier relationships, which are particularly important in the case of small companies providing knowledge-intensive business services (KIBS). A case study of a small KIBS company is illustrated, which has developed two different projects, based on different approaches to KM, for managing knowledge referring to clients. The case shows that, for a small company, an emergent approach to KM can be more suitable than a deliberate one for managing such knowledge. The implications of this result for KM research and practice are then examined. 相似文献
19.
《中国科学院院刊(英文版)》2003,17(3):137-137
After a decade-long arduouswork, CAS scientists suc-ceeded in developing thefourth generation of high-perfor-mance catalysts.The research breakthroughwas achieved by a research teamheaded by Prof. Liu Hanfan withthe CAS Institute of Chemistry. Thiswork includes a new method con-cerning the preparation of a nano-metallic colloid protected by poly-mers and demystification of the se-cret to raise the working efficacy ofmetal nanoclusters used as a catalyst.The success lays down a solid foun-d… 相似文献