共查询到20条相似文献,搜索用时 15 毫秒
1.
Tangirala Malati D. Murali Mohan Krishna V. R. Srinivasan V. Shantharam 《Indian journal of clinical biochemistry : IJCB》1992,7(2):138-142
Glycosylated Hemoglobin (GHb) was estimated using cation exchange resin binding method in 50 non diabetic healthy controls and 500 maturity onset diabetics. Percentage of glycosylated hemoglobin levels in controls was 7.27±0.456 (range 6.0–8.04) and 9.47±0.98 (range 8.2–13.63) in diabetic group. Glycosylated hemoglobin levels remain unaffected inspite of transient rise of serum glucose levels during an oral glucose tolerance test. Significantly elevated GHb A1. Furthermore significant elevation of GHb A1 was noticed in diabetics with all secondary complications suggesting poor glycemic control in these patients. The diabetics having retinopathy, nephropathy or diabetic foot had relatively higher GHb levels compared to patients having coronary artery disease or hypertension. 相似文献
2.
R. Giri M. M. Kesavulu B. Kameswara Rao V. Ramana Ch. Appa Rao 《Indian journal of clinical biochemistry : IJCB》1999,14(2):168-175
Plasma levels of lipids, lipoproteins and lipid peroxides and erythrocyte Na+−K+ ATPase, Mg2+ATPase and antioxidant enzymes were measured in type-2 diabetic patients. A significant decrease in Na+-K+-ATPase activity was observed in diabetic patients which was negatively correlated with blood glucose and lipid peroxides,
while the Mg2+-ATPase activity was increased. In the diabetic subjects the plasma concentrations of Na+ and K+ were increased where as erythrocyte levels of Na+ were increased and K+ were decreased. Hyperlipidaemia and increased levels of lipid peroxides were observed in the diabetic subjects. There was
a significant increase in erythrocyte catalase activity in diabetics which positively correlated with their lipid peroxides.
There was no change in GPx activities between controls and diabetics. 相似文献
3.
D. Rajasekhar K. S. S. Saibaba P. V. L. N. Srinivasa Rao S. A. A. Latheef G. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2004,19(2):53-59
In an attempt to search for risk factors which can explain the increasing prevalence of coronary heart disease (CHD) in Indian
population, we conducted a case-control study to assess the association of Lipoprotein (a)(Lp(a)) with CHD. One hundred and
fifty one consecutive patients with clinical and angiographic evidence of CHD and forty-nine healthy controls were drawn for
the study. Triglycerides, very low density cholesterol (VLDL-C), total cholesterol (total-C)/high density cholesterol (HDL-C)
ratio, low density cholesterol (LDL-C)/HDL cholesterol ratio and Lp(a) were found to be higher in patients than controls.
In female sex and in those with family history of CHD, higher total and LDL cholesterol levels were observed to be associated
with higher Lp(a) levels. Lp(a) levels were also found to be higher in triple vessel disease than other vessel disease patients.
Significant difference in Lp(a) levels were observed between normal coronaries vs. single and triple vessel disease(P<0.05)
and also between single vs. double and triple vessel disease (P<0.01).Lp(a) levels correlated positively with vessel severity(P<0.005).
Lp(a) levels >25 mg/dl were associated with coronary heart disease (Odds ratio 1.98 P<0.05 95% CI 0.007–1.18). Our findings
suggest a cut-off level of 25mg/dl for determination of risk of CHD. Studies from different areas involving larger sample
size are needed to confirm the findings of the present study. 相似文献
4.
Increased oxidative stress is a widely accepted participant in the development and progression of diabetes and its complications.
The present study has been undertaken to evaluate oxidative stress in type 2 diabetes mellitus and effect of vitamin E supplementation
on oxidative stress. In all 120 subjects were enrolled in the present study, 40 subjects are age and sex matched controls.
Test group comprised of clinically diagnosed (n = 80) type 2 diabetic patients. Biochemical parameters like serum MDA, nitric oxide, superoxide dismutase, erythrocyte reduced
glutathione and platelet aggregation were analyzed in control and diabetic group. Test group is further categorized as Group
I (n = 40) diabetics were treated by only hypoglycemic drugs and Group II (n = 40) diabetics were treated by hypoglycemic drugs with vitamin E supplementation. All above biochemical parameters were
again reassessed after 3 months follow-up in both group and its values were compared with its respective baseline levels.
The study shows, reduction of oxidative stress, improvement in antioxidant enzymes and endothelial dysfunction in group II,
those were on treatment of hypoglycemic drugs along with vitamin E supplementation. Hence the present study may conclude that
vitamin E supplementation along with hypoglycemic drugs may be beneficial to type 2 DM patients to minimize vascular complications. 相似文献
5.
Patients with type II Diabetes Mellitus (NIDDM) are more prone to Ischaemic Heart Disease (IHD). Although, oxygen free radicals
are known to contribute to the development of IHD, conflicting reports are available regarding the antioxidant status in patients
of NIDDM complicated with IHD. This study was undertaken to investigate the oxidative status in patients of NIDDM and to assess
their correlation with plasma glucose, glycosylated haemoglobin and duration of diabetes. The levels of malondialdehyde were
significantly increased where as levels of superoxide dismutase, Glutathione peroxidase and vitamin C were significantly decreased
in diabetics without complications and non-diabetics with IHD when compared with the controls. The levels of malondialdehyde
and Glutathione peroxidase were significantly increased where as levels of superoxide dismutase and vitamin C were significantly
decreased in diabetics with IHD when compared with diabetics without complications and non-diabetics with IHD. The implications
of the results are discussed. 相似文献
6.
G. P. Das B. Mandal P. Ghosh C. R. Maity 《Indian journal of clinical biochemistry : IJCB》1993,8(1):39-43
Serum levels of cholesterol, triglyceride, free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol were studied
in 10 undernourished and 10 better nourished diabetic patients at different periods of insulin treatment and in non-diabetic
controls. Serum concentrations of cholesterol, triglyceride and FFA were significantly higher in untreated diabetic patients
than in control but the elevated lipid levels gradually shifted towards normal on insulin treatment. The HDL cholesterol,
on the other hand, was significantly lower in untreated diabetic subjects than those in controls and the HDL cholesterol also
gradually modified on insulin therapy. However, the improvement of all the lipid parameters on insulin treatment was somewhat
delayed in undernourished compared to those of better nourished diabetics. These results, therefore, suggest that malnutrition
interferes with the serum lipid improvement in diabetics on insulin treatment and may make them more prone to develop vascular
complications. 相似文献
7.
Anuradha Bharosay Vivek V. Bharosay Debapriya Bandyopadhyay Ajoy Sodani Meena Varma Haren Baruah 《Indian journal of clinical biochemistry : IJCB》2014,29(3):372-376
Stroke is the third major cause of death worldwide. Elevated plasma concentration of low density lipoproteins and low plasma concentration of high density lipoprotein concentration are associated with an increased risk of atherosclerosis and coronary heart disease but the relation between serum lipids, and cerebrovascular disease is less clear. The aim of this study was to investigate the reliability and accuracy of serum lipid profile in assessing the prognosis/neurological worsening in patients with ischemic and hemorrhagic cerebrovascular stroke. The subjects in the present study comprised of 101 healthy controls and 150 cerebrovascular stroke patients (including 90 with ischemic stroke and 60 with intracerebral hemorrhagic stroke). In both the groups fasting lipid profile was determined within 72 h of the stroke. A statistically significant association was observed (p < 0.001) between the parameters of lipid profile of cases and healthy controls, and also with the prognosis of the stroke. 相似文献
8.
Murali Krishna Madisetty Konda Kumaraswami Shivakrishna Katkam Kankanala Saumya Y. Satyanarayana Raju Naval Chandra Maddury Jyotsna Sujatha Patnaik Vijay Kumar Kutala 《Indian journal of clinical biochemistry : IJCB》2016,31(3):278-285
We aimed to assess whether measuring carotid intima-media thickness (CIMT) and oxidative stress markers such as protein carbonyls, malondialdehyde, nitrate and glutathione in plasma of elderly patients without and with coronary artery disease (CAD) identifies early risk for CAD. A total of 50 cases with cardiovascular risk factors over the age of 60 years without CAD, and 50 patients with angiographically documented CAD over the age of 60 years were included in the study. Control group consists of 200 healthy individuals without the risk factors. Demographic details were obtained from all the subjects and CIMT measured by high frequency ultrasound and oxidative stress markers such protein carbonyls, malondialdehyde and total glutathione were determined in plasma by spectrophotometric methods. The distribution of cardiovascular risk factors in without CAD and CAD cases were smokers (16 vs 56 %), hypertension (26 vs 64 %), diabetes (16 vs 56 %) and dyslipidemia (18 vs 58 %) and positive family history (4 vs 38 %). None of the control group had any cardiovascular risk factors. Among the CAD cases, 16 % had single vessel disease, 44 % had double vessel disease and 40 % had triple vessel disease. The CIMT was significantly increased in CAD cases as compared to cases without CAD and healthy controls. On the other hand, CIMT was significantly increased in cases without CAD as compared to healthy controls. CIMT also increased with the duration of diabetes in patients without CAD and severity of disease in CAD cases. The levels of oxidants like plasma malondialdehyde, protein carbonyls, were significantly elevated and antioxidant glutathione levels and nitrate levels were significantly reduced in cases with and without CAD as compared to healthy controls. Oxidative stress markers and CIMT was found to be significantly increased in patients with cardiovascular risk factors like diabetes, family history of CAD, dyslipidemia, hypertension and smoking when compared to patients without risk factors. In patients with diabetes, CIMT increased as duration of disease increases and also in poorly controlled diabetes. In CAD group, when number of vessel involvement (severity of coronary disease) increases, the CIMT also increases confirming that CIMT is a quantifiable risk factor for CAD. 相似文献
9.
A. A. Momin M. P. Bankar G. M. Bhoite 《Indian journal of clinical biochemistry : IJCB》2016,31(3):286-293
Elevated plasma triglyceride and non-esterified fatty acid concentrations may cause insulin resistance and type 2 diabetes mellitus. Lipoprotein lipase (LPL) is a rate-determining enzyme in lipid metabolism. A variant in the LPL gene has been identified which alters the penultimate amino acid Serine at 447 to a stop codon (S447X), and results in a truncated LPL molecule lacking the C-terminal dipeptide Ser–Gly. The present study was designed to evaluate the frequency of S447X variant in the LPL gene and its effect on the lipid and lipoprotein levels in type 2 diabetic subjects. The genotype frequency distributions of type 2 diabetes patients and controls were in Hardy–Weinberg equilibrium. Comparison of the genotype and allelic frequencies of S447X in subjects with type 2 diabetics compared to controls demonstrated no significant difference. In subjects with type 2 diabetics having hypertriglyceridemia (TG ≥ 150 mg/dl) compared to diabetics with TG level <150 mg/dl, significant difference in genotype frequency was found among these groups, while allelic frequency of X was significantly differed. Logistic regression analysis showed the negative association of LPL S447X variant with TG and VLDL cholesterol, while no association with total cholesterol, HDL cholesterol and LDL cholesterol was found. The lipid levels except for HDL cholesterol were found to be significantly lower in carriers for S447X than wild type in diabetes group. The decreased level of TG and TG rich lipoprotein in subjects with SNP S447X in LPL, predicts anti-atherogenic activity of carriers for S447X variant in general population as well as type 2 diabetic patients. 相似文献
10.
Adinortey MB Gyan BE Adjimani J Nyarko P Sarpong C Tsikata FY Nyarko AK 《Indian journal of clinical biochemistry : IJCB》2011,26(3):261-268
In this study, differences in lipid levels amongst diabetics with and without complications were assessed to determine lipid
disorders that are associated with diabetic complications other than cardiovascular diseases. A Cross sectional study design
was employed. The study included 288 diabetics and 108 non diabetics with different types of complications such as hypertension,
nephropathy, neuropathy, and retinopathy. The mean serum total cholesterol was higher in patients with complications compared
to those without complications and the non-diabetic controls. The normotensive diabetic patients had the lowest total cholesterol
among the diabetic patients’ groups (4.65 ± 0.17 mmol/l) compared to the diabetics with hypertension (6.051 ± 0.20 mmol/l),
retinopathy (6.26 ± 0.29 mmol/l), neuropathy (5.80 ± 0.17 mmol/l) and nephropathy patients 5.74 ± 0.26 mmol/l (P < 0.05). The prevalence of dyslipidaemia among diabetic subjects was between 19.2 and 84.0%. The study shows that, in addition
to macrovascular complications, dyslipidaemia is common in type 2 diabetes mellitus patients with microvascular complications. 相似文献
11.
S. Jaya Kumari Nivedita Jayaram Lloyd Vincent T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):45-48
Type 2 diabetes is associated with a marked increase in the risk of coronary artery disease. Dyslipidaemia is believed to
be a major cause of this increased risk. Recently, elevated levels of lipoprotein (a), Lp(a), have been reported to be associated
with an increased risk. However there is very little data regarding Lp(a) concentrations and type 2 diabetes from India. The
objective of the study was to assess serum Lp(a) levels in type 2 diabetics with and with out evidence of clinical nephropathy.
We estimated serum Lp(a) levels in 30 control subjects, 30 diabetics without evidence of clinical nephropathy and 30 diabetics
with evidence of clinical nephropathy. Statistical analysis showed that Lp(a) levels were increased in diabetic patients with
nephropathy (mean 46.3±17.6 mg/dl). The Lp(a) levels however did not differ significantly between control (mean 20.2±15.9
mg/dl) and diabetics without nephropathy (mean 22.6±13.1mg/dl). Thus diabetes per se seems to have little or no influence
on serum Lp(a) levels, however elevated levels were seen in patients with nephropathy. 相似文献
12.
S. B. Sharma S. Dwivedi K. M. Prabhu Narendra Kumar M. C. Baruah 《Indian journal of clinical biochemistry : IJCB》1999,14(2):245-248
Serum lipid profile, apolipoprotein-B (apo-B), malondialdehyde levels(MDA) and superoxide dismutase (SOD) activity were assessed
in 12 cases of xanthelasma with and without coronary artery disease (CAD)/hypertension (HTN) and results are compared with
healthy controls. Dyslipidemia was found in 65% cases of xanthelasma as compared to 20% healthy controls. Xanthelasma patients
had significantly high malondialdehyde (MDA) levels (p<0.01) and significantly decreased (p<0.05) SOD activity as compared
to controls. Among xanthelasma patients, xanthelasma with CAD/HTN showed higher total cholesterol (236±32.7 vs 188±24.7 mg/dl),
low density lipoprotein cholesterol (157±35.5 vs 113±16 mg/dl) and Apo-B (120.5±9.4 vs 114±19.2 mg/dl) levels as compared
to xanthelasma without CAD/HTN. Results of our study indicate that xanthelasma patients with increased apo-B, MDA and decreased
SOD need cardiovascular monitoring. 相似文献
13.
Fariborz Ahmadi Yousef Mortazavi Koorosh Fouladsaz Saeede Mazloomzadeh 《Indian journal of clinical biochemistry : IJCB》2016,31(3):315-320
Atherosclerosis is a pathologic disorder which has an important role in the occurrence of coronary heart disease. It is determined as a focal, inflammatory proliferative response to several types of endothelial damage. Apolipoprotein B which is a requirement in the sustenance of cholesterol homeostasis, and is the major protein component of low density lipoprotein, characterized by multitude polymorphic sites, one of which (12669G>A) is related to the levels of serum lipid profiles, coronary artery disease and/or myocardial infarction. One Common polymorphism which is more important in this process is 12669G>A that is appraised in this research. We recruited 80 patients from the Mousavi hospital, Zanjan, Iran, diagnosed with coronary artery disease by the clinician on the basis of clinical symptoms, echocardiogram result, and angiography. Seventy-seven healthy individuals without any evident symptoms of Coronary stenosis and any past history of the disease were taken as controls from the general population. We carried out PCR using specific primers. Then, we digested PCR product by RFLP. Lipid parameters by biochemical methods and Apolipoprotein B serum level by immunoturbidometry method were done. Genotype frequencies for 12669G>A polymorphism were determined: 55 % R+R+, 45 % R+R? in case group, and 55.8 R+R+, 44.2 % R+R? in controls. The R?R? genotype was not seen. There was no significant relationship between this polymorphism and the risk of Coronary stenosis (P = 0.6). In the present study, higher plasma levels of cholesterol and low density lipoproteins in the subjects with R+R? genotype were found while there was no association between this polymorphism and coronary stenosis with ≥50 % in the Zanjan population. 相似文献
14.
Michael B. Adinortey Ben A. Gyan Jonathan P. Adjimani Philomena E. Nyarko Charity Sarpong Francis Y. Tsikata Alexander K. Nyarko 《Indian journal of clinical biochemistry : IJCB》2011,26(4):366-372
There is scanty information on the role of genetic factors, especially those relating to haptoglobin (Hp) phenotypes in the
expression of complications among diabetes mellitus patients in Ghana. In this study, we investigated whether there is any
association between Hp phenotypes and diabetic complications and to determine if association of the Hp phenotypes with diabetic
complications in Ghanaian diabetics differ from those in Caucasians. A total of 398 participants were randomly recruited into
the study. These comprised diabetic patients numbering 290 attending a diabetes Clinic in Ghana and 108 non-diabetic controls
from the same community. Analyses of the results indicate that most of the diabetics with complications were of the Hp 2–2
(35%) and Hp 2–1 (23.9%) phenotypes. Fewer diabetics were found to be of the Hp 2–1 M phenotype. The controls were mostly
of Hp 1–1 and Hp 2–1 M phenotypes. The odds ratio of having complications in a diabetic with an Hp 2–2 phenotype was 18.27
times greater than that for Hp 0–0. Hp 2–2 phenotype with its poor antioxidant activity may therefore be a useful predictor
for the propensity of an individual to develop diabetes complications. 相似文献
15.
T. Angeline RitaMary Aruna K. Ramadevi G. Mohan Nirmala Jeyaraj 《Indian journal of clinical biochemistry : IJCB》2003,18(1):103-106
Coronary artery disease is now a major health problem in India. In past few decades the battle to reduce the incidence of
coronary artery disease has led the researchers to look for various clinical markers, which would help early diagnosis of
the diseases. The present study was undertaken to assess the level of lipoprotein (a) [Lp(a)] and few other lipids in selected
myocardial infarction (MI) patients below 45 years without having any traditional risk factors but with positive family history.
Fasting blood samples were taken from 65 patients and their total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol,
triglycerides and serum Lp(a) were determined. The control group consisted of 50 age matched healthy individuals. The mean
Lp(a) level was 58.6±3.20 mg/dl in patients and 19.70±0.18 mg/dl in controls. Thus Lp(a) levels were found significantly higher
in patients with MI (p<0.05 for patients versus control) as compared to the controls. There was no significant difference
in the levels of total cholesterol (TC), LDL, VLDL HDL, TGL as compared to controls but there was an increase in TC/HDL cholesterol
ratio. The results of this study suggest that high level of Lp(a) and TC/HDL ratio has a distinctive association with MI,
independent of other common coronary risk factors. Hence, Lp(a) level in serum emerges to be a promising marker for diagnosis
of coronary artery diseases. 相似文献
16.
C. E. J. Udiong A. E. Udoh M. E. Etukudoh 《Indian journal of clinical biochemistry : IJCB》2007,22(2):74-78
The prevalence of abnormal thyroid hormone levels in diabetes mellitus in Nigeria is not well described. To determine the
incidence of abnormal thyroid hormone levels in diabetics in Calabar, Nigeria, fasting blood samples from 161 diabetic subjects
and 105 non-diabetic controls were analysed. Free thyroxine (FT), thyroid stimulating hormone (TSH), total triiodothyronine
(T3) and total thyroxine (T4) kits obtained from Biomerica Inc. of USA were used for the analysis. TSH levels (1.80±1.62) in diabetics were significantly
lower (p=0.016) than the level in non-diabetic controls (2.34±1.24). Male diabetics had lower (p<0.05) levels of TSH (1.192±0.68
miu/ml) than diabetic females (1.90±1.70 mlu/mt). The level of T3 in diabetic males (125±97ng/ml) was higher than the level in females (98±75ng/dl). TSH (F=2.74, p=0.049), T4(F=56.87, p=0.001), T3(F=56.44, P=0.001) in diabetics and FT4 (F=5.74, p=0.002) in controls showed significant variation with the ages of the subjects. Out of 161 diabetics subjects studies
26.6% had low plasma thyroid hormone levels (FT4>2.01 ng/dl). This study has shown a high incidence (46.5%) of abnormal thyroid hormone levels among the diabetics in Nigeria
(hypothyroidism 26.6%, hyperthyroidism, 19.9%). The prevalence of hypothyroidism was higher in women (16.8%) than in men (9.9%),
while hyperthyroidism was higher in males (11%) than in females (8%). This study has defined thyroid function status of diabetics
in Calabar, Nigeria probably the first of such work in Africa. 相似文献
17.
P. Sabitha Kannan Vaidyanathan D. M. Vasudevan Prakash Kamath 《Indian journal of clinical biochemistry : IJCB》2009,24(1):76-81
In this study, we compared the lipid profile and antioxidant enzymes of normal and diabetic subjects consuming two different
types of oil as cooking medium. 70 normal, healthy subjects were taken as controls and 70 subjects with Type 2 diabetes were
recruited in patient group. Each group was further subdivided into two subgroups of 35 subjects each, consuming coconut oil
and sunflower oil respectively as cooking medium. Samples of blood were collected and analyzed for serum total cholesterol,
triacylglycerols, and cholesterol in lipoprotein fractions. Total glutathione and glutathione peroxidase were measured in
erythrocytes and superoxide dismutase in serum. Triacylglycerols, LDL and VLDL cholesterol levels were high in the diabetic
subjects compared to the controls. Total glutathione and glutathione peroxidase values showed significant decrease in diabetic
subjects as compared to the controls, while superoxide dismutase values showed significant difference between coconut oil
consuming groups. Though lipid profile parameters and oxidative stress were high in Type 2 diabetic subjects compared to controls,
no pronounced changes for these parameters were observed between the subgroups (coconut oil vs. sunflower oil). 相似文献
18.
Suman B. Sharma Seema Garg Abhinav Veerwal Sridhar Dwivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):334-336
Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high
sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40
years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde,
antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased
serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP
levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young
patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP
levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians. 相似文献
19.
A. Madhusudhana Rao A. R. Bitla E. P. Reddy V. Sivakumar P. V. L. N. Srinivasa Rao 《Indian journal of clinical biochemistry : IJCB》2010,25(1):47-50
The present study was carried out to explore the altered lipid, lipoprotein and apoprotein abnormalities along with lipoprotein
(a) in chronic kidney disease patients with stage I to V which were further divided into group 1 (stage I and II), group 2
(stage III and IV) and group 3 (stage V). 50 chronic kidney disease patients with stage I to V and 20 healthy normal subjects
as controls were recruited for this study. Among the various parameters tested triglyceride levels were high in group 1 and
2, whereas VLDL cholesterol, Lp (a) and apo B levels were significantly high in all the groups when compared to controls (P<0.05).
However, LDL cholesterol level was significantly low in group 3 only as compared to control group (P<0.05). Apoprotein AI
values also showed significant decrease in all groups as compared to controls (P<0.05). Though total cholesterol levels in
group 1 and LDL levels in group 1 and 2 were higher than controls, but the values attained not statistically significant (P>0.05).
In conclusion high levels of VLDL cholesterol, Lp (a), apo B and low levels of apoprotein AI as reported in this study are
the major lipid disorders in the development of cardiovascular complications at all the stages in these patients. 相似文献
20.
Ritu Sharma Mridula Mahajan Ravi Kant 《Indian journal of clinical biochemistry : IJCB》2004,19(1):10-13
Serum total lipids (cholesterol and triglyceride), lipoproteins (VLDL, LDL and HDL) and Apolipoprotein-B levels of normal
healthy individuals (n=25) and coronary artery disease patients (n=25) were estimated. The objective of the present study
was to ascertain the role of apo-B in causation and inheritance of coronary artery disease. It was observed that on an average
serum total cholesterol and triglyceride more than 200 mg/dl bring the individuals to a risk of coronary artery disease (CAD)
irrespective of the age. CAD patients achieved this value at an early age (35–45 years). Similarly VLDL and LDL levels were
found to be significantly raised in CAD patients when compared to that of age matched normal individuals, with patients achieving
risk values at an early age. HDL levels were found to be significantly lower in CAD patients as compared to normal individuals.
Serum apo-B levels were significantly raised in CAD patients as compared to age matched normal individuals. Patients with
positive family history of CAD had raised serum apo-B levels than those having negative family history. A positive coefficient
of correlation was observed between serum apo-B and LDL levels suggesting that more the number of Apo-B particles, more will
be the synthesis of atherogenic particle (LDL). Patients with negative family history had serum apo-B levels closer to those
of normal individuals and in these individuals HDL levels were found to be significantly lowered, suggesting that loss of
scavenger role of HDL could be the risk factor responsible for the causation of CAD in these patients, with negative family
history of coronary artery disease. 相似文献