共查询到19条相似文献，搜索用时 280 毫秒
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Insulin is one of the most extensively studied protein hormones, and its structure and function have been elucidated in many vertebrate species, ranging from human to fish. Insulin-like peptides (ILPs) also have been found and characterized in different invertebrates, including nematodes, mollusks and insects. However, insect ILPs turned out to be a structurally diverse group encoded by large multi-gene families that are expressed in the brain and other tissues and serve functions different from vertebrate insulin. Recent physiological and genetic studies have revealed that, in different insect species, the conserved insulin signaling pathway plays a key role in the regulation of a variety of fundamental processes, such as metabolism, growth, reproduction and aging. Here, the structures, distributions, conserved signaling pathways, and physiological functions of insect ILPs are reviewed in detail. 相似文献
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Chunyan Zhou 《美中教育评论》2006,3(5):27-32
With some reflections on the management culture of higher educational institutions in China, this paper presents that it is not adequate to make analyses of rules and regulations from the mere perspective of institutional economics to get rid of short-term, which can be accounted for on a deeper level by the absence of management culture in the prevailing assessment system of teachers＇ achievements; while the key to reform the system of assessing teachers＇ work is to rebuild cultural conceptions in the management of higher educational institutions. 相似文献
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Slope stability hazard management systems 总被引：2，自引：0，他引：2
FREDLUND Delwyn G 《浙江大学学报(A卷英文版)》2007,8(11):1695-1711
Weather-related geo-hazards are a major concern for both natural slopes and man-made slopes and embankments. Government agencies and private companies are increasingly required to ensure that there is adequate protection of sloping sur- faces in order that interaction with the climate does not produce instability. Superior theoretical formulations and computer tools are now available to address engineering design issues related to the near ground surface soil-atmospheric interactions. An ex- ample is given in this paper that illustrates the consequences of not paying adequate attention to the hazards of slope stability prior to the construction of a highway in South America. On the other hand, examples are given from Hong Kong and Mainland China where significant benefits are derived from putting in place a hazard slope stability management system. Some results from a hazard management slope stability study related to the railway system in Canada are also reported. The study took advantage of recent research on unsaturated soil behaviour and applied this information to real-time modelling of climatic conditions. The quantification of the water balance at the ground surface, and subsequent infiltration, is used as the primary tool for hazard level assessment. The suggested hazard model can be applied at either specific high risk locations or in a more general, broad-based manner over large areas. A more thorough understanding of unsaturated soil behaviour as it applies to near ground surface soils, along with the numerical computational power of the computer has made it possible for new approaches to be used in slope hazard management engineering. 相似文献
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NARANJO José-eugenio 《浙江大学学报(A卷英文版)》2007,8(12):2017-2020
Estimating the global position of a road vehicle without using GPS is a challenge that many scientists look forward to solving in the near future. Normally, inertial and odometry sensors are used to complement GPS measures in an attempt to provide a means for maintaining vehicle odometry during GPS outage. Nonetheless, recent experiments have demonstrated that computer vision can also be used as a valuable source to provide what can be denoted as visual odometry. For this purpose, vehicle motion can be estimated using a non-linear, photogrametric approach based on RAndom SAmple Consensus (RANSAC). The results prove that the detection and selection of relevant feature points is a crucial factor in the global performance of the visual odometry algorithm. The key issues for further improvement are discussed in this letter. 相似文献
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At the very beginning of the book-Pride and Prejudice,the author said"It is universally acknowledged that a single man in possession of a good fortune must be want of a wife."From this line,we can find that marriage is the most important thing to women.Sometimes it even equals to men’s career at that time.It seems like once a woman married to a rich single man,she succeed in her lifetime"career".The question is what is the standard of that"succeed"? Married to a rich man,or the man you really love,or a man you had a crush on? Everyone keep these questions in mind since very early time,and different people have different opinions.In her short life,Jane Austin,the great novelist,composed six novels and created lot of female characters.Women in her novel had different attitudes toward marriage.Speaking of marriage,Pride and Prejudice must be the most representative work of it,and it is also Jane’s masterpiece.Through the different type of marriage of Mr.Bennet’s daughters,we can find the Jane’s atti tude towards marriage.In this article the author will discuss this issue based on Pride and Prejudice. 相似文献
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With the swift growth of China’s economy in recent years, the number of multinational corporations in China is increasing rapidly, and during their process of management, the strategy of human resources localization is widely used. Though there are a lot of scholars who have done research on advantages, negative effects and implementation of this strategy, there are still not enough studies have been made about the enlightenments for China. Therefore, this study aims at representing more modern and advanced opinions by stating superiority and inferior of multinational corporations’ human resources localization strategy on the basis of predecessors’ studies. This study is based on multinational corporation human resources localization theories, research on certain multinational corporations located in China, and data and information from relative journals, books,newspapers and internet. The conclusion of this paper is as below: though human resources localization strategy has obvious advantages, the management shall control the"degree"in case of"over-localization"; secondly, as Chinese corporations, it is necessary to possess their own core technology instead of being a manufacturer only; and last, Chinese corporations should learn from foreign multinationals that balancing between globalization and localization, to maximize the benefits. 相似文献
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YANG Tian-ping 《美中教育评论》2007,4(1):1-9
In spite of having undergone one Century＇s vicissitude, China＇s educational management studies are still lagging behind those abroad. Two research lines, one being induction and generalization, another being deduction and transplantation, have been roughly evolved over these studies. Both of them have reached the level of empirical science. Since 1980s, they have developed in an unprecedented way. However, there are still some problems existing in this field. The first one is tha（a clan of multi-echeloned and multi-typed educational management studies has been multiplied in the way of trying to jump over certain developing phases and to obtain instant success and quick profits. The second one is the concept of what is educational management studies is still unclear, thus leading to ambiguous ideas or even confusions on this issue. The third one is that the study on educational management and the study on educational economy are forced to be tied together and become one by human forces, thus hampering the development of either field. Therefore, it is necessary to make reflections on and criticisms on these confused phenomena so as to preserve standardization and identity of this discipline and promote its healthy development. 相似文献
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ZHO U Run -xian ZHOU Xiao-pin 《美中教育评论》2007,4(5):7-10
In recent years, ＂cheating＂ becomes a prevalent social phenomenon among the university students, which result in a bad influence to the quality of higher education, to the healthy growth of the university students, and to the social morale. To solve this problem, the key is to scoop out the root reason and get rid of it thoroughly. The emergence of cheating comes from various reasons, this paper is supposed to make an objective, systematic and dialectic analysis basing on Albert Bandura＇s reciprocal determinism. 相似文献
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Language teachers and researchers have shown high interest in providing effective classroom management. The purpose of this study is to explore successful classroom management from three aspects: effective time management in a classroom, effective teaching in small classes, and effective use of handouts for a lecture. The findings reveal that it is crucial for language teachers to deliver enough knowledge during the limited time. And then small class teaching is an inevitable trend that teachers should focus on. Finally, despite the disadvantages of handouts, using handouts effectively can benefit both teachers and students. 相似文献
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Zhu Wei Zhou Bo-lun Rong Li-juan Ye Li Xu Hong-juan Zhou Yao Yan Xue-jun Liu Wei-dong Zhu Bin Wang Lei Jiang Xing-jun Ren Cai-ping 《Journal of Zhejiang University. Science. B》2020,21(2):122-136
Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the other proteins of the PTBP family. PTBP1 mediates several cellular processes in certain types of cells, including the growth and differentiation of neuronal cells and activation of immune cells. Its function is regulated by various molecules, including microRNAs (miRNAs), long non-coding RNAs (IncRNAs), and RNA-binding proteins. PTBP1 plays roles in various diseases, particularly in some cancers, including colorectal cancer, renal cell cancer, breast cancer, and glioma. In cancers, it acts mainly as a regulator of glycolysis, apoptosis, proliferation, tumorigenesis, invasion, and migration. The role of PTBP1 in cancer has become a popular research topic in recent years, and this research has contributed greatly to the formulation of a useful therapeutic strategy for cancer. In this review, we summarize recent findings related to PTBP1 and discuss how it regulates the development of cancer cells.
相似文献13.
Bo Yang Guo-qiang Liao Xiao-fei Wen Wei-hua Chen Sheng Cheng Jens-Uwe Stolzenburg Roman Ganzer Jochen Neuhaus 《Journal of Zhejiang University. Science. B》2017,18(11):921-933
Prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Current PCa biomarkers lack sufficient sensitivity and specificity to cancer. Metabolite biomarkers are evolving as a new diagnostic tool. This review is aimed to evaluate the potential of metabolite biomarkers for early detection, risk assessment, and monitoring of PCa. Of the 154 identified publications, 27 and 38 were original papers on urine and serum metabolomics, respectively. Nuclear magnetic resonance (NMR) is a promising method for measuring concentrations of metabolites in complex samples with good reproducibility, high sensitivity, and simple sample processing. Especially urine-based NMR metabolomics has the potential to be a cost-efficient method for the early detection of PCa, risk stratification, and monitoring treatment efficacy. 相似文献
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植物体内活性氧代谢及功能研究进展 总被引：1，自引：0，他引：1
徐新娟 《河南科技学院学报》2007,35(2):10-12
最近生物化学和遗传学研究证明活性氧不仅仅是需氧生物细胞的代谢副产物,而且还是细胞内重要的信号分子,其中过氧化氢在介导植物体对生物和非生物胁迫响应中起一种信号分子作用。作为信号分子的活性氧有其特定的合成途径、专一性的代谢响应机制、专一性的作用靶标和信号调节完成之后的代谢消除途径。过氧化氢介导的信号调节作用包括ABA控制的气孔关闭、生长激素控制的根的向地性生长中、氧剥夺抗性的产生等。过氧化氢的合成和作用与一氧化氮有关系。过氧化氢调节的下游信号事件包括细胞内钙流动、蛋白质磷酸化和基因表达。钙和小G蛋白信号通路对于细胞内部过氧化氢的稳定状态维持具有重要作用。 相似文献
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LIU Ai-jun FURUSATO Bungo RAVINDRANATH Lakshmi CHEN Yong-mei SRIKANTAN Vasanta MCLEOD David G. PETROVICS Gyorgy SRIVASTAVA Shiv 《Journal of Zhejiang University. Science. B》2007,8(12)
Objective: To investigate molecular alterations associating with prostate carcinoma progression and potentially provide information toward more accurate prognosis/diagnosis. Methods: A set of laser captured microdissected (LCM) specimens from 300 prostate cancer (PCa) patients undergoing radical prostatectomy (RP) were defined. Ten patients representing "aggressive" PCa, and 10 representing "non-aggressive" PCa were selected based on prostate-specific antigen (PSA) recurrence,Gleason score, pathological stage and tumor cell differentiation, with matched patient age and race between the two groups.Normal and neoplastic prostate epithelial cells were collected with LCM from frozen tissue slides obtained from the RP specimens.The expressions of a panel of genes, including NPY, PTEN, AR,AMACR, DD3, and GSTP1, were measured by quantitative real-time RT-PCR (TaqMan), and correlation was analyzed with clinicopathological features. Results: The expressions of AMACR and DD3 were consistently up-regulated in cancer cells compared to benign prostate epithelial cells in all PCa patients, whereas GSTP1 expression was down regulated in each patient. NPY, PTEN and AR exhibited a striking difference in their expression patterns between aggressive and non-aggressive PCas (P=0.0203, 0.0284, and 0.0378, respectively, Wilcoxon rank sum test). The lower expression of NPY showed association with "aggressive" PCas based on a larger PCa patient cohort analysis (P=0.0037,univariate generalized linear model (GLM) analysis). Conclusion: Despite widely noted heterogeneous nature of PCa, gene expression alterations of AMACR, DD3, and GSTP1 in LCM-derived PCa epithelial cells suggest for common underlying mechanisms in the initiation of PCa. Lower NPY expression level is significantly associated with more aggressive clinical behavior of PCa; PTEN and AR may have potential in defining PCa with aggressive clinical behavior. Studies along these lines have potential to define PCa-associated gene expression alterations and likely co-regulation of genes/pathways critical in the biology of PCa onset/progression. 相似文献
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LIU Ai-jun FURUSATO Bungo RAVINDRANATH Lakshmi CHEN Yong-mei SRIKANTAN Vasanta MCLEOD David G. PETROVICS Gyorgy SRIVASTAVA Shiv 《Journal of Zhejiang University. Science. B》2007,8(12):853-859
Objective： To investigate molecular alterations associating with prostate carcinoma progression and potentially provide information toward more accurate prognosis/diagnosis. Methods： A set of laser captured microdissected （LCM） specimens from 300 prostate cancer （PCa） patients undergoing radical prostatectomy （RP） were defined. Ten patients representing ＂aggressive＂ PCa, and 10 representing ＂non-aggressive＂ PCa were selected based on prostate-specific antigen （PSA） recurrence, Gleason score, pathological stage and tumor cell differentiation, with matched patient age and race between the two groups. Normal and neoplastic prostate epithelial cells were collected with LCM from frozen tissue slides obtained from the RP specimens. The expressions of a panel of genes, including NPY, PTEN, AR, AMACR, DD3, and GSTP1, were measured by quantitative real-time RT-PCR （TaqMan）, and correlation was analyzed with clinicopathological features. Results： The expressions of AMACR and DD3 were consistently up-regulated in cancer cells compared to benign prostate epithelial cells in all PCa patients, whereas GSTP1 expression was down regulated in each patient. NPY, PTEN and AR exhibited a striking difference in their expression patterns between aggressive and non-aggressive PCas （P=0.0203, 0.0284, and 0.0378, respectively, Wilcoxon rank sum test）. The lower expression of NPY showed association with ＂aggressive＂ PCas based on a larger PCa patient cohort analysis （P=0.0037, univariate generalized linear model （GLM） analysis）. Conclusion： Despite widely noted heterogeneous nature of PCa, gene expression alterations ofAM,4CR, DD3, and GSTP1 in LCM-derived PCa epithelial cells suggest for common underlying mechanisms in the initiation of PCa. Lower NPY expression level is significantly associated with more aggressive clinical behavior of PCa; PTEN and AR may have potential in defining PCa with aggressive clinical behavior. Studies along these lines have potential to define PCa-associated gene expression alterations and likely co-regulation of genes/pathways critical in the biology of PCa onset/progression. 相似文献
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Maintenance of cellular homeostasis and genome integrity is a critical responsibility of DNA double-strand break(DSB)signaling.P53-binding protein 1(53BP1)plays a critical role in coordinating the DSB repair pathway choice and promotes the non-homologous end-joining(NHEJ)-mediated DSB repair pathway that rejoins DSB ends.New insights have been gained into a basic molecular mechanism that is involved in 53BP1 recruitment to the DNA lesion and how 53BP1 then recruits the DNA break-responsive effectors that promote NHEJ-mediated DSB repair while inhibiting homologous recombination(HR)signaling.This review focuses on the up-and downstream pathways of 53BP1 and how 53BP1 promotes NHEJ-mediated DSB repair,which in turn promotes the sensitivity of poly(ADP-ribose)polymerase inhibitor(PARPi)in BRCA1-deficient cancers and consequently provides an avenue for improving cancer therapy strategies. 相似文献
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尽管锂制剂在临床上使用了几十年,但其确切机制并不清楚。人们通过研究认识到锂可能是通过抑制糖原合成酶激酶3（glycogen synthase kinase 3,GSK3）而发挥抗抑郁作用的。锂可以调控GSK3下游的许多分子,许多抗抑郁类药物可以调控GSK3的信号。使用药理方法或基因沉默方法抑制GSK3均具有稳定情绪、抵抗抑郁的作用,这些研究表明GSK3可能是抗抑郁的潜在靶点。近些年来对GSK3在神经生物学中的作用机制的研究进一步证实了锂可能是通过作用于GSK3来达到治疗目的的。如GSK3可以调节生物体应激反应、炎症反应、神经发生、5-羟色胺（5-hydroxytryptamin,5-HT）传递过程,并参与生物周期节律的调控。因此,特异的GSK3抑制剂能否在临床上发挥抗抑郁作用有待进一步研究。该文对GSK3在应激反应、炎症反应、神经发生、5-HT传递过程以及生物周期节律这五个方面对抑郁发病机制的研究进行了综述。 相似文献