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1.
《学周刊C版》2017,(21):15-16
目的:分析足月儿和近足月儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)需重复应用肺表面活性物质(pulmonary surfactant,PS)的危险因素,以指导NRDS的治疗,提高合理用药水平。方法:回顾性分析2012年1月-2016年12月本院采用肺表面活性物质治疗的足月儿与近足月儿NRDS 184例,未重复使用对象纳入单次组,重复使用对象纳入重复组,对两组的情况进行对比分析。结果:重复使用71例纳入重复组,单次使用113例纳入单次组。两组的出生窒息、妊娠期高血压疾病、X线片Ⅲ~Ⅳ级、肺部感染、气胸、菌血症、肺出血、高血糖、多器官功能障碍、休克、动脉导管未闭、极危重及危险黄疸、NCPAP比重、出生体重、并发NRDS时间、使用PS时间、PaO_2、PaCO_2、pH、FiO_2、PIP、PEEP、呼吸困难改善时间比较,差异均有统计学意义(P<0.05)。多因素分析显示,X线片分级Ⅲ~Ⅳ级[OR=1.76,95%CI(1.985,4.765)]、出生窒息[OR=1.743,95%CI(1.398,14.587)]、动脉导管未闭[OR=3.195,95%CI(1.980,58.862)]、使用PS时间[OR=0.083,95%CI(1.001,1.185)]、经鼻持续正压[OR=0.77,95%CI(1.485,1.865)]均为独立影响因素。结论:足月儿和近足月儿NRDS重复应用PS与病情、治疗方式有关,需重视出生窒息的抢救,及早使用PS,必要时首剂也可预防性应用,加强通气管理。 相似文献
2.
《赤峰学院学报(自然科学版)》2016,(5)
目的:探讨血浆脂蛋白(a)[LP(a)]水平与冠状动脉粥样硬化性心脏病及冠状动脉病变程度之间的关系.方法:入选2011年1月~2014年12月在我心内科住院并行冠状动脉造影检查的患者203例,根据冠状动脉造影结果分为非冠心病组(n=49)和冠心病组(n=154),其中冠心病组分为冠状动脉单支病变组(n=40),双支病变组(n=46),三支病变组(n=68).测定患者空腹血浆LP(a)水平并进行比较,分析LP(a)水平与冠心病及冠脉病变程度的关系.结果:冠心病组患者血浆Lp(a)水平较非冠心病组明显升高,差异有统计学意义(P0.05),且冠心病组患者的冠脉病变支数越多,差异越明显.Gensini评分与血浆LP(a)水平呈正相关,有统计学意义(P0.01).结论:血浆Lp(a)水平与冠心病的发生及冠状动脉病变的严重程度相关,在临床上对血浆LP(a)水平高的患者应高度重视,及早给予强化治疗. 相似文献
3.
《赤峰学院学报(自然科学版)》2020,(2)
目的:通过Meta分析评价中药治疗结直肠癌的有效性及安全性,为临床提供参考.方法:通过检索中国期刊全文数据库、万方数据库、中国生物医学文献数据库、中文科期刊数据库、PubMed、EMBASE,收集符合要求的随机对照试验(RCT)文献,运用Cochrane系统评价的方法,使用RevMen5.2软件进行Meta分析.结果:最终纳入11项RCT,合计患者832例,Meta分析结果显示中药联合化疗治疗结直肠癌的总有效率优于对照组[总有效率:OR=2.66,0.95%CI(1.83,3.86),Z=5.15,P=0.35],此外还可以降低化疗期间不良反应发生率,如周围神经毒性差异有统计学意义.结论:中药联合化疗方案治疗大肠癌优于单纯化疗. 相似文献
4.
目的 :为了研究动脉粥样硬化性心脑血管疾病患者血浆脂蛋白 (a)水平与纤溶活性的关系 ,探讨脂蛋白 (a)促血栓形成和致动脉粥样硬化的机理。方法 :分别测定 4 2例心肌梗塞患者、4 2例心绞痛患者、4 4例脑梗塞患者及 38名健康对照者的脂蛋白 (a)浓度、组织型纤溶酶原激活剂 (tPA[lj1])及其抑制物 (PAI)活性 ,并分析其相关性。结果 :各组动脉粥样硬化性心脑血管疾病患者血浆脂蛋白 (a)浓度和PAI活性明显升高 ,tPA活性明显降低 ;各组脂蛋白 (a)与PAI活性均呈显著正相关。结论 :血浆高脂蛋白 (a)浓度是动脉粥样硬化性心脑血管疾病的主要危险因素之一 ,脂蛋白 (a)水平的升高与纤溶活性低下有关 相似文献
5.
目的:研究慢性肾功能衰竭患者血浆脂蛋白(a)与纤溶活性的关系.方法:应用酶联免疫吸附法分别测定58例慢性肾功能衰竭患者及51名健康对照者的血浆脂蛋白(a)浓度,并以底物显色法测定其组织型纤溶酶原激活剂(tPA)及其抑制物(PAI)活性.结果:慢性肾功能衰竭患者血浆脂蛋白(a)浓度和PAI活性明显升高,tPA活性明显降低;脂蛋白(a)浓度与血浆尿素氮水平、PAI活性均呈正相关;脂蛋白(a)浓度与tPA活性呈负相关.结论:肾功能对血浆脂蛋白(a)浓度起一定的调节作用,脂蛋白(a)水平的升高与纤溶活性低下有关. 相似文献
6.
目的:探讨心脑血管疾病患者脂蛋白(a)水平及其他脂类的关系,进一步阐明血浆高脂蛋白(a)水平为心脑血管疾病的独立危险因素,支持脂蛋白(a)的检测具有极为重要的意义.方法:采用ELISA法和酶法分别测定心肌梗塞、心绞痛、脑梗死等心脑血管疾病患者及健康对照者的Lp(a)、LDL-C、HDL-C、TG、TC含量.结果:心脑血管疾病患者血浆Lp(a)水平显著高于健康对照组(P＜0.01).血浆脂蛋白(a)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:Lp(a)是独立于其他血脂指标的心脑血管疾病的危险因子. 相似文献
7.
目的:探讨心脑血管疾病患者脂蛋白(a)水平及其他脂类的关系,进一步阐明血浆高脂蛋白(a)水平为心脑血管疾病的独立危险因素,支持脂蛋白(a)的检测具有极为重要的意义.方法:采用ELISA法和酶法分别测定心肌梗塞、心绞痛、脑梗死等心脑血管疾病患者及健康对照者的Lp(a)、LDL-C、HDL-C、TG、TC含量.结果:心脑血管疾病患者血浆Lp(a)水平显著高于健康对照组(P＜0.01).血浆脂蛋白(a)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:Lp(a)是独立于其他血脂指标的心脑血管疾病的危险因子. 相似文献
8.
目的:为了研究血浆脂蛋白(α)[Lp(α)]水平与慢性肾功能衰竭(CRF)的关系,探讨Lp(α)在CRF(常)合并心脑血管疾病中的作用.方法:用酶联免疫吸附法测定了36例CRF与30名健康对照者的Lp(α)浓度,并同时测定了TG、TC、LDL-C和HDL-C的含量.结果:CRF患者Lp(α)、TC、LDL-C水平均明显高于正常对照组,而HDL-C显著低于对照组,血浆Lp(α)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:CRF患者体内存在着Lp(α)等脂代谢紊乱的情况,高血浆Lp(α)水平是CRF合并心脑血管疾病的独立危险因素之一. 相似文献
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10.
目的:评价依沙佐米治疗难治性/复发性多发性骨髓瘤(RRMM)的疗效及安全性。方法:计算机检索依沙佐米治疗RRMM的临床试验,手工检索纳入查询到的所有文献,提取数据后,使用R软件3.5.0进行Meta分析。结果:共纳入8篇文献,包括1096例RRMM患者,含依沙佐米三联方案的疗效优于单联方案或双联方案,以依沙佐米联合来那度胺和地塞米松(IRD)方案疗效最佳;IRD方案腹泻,恶心,皮疹,血小板减少,呕吐,腹泻≥3级,低血压≥3级,恶心≥3级高于来那度胺和地塞米松(RD)方案,而失眠,贫血≥3级低于RD方案,差异有统计学意义(P<0.05)。结论:含依沙佐米三联方案治疗RRMM的疗效较依沙佐米单联方案或二联方案显著。IRD方案疗效最佳,其不良反应较RD方案增多。 相似文献
11.
Karin Hannes Katja Petry Mieke Heyvaert 《International Journal of Research & Method in Education》2018,41(3):291-305
The present article focuses on the meta-aggregative approach to qualitative evidence synthesis. Originally developed in Australia by the Joanna Briggs Institute, it mirrors the review process for reviews of effectiveness outlined by the international Cochrane and Campbell Collaboration, while remaining sensitive to the specific characteristics of qualitative research. Meta-aggregation is largely inspired by American pragmatism, hence its most distinct feature is that it produces synthesized statements in the form of ‘lines of action’ to be undertaken by practitioners and policy-makers. After a decade of implementing the meta-aggregative approach, we consider its challenges and outline how these can be dealt with in practice. We illustrate this by means of a worked example on experiences of pupils with special educational needs in inclusive education. 相似文献
12.
Systematic review of educational interventions for looked‐after children and young people: Recommendations for intervention development and evaluation 
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下载免费PDF全文 Rhiannon Evans Rachel Brown Gwyther Rees Philip Smith 《British Educational Research Journal》2017,43(1):68-94
Looked‐after children and young people (LACYP) are educationally disadvantaged compared to the general population. A systematic review was conducted of randomised controlled trials evaluating interventions aimed at LACYP aged ≤18 years. Restrictions were not placed on delivery setting or delivery agent. Intervention outcomes were: academic skills; academic achievement and grade completion; special education status; homework completion; school attendance, suspension, and drop‐out; number of school placements; teacher‐student relationships; school behaviour; and academic attitudes. Fifteen studies reporting on 12 interventions met the inclusion criteria. Nine interventions demonstrated tentative impacts. However, evidence of effectiveness could not be ascertained due to variable methodological quality, as appraised by the Cochrane risk of bias tool. Theoretical and methodological recommendations are provided to enhance the development and evaluation of educational interventions. 相似文献
13.
深圳市宝安区法院行政庭课题组 《惠州大学学报》2013,(5):101-106
法院对“司法强拆”的申请的审查包括对征收决定的实体性和程序性审查,实体性审查包括是否超越权限、遵循信赖利益保护原则、合乎比例,重在约束行政机关克服怠惰和恣意,依据公益和补偿的法律授权,作出不掺杂其他目标、事实清楚的合理的征收决定;程序性审查包括行政机关是否满足被征收人的受告知权、听证权和知情权,旨在克服行政意思决定的单方性,真实有效地保护私主体一方的利益,提高行政效能。法院的裁定不仅仅为被征收人及其财产权获得公平的对待和补偿,而且促使行政机关依法行政和建设法治政府。 相似文献
14.
Hotelling BA 《The Journal of perinatal education》2007,16(4):59-61
The handout presented in this article can be used by expectant parents to compare the evidence-based, expected occurrence of routine interventions with the usual care given by their chosen provider and place of birth. The known occurrence of these routine interventions is derived from Listening to Mothers II: Report of the Second National U.S. Survey of Women's Childbearing Experiences. The evidence of harm or benefit is derived from both the Cochrane Collaboration and the Coalition for Improving Maternity Services. 相似文献
15.
网络在线评论对于商家和顾客具有重要价值,因而日益受到虚假评论行为的冲击。作为两个重要的在线评论领域,产品类评论（如亚马逊、淘宝）和店铺类评论（如点评网、Yelp）在语言特性、评论行为等方面存在显著差异。虽然研究者们已提出大量针对产品类虚假评论的检测方法,但对于店铺类虚假评论的研究仍然较少。针对Yelp.com网站上旅店、饭店有标注的点评数据,提取并分析各种评论欺诈特征,利用多种有监督学习方法进行虚假评论检测。实验结果表明,检测精度最高可达74%,AUC值可达75%。虽然店铺类虚假评论具有极强的隐蔽性,但通过权衡检测精度和召回率,可利用有监督学习方法对店铺类虚假评论进行有效检测。 相似文献
16.
李颖 《集美大学学报(教育科学版》2014,(3):6-10
高校教师职称评审是被授权的高校在行政管理活动中行使行政职权,针对特定的教师,就职务任职资格评审工作作出的有关该教师权利义务的单方行为,是一种可诉的外部具体行政行为。以"王晓华与华中科技大学案"为例,案中王某的部分诉讼请求与教育部不予受理的决定仍有待商议,受诉法院的裁决在尊重学术自由方面值得肯定,但却采取了过于消极的姿态。因此,为使职称评审纠纷审判实践获得进一步完善,应考虑将高校教师职称评审行为纳入行政诉讼的受案范围,健全高校职称评审机制,同时修订与更新相关法律条款,使司法审查的限度更为明晰。 相似文献
17.
李明德 《华中科技大学学报(社会科学版)》2007,21(5):12-18
我国现有专利权和商标权确权机制中存在很多的问题,如环节过多,时间过长,甚至循环往复等弊病。美国和日本的专利权商标权确权机制中有许多值得借鉴的地方。通过对比,提出改革中国现有确权机制的建议,将有助于权利状态的尽快确定,从而有效保护权利人和他人的合法权益。 相似文献
18.
Anne Pirrie 《British Journal of Educational Studies》2001,49(2):124-136
This paper explores the reasons why the notion of 'evidence-based' practice has gained prominence in educational research. The ascendancy of 'evidence-based' practice is attributed to a crisis of legitimation in educational research. The paper offers a critical exegesis of a systematic review conducted under the auspices of the Effective Practice and Organisation of Care (EPOC) subgroup of the Cochrane Collaboration. 相似文献
19.
Lothian JA 《The Journal of perinatal education》2005,14(4):36-39
In this column, a childbirth educator describes feeling overwhelmed and alone in her work. Collaboration is presented as a key agent to creating change, staying connected, and “keeping going.” The Cochrane Library, the Coalition for Improving Maternity Services, the ongoing collaboration of Lamaze International with the Maternity Center Association and DONA International, and birth networks are presented as examples of valuable collaborations. Childbirth educators benefit from these collaborative efforts by being able to access and use evidence-based information and to feel connected with like-minded colleagues. 相似文献
20.
Zheng Zhang Joelle Nagle Bethany McKishnie Zhen Lin Wanjing Li 《Pedagogies: An International Journal》2019,14(1):33-61
This systematic review is built on the seminal work by the New London Group in 1996. Few endeavours have synthesized findings of empirical studies pertaining to the effects and challenges of multiliteracies practices in various schooling and geographical contexts. Through a five-point Likert scale and a deductive and inductive thematic analysis, we conducted a systematic review of 66 multiliteracies articles from the ProQuest® database. These studies were empirical, qualitative/mixed-method, and ranged from 2006 to 2015. Findings show a burgeoning number of multiliteracies studies occurring in 15 countries, with Canada being the most prominently involved. Our evaluation of the reviewed studies was generally favourable with strengths identified in researchers’ articulation of pertinent theoretical frameworks and connections to existent literature. Our findings refer to insufficient information of data collection and data analysis in a certain number of papers. We also elaborate on major affordances, challenges, and oversights of the multiliteracies practices as reported by the reviewed studies and discuss implications for future multiliteracies research, policies on literacy education, and teacher education in diverse contexts. 相似文献