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1.
K. Srikrishna A. S. Kanagasabapathy 《Indian journal of clinical biochemistry : IJCB》1994,9(2):112-113
Lactate dehydrogenase (LDH) and its isoenzyme profile, Nacety-β-d-glucosaminidase (NAG) and alanine aminopeptidase (AAP) enzyme activities were measured in 21 cases with well documented acute
untreated urinary tract infections (UTI) and compared with a group of 68 normal healthy subjects matched for age and sex.
Urinary NAG, AAP and LDH total activities were highly elevated (3–30 fold for NAG, 2–10 fold for AAP and 2–50 fold for LDH
over upper limit of normal) in upper tract infections. In lower tract infections there was a marginal elevation in NAG and
LDH while AAP activity was very high; though there was no overlap. Further, the isoenzyme profile of LDH showed predominance
of LD-5 isoenzyme in all cases of pyelonephritis, while it was completely absent in all the cases of lower tract infections.
We conclude that urinary NAG and LDH-5 isoenzyme would serve as specific non-invasive parameters for differential localization
of urinary tract infections. 相似文献
2.
Manaswini Mangaraj S. Kumari R. Nanda M. R. Pattnaik P. C. Mohapatra 《Indian journal of clinical biochemistry : IJCB》2008,23(1):81-84
Pleural fluid malondialdehyde (PMDA) and serum effusion albumin gradient(SEAG) were estimated in 60 patients of pleural effusion
of diverse etiologies. The results were compared with Light’s criteria to distinguish between transudates and exudates. The
mean PMDA level was 0.68±0.24nmol/ml and 1.17±0.25nmol/ml in transudates and exudates respectively showing a statistically
significant (p<0.05) rise in exudates in comparison to transudates. SEAG registered a significant fall in exudates (P<0.001)
when compared with transudates. PMDA revealed a positive correlation with pleural protein(r=+0.30) and a significant negative
association with SEAG (r= −0.33).Sensitivity and specificity of PMDA were better than the parameters of Light’s criteria.
Whereas SEAG documented approximately equal sensitivity, specificity, positive predictive value (PPV) and negative predictive
value (NPV) with Light’s criteria. Therefore PMDA and SEAG can be taken together in addition to Light’s criteria to strengthen
the discrimination between transudates and exudates in borderline cases of pleural effusion. 相似文献
3.
J. Pramanik A. N. Lodam C. M. Badole M. V. R. Reddy K. R. Patond B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2000,15(1):22-28
Trichloroacetic acid (TCA) solubilized and DEAE fractionatedMycobacterium tuberculosis H37Ra excretory-secretory (ES) antigen viz., Mtb EST DE1 and affinity purified goat antibodies to the TCA solubilized ES antigen
(Mtb EST) were explored in detecting tubercular antibody and antigen respectively in sera of bone and joint tuberculosis by
indirect and sandwich ELISA. Out of total 36 bone & joint tuberculosis cases, tubercular antibody was detected by indirect
ELISA in 30 patients (sensitivity 83%), while circulating tubercular antigen was detected by sandwich ELISA in 27 patients
(sensitivity 75%). Out of 34 non tubercular disease control cases, 10 patients showed positive reaction for antibody while
only 4 patients showed positive reaction for antigen. In another group of 34 healthy subjects who were screened, 4 individuals
showed positive reaction for tubercular antibody and 2 cases for antigen. This study shows that antigen detection assay using
affinity purified anti Mtb EST antigen antibody is superior with overall specificity of 91% as compared to antibody detection
assay with 75% specificity in bone & joint tuberculosis. 相似文献
4.
Dil-Afroze Dinesh Sharma G. N. Dhobi Sonaullah Shah Rafiqa Eachkoti Ishraq Hussain Zafar A. Shah Mushtaq A. Siddiqi 《Indian journal of clinical biochemistry : IJCB》2006,21(2):76-79
Pleural effusion is one of the commonest presentations of tuberculosis, the clinical manifestations being typically abrupt
resembling bacterial pneumonia. Since delayed hypersensitivity is the underlying immune response, bacterial load is very low.
Owing to these facts, tuberculous pleurisy as an extra-pulmonary disease poses a diagnostic dilemma. The conventional bacteriological
methods rarely detect Mycobacterium tuberculosis in pleural fluid and are of limited use in diagnosis of tuberculous pleurisy.
We evaluated the efficacy of polymerase chain reaction (PCR) in the diagnosis of tuberculous pleurisy by targeting the gene
segment coding for MPB64 protein specific forMycobacterium tuberculosis. Based on the clinical criteria, 82 patients with lymphocytic exudative pleural effusion were included in the study. Patients
were analyzed in two groups; one group consisting of 48 patients of tubercular pleural effusion confimed by various diagnostic
procedures and another group of 34 patients comprising of non-tubercular pleural effusion. There were no false positive results
by PCR and the specificity worked out to be 100%. Twenty two patients tested positive for Mantoux with a sensitivity of 45%.
ZN-staining for AFB was found in samples from 15 patients (20% sensitivity). ADA was positive for 28 patients with a sensitivity
of 53%. PCR was positive for 32/48 patients (67% sensitivity). Thus, PCR was found to be more sensitive than any other conventional
method in diagnosis of clinically suspected tubercular pleurisy. 相似文献
5.
E. Raji Nair Satish Kumar M. V. R. Reddy B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》1998,13(2):98-105
A mycobacterial excretory-secretory protein fraction ESAS-7 purified by 50% ammonium sulphate precipitation followed by SDS-PAGE
fractionation was evaluated by penicillinase enzyme linked immuno-sorbent assay (ELISA) for its sensitivity and specificity
in the diagnosis of pulmonary tuberculosis. At a “cut off” serum dilution of 600, 38 (90%) of 42 sera from bacteriologically
confirmed tuberculosis cases, 15 (100%) of 15 sera from bacteriogically negative but anti tubercular therapy (ATT) responded
cases, 3 (7%) of 43 sera from normal healthy subjects and 4 (8%) of 48 sera from non tuberculous disease control cases gave
positive reaction for tubercular antibody to ESAS-7 antigen fraction containing predominantly 33-kDa protein with a sensitivity
of 90% in bacteriologically confirmed cases and specificity of 92%. Further, this diagnostic assay using the ESAS-7 antigen
is more sensitive requiring as little as one nanogram antigen per test compared to use of 100 nanogram EST-6 antigen reported
earlier. Thus use of ESAS-7 antigen for antibody detection has good diagnostic potential with improved specificity in pulmonary
tuberculosis. 相似文献
6.
Fleming JJ Janardhan HP Jose A Selvakumar R 《Indian journal of clinical biochemistry : IJCB》2011,26(1):32-40
In the present study, the cause of suspected false-positive (anomalous) values for CK-MB activity, in Indian patients investigated
for ACS. Total serum CK and CK-MB activity, serum Troponin I were measured and CK-MB as a percentage of the total CK activity
(%CK-MB) calculated. CK-MB was also estimated using densitometry and CK-MB mass assay. Anomalous specimens were tested for
the presence of CK isoenzymes. In 22 healthy subjects, 11 male and female, the %CK-MB ranged from 3.6 to 30.2. In 11 male
patients, with proven ACS, the %CK-MB was from 4.0 to 17.5. The cut off for anomalous CK-MB activity values was set as >33.0%.
In 35 patients with anomalies, total CK values ranged from 39 to 231 U/L, CK-MB from 30 to 161 U/L. Investigation of CK isoenzymes,
showed 10 patients had a CK-BB band, 14 an intermediate band between CK-MM and CK-MB (macro-CK type 1), 7 had a cathodal band
(macro-CK type 2), and 3 had a band intermediate between CK-MB and CK-BB. This later band does not seem to have been previously
reported. Against the CK-MB mass assay, the activity assay showed no correlation, in 43 patients (19 M, 24 F), Pearson coefficient
(R2) was 0.006. The CK-MB immunoinhibition assay is better described as measuring “non-CK-MM activity.” A %CK-MB activity >6%
as a marker of ACS is not valid in our patient population. Laboratories should not use only CK-MB activity as a biochemical
marker of ACS. 相似文献
7.
Separation and quantitative estimation of the isoenzymes of lactate dehydrogenase(LD) in serum were accomplished with capillary electrophoresis system. An uncoated fused silica capillary column 50 cm long, 75μm I.D. and substrate containing running buffer including L-lactic acid and NAD+ were used for the separation of serum LD isoenzymes. The resulting product of “NADH” was detected at 340 nm. Injection of 10 nL of five fold diluted serum sample were performed by pressure injection within 2 seconds. The isoenzymes were separated at 10 kV of voltage for 5 min, by turning off the voltage applied for 30 min incubation at 24°C for reaction between substrate and isoenzymes, and applying voltage of 30 min. Under these conditions, the isoenzymes of LD were detected by a NADH generated as isoenzyme of LD-5 emerged at 20 min, LD-1 peak at 23.5 min with close to baseline separation of the other isoenzymes which emerge between LD-5 to LD-1, after the emergence to LD-1 peak, followed another peak, termed “sample shock”: The results obtained by the proposed method correlated well with those by gel electrophoresis systemes (r=0.92∼0.98) for each five LD isoenzymes, respectively. Within-run precision CVs for 5 replicate analysis were 3.01 (LD-3, mean 14.6%)%∼7.82% (LD-4, mean 4.22%.), respectively. 相似文献
8.
Jain A 《Indian journal of clinical biochemistry : IJCB》2011,26(3):269-273
Tuberculosis remains a major public health problem globally, with India being one of the high burden countries. The common
causative agent is Mycobacterium tuberculosis but in developing countries M. bovis is reported as a potential human pathogen. Almost 20% of all reported cases of tuberculosis are of extra pulmonary form of
disease. Diagnosis of extra pulmonary tuberculosis (EPTB) is not always possible with conventional methods, due to the long
time required and the paucibacillary nature of samples; hence the need of rapid molecular methods. A prospective study was
conducted on 300 patients of EPTB over a period of 5 years. These patients were suspected cases of tubercular meningitis,
tubercular ascites and tubercular lymphadenitis. Samples analyzed were cerebrospinal fluid, ascitic fluid and lymph node fine
needle aspirate. A two step PCR targeting hup B gene was used. Clinical response to anti tubercular therapy (ATT) was taken as positive (gold standard). PCR for hup B gene was positive in 147 samples out of 155 ATT responders. Of these 85.71% were infected with M. tuberculosis, 9.52% with M. bovis alone and 4.76% showed co infection with both M.tb and M. bovis. The sensitivity and specificity of PCR was 90.32 and 94.48% respectively. 相似文献
9.
Meena Verma Sanjeev Narang Ashish Moonat Akshra Verma 《Indian journal of clinical biochemistry : IJCB》2004,19(1):129-131
Tuberculosis has, in a short span of time, become a major health problem in the third world or developing countries like India.
In view of this, a retrospective study was conducted to study Adenosine deaminase activity in serum and pleural fluid in patients
affected with Pulmonary Tuberculosis and other common non-tubercular chronic respiratory diseases. The study was carried out
on 100 patients suffering from various pulmonary disorders, between January 2002 and August 2002. Thirty-five normal healthy
individuals were included as control subjects. ADA estimation was done by sensitive colorimetric method. The study revealed
that the serum ADA activity was higher in patients of tuberculous pulmonary and pleural diseases and non-tuberculous pulmonary
diseases than in control subjects. The mean serum ADA activity in the patients’ group was 35.5±6.93 u/l as compared to 16.20±2.85
u/l in control group, showing a highly significant (P≪0.001) difference. ADA activity was highest in tuberculous pleuropulmonary
diseases. The pleural fluid ADA activity was higher in pyogenic pleural effusion than in tuberculous pleural effusion. 相似文献
10.
P. R. Sharma S. Jain R. N. K. Bamezai P. K. Tiwari 《Indian journal of clinical biochemistry : IJCB》2010,25(1):57-63
The present study was carried out in the Sahariya tribe of Central India, which reportedly have high prevalence of pulmonary
tuberculosis. Total serum LDH and its tissue specific isoforms were estimated in TB patients and matched healthy controls
to test the utility of LDH as diagnostic marker for tuberculosis. About 210 sputum positive cases and 328 age and sex matched
sputum negative controls were recruited. The spectrophotometeric and densitometric analysis of each LDH isoform was carried
out in both cases and controls. The mean values of serum LDH were estimated and compared for each class by t-test. The statistical
comparisons were made between sputum negative controls and sputum positive cases by Mann-Whitney’s U test. The spectrophotometric
estimation of serum LDH revealed significant (P=0.0016) increase in its level in cases (290 IU/L) as compared to controls
(248 IU/L). The densitometric analysis of individual LDH isoforms in cases and controls demonstrated significant elevation
in LDH1 (P>0.05), LDH2 (P>0.05) and LDH3 (P<0.005) in sputum positive cases in comparison to sputum negative controls. Our
study revealed a positive correlation between serum LDH level and the presence of mycobacteria and their load, suggesting
utility of LDH as an important diagnostic marker of tuberculosis induced stress, at least in tribal areas lacking access to
modern clinical tests. 相似文献
11.
Singh TD Barbhuiya MA Gupta S Shrivastav BR Jalaj V Agarwal N Tiwari PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):146-153
We have studied the expression of lactate dehydrogenase and its isoforms in gall bladder cancer, cholelithiasis and chronic
cholecystitis. Quantitative and qualitative assays of lactate dehydrogenase and its various isoforms were carried out in the
blood sera of patients and healthy controls along with parallel estimation of various liver function test enzymes. Statistical
analysis was done using the software Graph Pad Prism. Significantly high expression of lactate dehydrogenase along with alkaline
phosphatase and total bilirubin (P ≤ 0.05) was observed in all the three clinical conditions as compared to controls. LDH showed an increasing trend from stage
I to stage IV of GBC indicating a significant positive association with the disease progression. The levels of LDH 3 and 4
isoforms appeared significantly more elevated in GBC than cholelithiasis or chronic cholecystitis. We suggest that a careful
estimation of total LDH and its isoforms 3 and 4 alone or along with alkaline phosphatase and total bilirubin during different
clinical stages, like chronic cholecystitis, cholelithiasis and GBC, may prove to be a potentially useful biomarker in the
prognostic management of gall bladder diseases, specifically GBC. 相似文献
12.
R. Kumar S. B. Pachori G. K. Senger Satyanand L. D. Joshi 《Indian journal of clinical biochemistry : IJCB》1994,9(2):72-74
Aim of present study was to compare the adenosine deaminase (ADA) activity in various types of arthritis conditions with synovial
effusion. No. significant difference was observed in ADA activity in serum of control and study groups but results have shown
a definite pattern of ADA activity in synovial fluid in various arthritic conditions. The highest value of ADA activity was
observed in synovial fluid of patients with tubercular arthritis followed by rheumatoid, septic, osteo and post traumatic
arthritis. Thus measurement of ADA activity in synovial fluid can be used as a parameter of differential diagnosis of arthritis
specially tubercular in initial stages. 相似文献
13.
P. Pragathi P. V. Bharath Kumar P. Amar Kumar M. Ramakanth Reddy V. Sravani J. Neeraja Eapen Reeba Mary K. Gopalakrishna 《Indian journal of clinical biochemistry : IJCB》2005,20(2):195-197
Adenosine deaminase (ADA) and 5′-nucleotidase (5′-NT) activities were measured in sera of patients with ovarian cancer and
patients with benign ovarian tumour. The results were compared with that of a control group consisting of healthy women. ADA
levels were significantly increased (P<0.001) in the ovarian cancer group (n=50) but not in the benign group (n=28) when compared
to the controls (n=20). The results indicate that ADA and 5′-NT levels may help to differentiate malignant conditions from
benign tumours of the ovary in addition to the existing tests such as serum CA-125 levels and histopathological study. 相似文献
14.
Swati Banerjee E Raji Nair Satish Kumar M. V. R. Reddy Bhaskar C. Harinath 《Indian journal of clinical biochemistry : IJCB》2001,16(2):203-206
Analysis of tubercular antibody, circulating free and immune complexed antigen (CIC-Ag) was done in confimed pulmonary tuberculosis
sera by ELISA, using ES-31 antigen and affinity purified anti ES-31 antibody. Twenty three of 25 (92%) tuberculosis sera were
positive for IgG antibody to ES-31 antigen. Using anti ES-31 antibody, free tubercular antigen could be detected in 20 of
25 (80%) cases whereas circulating immune complexed antigen (CIC-Ag) in 18 of 25 (72%) cases by sandwich ELISA. Of the two
sera showing absence of antibody, one showed presence of free and CIC-Ag whereas the other showed the presence of free antigen.
Thus antigen assay may be used as an adjunct tool for confirmation of pulmonary tuberculosis. 相似文献
15.
Vitamin B12 being water soluble is excreted in the urine when administered in excess. The probability of finding an abnormally excess
serum concentration would be almost surreal. We report a peculiar clinical situation that may impact the vitamin B12 immunoassay on the Roche Elecsys 2010 due to excess analyte concentration. In separate episodes (Feb and June 2010), the
Biochemistry laboratory of a tertiary-care hospital, Kolkata, India, encountered two critically ill patients with background
chronic kidney disease (CKD), low urine output, and on cyanocoabalamin supplementation, who had serum vitamin B12 concentrations far exceeding expected values; even post dialysis. The B12 assays (pmol/l) were performed using electrochemiluminiscence immunoassay on Roche Elecsys 2010, the assay validity confirmed
by concomitant quality control runs. The immunoassays failed to deliver results, flagged with “signal level below limit”. Biotin therapy was ruled out as a possible interferent. In the first episode, re-assay of a repeat draw yielded same outcome;
outsourcing on Immulite provided concentration of >738 pmol/l. Serial dilution gave result of >29520 pmol/l on Elecsys 2010.
In the second, we gained from past experience. Vitamin B12 concentration >59040 pmol/l was conveyed to the treating nephrologist the very day. The B12 immunoassay on the Elecsys 2010 employs sequential incubation steps for competitive binding that is compromised in the event
of abnormally excess B12 concentration in patient sera akin to the prozone effect. This knowledge may be beneficial while assaying sera of CKD patients
to avoid financial loss due unnecessary repeats and delay in turnaround time. 相似文献
16.
P. Faizal S. Suresh R. Satheesh Kumar K. T. Augusti 《Indian journal of clinical biochemistry : IJCB》2009,24(1):82-87
A study was undertaken for evaluating the hypoglycemic and hypolipidemic effects of an ayurvedic medicine “Rajanyamalakadi”
containing Curcuma longa, Emblica officinalis and Salacia oblonga in type II diabetic patients over a period of 3 months.
Ethical committee consent for the study was given by the Director, Indian Systems of Medicine, Kerala. A total of 43 patients
with established diabetes mellitus as adjudged from clinical features and FBS values, appeared for the camp (Age group 35–75
yrs). An informed consent for the study was obtained from each patient. The clinical proforma was given to each patient to
collect data such as height, weight, diet pattern, previous history of illness etc. The ongoing antidiabetic medications were
stopped under medical supervision and the patients were provided with ‘Rajanyamalakadi’ tablets (dose 1–2 tablets each weighing
500mg). The dosage of the drug was decided by the supervising medical officer on a case to case basis, taking note of the
clinical conditions and responsiveness of the patients. The patients were monitored for three months, who were divided into
6 groups based on their age and again into two groups, 5 & 6, based on their mean FBS values. ie; Normal Persons, Diabetics
of age groups 35–45yrs, 46–55yrs, >55yrs and those with FBS < 145.9 mg% and > 145.9 mg%. The Ayurvedic medicine “Rajanyamalakadi”
has showed significant antidiabetic, hypolipidemic and antioxidant effects. In addition to that significant ameliorating effects
on the elevated serum AST and ALT activities were also demonstrated by the treatment. The nutraceuticals present in the drug
like Terpenoids, Polyphenols, Curcumin etc are responsible for the medicinal effects. 相似文献
17.
Kavita Shalia Sudha Savant Vijaya A. Haldankar Tulip Nandu Poonam Pawar Siddhi Divekar V. K. Shah Purvi Bhatt 《Indian journal of clinical biochemistry : IJCB》2012,27(1):74-82
To analyse the association of high sensitivity C-reactive (hsCRP) protein levels and −717A/G single nucleotide polymorphism
of CRP with acute myocardial infarction (AMI) in the Indian population. Study population included 100 MI cases wherein 32
patients had experienced previous MI (MI-Group-1), 68 MI cases were recruited at presentation (MI-Group-2) and equal number
of age and gender matched healthy individuals. hsCRP levels were determined by ELISA and genotyping of −717A/G was carried
out by polymerase chain reaction-based restriction digestion method. The −717A/G genotypes did not influence hsCRP level and
their distribution did not differ between groups. However, in the present study hsCRP demonstrated significant correlation
with BMI in controls of both the genders and with triglycerides in females of AMI at presentation who otherwise are with low
risk profile. Identifying traditional risk factors associated with inflammation may help in controlling the acute event. 相似文献
18.
Benign prostate hyperplasia (BPH) is a common condition in aged men and result from prolong chronic inflammation in prostate
gland. Cytokines are important molecules responsible for inflammation. Single nucleotide polymorphisms (SNPs) in promoter
region of cytokine genes have been shown to alter the level of cytokines. Hence we evaluated the association of pro-inflammatory
and anti-inflammatory cytokine SNPs in a North Indian cohort of BPH patients. We observed that IL-1B −511 CT + TT genotypes conferred protective effect for susceptibility to BPH (OR 0.39, P 0.001). Our results also demonstrated that TNF-A −1031 C allele to be associated with risk for BPH (OR 1.89, P < 0.0001). Moreover, we also observed twofold risk for IL-10 −1082 cytokine gene polymorphism (OR 1.96, P 0.048). No association was observed with risk of BPH for IFN-G +874, IL-1 RN VNTR, IL-6 −174, IL-10 −819 and TGF-B +28. Our findings of IL-1B −511, TNF-A −1031 and IL-10 −1082 suggested that these variants play important role in susceptibility to BPH. Future studies in large cohort of different
ethnicity BPH groups are warranted to establish definite associations with other cytokine gene polymorphisms as well. 相似文献
19.
Nilima N. Dongre Adinath N. Suryakar Arun J. Patil Jeevan G. Ambekar Dileep B. Rathi 《Indian journal of clinical biochemistry : IJCB》2011,26(4):400-406
The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis
related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared
with 30 age matched healthy control subjects. Significantly increased blood lead (364%, P < 0.001) and urinary lead (176%, P < 0.001) levels were observed in automobile workers (study group) as compared to controls. Systolic blood pressure (5.32%,
P < 0.05) and diastolic blood pressure (5.87%, P < 0.05) were significantly increased in the automobile workers as compared to controls. The significantly decreased non-activated
erythrocyte δ-aminolevulinic acid dehydratase (δ-ALAD) (−18.51%, P < 0.01) and activated δ-ALAD (−13.29%, P < 0.05) levels were observed in automobile workers as compared to normal healthy control subjects. But the ratio of activated/non-activated
δ-ALAD was significantly increased (43.83%, P < 0.001) in automobile workers as compared to controls. Excretions of δ-aminolevulinic acid (83.78%, P < 0.001) and porphobilinogen (37%, P < 0.001) in urine were significantly increased in the study group as compared to the controls. In automobile workers heamoglobin
(−11.51%, P < 0.001), hematocrit (−4.06%, P < 0.05), mean corpuscle volume (−3.34%, P < 0.05), mean corpuscle hemoglobin (−5.66%, P < 0.01), mean corpuscle hemoglobin concentration (−7.67%, P < 0.001), red blood cell count (−14.6%, P < 0.001) were significantly decreased and total white blood cell count (11.44%, P < 0.05) increased as compared to the controls. The results of this study clearly indicate that the absorption of lead is
more in automobile workers and it affects on blood pressure, heme biosynthesis and hematological parameters observed in this
study group. 相似文献
20.
R. L. Gupta Sundeep Jain V. Talwar H. C. Gupta P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》1999,14(1):12-18
Based on our demonstration earlier that ethanol extract, water extract and a compound purified from garlic possessedin vitro antitubercular activity against drug resistant and susceptibleMycobacterium tuberculosis, we tried the effect of garlic extract in 30 patients of tubercular lymphadenitis. For ethical considerations, two groups
of patients, 30 each, were given antitubercular therapy (ATT) consisting of isoniazid, rifampicin, ethambutol and pyrazinamide
for 30 days. For the next 15 days (31 to 45 days) group 1 patients received 3–6 garlic pearls per day in addition to ATT while
group 2 patients received ATT only. From 46th day onwards both the groups received ATT only for 6–8 months. Antitubercular
activity of the serum samples collected on 45th day was assessed by its effect on the growth ofM. tuberculois. The serum of group 1 patients showed significantly much higher antitubercular activity than that of group 2 patients. Further,
there was relief of dyspeptic symptoms caused by ATT therapy in patients of group 1 with garlic plus ATT therapy but no change
in group 2 patients with ATT only. Liver function and hematological tests were normal in both the groups after 6 months of
therapy. Garlic extracts or compounds have a good potential as antitubercular(s) drug if given as a supplement to ATT. 相似文献