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1.
Qiu-xia Jin Xin-ran Dong Jing-meng Chen Ke Yao Ya-lin Wu 《Journal of Zhejiang University. Science. B》2014,15(7):661-669
Gene and drug therapies are being developed to alleviate vision loss in patients with Stargardt’s disease and age-related macular degeneration (AMD). To evaluate the therapeutic effects of these treatments, organic solvents are routinely used to extract and quantify bisretinoid lipofuscin constituents, such as N-retinylidene-N-retinyl-ethanolamine (A2E) and all-trans-retinal dimer (ATR-dimer). By high-performance liquid chromatography (HPLC), we found that A2E and ATR-dimer were both altered by tetrahydrofuran (THF) and chloroform, but were stable in dimethyl sulfoxide (DMSO) or methanol (MeOH). In addition, cyclohexane and ethanol (EtOH) did not alter ATR-dimer, whereas an alteration of A2E occurred in EtOH. On the basis of these findings, we designed processes II–IV, generated by modifications of process I, a routine method to measure bisretinoid compounds in vivo. Extra amounts of either ATR-dimer or A2E in mouse eyecups were released by processes II–IV versus process I. Efforts to clarify the effects of organic solvents on lipofuscin pigments are important because such studies can guide the handling of these fluorophores in related experiments. 相似文献
2.
Lei Feng Jiang-hua Hu Jie Chen Xin Xie 《Journal of Zhejiang University. Science. B》2018,19(4):327-332
Objective
To evaluate the effect of anti-vascular endothelial growth factor (VEGF) on juxtafoveal choroidal neovascularization (CNV) secondary to multifocal choroiditis (MFC) and wet age-related macular degeneration (AMD). Methods: In this retrospective, comparative study, 20 unique eyes with CNV were divided into two groups: 10 patients affected by MFC and 10 patients diagnosed with wet AMD. They all received local intravitreal (IVT) injections of ranibizumab, with 6 months of follow-up. Retreatment injections were performed based on findings suggestive of active neovascularization.Results
Significant improvements were observed in the juxtafoveal CNV lesions, and average central macular thickness decreased in both groups following the anti-VEGF therapy (P<0.05). The average number of injections used in MFC patients was 1.6, while three injections on average were used in wet AMD patients (Z=?2.844, P=0.009). Best-corrected visual acuity was significantly improved in MFC patients after anti-VEGF therapy (P<0.05), and there was no significant difference in wet AMD patients between before anti-VEGF therapy and 6 months later (P>0.05).Conclusions
IVT ranibizumab resulted in good clinical outcomes for juxtafoveal CNV secondary to MFC and wet AMD, but the average number of injections used in MFC was fewer than that used in wet AMD over a 6-month observation period. Compared with the wet AMD group, visual acuity was obviously improved in the MFC group at 6 months.3.
目的:研究波能酒疗对人体运动性疲劳及血乳酸(BLA)的影响。广东省柔道队20名男运动员以递增负荷蹬踏功率自行车至力竭,随机分为对照组和波能酒疗组进行单盲试验。在运动前、结束后5min及8h取上臂静脉血2ml,测RPE、脉搏及血清BLA含量。运动后8h时,波能酒疗组RPE、BLA含量明显低于对照组(p<0.05)。结论:波能酒疗能加速运动性疲劳消除,这与加速机体血乳酸的清除有关。 相似文献
4.
对《上海博物馆藏战国楚竹书》(三)《周易》简21“亡忘又疾,勿药又菜”这句话的理解,目前学术界有多种意见,我们通过与传世本对照,认为此句的“忘”通“妄”,作“妄为”解;“菜”通“喜”,作“病愈”解。此句意为“不妄为却偶染微疾,无需用药将自愈”。 相似文献
5.
The Good School Toolkit is effective in reducing staff violence against children in Ugandan primary schools. A secondary analysis of cluster-randomised trial data was conducted to investigate intervention effects on school operational culture, and on normative beliefs and violence against children from caregivers outside of school. Students and staff completed cross-sectional surveys at baseline in 2012 and follow-up in 2014. Students’ caregivers completed follow-up surveys only. Data from 3820 students, 597 staff, and 799 caregivers were included in cross-sectional analyses at follow-up. Statistically significant intervention effects were observed for aspects of school operational culture, including students’ greater perceived emotional support from teachers and peers, students’ greater identification with their school, students’ and staffs’ lower acceptance of physical discipline practices in school, and students’ and staffs’ greater perceived involvement in school operations. Outside the school, the intervention was associated with significantly lower normative beliefs accepting the use of physical discipline practices in schools (adjusted mean difference, AMD: −0.77; 95%CI: −0.89 to −0.66; p < 0.001) and at home (AMD: −0.67; 95%CI: −0.80 to −0.54; p < 0.001), based on aggregated caregiver reports. No differences between groups were observed in past-week violence against children at home. This intervention shows promise as a platform for addressing violence against children within the school environment and surrounding community. 相似文献
6.
目的：研究金莲花中荭草苷和牡荆苷对D-半乳糖（D-galactose,D-Gal）致衰老小鼠脑组织抗氧化酶活性的动态影响,探讨荭草苷和牡荆苷对脑组织抗氧化酶系活性作用的时效关系。方法：采用D-Gal腹腔注射（intraperitoneal injection,ip）致亚急性衰老小鼠模型,8周造模成功后,分成正常组、模型组、荭草苷和牡荆苷各三个剂量组（40,20,10 mg·kg-1）,维生素E（20 mg·kg-1）对照组。各治疗组从第9周开始每日上午分别灌胃（intragastric perfusion,ig）给药,每日一次。给药第2,4,6,8周时,分别断头处死小鼠,用预冷的生理盐水制成10％的脑组织匀浆,8000 rpm离心得上清液,检测超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶以及脑脂褐素含量。结果：与模型组相比,给药2,4周后,各治疗组抗氧化酶系虽有提高但差异无统计学意义,给药6,8周后,各治疗组在提高抗氧化酶系活性以及降低脑脂褐素含量上差异有显著性。荭草苷组和牡荆苷组相比,给药2,4周后,各剂量组在提高抗氧化酶活性及降低脑脂褐素含量上差异无统计学意义,给药6周后,荭草苷40,20,10 mg·kg-1三个剂量组在提高抗氧化酶活性及降低脑脂褐素含量上优于同等剂量的牡荆苷,给药8周后,荭草苷20 mg·kg-1和10 mg·kg-1剂量组在提高抗氧化酶系的活性及降低脑脂褐素含量上高于同等剂量的牡荆苷,而40 mg·kg-1剂量组差异无显著性。与维生素E组相比,给药8周后,荭草苷和牡荆苷20,10 mg·kg-1两个剂量组在提高脑组织抗氧化酶系活性及降低脑脂褐素含量上低于维生素E组,40 mg·kg-1剂量组差异无显著性。结论：荭草苷和牡荆苷具有提高D-Gal致衰老小鼠脑组织抗氧化酶活性的作用,随给药时间和给药剂量的增加,其提高抗氧化酶活性的作用增强。40 mg·kg-1的荭草苷和牡荆苷抗氧化作用? 相似文献
7.
Making Design Education (Even More) Complex: Exploring Complexity for an Amplified Mindset of Design
Mafalda Moreira 《The International Journal of Art & Design Education》2019,38(4):769-784
An Amplified Mindset of Design (AMD) has emerged from recent research on emerging design practices, as designers are once again re‐inventing their identity to include an adaptability to uncertainty and paradox. However, this is not yet visible in what design education offers. As designers intervene in complex contexts and embrace participatory, collaborative and interdisciplinary practices informed by strong ethical and sustainability concerns, design education must adjust and expand its scope to include, for example, collaboration, cross‐cultural and interdisciplinary skills, and a way of being in the world through design. In this article, I argue for the formal introduction and exploration of social complexity in design education to assist the development of an AMD in design students. Boundaries, dependence on context, edge of chaos, emergence and organisation were identified as key qualities of complex systems to introduce to students. Embodiment and visualisation techniques were used as the most appropriate vehicles for such an endeavour. In this article, I discuss the results of a qualitative research informed by action research in which I explore ways of teaching complexity to design students. The inquiry was driven by the following core research question: How can complexity can be taught in design education using visual and embodiment methods to encourage the development of an Amplified Mindset of Design? 相似文献
8.
道:中国文化的字徽 总被引：1，自引：0，他引：1
张法 《华中师范大学学报(人文社会科学版)》2004,43(2):119-123
道是中国化最根本的概念,它起源于原始仪式,理性化于先秦,关联到中国化的方方面面,通过与无、气、理的关联,与心、路、言的关联而展示了中国化的特质。 相似文献
9.
The Ethernet passive optical network (EPON) is the next generation of broad-band network technique. A crucial issue in EPONs is the sharing of uplink bandwidth among optical network units (ONUs). This article provides a novel dynamic bandwidth allocation algorithm, i.e. threshold dynamic bandwidth allocation (TDBA), which is based on adaptive threshold, to increase resource utilization. The algorithm uses ONU data-transmitting rate to adjust optical line terminal (OLT) receiving data threshold from an ONU. Simulation results show that this algorithm can decrease average packet delay and increase network throughput in a 10G EPON system. 相似文献
10.
施建平 《江苏经贸职业技术学院学报》2013,(2):33-35,80
"跩"这个词,自从有了"显摆、炫耀"乃至"洒脱、快乐、霸气"的词义后,一直被人们误解和误用:一是误解为方言词——其实它的使用已远远超出了方言的范畴;二是其字形常常被人们误写作"拽"。其实,"显摆,炫耀"的新义是由"跩"的本义"(走路)摇摆"引申而来的。"拽"字不具有"显摆、炫耀"的词义。 相似文献
11.
何英 《蒙自师范高等专科学校学报》1999,1(2):49-52
用稀硫酸和盐酸处理天然二氧化锰制备活化二氧化锰．经XRD、ICP分析,确定了活化二氧化锰的晶型与天然二氧化锰相同,仍为β型,但锰和二氧化锰含量增加．经恒流放电、电位扫描测试,发现活化二氧化锰的电性能较天然二氧化标有所改善：开路电压、工作电压提高,放电容量增大．对此进行了初步的理论探讨． 相似文献
12.
人参抗衰老作用的实验研究 总被引：4，自引：0，他引：4
徐承水 《赣南师范学院学报》2000,(3):54-56
采用人参水提取液 ,对小鼠的试验研究表明 :人参提取物能有效提高心、脑组织超氧化物歧化酶 (SOD)活性 ,降低过氧化脂质 (LP0 )和脂褐素含量 ,拮抗过氧化损伤 ,具有明显的抗衰老作用 相似文献
13.
“解手”来源纠谬 总被引：1，自引：0，他引：1
顾劲松 《常熟理工学院学报》2011,25(1):89-91
排便义＂解手＂,既不是＂解溲＂音近而讹,也不是缘于排便义＂解＂的双音化,跟明清时期的移民传说也无关,而是由唐宋时期解决义＂解手＂引申发展而来,是一个婉辞用法。 相似文献
14.
The effects of the concentration of dissolved total organic carbon(TOC),the TOC/Br-ratio,bromide ion levels,the chlorine to ammonia-N ratio(Cl:N),the monochloramine dose and the chlorine dose on the formation of trihalomethanes(THMs)(including chloroform,bromodichloromethane,chlorodibromomethane,and bromoform)from chlorination were investigated using aqueous humic acid(HA)solutions.The profile of the chloramine decay was also studied under various bromide ion concentrations.Monochloramine decayed in the presence of organic material and bromide ions.The percentage of chloroform and brominated THMs varied according to the TOC/Br-ratio.Total THMs(TTHMs)formation increased from 112 to 190 μg/L with the increase concentrations of bromide ions from 0.67 to 6.72 mg/L,but the chlorine-substituted THMs were replaced by bromine-substituted THMs.A strong linear correlation was obtained between the monochloramine dose and the formation of THMs for Cl:N ratios of 3:1 and 5:1.These ratios had a distinct effect on the formation of chloroform but had little impact on the formation of bromodichloromethane or chlorodibromomethane.The presence of bromide ions increased the rate of monochloramine decay. 相似文献
15.
Ecological compensation is becoming one of key and multidiscipline issues in the field of resources and environ-mental management. Considering the change relation between gross domestic product (GDP) and ecological capital (EC) based on remote sensing estimation, we construct a new quantitative estimate model for ecological compensation, using county as study unit,and determine standard value so as to evaluate ecological compensation from 2001 to 2004 in Zhejiang Province, China. Spatial differences of the ecological compensation were significant among all the counties or districts. This model fills up the gap in the field of quantitative evaluation of regional ecological compensation and provides a feasible way to reconcile the conflicts among benefits in the economic, social, and ecological sectors. 相似文献
16.
INTRODUCTION With the widespread deployment of broadband access, Video-on-Demand (VoD) streaming on the Internet has received increasing attention recently. In VoD service, video streams are delivered to asyn- chronous users with low delay and VCR-like opera- tion support (e.g., pause, fast-forward, and rewind). However, streaming to a large population of clients is very challenging due to the limited server capacity and little deployment of IP multicast in today’s Internet (Quinn a… 相似文献
17.
A new quantitative model of ecological compensation based on ecosystem capital in Zhejiang Province, China 总被引：1，自引：0，他引：1
Yan Jin Jing-feng Huang Dai-liang Peng 《Journal of Zhejiang University. Science. B》2009,10(4):301-305
Ecological compensation is becoming one of key and multidiscipline issues in the field of resources and environmental management.
Considering the change relation between gross domestic product (GDP) and ecological capital (EC) based on remote sensing estimation,
we construct a new quantitative estimate model for ecological compensation, using county as study unit, and determine standard
value so as to evaluate ecological compensation from 2001 to 2004 in Zhejiang Province, China. Spatial differences of the
ecological compensation were significant among all the counties or districts. This model fills up the gap in the field of
quantitative evaluation of regional ecological compensation and provides a feasible way to reconcile the conflicts among benefits
in the economic, social, and ecological sectors.
Project (No. 2006AA120101) supported by the Hi-Tech Research and Development Program (863) of China 相似文献
18.
目的：了解非淋菌性尿道炎(NGU)患者的沙眼衣原体(Ct)、解脲支原体(Uu)、人型支原体(Mh)的感染情况；同时观察强力霉素治疗单独由Ct感染引起的NGU的疗效。方法：Ct采用抗原快速检测法，Uu与Mh的检查采用培养法；给Ct引起的NGU患者口服强力霉素200mg2次／日共14天进行治疗。结果：lll4例被检者，Ct抗原阳性者238例(21．36％)，Uu培养阳性者368例(33．03％)，Mh培养阳性者109例(9．78％)，其中有130例(11．67％)为混合感染；强力霉素治疗Ct引起的NGU有效率达97．25％。结论：对拟诊为NGU患者应作多种病原体的检测，阳性者及时进行规范化治疗，是防治NGU的有效措施。 相似文献
19.
李珊珊 《福建工程学院学报》2018,(1):91-95
以2014年至2015年我国中小板上市公司为研究对象,以资产收益率、总资产增长率和净利润增长率等三个指标建立中小板上市公司绩效评估分析指标体系,从风投公司行为特征视角分析首次公开募股（initial public offerings,以下称IPO）前后绩效变化。研究结果表明,风险投资的进入和参与程度能显著影响企业的IPO绩效,同时进一步加强市场监管、发挥风投企业认证功能和鼓励风投公司联合投资可以为中小企业成长发挥增值职能。 相似文献
20.
Distributed inverted index technology is used in many peer-to-peer (P2P) systems to help find rapidly document in -set search system for peer-to-peer networkswhich a given word appears. Distributed inverted index by keywords may incur significant bandwidth for executing more complicated search queries such as multiple-attribute queries. In order to reduce query overhead, KSS (keyword-set search) by Gnawali partitions the index by a set of keywords. However, a KSS index is considerably larger than a standard inverted index,since there are more word sets than there are individual words. And the insert overhead and storage overhead are obviously unacceptable for full-text search on a collection of documents even if KSS uses the distance window technology. In this paper, we extract the relationship information between query keywords from websites' queries logs to improve performance of KSS system.Experiments results clearly demonstrated that the improved keyword-set search system based on keywords relationship (KRBKSS) is more efficient than KSS index in insert overhead and storage overhead, and a standard inverted index in terms of communication costs for query. 相似文献