共查询到17条相似文献，搜索用时 218 毫秒
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静注γ—氨基丁酸100mg/kg,可对抗乌头碱致麻醉大鼠心律失常;明显降低CaCl_2引起麻醉大室颤发生率及死亡率;可明显延长肾上腺素致麻醉大鼠出现室早时间及缩短心律失常持续时间。 相似文献
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心喘灵(xc-1)能明显对抗乌头硷,BaCl_2和结扎左冠状动脉前降支诱发大鼠的室性心率失常,并能降低大鼠再灌注诱发的心律失常。xc-1能降低离体大鼠右心房的自发频率。对大鼠心电图实验,证明 xc-1有负性频率怍用,负性传导作用,负性自律性、负性频率、负性传导作用可能是 xc-1抗心率失常作用的药理基础。 相似文献
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绞股蓝总皂甙给小鼠灌胃的最大耐受量为9g/kg.绞股蓝皂甙700,350,180mg/kg经大鼠灌胃,可抑制大鼠实验性血栓形成,抑制率分别为60.7％,73.3％,26.5％;使大鼠血清总胆固醇(CH),甘油三脂(TG),β—脂蛋白(β—LP)均有不同程度的降低.1000 mg/kg,500mg/kg绞股蓝皂甙可抑制氯仿及乌头碱诱发的心律失常.绞股蓝皂甙还有一定程度的急性降压作用. 相似文献
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目的:研究蛇床子素(Osthol,Ost)的抗实验性心律失常作用。方法:采用氯仿、氯化钙诱发动物室颤,肾上腺素诱发动物心律失常试验,给予不同剂量Ost观察其抗实验性心律失常的效果。结果:Ost 20,10mg.kg~(-1)ip对氯仿诱发的小鼠室颤具有保护作用,Ost 10,5mg.kg~(-1)iv对5％氯化钙140mg.kg~(-1)iv诱发的大鼠室颤均有明显的预防作用,Ost 50mg.kg~(-1)iv能明显延长肾上腺素(AD)75μg.kg~(-1)iv诱发家兔心律失常的发生时间,并缩短心律失常的持续时间。结论:蛇床子素有抗心律失常作用。 相似文献
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静注硫酸镁125mg/kg,可拮抗氯化钡及肾上腺素所致麻醉家兔室性心律失常,但对乌头碱引起的大鼠心律失常无拮抗作用。 相似文献
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Treatment of lake sediments with salts is a promising approach for preventing phosphorus release from sediments. Five 35-d treatments of undisturbed sediment cores in the East Lake, Wuhan, China were applied under anoxic conditions： nothing added （control）, Al2（SO4）3 added, FeCl3 added, CaCl2 added, and NaNO3 added. To identify changes in the P binding sites in the sediment caused by the treatments, different P binding forms were extracted from the sediment before and after the treatments. We found that the mean P release rates for anoxic treatments with Al2（SO4）3, FeCl3, CaCl2 and NaNO3 were -0.6, 0.03, 0.6 and 2.6 mg/（m^2·d）, respectively, while the P release rate with no additives was 7.3 mg/（m^2·d）. In suboxic conditions, the concentration of total phosphorus （TP ge 657 mg/kg） in sediment was much lower than that of untreated sediment （TPaverage 688 mg/kg） and treatments with salts （TP（Al2（SO4）3） 793 mg/kg, TP（FeCl3） 781 mg/kg, TP（NaNO3） 802 mg/kg, TP（CaCl2） 747 mg/kg）. We also found that adding CaCl2 prevented P release because of apatite formation and because PCa （Ca bound P） increased at the sediment surface. Addition of Fe^3＋ and NO3^- to the sediment increased the amounts of PFe. Mn （Redox-sensitive P, mostly Fe and Mn compounds）, since iron oxide has the ability to combine P. Addition of Al2（SO4）3 increased the fraction of PAl, Fe （P bound to metal oxides （Al, Fe）） and decreased the P and Fe in the water above the anoxic sediment, showing the greater ability orAl in binding P. The results showed that Al2（SO4）3, FeCl3, CaCl2 and NaNO3 all had an effect in controlling phosphorus release. The effect was related to the forms of phosphorus existing in the sediment before treatment and the forms resulting after adding the four reagents. The combination of Al^3＋ or Fe^3＋ with NO3^- promises to be a reasonable chemical treatment for increasing the P retention capacity of sediments in eutrophic lakes. If chemical treatment is combined with bioremediation, the aim of environmental repair may be achieved. 相似文献
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多氯二肽DN_5,DN_(1653)等化合物在65μg/kg和30μg/kg时均具明显的降压作用,作用时间可持续5h以上,DN_(1653)有先升压后降压的特点,在大鼠侧脑室注射1μg/kg DN_(1563)和DN_5有明显的降压效果,说明此化合物的降压作用与中枢有关.30mg/L DN_5和DN_(1653)对诱导SD大鼠,家兔血小板聚集作用较弱,但能诱导猴血小板聚集达50％以上,α肾上腺素受体阻断剂酚妥拉明可完全对抗两者的促血小板聚集作用.结果揭示DN_5和DN_(1653)有显著生理活性,其作用可能与α受体有关. 相似文献
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目的：观察戊四氮（PTZ）致痫大鼠海马神经元caspase-3表达以及中药复方AAP的脑保护作用.方法：144只健康成年雄性Wistar大鼠随机分为对照组（CK组）、模型组（PTZ组）、中药大剂量组（AAPl组）、中药中剂量组（AAPm组）、中药小剂量组（AAPs组）和丙戊酸钠组（VPA组）;每组各6只.CK组和PTZ组分别给予生理盐水（4mL/kg.d）灌胃;中药各组分别给予中药复方大、中、小剂量（10.26g/kg、5.13g/kg、2.56g/kg）灌胃,每天1次;VPA组腹腔注射VPA（20mg/kg.d）.造模第一天,除CK组外,其余各组大鼠均腹腔注射戊四氮（PTZ）75mg/kg,观察记录大鼠行为学变化;于致痫后12h、2d、5d、7d相应时间点取材,制备脑标本;免疫组化检测caspase-3表达.结果：致痫后,除CK组外,其余各组海马区caspase-3阳性表达增强;7天,与PTZ组相比,AAPl组、AAPm组和AAPs组海马CA3区caspase-3阳性表达减弱（P〈0.05）.结论：caspase-3参与致痫大鼠海马神经元凋亡过程;AAP能降低caspase-3表达,减少神经元凋亡,有神经保护作用. 相似文献
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Stephen A. Shumake Ray T. Sterner Stanley E. Gaddis Kenneth A. Crane 《Learning & behavior》1982,10(4):499-504
The effects of select drugs, dosages, and modes of administration upon learned taste aversions were compared among groups of wild-caught male and female Philippine rice rats (R. r. mindanensis). Experiment 1 compared two-choice saccharin aversions for 28 days among groups intubated with copper sulfate, cyclophosphamide, lithium chloride, red squill, sodium chloride (control), or deionized water (control). Main results were that 375 mg/kg lithium chloride produced the greatest sustained aversions, whereas 198 mg/kg cyclophosphamide and 210 mg/kg red squill produced moderate aversions, with males showing more resistance to extinction than females. Experiment 2 compared saccharin aversion among matched groups of male and female rats that received low (36 mg/kg), moderate (105 mg/kg), or high (368 mg/kg) dosages of lithium by gavage, ip injection, or ingestion. Sex differences in rates of extinction were found for the ingestion and injection-dosed rats, but no sex difference was again found for rats dosed by gavage. A significant mode × day interaction indicated that extinction progressed more rapidly for rats dosed by gavage. For all modes of administration, high dosages yielded intense 28-day aversion, moderate dosages produced intermediate 3–5 day aversion, and low dosages caused no aversion. 相似文献
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Gunnur Ozbakis-Dengiz Aysegul Bakirci 《Journal of Zhejiang University. Science. B》2009,10(4):317-322
Amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart.Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. Convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine model; none of the animals treated with 150 mg/kg dose amiodarone had died in the PTZ model. For hypnotic effect, sleeping was induced with pentobarbital (35 mg/kg) in rats. Amiodarone dose-dependently increased the sleeping time (677.7%～725.9%). In the sleeping test, all rats in 200 mg/kg amiodarone group died. In conclusion, anticonvulsant and hypnotic effects of amiodarone have shown the depressant effects on CNS. These effects may be dependent on its pharmacological properties. 相似文献
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醋酸铅对雄性小白鼠精子形态的影响 总被引：1，自引：0，他引：1
将 5 0只小白鼠随机分成 5组 ,分别腹腔注射甲基磺酸乙脂 6 0mg/kg ,去离子水 16 6ml/kg ,醋酸铅 2 1mg/kg ,10 5mg/kg ,5 2 5mg/kg ,每天一次 ,连用 5天。试验 35天时处死小白鼠 ,检查各组小白鼠的精子形态。结果显示精子畸形率为 :甲基磺酸乙脂组为 4 4 5 % ,去离子水组为 1.8% ,高、中、低剂量醋酸铅组分别为 4 0 .5 % ,30 .4 %和 15 .6 % ,说明醋酸铅对小白鼠精子有致畸形作用 ,而且随着剂量的增大精子畸形率增加。 相似文献
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Liu YM Zhu SM Wang KR Feng ZY Chen QL 《Journal of Zhejiang University. Science. B》2008,9(11):895-902
Objective: To evaluate the effects oftramadol on the proinflammatory responses in a rat model of incisional pain by investigating its effects on nociceptive thresholds and serum interleukin-6 (IL-6) and IL-2 levels. Methods: Forty-two male Sprague-Dawley (SD) rats scheduled for plantar incision were randomly divided into 7 groups (n=6 in each group). Rats in Group 1 receiving general anesthesia with no incision were served as control; At 30 min before skin incision, Groups 2～5 were given 5 ml normal saline or 1, 10, and 20 mg/kg tramadol, respectively, intraperitoneally (i.p.); Group 6 received 10 mg/kg tramadol after operation; Group 7 received 10 mg/kg tramadol before incision, followed by 200 μg/kg naloxone after operation. Mechanical allodynia was measured by electronic von Frey filament to evaluate the nociceptive thresholds 1 h before incision, and 1 h and 2 h after operation. Serum IL-6 and IL-2 levels were measured by enzyme-linked immunosorbent assay (ELISA) 2 h after operation. Results: Mechanical thresholds decreased significantly and serum IL-6 level increased significantly after operation in Group 2 compared with control (P＜0.01), and these changes were reversed respectively by tramadol in a dose-dependent manner (P＜0.05 and P＜0.01, respectively). IL-2 level remained unchanged after operation in Group 2, but decreased in Group 3 (P＜0.05), then gradually returned to the normal level in Groups 4 and 5. The intraperitoneally injected tramadol (10 and 20 mg/kg) produced a potent and dose-dependent antinocicptive effect on the lesioned paw. The antinocicptive effects of tramadol were partially an-tagonized by naloxone (200 μg/kg), suggesting an additional non-opioid mechanism. Conclusion: The results suggest that tramadol could be a good choice for the treatment of pain under the conditions that immunosuppression may be particularly contraindicated. 相似文献
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柚皮苷和新橙皮苷抗过敏作用的研究 总被引：9，自引：0，他引：9
[目的]为了研究柚皮苷和橙皮苷的抗过敏作用.[方法]采用DNFB法诱导小鼠3相皮肤炎后,第2~8 d连续口服给以柚皮苷和橙皮苷.观察即时相(IPR)、迟发相(LPR)和超迟发相(vLPR)的抑制率.[结果]柚皮苷在投药量为20 mg/kg时,对IPR、vLPR的耳缘浮肿产生有效的抑制,抑制率分别为2 8.2%,2 6.1%;投药量为100 mg/kg,对浮肿各相都产生有效的抑制,抑制率分别为31.7%,25.1%,29.9%.新橙皮苷在20和100 mg/kg投药量下,对vLPR相产生有效的抑制,抑制率分别为19.1%,23.6%.[结论]柚皮苷和橙皮苷表现出较好的抑制3相皮肤炎作用,在抗过敏方面具有一定的开发价值. 相似文献
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目的：观察天麻素对癫痫大鼠海马Caspase-3表达的影响及其脑保护作用。方法：120只健康成年雄性Wistar大鼠随机分为对照组、PTZ（戊四氮）组、VPA（丙戊酸钠）组、Gb（天麻素大剂量）组和Gs（天麻素小剂量）组（n=24）。对照组和PTZ组分别以生理盐水（4mL/kg·d）灌胃;VPA组给予丙戊酸20mg．kg^-1,Gb组和Gs组分别给予天麻素200mg．kg^-1和100mg．kg^-1;每天1次,连续7天。造模第一天,除对照组大鼠外,余者均腹腔注射戊四氮75mg／kg,记录动物行为学变化。于致痫后12h、2d、5d和7d相应时间点取材,制备脑标本,免疫细胞化学术检测caspase-3表达。结果：致痫后12h,P11Z组Caspase-3有微量表达,其余各组几乎无表达;2—7d。PTZ组Caspase-3表达增加。与PTZ组比较,Gb组、Gs组及VPA组Caspase-3阳性表达降低,差异显著（P〈0．05）;与VPA组比较,Gb组和Gs组Caspase-3表达无显著差异（P〉0．05）。结论：天麻素能降低致痫大鼠海马神经元Caspase-3表达;可能通过抑制神经元凋亡发挥脑保护作用。 相似文献
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襄阳区水稻测土配方施肥“3414”试验初报 总被引：1，自引：0，他引：1
通过“3414”试验,确定了襄阳区水稻主推品种华两优1206,在有机质含量为2．11％,碱解氮为79．97mg／kg,有效磷为13．34mg／kg,速效钾为74．20mg／kg,pH为7．1的淹育型水稻土田块上种植,氮、磷、钾肥的施肥量分别为N13．3kg／666．7m2、P2O5 4．0kg／666．7m2,K205．9kg／666．7m2时,水稻可获得最高产量,分别为450．9kg／666．7m2,445．6kg／666．7m2、443．9kg/666．7m2;氮、磷、钾肥的施肥量分别为N9．6kg／666．7m2,P2052．7kg/666．7m2、K204．1kg/666．7m2时,水稻可获得经济最佳产量,分别为446．7kg/666．7m2．443．7kg／666．7m2,441．6kg/666．7m2。 相似文献