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他汀类药物作为心血管疾病临床治疗的一线用药,是一类广泛口服临床应用的降脂药物,对血浆低密度脂蛋白胆固醇水平具有降低作用.经研究显示在治疗代谢性疾病、脑血管疾病以及心血管疾病中他汀类药物具有重要地位,该药物还同时具备抗肿瘤、抑制肾脏细胞增殖、免疫抑制、预防痴呆、抗炎等临床作用.随着国际指南的不断推荐以及他汀类药物使用的广泛性,临床上了解该药物长期与短期效果尤为重要.本文将对他汀类药物用药安全性进行论述,且为合理用药提供依据. 相似文献
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目的 分析阿托伐他汀在急性缺血性脑卒中治疗中的应用效果。方法 68例急性缺血性脑卒中患者随机分为对照组和研究组,各34例。给予对照组常规治疗,研究组在对照组基础上加用阿托伐他汀治疗,回顾分析两组临床疗效。结果 研究组各项血脂水平、神经功能缺损评分及临床总有效率均优于对照组,两组比较差异有统计学意义(P<0.05)。结论 给予急性缺血性脑卒中患者阿托伐他汀治疗的效果较为显著,值得在临床上推广应用。 相似文献
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《新课程学习(社会综合)》2014,(3):4-4
他汀广泛应用于高血脂、冠心病及其他心血管病的预防和治疗。但在长期运用时，可能出现肝功能异常和肌肉损害等不良反应，其中后者可表现为肌无力、肌肉疼痛。体格瘦弱者使用他汀类药物时，更应该警惕。 相似文献
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目的:他汀类药物在治疗骨质疏松症时会加重肌肉损伤。本实验研究左卡尼汀和辅酶Q10对阿托伐他汀在切除卵巢的老鼠的抗骨质疏松作用的影响。创新点:研究新的治疗骨质疏松症及其并发症的方法。方法:选取48只雌性SD大鼠,40只大鼠切除卵巢,8只为假手术组。切除卵巢8周后,大鼠被分成去卵巢非治疗组和4个去卵巢治疗组(每组8只),通过灌胃法给药(单位为mg/(kg·d),为期8周):雌二醇(0.1)、阿托伐他汀(50)、阿托伐他汀(50)+左卡尼汀(100)或阿托伐他汀(50)+辅酶Q10(20)。在治疗结束时,测量骨矿物质密度、骨矿物质含量及骨代谢标志物和肌酸激酶的血清水平,利用股骨研究抗断强度和组织病理学变化。结论:相比辅酶Q10,合并给药左卡尼汀可在提高阿托伐他汀对切除卵巢的老鼠的抗骨质疏松作用的同时避免肌肉损伤。 相似文献
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青蒿素类药物的药理和毒理学研究 总被引：5，自引：0，他引：5
为了解青蒿素类药物的药理和毒理学研究进展,笔者查阅有关文献,综述了青蒿素类药物的药理与毒理学研究进展.研究结果表明:药动学研究显示此类药物吸收快、分布广、代谢与排泄快;青蒿素类药物除具有抗疟作用外,还有免疫调节、抗肿瘤、抗炎、抗血吸虫及其它寄生虫等作用;无严重的不良反应. 相似文献
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肾病综合征（NS）即具有低蛋白血症、大量蛋白尿、高脂血症、浮肿症状的一组患者。研究证实，血脂异常能加速肾脏疾病的进展。高脂血症能导致肾小球硬化，加速肾功能衰竭，降脂治疗能预防和延缓肾损伤。阿托伐他汀是3-羟基-3-甲基戊二酰辅酶A（HMG—CoA）还原酶抑制剂，不仅能有效降低血脂水平，尚有不依赖于降脂的肾脏保护作用。本文旨在观察阿托伐他汀在治疗肾病综合征中的疗效。 相似文献
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浅谈临床几类药物的不良反应 总被引：1，自引：0，他引：1
临床常用的抗生素类药物、抗结核病药物、抗原虫类药物在治疗疾病时发挥治疗作用的同时也具有一些不良反应，临床使用时必须加以注意，就利避害。 相似文献
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美国研究人员报告说,病人若在心肌梗塞发作后24小时内服用他汀类降胆固醇药物,可将死亡风险减少至少一半.
研究人员调查了超过17万名因心肌梗塞入院病人的治疗记录并发现,入院前服用过他汀类降胆固醇药且在心肌梗塞发作后24小时内继续服药的病人,其死亡风险与不服该类药物的病人相比减少了54%;而从未服过他汀类降胆固醇药但在心肌梗塞发作后24小时内服用该类药物的病人,其死亡风险可下降58%. 相似文献
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本概述了喹诺酮类药物的分类、作用机制、抗菌谱、抗菌活性、耐药性及其机制、药物动力学性质、临床应用、不良反应、药物相互作用。并对喹诺酮类药物发展前景进行了预测。 相似文献
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喹诺酮类抗菌药物是由萘啶酸发展起来的合成抗菌药物。因其抗菌谱广、抗菌作用强、药物动力学性能好和耐受性好 ,从而扩大了适应证 ,用于各种感染的治疗 ,因而喹诺酮类药物的发现和发展 ,开创了合成抗菌药的新时代。喹诺酮类抗菌药从 196 2年进入临床以来 ,经 30余年发展 ,尤其是 2 0世纪 80年代以来 ,喹诺酮类药物快速发展 ,已成为临床上最常用的抗菌药。喹诺酮类药物都具有吡啶酮酸的共同结构 ,通过抑制DNA螺旋酶 ,阻断DNA的复制而产生抗菌作用。此类药物具有良好的药动学特征 ,口服给药生物利用度高 ,半衰期较长 ,血药浓度高 ,组织分… 相似文献
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YUAN Bo MURAYAMA Koichi 《浙江大学学报(A卷英文版)》2007,8(2):171-175
INTRODUCTION The bands of near-infrared (NIR) spectra have low absorptivities, which allow in situ analysis of chemical and biological materials with no or little sample preparation. Therefore, as one of the most important nondestructive analytical techniques, NIR spectroscopy is being extensively applied in the fields of agriculture, industry, biotechnology and medicine (Siesler et al., 2002; Scarff et al., 2006; Ward et al., 2006). Recently, with instrumental developments such as Fou… 相似文献
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Optimization study of a PEM fuel cell performance using 3D multi-phase computational fluid dynamics model 总被引：1，自引：0，他引：1
AL-BAGHDADI Maher A.R. Sadiq AL-JANABI Haroun A.K. Shahad 《浙江大学学报(A卷英文版)》2007,8(2):285-300
INTRODUCTION Water management is one of the critical opera-tion issues in proton exchange membrane (PEM) fuelcells. Spatially varying concentrations of water inboth vapour and liquid form are expected throughoutthe cell because of varying rates of production andtransport (Sui and Djilali, 2005). Devising betterwater management is therefore a key issue in PEMFCdesign, and this requires improved understanding ofthe parameters affecting water transport in the mem-brane. Proper thermal m… 相似文献
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洛伐他汀工艺现状及研究进展 总被引：1，自引：0，他引：1
洛伐他汀在防治心脑血管疾病药物中,因其作用机理明确,临床疗效显著,近年来其研究和应用受到世界各国医药学界和企业的普遍重视.从洛伐他汀的发现出发,对国内外洛伐他汀的工艺现状及研究进展做了全面的综述. 相似文献
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冯明华 《泰州职业技术学院学报》2011,11(5):62-63,68
目的探讨护理干预对轻、中度血管性痴呆患者的影响。方法将56例轻、中度血管性痴呆患者采用在一般护理的基础上予心理、康复等干预。结果对轻中度血管性痴呆患者采取综合护理干预方法,效果满意。结论护理干预可提高血管性痴呆患者的认知功能、智能和日常活动能力,对疾病康复有积极的促进意义。 相似文献
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Shan-zhi Gu Xin-han Zhao Ling-xiao Zhang Li Li Zhi-yu Wang Min Meng Gai-li An 《Journal of Zhejiang University. Science. B》2009,10(3):159-167
Objective: To study the effects of the generation 4 polyamidoamine/vascular endothelial growth factor antisense oligodeoxynucleotide (G4PAMAMNEGFASODN) compound on the expressions of vascular endothelial growth factor (VEGF) and its mRNA of breast cancer cells and on the inhibition of vascular endothelial cells. Methods: We examined the morphology of G4PAMAM/VEGFASODN compound and its pH stability, in vitro transfection efficiency and toxicity, and the expressions of VEGF and its mRNA. Methyl thiazolyl tetrazolium assay was used to detect the inhibitory function of the compound on vascular endothelial cells. Results: The compound was about 10 nm in diameter and was homogeneously netlike. From pH 5 to 10, it showed quite a buffered ability. The 48-h transfection rate in the charge ratio of 1:40 was 98.76%, significantly higher than that of the liposome group (P<0.05). None of the transfection products showed obvious toxicity on the cells. The expressions of both VEGF protein and its mRNA after G4PAMAM/VEGFASODN transfection decreased markedly. Conclusion: With a low toxicity, high safety, and high transfection rate, G4PAMAMNEGFASODN could be a promising gene vector. Specifically, it inhibits VEGF gene expression efficiently, laying a basis for further in vivo animal studies. 相似文献
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电化学实验中,原电池装置是影响实验效果的重要因素。为了进一步简化实验准备工作量,提高电化学实验效果,研制了盐通式原电池,阐述了盐通的功能和盐通式原电池的工作原理,并与盐桥式原电池进行了比较分析。盐通式原电池可应用于浓度、酸度对电极电位的影响;酸度对氧化还原反应方向的影响等实验。结果表明,盐通式原电池结构简单、使用方便、宜于保存,内阻低、功率高、电流平稳,实验效果好。盐通不但完全能够取代传统盐桥,而且性能大大优于盐桥。盐通式原电池是一种新的原电池,经过文献检索,国内外目前尚无同类装置,属于一种实用新型电化学实验装置。 相似文献
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Cellular growth under hydrostatic pressure using bovine aortic EC-SMC co-cultured ePTFE vascular graft 总被引：1，自引：0，他引：1
High blood pressure (hypertension) is implicated in the development of atherosclerosis. Blood vessels are constantly subjected to stretch due to blood pressure and changes in stretch usually instigate adaptive vascular remodeling, including abnormal growth and proliferation of vascular smooth muscle cells (VSMCs) as well as extracellular matrix (ECM). In this experiment, we used bovine aortic endothelial cells and smooth muscle cells (EC-SMC) co-cultured ePTFE vascular grafts subjected to normal atmospheric pressure (as a control), and 100 mmHg hydrostatic pressure for 7 d. The increase of cell layer thickness was observed. When measured, the cell layer thickness increased by 116.2%. The increase of collagen (Type IV) synthesis was also observed in the immunohistochemistry assay. When stained with toluidine blue, the cells showed metachromatic phenomenon. 相似文献
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Shao-xiang Weng Mei-hua Sui Shan Chen Jian-an Wang Geng Xu Ji Ma Jiang Shan Lu Fang 《Journal of Zhejiang University. Science. B》2009,10(7):528-535
Objective This study is to determine the effect of the natural product parthenolide, a sesquiterpene lactone isolated from extracts
of the herb Tanacetum parthenium, on the proliferation of vascular smooth muscle cells (VSMCs).
Methods Rat aortic VSMCs were isolated and cultured in vitro, and treated with different concentrations of parthenolide (10, 20 and
30 μmol/L). [3H]thymidine incorporation was used as an index of cell proliferation. Cell cycle progression and distribution were determined
by flow cytometric analysis. Furthermore, the expression of several regulatory proteins relevant to VSMC proliferation including
IκBα, cyclooxygenase-2 (Cox-2), p21, and p27 was examined to investigate the potential molecular mechanism.
Results Treatment with parthenolide significantly decreased the [3H]thymidine incorporation into DNA by 30%∼56% relative to control values in a dose-dependent manner (P<0.05). Addition of parthenolide also increased cell population at G0/G1 phase by 19.2%∼65.7% (P<0.05) and decreased cell population at S phase by 50.7%∼84.8% (P<0.05), which is consistent with its stimulatory effects on p21 and p27. In addition, parthenolide also increased IκBα expression
and reduced Cox-2 expression in a time-dependent manner.
Conclusion Our results show that parthenolide significantly inhibits the VSMC proliferation by inducing G0/G1 cell cycle arrest. IκBα and Cox-2 are likely involved in such inhibitory effect of parthenolide on VSMC proliferation. These
findings warrant further investigation on potential therapeutic implications of parthenolide on VSMC proliferation in vivo.
Project (No. 491020-W50315) supported by the Foundation of the Health Bureau of Zhejiang, China 相似文献