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1.
Soma Gupta M. V. R. Reddy B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2004,19(1):138-141
Lipid peroxidation product, malonaldehyde (MDA) and antioxidants were estimated in plasma and erythrocytes of 34 cases of
oral submucous fibrosis (OSMF) of different grades with equal number of healthy controls to evaluate the association of reactive
oxygen species (ROS) and OSMF. While plasma MDA was found to be significantly higher in patients (3.3±0.4 nmole/ml, P<0.001)
as compared to controls (2.4±0.5 nmole/ml), plasma beta carotene and vitamin E levels were found to be decreased significantly
in patients (81.7±14.3 μg/100 ml, P<0.001; 9.3±0.9 mg/L, P<0.01 respectively) with respect to healthy controls (110±20.8 μg/100
ml and 10.1±1.2 mg/L). The decrease in beta-carotene and vitamin E was found to be more significant in OSMF grade II and III
than in grade I. After 6 weeks of oral administration of beta-carotene and vitamin E, patients showed increase in plasma level
of these two antioxidants along with decrease in MDA level associated with clinical improvement. 相似文献
2.
V. N. Thorat A. N. Suryakar A. S. Sardeshmukh S. S. Sarawade 《Indian journal of clinical biochemistry : IJCB》2004,19(2):32-35
In the present study, the role of serum lipid peroxide and serum nitric oxide as oxidants and erythrocytic superoxide dismutase
& serum vitamin E as antioxidants were determined in the 50 neonates with hypoxic ischaemic encephalopathy. (HIE) as against
25 healthy neonates as controls 50 patients of HIE were further divided into two groups i. e. mild and moderate HIE patients.
All subjects were in the age group of 37–41 weeks of gestation. The levels of serum lipid peroxide, serum nitric oxide and
erythrocytic superoxide dismutase were significantly elevated in both groups of neonates with HIE than those of controls (P<0.001),
whereas serum vitamin E levels were significantly decreased in both groups of HIE patients than those of controls (P<0.001).
A positive correlation was obtained between serum lipid peroxide and erythrocytic superoxide dismutase (r=+0.86). Alterations
in the status of oxidants and antioxidants indicate role of free radicals in the development of HIE. 相似文献
3.
A. Sarkar S. Dash B. K. Barik Manjunatha S. Muttigi V. Kedage J. K. Shetty M. Prakash 《Indian journal of clinical biochemistry : IJCB》2010,25(1):74-76
Presence of oxidative stress in type 2 diabetes mellitus (DM) is well proved. Current study was undertaken to know the relation
between fasting plasma glucose (FPG) and copper along with antioxidants like total thiols and ceruloplasmin, and antioxidant
enzyme glutathione S transferase (GST). The study group consisted of a total of 201 subjects which included nondiabetic healthy
control subjects (n = 78) and diabetic patients (n = 123). Plasma total thiols, GST, copper and ceruloplasmin levels were
measured all the subjects using spectrophotometric methods and FPG levels were determined in clinical chemistry analyzer Hitachi
912. There was significant increase in FPG (P<0.001) and copper (P<0.001) and decrease in ceruloplasmin (P<0.001) and protein
thiols (P<0.001) in type 2 DM cases compared to healthy controls. There was no significant change in GST between type 2 DM
cases and controls. There was significant negative correlation of FPG with antioxidants like ceruloplasmin (r = −0.420, P<0.001)
and total thiols (r = −0.565, P<0.001). Protein thiols correlated positively with ceruloplasmin (r = 0.364, P<0.001). Our
study indicates possible increase in copper mediated generation of ROS leading to increased consumption of available antioxidants
in the body. 相似文献
4.
Santoshi R. Ghodake A. N. Suryakar R. D. Ankush K. Shaikh A. V. Katta 《Indian journal of clinical biochemistry : IJCB》2010,25(1):82-85
Nephrotic syndrome is the common chronic disorder characterized by alteration of permeability of the glomerular capillary
wall, resulting in its inability to restrict the urinary loss of proteins. Nephrotic syndrome is characterized by heavy proteinuria,
hypoalbuminemia, hyperlipidemia associated with peripheral edema. The molecular basis of glomerular permselectivity remains
largely unknown. In recent years it has been proposed that Nephrotic syndrome is a consequence of an imbalance between oxidant
and antioxidant activity. The present study was aimed to test that the reactive oxygen species are the mediators of excessive
protein permeability and other complications of Nephrotic syndrome. For this 30 adults with Nephrotic syndrome were studied.
The control group comprised 30 healthy adults matched for age. Serum levels of lipid peroxides, nitric oxide (NO⊙), α- tocopherol,
ascorbic acid, erythrocyte superoxide dismutase activity, serum albumin, uric acid, cholesterol and plasma total antioxidant
capacity were measured. Student’s ‘t’ test was applied for statistical analysis. There was a significant increase in lipid
peroxide (1.58 ± 0.42 in controls, 3.64 ±1.3 in patients) (P<0.001) levels in study group as compared with controls. α-tocopherol
(12.95 ± 1.04 in controls, 9.93 ± 1.43 in patients) (P<0.001), erythrocyte SOD activity(1.88 ± 0.9 in controls 1.07 ± 0.5
in patients) (P=0.01), serum albumin(4.06 ± 0.50 in controls, 3.04 ± 0.11 in patients) (P<0.001), and plasma total antioxidant
capacity (847.33 ± 126.83 in controls, 684.00±102.94 in patients) (P<0.001) were significantly decreased. There was non-significant
increase in uric acid (P>0.05), a non-significant decrease in NO⊙ (38.48 ± 15.47 in controls 37.47 ± 14.27 in patients) (P>0.05)
and ascorbic acid levels ascorbic acid,( 0.95 ± 0.31in controls 0.79 ± 0.30 in patients) (P>0.05) in study group as compared
with controls. Imbalance between oxidants and antioxidants may contribute to pathogenesis of proteinuria and related complications
in nephrotic syndrome. 相似文献
5.
Renu Garg Manju Verma S. P. Mathur P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》1996,11(2):182-186
Lipid peroxidation products and antioxidants were estimated in either blood, serum or erythrocytes of 25 cases of early and 25 of advanced senile (50–60 years) cataract and 30 persons of age matched healthy controls. Serum lipid peroxidation products (as malondialdehyde) were significantly higher in patients with early senile (0.25±0.05 μm/dl, P<0.05) and advanced senile cataract (0.29±0.05 μm/dl, P<0.001) as compared to healthy controls (0.22±0.07 μm/dl). Erythrocyte superoxide dismutase levels were lower in patients with early senile (730±60.5 units/gm Hb) and significantly lower in advanced senile (712±50.2 units/gm Hb, P<0.05) cataract than those in healthy controls (767±59.5 units/gm Hb). Serum α-tocopherol was significantly lower (P<0.05) in only advanced senile cataract (0.69±0.08 mg/dl) but not in early senile cataract (0.75±0.08 mg/dl) when compared with healthy controls (0.75±0.09 mg/dl). There was no significant difference in the erythrocyte concentration of reduced glutathione and serum levels of total proteins, β-carotene, vitamin A, ascorbic acid, calcium, magnesium and zinc. 相似文献
6.
P. Pragathi P. V. Bharath Kumar P. Amar Kumar M. Ramakanth Reddy V. Sravani J. Neeraja Eapen Reeba Mary K. Gopalakrishna 《Indian journal of clinical biochemistry : IJCB》2005,20(2):195-197
Adenosine deaminase (ADA) and 5′-nucleotidase (5′-NT) activities were measured in sera of patients with ovarian cancer and
patients with benign ovarian tumour. The results were compared with that of a control group consisting of healthy women. ADA
levels were significantly increased (P<0.001) in the ovarian cancer group (n=50) but not in the benign group (n=28) when compared
to the controls (n=20). The results indicate that ADA and 5′-NT levels may help to differentiate malignant conditions from
benign tumours of the ovary in addition to the existing tests such as serum CA-125 levels and histopathological study. 相似文献
7.
Vaishali N. Thorat Adinath N. Suryakar Pradeep Naik Bipin M. Tiwale 《Indian journal of clinical biochemistry : IJCB》2009,24(1):102-104
Liver transplantation is an accepted therapy for chronic liver disease patients. These patients generally have low levels
of fat soluble vitamins, which have important antioxidant roles. Therefore, this study was undertaken to investigate whether
such patients had evidence of antioxidant depletion and increased lipid peroxidation before transplant and whether the subsequent
ischemia and reperfusion encountered during liver transplantation have any effect on antioxidant levels and lipid peroxidation.
We assessed plasma total antioxidant capacity and serum lipid peroxide in 12 patients undergoing liver transplantation and
equal numbers of healthy subjects. We found that before reperfusion, antioxidant levels were significantly decreased along
with significantly elevated lipid peroxidation levels as compared with healthy controls (P<0.001). On reperfusion of the liver
graft, further declined values of total antioxidant accompanied with highly elevated lipid peroxidation were seen than those
of pre-reperfusion samples (P<0.001). This data shows that patients undergoing liver transplant have lowered antioxidant defenses
and evidence of free radical damage, which compound the additional insult of reperfusion injury. Therefore antioxidant therapy
in these patients before transplantation may ameliorate the effects of reperfusion. 相似文献
8.
Salivary β-glucuronidase activity was studied in 20 healthy subjects without habits and 10 with habits, 38 untreated patients
of advanced head and neck cancer and 21 patients after treatment either after surgery or radiation.
Salivary β-glucuronidase activity was elevated in untreated cases of head and neck cancer (p<0.001), with a fall in the activity
after treatment. The post operative fall in the activity of salivary β-glucuronidase activity was highly significant (p<0.001)
as compared to post radiation. This test can be utilized in the diagnosis and also for monitoring the course of the disease. 相似文献
9.
K Sudha Ashalatha V Rao S. N. Rao Anjali Rao 《Indian journal of clinical biochemistry : IJCB》2002,17(1):34-41
Oxidative stress is implicated in the etiopathogenesis of a variety of human diseases. Therefore, in the present study, erythrocyte
lipid peroxidation, percentage hemolysis, antioxidant enzymes viz., glutathione reductase, glutathione peroxidase, superoxide
dismutase and plasma antioxidants viz., ceruloplasmin, vitamins A,E and C have been determined in 19 patients with tubercular
meningitis (TBM) and 50 normals. Six patients who were treated with antibiotics were considered for the follow up. The statistical
analysis was carried out by Mann Whitney U test and Wilcoxon rank sum test. Lipid peroxidation (P<0.02), percentage hemolysis
(P<0.001) and plasma ceruloplasmin (P<0.0001) of TBM patients were significantly higher, whereas erythrocyte glutathione reductase
(P<0.05) and plasma antioxidant vitamins A, E and C (P<0.01, P<0.05 respectively) were significantly lower than those of the
controls. In the follow up patients the glutathione reductase and catalase levels were significantly high (P<0.05) compared
to their pre-treated condition. Vitamin C and E levels have attained normal range. This study indicated that the blood antioxidant
status of TBM patients which was low compared to controls improved after treatment, suggesting the role of free radicals in
TBM. 相似文献
10.
H. R. Mali M. L. B. Bhatt M. P. Singh S. M. Natu J. P. Gupta 《Indian journal of clinical biochemistry : IJCB》1996,11(1):56-58
Serum sialic acid levels were determined in 66 patients of carcinoma cervix and 25 control women matched for age. Mean sialic acid level was significantly elevated (p<0.001) in cancer cervix patients as compared to controls. Patients were treated with 50–65 Gy of radiation in 5–6.5 weeks. Post-therapy levels were again determined. Radiotherapy caused decline in serum sialic acid level in all the patients except one. Mean post-therapy level was significantly lower as compared to pretreatment level (p<0.001). It was also observed that fall in sialic acid level was significantly higher (p<0.05) in early stage patients as compared to late stage. No relationship was observed in the dose of radiation and fall in serum sialic acid level. A significantly higher fall in serum sialic acid level was observed in patients having complete clinical response as compared to partial or nonresponders to radiation treatment (p<0.001). 相似文献
11.
M. Shafi Dar A. A. Pandith A. S. Sameer M. Sultan A. Yousuf Syed Mudassar 《Indian journal of clinical biochemistry : IJCB》2010,25(2):208-212
Hypertension is the most important public health problem in developing countries and one of the major risk factors for cardiovascular
diseases, and it has been reported that hypertension is in part an inflammatory disorder and several workers have reported
elevated levels of CRP in hypertensive individuals. The main aim of the present study was to evaluate the association between
blood pressure and serum CRP levels across the range of blood pressure categories including prehypertension. A total of 104
patients and 63 control subjects were included in the present study. The level of CRP in the serum samples was estimated by
a high sensitivity immunoturbidometric assay. Standard unpaired student’s ‘t’ test was used for comparison of hs-CRP levels
between hypertensive patients and normotensive control subjects and between patient groups with different grades of hypertension
and different durations of hypertensive histories. The mean serum hs-CRP level in hypertensive patients was 3.26 mg/L compared
with 1.36 mg/L among normotensive control subjects (P<0.001). On comparison with normotensive control subjects, the hs-CRP
levels vary significantly both with grades and duration of hypertension, with most significant difference found in patients
with prehypertension (P<0.001), followed by Stage-I (P=0.01) and Stage-II(P=0.02) hypertensives. Significant difference in
hs-CRP levels was also found in patients with shorter duration of hypertensive history (≤ 1year) when compared with those
with ≥5 years of hypertensive history (P<0.01). Our study reveals a graded association between blood pressure and CRP elevation
in people with hypertension. Individuals with prehypertension or with shorter duration of hypertension (≤1 Year) had significantly
a greater likelihood of CRP elevation in comparison to chronic stage-I or stage-II hypertensives. 相似文献
12.
Kiran Chaudhari S. Khanzode S. Khanzode G. Dakhale A. Saoji S. Sarode 《Indian journal of clinical biochemistry : IJCB》2010,25(1):77-81
Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective
Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined.
This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale
for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects
before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly
diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more
significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant
and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= −0.864,
P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid
and improves Hamilton Rating Scale for Depression score in major depressive disorder. 相似文献
13.
D. Rajasekhar K. S. S. Saibaba P. V. L. N. Srinivasa Rao S. A. A. Latheef G. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2004,19(2):53-59
In an attempt to search for risk factors which can explain the increasing prevalence of coronary heart disease (CHD) in Indian
population, we conducted a case-control study to assess the association of Lipoprotein (a)(Lp(a)) with CHD. One hundred and
fifty one consecutive patients with clinical and angiographic evidence of CHD and forty-nine healthy controls were drawn for
the study. Triglycerides, very low density cholesterol (VLDL-C), total cholesterol (total-C)/high density cholesterol (HDL-C)
ratio, low density cholesterol (LDL-C)/HDL cholesterol ratio and Lp(a) were found to be higher in patients than controls.
In female sex and in those with family history of CHD, higher total and LDL cholesterol levels were observed to be associated
with higher Lp(a) levels. Lp(a) levels were also found to be higher in triple vessel disease than other vessel disease patients.
Significant difference in Lp(a) levels were observed between normal coronaries vs. single and triple vessel disease(P<0.05)
and also between single vs. double and triple vessel disease (P<0.01).Lp(a) levels correlated positively with vessel severity(P<0.005).
Lp(a) levels >25 mg/dl were associated with coronary heart disease (Odds ratio 1.98 P<0.05 95% CI 0.007–1.18). Our findings
suggest a cut-off level of 25mg/dl for determination of risk of CHD. Studies from different areas involving larger sample
size are needed to confirm the findings of the present study. 相似文献
14.
Y. S. Mahindrakar A. N. Suryakar R. D. Ankush R. V. Katkam K. M. Kumbhar 《Indian journal of clinical biochemistry : IJCB》2007,22(1):91-94
New findings on organization of blood cell cytoskeleton represent an exciting aspect of modem cell biology and hematology,
which is an interesting investigation to study diabetes. The present study was undertaken in 150 subjects. Out of these, 30
subjects were controls (Group I) and 30 were type-2 diabetics without any complication (Group II), while remaining 90 subjects
were type-2 diabetics with complication (Group III). We determined erythrocyte spectrin and hemoglobin glycosylation and also
estimated plasma lipid peroxide, nitric oxide and erythrocyte glutathione peroxidase activity to assess the status of oxidative
stress. There was a significant increase in spectrin (P<0.001) and hemoglobin (P<0.001) glycosylation in Group II and III
as compared to Group I and spectrin glycosylation was nearly three times more as compared to hemoglobin, whereas plasma levels
of lipid peroxide (P<0.001) as well as nitric oxide (P<0.001) were found to be significantly increased and GPx activity (P<0.001)
was significantly decreased in Group II and III as compared to Group I. However, it was also observed that spectrin (P>0.05)
and hemoglobin (P>0.05) glycosylation was not significantly different in Group II and III. In contrast, there was significant
rise in lipid peroxide (P<0.001), nitric oxide (P<0.001) and fall in GPx activity (P<0.001) in Group III when compared to
Group II. Increased erythrocyte protein glycosylation and oxidative stress is clearly evident from our study. However, to
understand the exact interplay between these two mechanisms, further studies are required. 相似文献
15.
A. Madhusudhana Rao A. R. Bitla E. P. Reddy V. Sivakumar P. V. L. N. Srinivasa Rao 《Indian journal of clinical biochemistry : IJCB》2010,25(1):47-50
The present study was carried out to explore the altered lipid, lipoprotein and apoprotein abnormalities along with lipoprotein
(a) in chronic kidney disease patients with stage I to V which were further divided into group 1 (stage I and II), group 2
(stage III and IV) and group 3 (stage V). 50 chronic kidney disease patients with stage I to V and 20 healthy normal subjects
as controls were recruited for this study. Among the various parameters tested triglyceride levels were high in group 1 and
2, whereas VLDL cholesterol, Lp (a) and apo B levels were significantly high in all the groups when compared to controls (P<0.05).
However, LDL cholesterol level was significantly low in group 3 only as compared to control group (P<0.05). Apoprotein AI
values also showed significant decrease in all groups as compared to controls (P<0.05). Though total cholesterol levels in
group 1 and LDL levels in group 1 and 2 were higher than controls, but the values attained not statistically significant (P>0.05).
In conclusion high levels of VLDL cholesterol, Lp (a), apo B and low levels of apoprotein AI as reported in this study are
the major lipid disorders in the development of cardiovascular complications at all the stages in these patients. 相似文献
16.
M. Smita K. Naidu A. N. Suryakar Sanjay C. Swami R. V. Katkam K. M. Kumbar 《Indian journal of clinical biochemistry : IJCB》2007,22(2):140-144
Cervical cancer (CaCx) is a global public health problem as it is the second most common cancer leading to the death of women
worldwide. Many references revealed that the low levels of antioxidants induce the generation of free radicals leading to
DNA damage and further mutations. In the present study attempt have been made to evaluate the levels of serum Lipid peroxide,
Nitric Oxide (NO.) Erythrocytic—Superoxide Dismutase (RBC-SOD), Vitamin-C, serum Copper (Cu) and serum Zinc (Zn). 120 patients were divided
in 4 groups according to the increasing CaCx stages i.e. stage I, II, III & IV respectively. All the patients were around
the age group of 25–65 years. 30 healthy women between the same age group were treated as controls. Highly significant increased
values of MDA, NO. and Cu were observed (p<0.001) whereas the activity of RBC-SOD, levels of Vitamin-C and Zn were significantly decreased in
CaCx patients as compared with healthy controls (p<0.001). Cu/Zn ratio was found to be altered in CaCx patients. From our
findings it can be concluded that the oxidative stress is induced among CaCx patients, which inturn increases the risk of
CaCx. 相似文献
17.
S. Mohanty P. K. Sahu M. K. Mandal P. C. Mohapatra A. Panda 《Indian journal of clinical biochemistry : IJCB》2006,21(1):101-105
This work was undertaken to investigate correlation between oxidative stress and initiation of pathogenesis of pregnancy induced
hypertension (PIH). Fifty primigravidae in age group of 20–35 years and gestational age 28–42 weeks with PIH were taken as
cases. Twenty healthy primigravidae with no medical and surgical complications of pregnancy and with blood pressure ≤140/90
mm Hg served as controls. The cases were again subgrouped as severe preeclampsia (12 in number) and mild pre-eclampsia (38
in number). All of them were evaluated for serum malondialdehyde (MDA), Serum vitamin E and plasma vitamin C levels. The serum
MDA levels were raised significantly in women with mild preeclampsia (P<0.01) and in women with severe preeclampsia (P<0.01)
in comparison to normal primi gravida. The serum vitamin E levels were decreased in primi gravida with mild preeclampsia (p<0.1)
and in primi with severe pre eclampsia (P<0.1) in comparison to normal primi gravida but the fall was not statistically significant.
There was a significant fall (P<0.05) in the vitamin C levels in primi with mild preeclampsia than in the normal primi. The
vitamin C levels in severe preeclamptic patients were lower than the normal primi but the fall was not statistically significant
(P=0.10). The serum MDA and vitamin E showed a negative correlation in all the cases. The serum MDA and plasma vitamin C also
showed a negative correlation in the control and study group. This observation suggests that in hypertensive disorders of
pregnancy there is an imbalance between lipid peroxidation and antioxidant vitamin status because of oxidative stress. The
decreased serum concentrations of the antioxidant vitamins supports the hypothesis that lipid peroxidation is an important
causative factor in the pathogenesis of preeclampsia. The rise in antioxidants is probably to compensate the increased peroxide
load in severe preeclampsia. 相似文献
18.
Nilima N. Dongre Adinath N. Suryakar Arun J. Patil Jeevan G. Ambekar Dileep B. Rathi 《Indian journal of clinical biochemistry : IJCB》2011,26(4):400-406
The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis
related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared
with 30 age matched healthy control subjects. Significantly increased blood lead (364%, P < 0.001) and urinary lead (176%, P < 0.001) levels were observed in automobile workers (study group) as compared to controls. Systolic blood pressure (5.32%,
P < 0.05) and diastolic blood pressure (5.87%, P < 0.05) were significantly increased in the automobile workers as compared to controls. The significantly decreased non-activated
erythrocyte δ-aminolevulinic acid dehydratase (δ-ALAD) (−18.51%, P < 0.01) and activated δ-ALAD (−13.29%, P < 0.05) levels were observed in automobile workers as compared to normal healthy control subjects. But the ratio of activated/non-activated
δ-ALAD was significantly increased (43.83%, P < 0.001) in automobile workers as compared to controls. Excretions of δ-aminolevulinic acid (83.78%, P < 0.001) and porphobilinogen (37%, P < 0.001) in urine were significantly increased in the study group as compared to the controls. In automobile workers heamoglobin
(−11.51%, P < 0.001), hematocrit (−4.06%, P < 0.05), mean corpuscle volume (−3.34%, P < 0.05), mean corpuscle hemoglobin (−5.66%, P < 0.01), mean corpuscle hemoglobin concentration (−7.67%, P < 0.001), red blood cell count (−14.6%, P < 0.001) were significantly decreased and total white blood cell count (11.44%, P < 0.05) increased as compared to the controls. The results of this study clearly indicate that the absorption of lead is
more in automobile workers and it affects on blood pressure, heme biosynthesis and hematological parameters observed in this
study group. 相似文献
19.
Rama Devi Mittal Amita Pandey Balraj Mittal Kailash Nath Agarwal 《Indian journal of clinical biochemistry : IJCB》2002,17(2):1-6
Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet
(18–20 mg/Kg) did not significantly change the gross body weight and tissue weights of brain and liver. Packed cell volume
(PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly
(P<0.001). The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain
decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (P<0.001) in synaptic vesicular membranes from iron-deficient
rats as compared to the controls.3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding
was reduced by 63% in the vesicular membranes of iron deficient animals. These studies in dicate that iron plays an important
functional role in both excitatory and inhibitory neurotransmitter receptors. 相似文献
20.
Asaolu Modupe Fisayo 《Indian journal of clinical biochemistry : IJCB》2007,22(2):93-95
The plasma concentrations of total protein, albumin, immunoglobulins IgG, IgA and IgM and urinary protein were assayed in
250 pregnant Nigerian women with malaria and compared with 250 healthy pregnant women which served as controls. The mean values
of plasma total proteins, albumin, IgG and IgA were significantly lowered (P<0.05) while a slight increase in IgM was observed
in the malaria patients. Urinary proteins value of 23.10±0.50 mg/dl was obtained for the pregnant women with malaria, this
was significantly higher (P<0.05) than that of the controls with the corresponding value of 15.32±0.09 mg/dl. This study has
therefore demonstrated elevations of the urinary and decrease in plasma proteins in gestational malaria. These findings suggest
that the protein profile should be considered in the diagnosis and treatment of malaria. 相似文献