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1.
The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-α were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS.  相似文献   

2.
Polycystic ovarian syndrome is one of the most common hormonally leading cause infertility disorders. The effect of oxidant-antioxidant imbalance on disease progression has been studied in many disorders. The present study was aimed to evaluate prooxidant–antioxidant balance (PAB) in patients with polycystic ovarian syndrome compared to healthy subjects. We also studied the possible effect of treatment with available drugs on serum PAB. In this case–control study 100 polycystic ovary syndrome (PCOS) patients and 100 healthy individuals were enrolled in the study. The laboratory features of patients and controls like as serum LH and FSH concentration and hematological examinations were collected. PAB was evaluated by a colorimetric method. Serum PAB value was significantly higher before treatment compared to after treatment and healthy subjects. PAB values were also higher in subjects with irregular menstrual cycle compared to normal subjects. Our results represented that serum PAB values has an indirect significant correlation with serum LH concentration. We also found that drugs regimen containing spironolactone effectively reduced the serum PAB values. Our results showed that PCOS patients had increased level of PAB and treatment with spironolactone mainly decreases the level of serum PAB. Our results indicate that the measurements of PAB may be used as a potential laboratory marker for assessment of PCOS patients.  相似文献   

3.
Bat Flower ( Taccachantrieri) is a south-west China’s species of a tropical plant genus called Tacca,which features near black flowers,conspicuous involucral bracts andwhisker-like fili form bracteoles.These features have been as-sumed to function as a “deceit syn-drome” in which reproductive struc-tures construct a maze and emit scentto resemble decaying organic mate-rials to attract flies that facilitatecross-pollination. However, throughexperimental studies of the pollina-tion biology a…  相似文献   

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End stage renal disease (ESRD) represents a clinical condition in which there is an irreversible loss of endogenous renal function. Both structural and functional abnormalities of the kidney are associated with increased morbidity, mortality. Bardet–Biedel syndrome (BBS) is one of the rare genetic disorders with prevalence of 1 in 1, 40,000–1 in 1,60,000 worldwide. ESRD in BBS patients is the final stage of the disease, increasing mortality in youth.  相似文献   

5.
Bardet-Biedl syndrome (BBS) is a rare autosomal recessive condition characterized by retinitis pigmentosa, postaxial polydactyly, central obesity, and renal involvement. Renal failure is the commonest cause of death. We report a case of BBS with chronic kidney disease (CKD) at younger age (17 year) from India. This diagnosis should be considered in patients with renal disease and the characteristic phenotype of retinitis pigmentosa, postaxial polydactyly and central obesity. These patients should undergo regular monitoring of renal function test to early diagnosis and treatment of CKD to prevent morbidity and mortality. Renal transplantation is a viable option of renal replacement therapy in these patients. These findings are valuable for comparing phenotype of BBS patients with CKD from various national and international centers.  相似文献   

6.
Theseparationofenantiomers ,whichdemandshighsensitivity ,highselectivityandhighseparationefficiency ,ismainchallengetochemistry ,especiallyanalyticalchemistry .Chromatographytechniques,includingHPLC ,thinlayerchromatography(TLC) ,gaschromatography(GC)andhighp…  相似文献   

7.
GARSAIRSGART is crucial in studies of Down syndrome (DS)-related mental retardation due to its chromosomal location (21q22.1), involvement in de novo purine biosynthesis and over-expression in fetal DS brain postmortem samples. GARSAIRSGART regions important for structure–function were screened for mutations that might alter protein levels in DS patients. Mutation screening relied on multiplex/singleplex PCR-based amplification of genomic targets followed by amplicon size determination/fingerprinting. Serum protein samples were resolved by SDS-PAGE and immunoblotted with a GARS–AIRS–GART monoclonal antibody. No variation in amplicon size/fingerprints was observed in regions encoding the ATP-binding, active site residues of GARS, the structurally important glycine-rich loops of AIRS, substrate-binding, flexible and folate-binding loops of GART or the poly-adenylation signal sequences. The de novo occurrence or inheritance of large insertion/deletion/rearrangement-type mutations is therefore excluded. Immunoblots show presence of GARS–AIRS–GART protein in all patient samples, with no change in expression levels with respect to either sex or developmental age.  相似文献   

8.
动词不定式与动名词都属非谓语动词,用法复杂且灵活,不受人称和数的限制.都可充当主语、表语、宾语、定语等,但也有不同,动词不定式还可作补语、状语,而动名词可作介词宾语、短语动词等.本文就它们在语法、词法、句子结构中的异同作了详尽的比较,提出此看法.  相似文献   

9.
动词不定式与动名词都属非谓语动词,用法复杂且灵活,不受人称和数的限制。都可充当主语、表语、宾语、定语等,但也有不同,动词不定式还可作补语、状语,而动名词可作介词宾语、短语动词等。本文就它们在语法、词法、句子结构中的异同作了详尽的比较,提出此看法。  相似文献   

10.
<正>he year 2014 may prove to be a major turning point in China’s development of world-class science and innovation system.At the mid-term juncture of China’s Medium-and Long-Term Program(MLP)for Science and Technology(ST)development,the Ministry of Science and Technology conducted a comprehensive review and assessment  相似文献   

11.
This article elucidates the background and significance of astronomy, overviews the important progress over the past decade, and points out the main scientific problems for world astronomy. Based on a comparison between China's astronmical facilities, existing and in planing, and the major international facilities, the author proposes some strategies for promoting China's astronomy.  相似文献   

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The common goals and the almost perfect complement of the initiatives taken in parallel at Kunming and at several Max Planck sites could serve as valuable starting points for further promoting the CAS/MPS partnership in all matching areas of ecological research.  相似文献   

14.
Contemporary ICTs such as speaking machines and computer games tend to create illusions. Is this ethically problematic? Is it deception? And what kind of “reality” do we presuppose when we talk about illusion in this context? Inspired by work on similarities between ICT design and the art of magic and illusion, responding to literature on deception in robot ethics and related fields, and briefly considering the issue in the context of the history of machines, this paper discusses these questions through the lens of stage magic and illusionism, with the aim of reframing the very question of deception. It investigates if we can take a more positive or at least morally neutral view of magic, illusion, and performance, while still being able to understand and criticize the relevant phenomena, and if we can describe and evaluate these phenomena without recourse to the term “deception” at all. This leads the paper into a discussion about metaphysics and into taking a relational and narrative turn. Replying to Tognazzini, the paper identifies and analyses two metaphysical positions: a narrative and performative non-dualist position is articulated in response to what is taken to be a dualist, in particular Platonic, approach to “deception” phenomena. The latter is critically discussed and replaced by a performative and relational approach which avoids a distant “view from nowhere” metaphysics and brings us back to the phenomena and experience in the performance relation. The paper also reflects on the ethical and political implications of the two positions: for the responsibility of ICT designers and users, which are seen as co-responsible magicians or co-performers, and for the responsibility of those who influence the social structures that shape who has (more) power to deceive or to let others perform.  相似文献   

15.
Both cancellation and invalidation of the trademark right cause termination of a trademark right.Most national trade- mark laws clearly distinguish the system of trademark can- cellation from that of trademark invalidation.In the current Chinese Trademark Law,however,the concept of"trade- mark right invalidation"is absent.Instead,the term of"can- cellation"is used to refer to the above two circumstances.In fact,"cancellation"as provided for in Article 41 of the  相似文献   

16.
We propose that the effect of trust on knowledge sharing (KS) and knowledge integration (KI) is mediated by organizational identification (OI) and organization-based self-esteem (OBSE). We focus on the relationship among different foci of trust and take into consideration that trust is a culturally dependent variable. We draw from a large-scale questionnaire survey with 50 Chinese companies and find support for our hypotheses in general. The study finds that employees’ trust within the organization is a multifaceted construct that includes their trust in the organization, trust in the supervisor and trust in peers. Trust with these different foci positively impact KS and KI. However, such effects are largely indirect and we find support for our expectation that OI and OBSE function as mediators. We conclude that trust in itself is a precondition but not sufficient condition for the actualization of KS and KI.  相似文献   

17.
This literature review highlights some Social Network Analysis (SNA) concepts applicable to the study of organizational knowledge and, more particularly, to knowledge heterogeneity. Knowledge being all at the same time decentralized and distributed, knowing up to what point knowledge can be heterogeneous or homogeneous across organizational units becomes as important as the question of knowing how to structure the organization. SNA applied to knowledge management thus seems a stimulant for future research in the fields of management.  相似文献   

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