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1.
运动对血管内皮细胞及其活性物质的影响 总被引：1，自引：1，他引：0
谢红 《西安体育学院学报》2001,18(2):38-41
血管内皮细胞及其分泌的生物活性物质 (EDRF和ET)在调节血管张力中发挥着重要作用 ,他们与高血压和AS等心血管疾病的形成有密切的关系。体育运动对血管内皮细胞和生物活性物质产生的影响 ,是运动防治高血压、AS等心血管疾病的生理机制之一。 相似文献
2.
马晓宁 《体育科技文献通报》2011,19(5):119-121
本文采用分类比较法、推理归纳法等文献资料研究的方法,通过研究心血管疾病与内皮素、不同运动对内皮素的影响及其生物学分析,显示,内皮素作为一种丝裂原可导致心血管疾病及疾病的加剧,与心脑血管疾病的发生、发展和演化与内皮素的关系密切;不同运动强度对内皮素水平影响不同。运动训练对血管内皮素的影响机理可能主要是通过运动加快血液循环,增加血管壁面侧压力和切应力,导致血管内皮细胞形态发生改变,引起细胞内部一系列物理化学变化,导致内皮素基因表达的变化,最终引起内皮细胞分泌内皮素的功能发生变化,且与运动强度密切相关。 相似文献
3.
内皮素与心血管疾病的研究进展 总被引：3，自引：0，他引：3
内皮素由多种组织中的血管内皮细胞分泌,有强大持久的血管收缩效应,与高血压、高血脂、高血糖及心肌肥厚有密切的关系。综述了近10年来有关内皮素的研究进展,探讨血浆内皮素在心血管疾病发生发展中的作用以及运动对其影响,为心血管疾病的运动康复提供参考。 相似文献
4.
心血管疾病(cardiovascular disease,CVD)是包括动脉粥样硬化、心力衰竭、心脏缺血后再灌注损伤和心肌梗死等血管和心脏的复杂病症。血管内皮细胞、平滑肌细胞和心肌细胞生理功能障碍是诱发CVD的关键因素。研究表明,运动能够对心脏和动脉的形态、功能起到积极的调控作用,可作为CVD非药物疗法的重要手段之一。运动可通过调控多种运动因子的表达水平,如肌肉分泌的Fstl1、Irisin和MSTN,脂肪分泌的Omentin、Apelin、CTRP3和CTRP9,肝脏分泌的FGF21、ANGPTL3和ANGPTL4等,进而调控血管内皮细胞、平滑肌细胞和心肌细胞的分化、增殖和凋亡,从而发挥其防治CVD作用。本文试图梳理肌肉、脂肪和肝脏分泌的运动因子与调控心脏和动脉功能之间的相关信号通路及其机制,为运动干预防治CVD提供新的思路。 相似文献
5.
血管内皮生长因子具有促进血管内皮细胞分裂的功能,可促进血管内皮细胞的增殖和血管生成,还可增加血管的通透性,在血管的增殖和新生方面有重要作用的心脏促血管内皮生长因子(VEGF,VEGFmRNA)是组织形成因子中极其重要的一种。认识不同形式和强度的运动训练对心肌VEGF不同的影响,为合理安排运动训练提供一定的理论依据。 相似文献
6.
运动与脂蛋白代谢研究进展 总被引：6，自引：0，他引：6
脂蛋白代谢紊乱与心血管疾病密切相关。研究表明，运动对改善脂质代谢，预防和治疗心血管疾病有积极作用。本文回顾了近几年有关运动与脂质、脂蛋白代谢研究的进展。 相似文献
7.
采用文献综述法,分析NADPH氧化酶与心血管疾病病理之关系,及运动激活NADPH氧化酶介导产生的ROS在信息传递、基因转录、细胞生长、凋亡以及调节内皮依赖性一氧化氮合酶脱偶联等血管舒张中的作用相关研究成果.提示:NADPH氧化酶介导产生的ROS是诱发心血管疾病的潜在因子,诱导参与心血管疾病的发生、发展的病理过程.适度运动可适度激活NADPH氧化酶产生的ROS,可作为预防治疗心血管疾病的有效手段. 相似文献
8.
对运动时内皮细胞功能改变的生理机制以及运动对预防和治疗动脉粥样硬化的作用机理的研究进展进行综述，以推动我国今后对该领域的研究。 相似文献
9.
高校大学生运动性猝死原因及预防对策 总被引：2，自引：0，他引：2
通过调查分析近年来高校大学生运动性猝死的案例,认为,大学生运动性猝死发生的主要原因是:心血管疾病和器质性异常;过度疲劳和超负荷运动;缺乏锻炼体力不足;特殊的运动心理等.根据目前预防运动性猝死研究的进展以及对运动性猝死高危群体的预防教育与监督管理,提出应及早识别可能发生运动性猝死的高危学生群体;对运动性猝死的高危学生群体要建立运动前的"互动告知"制度;要掌握特殊的运动保健知识;要重视体育教学过程中的医务监督;要普及运动现场的急救知识等预防对策. 相似文献
10.
运动与内皮细胞内皮素分泌的研究进展 总被引：1，自引：0，他引：1
运动作为一种特殊刺激将引起机体内皮细胞分泌内皮素水平发生改变 ,而内皮素具有强缩血管效应。总结以前不同运动强度、运动形式及运动训练对内皮细胞内皮素分泌的影响 ,以促进今后进一步研究运动过程中内皮素分泌的变化情况 ,从而了解心血管系统对运动过程的适应性。 相似文献
11.
Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an evolutionarily conserved degradation pathway,which is a highly conserved cellular degradation process in which lysosomes decompose their own organelles and recycle the resulting macromolecules.Autophagy is critical in maintaining cardiovascular homeostasis and function, and excessive or insufficient autophagy or autophagic flux can lead to cardiovascular disease. Enormous evidence indicates that exercise training plays a beneficial role in the prevention and treatment of cardiovascular diseases. The regulation of autophagy during exercise is a bidirectional process. For cardiovascular disease caused by either insufficient or excessive autophagy, exercise training restores normal autophagy function and delays the progression of cardiovascular disease.An in-depth exploration and discussion of exercise-mediated regulation of autophagy in the cardiovascular system can broaden our view about the prevention of various autophagy-related diseases through exercise training. In this article, we review autophagy and its related signaling pathways,as well as autophagy-dependent beneficial effects of exercise in cardiovascular system. 相似文献
12.
《运动与健康科学(英文)》2021,10(6):660-674
Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However, the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated. Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection. However, standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective, high-quality animal studies using exercise to prevent and treat cardiovascular diseases. In our review, we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training, emphasizing the appropriate measurements and analysis in these chronic exercise models. We also provide recommendations for optimal design of animal exercise studies in cardiovascular research, including the choice of exercise models, control of exercise protocols, exercise at different stages of disease, and other considerations, such as age, sex, and genetic background. We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. 相似文献
13.
Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao 《运动与健康科学(英文)》2021,10(6):660
Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However, the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated. Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection. However, standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective, high-quality animal studies using exercise to prevent and treat cardiovascular diseases. In our review, we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training, emphasizing the appropriate measurements and analysis in these chronic exercise models. We also provide recommendations for optimal design of animal exercise studies in cardiovascular research, including the choice of exercise models, control of exercise protocols, exercise at different stages of disease, and other considerations, such as age, sex, and genetic background. We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. 相似文献
14.
运动作为一种很好的心脏保护方式,对心血管系统的潜在效应是复杂而矛盾的.自主神经功能调节与心血管疾病密切相关.提高迷走张力,维持自主神经平衡对于心血管疾病的治疗、康复及预防都至关重要.但运动对自主神经的心肌保护作用及机制是什么,不同运动强度、方式对心肌自主神经功能调节的影响规律还不清楚. 相似文献
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16.
脂蛋白(a)[LP(a)] 在结构上类似低密度脂蛋白(LDL) 。血清中Lp(a) 浓度基本上受遗传决定,但有种族差异。Lp(a) 与心血管疾病之间联系有明显的独立性。冠心病是世界许多发达国家中引起死亡的主要因素,运动是预防冠心病的重要手段之一。因此近年来人们开始注意各种运动训练对Lp(a) 浓度的影响,以期探讨运动防治冠心病之机理。结果表明,长期耐力训练可轻度升高Lp(a) 浓度。初步推测,这种运动可能较有利于运动引起的血管微小创伤的修复,与其他血浆脂蛋白的变化一起对防治冠心病(CHD) 有积极作用。急性大强度运动后,可使受试者血Lp(a)浓度下降,表现出组织损伤之应激反应。 相似文献
17.
Pelagia Koufaki Sharlene Greenwood Patricia Painter Thomas Mercer 《Journal of sports sciences》2015,33(18):1902-1907
Chronic kidney disease (CKD) is becoming a serious health problem throughout the world and is one of the most potent known risk factors for cardiovascular disease, which is the leading cause of morbidity and mortality in this patient population. Physical inactivity has emerged as a significant and independent risk factor for accelerated deterioration of kidney function, physical function, cardiovascular function and quality of life in people in all stages of CKD. CKD specific research evidence, combined with the strong evidence on the multiple health benefits of regular and adequate amounts of PA in other cardiometabolic conditions, has resulted in physical inactivity being identified by national and international CKD clinical practice guidelines as one of the multiple risk factors that require simultaneous and early intervention for optimum prevention/management of CKD. Despite this realisation, physical inactivity is not systematically addressed by renal care teams. The purpose of this expert statement is therefore to inform exercise and renal care specialists about the clinical value of exercise therapy in CKD, as well as to provide some practical recommendations on how to more effectively translate the existing evidence into effective clinical practice. 相似文献
18.
R Scott Van Zant Kelly Jo Cape Katrina Roach Janie Sweeney 《Cardiopulmonary Physical Therapy Journal》2013,24(2):18-26
Purpose
The study purpose was to assess perceptions of physical therapists (PTs) regarding the role of physical therapy in cardiovascular disease (CVD) prevention.Methods
A 25-item survey, validated by expert cardiovascular/pulmonary (CVP) PTs, was sent electronically to 2,673 PTs. Each item represented an element of clinical practice behavior: education of CVD/risk factors (EDCVD), administration of primary CVD prevention (PRECVD), identifying underlying CVD/risk factors (IDCVD), monitoring CV status in patients with CVD (MONCVD). Responses were assigned numeric values (strongly agree = 5 to strongly disagree = 1), and mean element scores were analyzed.Results
Most of the 516 respondents were APTA Section members (34% CVP Section, 42% other Section membership) and worked in academia (53%). Items showing a high (> 95%) level of agreement included patient education of smoking (97%) and monitoring exercise intensity (99%), assessing exercise benefits (99%), clinically identifying obesity (97%) and hypertension (97%), and monitoring CV response to exercise (99%). Items failing to reach 80% overall agreement were patient education of CVD medications (79%) and blood chemistry (72%), and assessing CVD family history (75%), patient BMI (60%), and body composition (33%). Identifying underlying CVD (77.2%) was the only practice behavior failing to reach 80% agreement. Outpatient PTs agreed significantly less to all elements vs. academics, and to IDCVD vs. all PTs except home health.Conclusions
Physical therapists support most CVD prevention behaviors, but not given elements of patient education and identifying underlying CVD/risk factors.Key Words: cardiovascular disease, primary disease prevention, secondary disease prevention 相似文献19.
刘路 《体育科技文献通报》2011,19(10):119-121
采用文献资料法,回顾了近年来美国、意大利等国家对运动前心血管疾病筛查体系的相关研究。关国普遍采用美国心脏学会推荐的心血管疾病筛查12要素,意大利着重强调了12导联心电图的作用。大量研究证实,心电图确实在疾病筛查方面起到了积极作用。但它需要耗费大量的医疗资源,且费用过高的特性也被人所质疑,因此如何发挥其效用还有待进一步研究与证实。 相似文献