共查询到20条相似文献，搜索用时 218 毫秒
1.
目的:探讨阿尔茨海默病(AD)和遗忘型轻度认知功能障碍(aMCI)在默认脑网络(DMN)、突显网络(SN)和执行控制网络(ECN)这三个脑网络中的半球间脑功能连接的差异性。创新点:利用体素镜像同伦功能连接(VMHC)来观察AD和aMCI在多个脑网络基础上的半球间功能连接特点。方法:该研究纳入了浙江省人民医院就诊的30例AD患者、14例aMCI患者和18例老年健康对照者,均给予静息态功能磁共振扫描,利用VMHC进行数据分析,联合简易智力状态检查量表(MMSE)和蒙特利尔认知评估量表(MOCA)进行相关分析。结论:(1)位于三个脑网络的异常半球功能连接主要存在于AD组,可以作为AD诊断的一个敏感性指标;(2)VMHC值可以作为预测AD进展包括aMCI发展为AD的一个敏感性指标。 相似文献
2.
基于核独立成分分析的静息态fMRI数据研究（英文） 总被引：1，自引：0，他引：1
为了方便提取静息态默认网络,降低功能核磁共振（fMRI）数据复杂度,克服独立成分分析只适合于源信号线性混合的限制,提出了特征降维和非线性变换的框架.首先采用主成分分析对fMRI信号的时间维度进行降维,将原始维度为153 594×128的fMRI数据降至153 594×5,以达到降低计算复杂度的目的,并保留95%的信息成分.然后利用基于高斯核的非线性独立成分分析即核独立成分分析来分析静息态fMRI数据并提取默认网络.实验结果表明,在分析静息态fMRI数据的过程中,核独立成分分析不仅能准确提取默认网络,而且降低了噪声,所得到的结果优于普通独立成分分析. 相似文献
3.
肌钙蛋白I、CK、CK-MB的测定在心肌损伤性疾病中的诊断价值 总被引：5，自引：0，他引：5
[目的]通过测定心肌梗死、不稳定心绞痛患者的血清肌钙蛋白I(CTNI)、肌酸激酶(CK)及其同工酶(CK-MB),探讨其对早期心肌损伤性疾病的诊断价值.[方法]CTNI的测定利用BeckmanAccess全自动免疫分析仪,采用免疫散射比浊法;CK-MB的测定利用日本OLYMPUSAU400全自动生化分析仪,采用酶法.测定56例急性心肌梗塞(AMI)患者、43例不稳定性心绞痛(UAP)患者和50例健康体检者血清肌钙蛋白I(CTNI)、CK、CK-MB;并作相关统计学分析.[结果]AMI组血清CTNI明显高于正常对照组(P<0.01),敏感度为92.98％,特异性为97.96％,UAP组血清CTNI亦明显高于正常对照组(P<0.01).[结论]肌钙蛋白I联合检测CK、CK-MB,在早期心肌损伤的诊断、疗效检测方面具有重要意义. 相似文献
4.
肌钙蛋白Ⅰ、CK、CK-MB的测定在心肌损伤性疾病中的诊断价值 总被引：5，自引：0，他引：5
[目的]通过测定心肌梗死、不稳定心绞痛患者的血清肌钙蛋白I(CTNI)、肌酸激酶(CK)及其同工酶(CK-MB),探讨其对早期心肌损伤性疾病的诊断价值.[方法]CTNI的测定利用Beckman Access全自动免疫分析仪,采用免疫散射比浊法;CK-MB的测定利用日本OLYMPUS AU400全自动生化分析仪,采用酶法.测定56例急性心肌梗塞(AMI)患者、43例不稳定性心绞痛(UAP)患者和50例健康体检者血清肌钙蛋白I(CTNI)、CK、CK-MB;并作相关统计学分析.[结果]AMI组血清CTNI明显高于正常对照组(P＜0.01),敏感度为92.98%,特异性为97.96%,UAP组血清CTNI亦明显高于正常对照组(P＜0.01).[结论]肌钙蛋白Ⅰ联合检测CK、CK-MB,在早期心肌损伤的诊断、疗效检测方面具有重要意义. 相似文献
5.
目的:探讨自然流产病因.方法:取37例自然流产者新鲜蜕膜组织(被测组)进行IgE水平测定,与41例正常妊娠子宫蜕膜组织(对照组)测定的IgE水平相比较.结果:正常对照组IgE水平(X±S)为1.04±0.30u／ml,被测组IgE水平为3.6±7.05u／ml以正常对照IgE水平(X±2S)为上限,即≥2.1u／ml为升高,被测组中IgE升高者有10例,占27％,IgE水平9.98±13.09u／ml,显著高于正常对照(t=2.60,P<0.05).结论:反复自然流产患者,与子宫局部组织中存在较高浓度的IgE水平有关. 相似文献
6.
目的:探讨高血压病患者动态血压与左心室舒张功能的关系.方法:应用无创动态血压监测系统及彩色多普勒超声心动描记技术对76例老年高血压病患者(高血压组)和20例老年健康体检志愿者(对照组)进行检测,并对检测结果进行分析.结果:①高血压组患者发现有收缩功能不全者11例,占14.5%;舒张功能下降者41例,占53.9%; ②根据二尖瓣血流A峰速度(A)与E峰速度(E)的大小分组,A>E组患者的白天、夜间及24h平均收缩压均高于A相似文献
7.
《东南大学学报》2015,(4)
为了将轻微型肝性脑病(MHE)患者从正常人中区分出来,首先使用独立分量分析(ICA)从静息态f M RI中提取默认网络(DM N),然后使用基于图像模型的多元分析方法(GAM M A),该算法为基于像素水平贝叶斯方法,用来探索默认网络中的功能整合异常现象和临床参数之间的关系.在没有先验知识的前提下,使用5种机器学习的方法(支持向量机,分类回归树,逻辑回归,贝叶斯网络及C4.5)来进行分类.研究发现DMN中功能整合出现异常,并对MHE有很高的预测能力,准确率达到98%.因此,认为基于GAMMA提取的DMN功能整合异常可作为一个简单、客观的神经影像学标志物来区分MHE,并可成为现有MHE诊断方法的有力补充. 相似文献
8.
目的:观察悦容丹内服治疗黄褐斑的临床疗效,重点探讨其对患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平的影响。方法:80例黄褐斑患者随机分成治疗组(40例)、对照组(40例),正常组(38例)。治疗组采用悦容丹口服加外用广谱防晒霜,对照组维生素C片和维生素E胶丸口服加外用广谱防晒霜,治疗12周,正常组不治疗。观察分析临床疗效及不良反应。结果:治疗组有效率95.00%,对照组有效率72.5%,两组相比较有统计学意义(P<0.05);较正常组,治疗组与对照组SOD显著升高、MDA显著降低,差异有显著性(P<0.05);治疗组血清SOD水平治疗后明显高于治疗前,MDA水平治疗后明显低于治疗前,差异有统计学意义(P<0.01);治疗后,治疗组血清SOD、MDA水平改善程度明显优于对照组(P<0.05)。结论:悦容丹对黄褐斑疗效显著,无不良反应。其机制与调控机体SOD、MDA水平有一定相关性,值得临床深入探讨。 相似文献
9.
探讨人绒毛膜促性腺激素(hCG)是否具有垂体促甲状腺激素(TSH)样作用。方法:应用放射免疫方法(RIA)对65例旱孕妇女hCG与甲状腺激素水平进行测定。结果:早孕妇女Ⅰ组(停经35—50天)3,3’,5’-三碘甲状腺原氨酸(rT_3)水平升高,与正常对照组差异显著(P<0.01);早孕妇女Ⅱ组(停经51—80天)甲状腺素(T_4)、游离甲状腺素(FT_4)、rT_3水平均升高,与正常对照组差异显著(P<0.01);而两组早孕妇女的三碘甲状腺原氨酸(T_3)、游离三碘甲状腺原氨酸(FT_3)水平与正常对照组无明显差异(P>0.05)。结论:hCG具有TSH样作用,早孕妇女甲状腺激素水平升高为hCG促使甲状腺功能增强所致。 相似文献
10.
欧阳卫东 《赤峰学院学报(自然科学版)》2012,(23):145-146
目的:观察多潘立酮治疗胃癌术后胃瘫综合症的临床疗效.方法:多潘立酮治疗组14例除常规治疗外,加用多潘立酮.对照组12例给予常规治疗加安慰剂,通过监测胃肠动力恢复时间及正常饮食恢复时间,对其疗效进行分析.结果:多潘立酮治疗组胃肠动力恢复时间和正常饮食恢复时间均早于对照组,两组比较有显著统计学差异(p<0.05).结论:多潘立酮治疗可明显改善胃癌术后胃肠道功能,促进胃瘫恢复. 相似文献
11.
Zheng-luan Liao Yun-fei Tan Ya-ju Qiu Jun-peng Zhu Yan Chen Si-si Lin Ming-hao Wu Yan-ping Mao Jiao-jiao Hu Zhong-xiang Ding En-yan Yu 《Journal of Zhejiang University. Science. B》2018,19(12):924-934
The purpose of this study was to explore the differences in interhemispheric functional connectivity in patients with Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI) based on a triple network model consisting of the default mode network (DMN), salience network (SN), and executive control network (ECN). The technique of voxel-mirrored homotopic connectivity (VMHC) analysis was applied to explore the aberrant connectivity of all patients. The results showed that: (1) the statistically significant connections of interhemispheric brain regions included DMN-related brain regions (i.e. precuneus, calcarine, fusiform, cuneus, lingual gyrus, temporal inferior gyrus, and hippocampus), SN-related brain regions (i.e. frontoinsular cortex), and ECN-related brain regions (i.e. frontal middle gyrus and frontal inferior); (2) the precuneus and frontal middle gyrus in the AD group exhibited lower VMHC values than those in the aMCI and healthy control (HC) groups, but no significant difference was observed between the aMCI and HC groups; and (3) significant correlations were found between peak VMHC results from the precuneus and Mini Mental State Examination (MMSE) and Montreal Cognitive Scale (MOCA) scores and their factor scores in the AD, aMCI, and AD plus aMCI groups, and between the results from the frontal middle gyrus and MOCA factor scores in the aMCI group. These findings indicated that impaired interhemispheric functional connectivity was observed in AD and could be a sensitive neuroimaging biomarker for AD. More specifically, the DMN was inhibited, while the SN and ECN were excited. VMHC results were correlated with MMSE and MOCA scores, highlighting that VMHC could be a sensitive neuroimaging biomarker for AD and the progression from aMCI to AD. 相似文献
12.
Chad M. Sylvester Diana J. Whalen Andy C. Belden Shana L. Sanchez Joan L. Luby Deanna M. Barch 《Child development》2018,89(3):734-745
High shyness during early adolescence is associated with impaired peer relationships and risk for psychiatric disorders. Little is known, however, about the relation between shyness and trajectories of brain development over early adolescence. The current study longitudinally examined trajectories of resting‐state functional connectivity (rs‐fc) within four brain networks in 147 adolescents. Subjects underwent functional magnetic resonance imaging at three different time points, at average ages 10.5 (range = 7.8–13.0), 11.7 (range = 9.3–14.1), and 12.9 years (range = 10.1–15.2). Multilevel linear modeling indicated that high shyness was associated with a less steep negative slope of default mode network (DMN) rs‐fc over early adolescence relative to low shyness. Less steep decreases in DMN rs‐fc may relate to increased self‐focus in adolescents with high shyness. 相似文献
13.
Tehila Nugiel Mackenzie E. Mitchell Damion V. Demeter AnnaCarolina Garza Paul T. Cirino Arturo E. Hernandez Jenifer Juranek Jessica A. Church 《Mind, Brain, and Education》2023,17(2):149-160
English Learners (ELs), students from non-English-speaking backgrounds, are a fast-growing, understudied, group of students in the U.S. with unique learning challenges. Cognitive flexibility—the ability to switch between task demands with ease—may be an important factor in learning for ELs as they have to manage learning in their non-dominant language and access knowledge in multiple languages. We used functional MRI to measure cognitive flexibility brain activity in a group of Hispanic middle school ELs (N = 63) and related it to their academic skills. We found that brain engagement during the cognitive flexibility task was related to both out-of-scanner reading and math measures. These relationships were observed across the brain, including in cognitive control, attention, and default mode networks. This work suggests the real-world importance of cognitive flexibility for adolescent ELs, where individual differences in brain engagement were associated with educational outcomes. 相似文献
14.
孙海艳 《江苏经贸职业技术学院学报》2022,(1):66-68
采用SCL-90和POMS量表对930名高职生进行心理健康和心境测试,并探讨运动群体与非运动群体高职生心理健康、心境的差异,以及运动与性别对心理健康和心境的主效应。研究结果:只有36.6%的高职生属运动群体,且男生运动群体(48.3%)比例远高于女生(17.1%);运动群体心理健康状况优于非运动群体,运动对心境状态主效应显著(P<0.05)。研究结论:运动对促进高职生心理健康、改善心境具有积极作用。 相似文献
15.
王利荣 《西南师范大学学报(人文社会科学版)》2009,35(2):88-92
随着《禁毒法》的实施,统一强制隔离戒毒的管理体制将促使劳教退出现制;戒毒的双重特性是绝大多数成瘾人员因吸毒过错负有接受治疗的义务,因脑部疾患拥有被治疗的权利;强制隔离旨在治疗而非惩戒或者贬损性教育,因而传统的管控模式须让位于真正意义上的治疗模式;但限于制度成本和客观可能,场所强戒应限于有治愈可能且具须与隔离的吸毒成瘾人员。 相似文献
16.
社会规范方法认为,过度估计同辈群体的上网行为会导致网络成瘾。矫正网络成瘾者头脑中不正确的上网社会规范,可以防治网络成瘾行为。该方法重视同辈群体在传播正确上网社会规范中的作用。 相似文献
17.
Heidemarie Laurent 《Parenting, science and practice》2019,19(1-2):94-96
SYNOPSISParental neuroimaging promises to shed light on how humans adapt to the demands of parenthood, but this research is not without challenges. A study in this issue reports differences between mothers’ and non-mothers’ default mode network activation during a goal-oriented task accompanied by human vocalizations. However, they did not find hypothesized differences in response specifically to infant cry, and the reach of conclusions that can be made based on these findings is limited. In my commentary, I present ideas for ways this work could be extended to make more definitive statements about the nature and potential benefits of parental brain adaptations. 相似文献
18.
A paradigm of specialized brain hemisphere processing abilities was used to test cognitive skills and cognitive style in "learning-disabled" (LD) and "normal" children. Results indicate that (1) verbal ability is not a unitary factor, and LD children are deficient in only some aspects of verbal ability; (2) the LD group perform as well as the control group on right-hemisphere tests; (3) LD boys are more field sensitive (field dependent) than the control boys; (4) LD children may be attempting to use a nonverbal information processing mode to deal with academic tasks. The need for information on nonverbal processing skills in order to aid verbal processing is discussed. 相似文献
19.
在日常网络管理维护的工作中,如何有效地监测网络流量而较小地干涉网络运行,是当前网络流量监测的热点。对SNMP网络管理模型及流量监测体系结构进行了介绍,利用MRTG建立了一个采用被动监测方式的流量监测系统。该系统可以实时地通过收集网络上路由器、交换机或者需要被监测设备上的状态数据直观地生成流量向量图,而对网络参数的测量基本上不会影响到网络的正常运行。列举了两个利用流量监测系统的应用实例。 相似文献
20.
五环节教学模式,即“问题激活”“自主探究”“尝试应用”“分组展示”“改进与完善”。基于五环节教学模式的体育微课以“解决体育问题”为核心设计教学内容,将运动知识、技能的掌握过程呈现在不同的问题情境中,并在问题情境中突出五环节,从而增强体育教学的可操作性。 相似文献