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报告１０８例病毒性肝炎患者血清总补体（ＣＨ＿（５０））和Ｃ＿３值的检测结果：急性肝炎的ＣＨ＿（５０）为６８．４±６．１３单位／ｍｌ，Ｃ＿３为１３０．２±６．６７ｍｇ％，均高于正常组（ＣＨ＿（５０）为４８．５±５．７５单位／ｍｌ，Ｃ＿３为１０２±５ｍｇ％），Ｐ＜０．０１；其他类型的肝炎患者组的补体均低于正常组，Ｐ＜０．０１．补体的含量与Ｔ细胞花环（Ｅｔ花环）呈中度相关，与ＧＰＴ呈高度相关，因此测定ＣＨ＿（５０）和Ｃ＿３可作为衡量患者机体免疫功能和判断病毒性肝炎预后的指标之一。 相似文献
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对以上消化道症状而就诊的３２１例慢性胃炎患者行胃镜及幽门螺杆菌（ＨＰ）检测和胃粘膜病理学检查，结果显示慢性萎缩性胃炎的ＨＰ检出率为７６．１％，显著高于慢性浅表性胃炎的检出率５６．３％（Ｐ＜０．０１），ＨＰ感染患者胃粘膜萎缩和肠化生的发生率分别为２６．３％和２９．９％，显著高于无ＨＰ感染者胃粘膜萎缩和肠化生的发生率１２．６％及１９．７％（Ｐ＜０．０１和Ｐ＜０．０５）．且ＨＰ感染与胃粘膜萎缩程度有显著关系，而与肠化生程度和不典型增生无显著关系（Ｐ＞０．０５）．提示ＨＰ感染可以使胃粘膜萎缩和肠化生的发病率升高，并认为ＨＰ感染可能为胃癌发生的危险因素之一． 相似文献
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茶多酚抗突变和消除自由基作用的研究 总被引：6，自引：0，他引：6
采用Ｅ．ＣｏｌｉＳＯＳ显色法，小鼠骨髓细胞微核及染色体畸变试验和体外自由基消除实验等方法测定了茶多酚复合物（ＴＰ）的抗突变和消除自由基作用．结果表明：（１）ＴＰ的终浓度在２．５和５ｍｇ／ｍｌ时，对由阳性致突变物ＭＮＮＧ，ＥＭＳ和ＮａＮ＿３诱导的ＳＯＳ应答反应均具有明显的抑制作用；（２）小鼠每日ｉｇ４０、８０和１２０ｍｇ／ｋｇ剂量的ＴＰ能明显抑制由环磷酰胺（ＣＰ）诱发的骨髓ＰＣＥ的ＭＮＣＦ，三种剂量ＴＰ的抑制率分别为４０．９８％、６６．７６％和６５．９４％；（３）ＴＰ对ＭＭＣ诱发的骨髓细胞染色体畸变（ＣＡ）的抑制率分别为６２．５６％、５５．７１％和４７．９５％；（４）在Ｘ／ＸＯ－ＥＳＲ、Ｘ／ＸＯ／Ｌｕｍｉｎｏｌ－ＢＣＬ和ＩＲ／ＮＢＴ－ＳＰＭ三种模型中ＴＰ对超氧阴离子Ｏ＿２自由基均具有极强的消除作用，消除率分别为９８±６％、９８±１．２％和９５±１．５％，对Ｏ＿２的消除效率明显强于维生素Ｃ和Ｅ，对不同工艺制备的ＴＰ消除活性氧自由基作用的测定结果显示：脱咖啡碱程度高，ＥＧＣ和Ｌ－ＥＧＣＧ含量比例高的ＴＰ－３制剂消除Ｏ＿２的效率最高．因此，ＴＰ消除有害自由基，中断或终止自由基的氧化反应是抗突变，抗肿瘤作用的主要机制 相似文献
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我院自１９９３年３月～１９９９年６月共收治急性口服有机磷中毒１１２例,其中发生反跳７例,占１６％,现报告如下：１ 一般资料：口服有机磷农药中毒１１２例中,男１１例,女１０１例,男：女＝１∶９－２,出现反跳７例中男１例,女６例,男：女＝１∶６,男女发生无明显差异。２ 结果：所有病例反跳前均采用洗胃、导泻、利尿,应用阿托品、解磷定治疗,发生反跳时间均在中毒后１～７天,其中死亡２例,死亡率为２８－６％,死亡时间均在发生反跳的１～６天内。３ 讨论：反跳原因：洗胃不够彻底,有机磷中毒洗胃用液量一般不应低于… 相似文献
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马维志 《内蒙古科技与经济》1998,(4)
１原理①２〔Ａｇ（Ｓ２Ｏ３）２〕３－＋Ｓ２－Ａｇ２Ｓ↓＋４Ｓ２Ｏ２－３②３Ａｇ２Ｓ＋２ＡｌΔ６Ａｇ＋Ａｌ２Ｓ３＋热量注：②反应放出的热量极大,类似铝热反应,可使银在反应中熔为液态而聚集于钳锅底部结为银块。２步骤２．１从医院或照相部购买废定影液后,加入... 相似文献
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美国研究开发政策和投入的新发展 总被引：3，自引：0，他引：3
１９９７年美国全国用于研究与发展（Ｒ＆Ｄ）的经费首次突破了２０００亿美元大关,达到了２０５７亿美元,比１９９６年增长了１２５亿美元,比１９８４年的１０１９．４０亿美元翻了一番。这是美国长期重视Ｒ＆Ｄ的结果。这一数字使美国的Ｒ＆Ｄ在国内生产总值（ＧＤＰ）中所占的比例达到了２．６％（扣除国防方面的因素后,Ｒ＆Ｄ在ＧＤＰ中占２．２％）,创历史最高水平。根据１９９６年度的统计,世界各国科研经费占国民生产总值的比例,居第一位的是瑞典３．６％,其次是日本２．９６％,美国２．５２％,法国２．３１％,德国２．２… 相似文献
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对７０例肺结核患者进行全程管理化疗，在管理中以乡医生，病人家属为主体，均按照我科制定的治疗管理合同协议，为病人进行宣传，监督。病人能坚持定期规则服药，完成全疗程的治疗与检查。随该和记录，化疗结果为痰菌阴转率为９２．６６％，空洞闭合率为８０．５６％，治疗有效率为９７．５６％，在９种方案中疗效最显著的是：初治涂阳方案Ⅱ，２Ｅ３Ｈ３Ｒ３Ｚ３／４Ｈ３Ｒ３；初治涂阳方案甲，４Ｈ３Ｉ３Ｌ１／２；复治涂最方案Ｂ 相似文献
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Chetna Bhatt Zarangis Misra Neelam Goyel 《Indian journal of clinical biochemistry : IJCB》2008,23(1):10-16
Mental Retardation is a condition where complex interactions of intrinsic and extrinsic factors hamper mental and sometimes
physical growth of the child during developmental period. This study was carried out to detect cause of Mental Retardation
in 2000 cases of developmental delay by a multidisciplinary team comprising of a Pediatrician, Cytogeneticist, Biochemist,
Psychologist and Speech and Occupational therapists. The causes for developmental delay are broadly divided into Genetic,
Environmental and Idiopathic (no specific cause found) factors. The complete diagnosis was possible in 1192(60%) cases. Genetic
factors were found in 477(23.8%) cases and environmental factors covered 692(34.6%) cases as a cause of retardation. The most
common genetic cause is chromosomal abnormalities which were found in 355 (17.75%) cases. Another major group comprising of
122 (6.1%) cases was that of the disorders which follow Mendelian inheritance. Autosomal recessive conditions, which covers
majority of metabolic disorders, are detected in 48(2.4%) cases. During this screening the most common inherited metabolic
condition detected is Mucopolysaccharidosis, a Lysosomal Storage Disorder followed by Amino acid abnormalities like Phenylketonuria,
Alkaptonuria and Tyrosinuria. 相似文献
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对３２例肾囊肿做了Ｘ线和Ｂ超分析．显示尿路平片可见肾外形的改变，静脉尿路造影表现出肾盂、肾盏移位、变形的各种形态．并探讨了其形成的机理．通过Ｘ线检查７例肾囊肿误为正常或肾癌，分析造成误诊的原因。Ｂ超检查显示边界清楚的圆形或椭圆形无回声液性暗区，其中仅１例将肾囊肿误诊为肾积水，诊断符合率为９７％（３１／３２）．因此，临床上颖有肾囊肿的影象检查应首选Ｂ超检查，Ｘ线检查能显示肾解剖结构和轮廓，提高对本病的诊断率，并讨论了ＣＴ对肾囊肿诊断的价值。 相似文献
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目的:观察复方两面针通络散外敷治疗神经根型颈椎病的临床疗效。方法:采用回顾性分析的方法,对广西中医药大学第一附属医院2014年6月至2015年6月收治的100例神经根型颈椎病患者,随机分成2组,对照组50例采用常规手法及针刺进行治疗,治疗组50例在对照组手法针刺治疗的基础上应用复方两面针通络散外敷。结果对照组有效率为92%,治疗组有效率100%,2组疗效分析,差异具有统计学意义。结论:复方两面针通络散外敷治疗神经根型颈椎病有较好疗效。 相似文献
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对海北州１９９０￣１９９９年麻疹发病情况进行了分析,结果表明：１０年里共发生麻疹病例５８７例,男性３２０例,占５４．５１％,女性２６７例,占４５．４９％,１９９３年和１９９７年各出现一次流行高峰;发病季节仍以２￣６月为主,占８６．０３％,年龄分布主要在０￣６岁和７￣１５岁组,发病趋向大年龄组。 相似文献
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Rachita Nanda Pramila K. Mishra U. K. Das S. B. Rout P. C. Mohapatra A. Panda 《Indian journal of clinical biochemistry : IJCB》2004,19(1):93-96
Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one
complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde
level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated
falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin
levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication
with rise of lipid peroxides in falciparum malaria induced acute renal failure cases. 相似文献
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Kannapiran M Nisha D Madhusudhana Rao A 《Indian journal of clinical biochemistry : IJCB》2010,25(4):380-384
Serum creatinine (SCr) levels are frequently used as a screening test to assess impaired renal function; however, patients
can have significantly decreased glomerular filtration rate (GFR) with normal SCr values and making the recognition of kidney
dysfunction more difficult. Hence, this study was designed to determine the extent of misclassification of the patients who
have significantly reduced GFR as calculated by reexpressed four variable modification of diet in renal disease (MDRD) equation
but, normal range of SCr. The study included 1040 in and out patients referred by physicians for serum creatinine measurement.
When an exclusion criterion was applied 928 patients were qualified for the study. SCr was measured in 928 patients by a Roche
kinetic compensated Jaffe’s assay. GFR was calculated using reexpressed four variable MDRD study equation. Of the 928 patients
270 (29.1%) had renal dysfunction on the basis of eGFR (<60 ml/min/1.73 m2). However, with SCr only 162 (17.5%) patients had abnormal renal function (>1.5 mg/dl) and SCr values misrepresented (108)
11.6% patients with impaired kidney function. In addition, more females, about 15% were failed to detect by SCr method in
contrast to males of 9%. This study documented that, a large proportion of patients with impaired renal function are not diagnosed
if clinicians rely solely on normal SCr as evidence of normal renal function. Inclusion of eGFR calculated by re-expressed
4 variable MDRD equation may facilitates the early identification and intervention of patients with renal impairment. 相似文献
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Pradeep Naik B. Premsagar M. Mallikarjuna 《Indian journal of clinical biochemistry : IJCB》2015,30(1):94-98
The acute renal failure is the frequent medical complication observed in liver transplant patients. The objective of this study was to determine the cause of acute renal failure in post liver transplant patients. A total of 70 patients who underwent (cadaveric 52, live 18) liver transplantation were categorized based on clinical presentation into two groups, namely hepatorenal failure (HRF, n = 29), and Hepatic failure (HF, n = 41). All the patients after the liver transplant had received tacrolimus, mycophenolate and steroids. We analyzed the modification of diet in renal disease, (MDRD) serum urea, creatinine and albumin before and after 5th and 30th day of liver transplant and data was categorized into survivors and non-survivors group. In HRF survivor group, serum creatinine, and urea levels were high and, albumin, MDRD were low in pre- transplant and reached to normal levels on 30th day of post transplant, and 79.3 % of patients in this group showed resumption of normal kidney function. On the contrary in HRF nonsurvivor group, we did not observed any significant difference and 20.7 % of patients showed irreversible changes after the liver transplant. In HF survivor group, 82.9 % of liver failure patients did not show any deviation in serum creatinine, urea, albumin and MDRD, whereas in HF non survivor group, 17.1 % of liver failure patients who had HCV positive before the transplant developed acute renal failure. The levels of creatinine, urea, albumin and MDRD were normal before the transplant and on day 30th, the levels of albumin and MDRD were significantly low whereas serum urea, creatinine levels were high. In conclusion, based on these observations, an diagnosis and treatment of Acute renal failure is important among the liver transplantation cases in the early postoperative period. 相似文献
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Mungli Prakash Jeevan K. Shetty Sambit Dash Bijay K. Barik Abhirup Sarkar Sharanabasappa M. Awanti Ravindra Prabhu 《Indian journal of clinical biochemistry : IJCB》2008,23(4):404-406
Total thiol status of plasma, especially thiol groups over protein contributes maximum to the plasma antioxidant status of
the body. Serum protein thiols were found to be decreased in various disease conditions including chronic renal failure patients.
Only few studies determined the levels of urinary protein thiols in disease conditions. The current study was designed to
know the levels of urinary protein thiols in patients with different grades of proteinuria. The study was conducted on urine
of 40 healthy controls and 61 cases with proteinuria. Based on proteinuria cases were further divided into two groups; group
I - microproteinuria (150–300 mg protein/d), 32 cases, group II - frank proteinuria (>300 mg protein/d), 29 cases. Urinary
thiol levels were determined by spectrophotometric method using dithionitrobenzoic acid. A significant decrease (p<0.01) in
urinary thiol in group I and group II cases was observed in present study and this decrease was associated with proteinuria. 相似文献
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Shaymaa M. M. Yahya Shadia A. Fathy Zakaria A. El-Khayat Safinaz E. El-Toukhy Ahmed R. Hamed Marwa G. A. Hegazy Heba K. Nabih 《Indian journal of clinical biochemistry : IJCB》2018,33(1):21-30
Hepatocellular carcinoma (HCC) is a hypervascular primary liver cancer characterized by rapid progression, besides, resistance to traditional chemotherapeutic agents. It has been shown that microRNAs play critical roles in regulation of tumor cell sensitivity to drugs through modulating the expression of genes involved in drug transport. The present study investigated whether restoration of miR-122 in HCC cells could alter the cell cycle distribution and the expression of multidrug resistance (MDR)-related genes (ABCB1, ABCC1, ABCG2 and ABCF2). After overexpression of miR-122 in HepG2 cells treated or untreated with doxorubicin doses, total RNAs and protein extracts were isolated for application of QRT-PCR and western blotting techniques. Moreover, cell cycle distribution was monitored by flow cytometry. Our results revealed that, the over expression of miR-122 in HepG2 cells treated or untreated with doxorubicin could modulate the sensitivity of cells to chemotherapeutic drug through downregulation of MDR-related genes, ABCB1 and ABCF2. Interpretation of cell cycle distribution revealed that, the anti-proliferative effect of miR-122 is associated with the accumulation of cells in G0/G1 phase. Moreover, treatment with miR-122 and doxorubicin resulted in high percentage of HCC cells in G0/G1 phase. Taken together, our findings revealed that, overexpression of miR-122 inhibited HCC cell growth by inducing cell cycle arrest and this arrest is associated with down-regulation of MDR-related genes. 相似文献