共查询到20条相似文献,搜索用时 187 毫秒
1.
C. I. Jhala U. V. Shah T. K. Shah B. K. Naik J. D. Dafda 《Indian journal of clinical biochemistry : IJCB》1998,13(1):1-7
Fasting samples of 1329 apparently healthy vegetarian Gujarati population were tested for total cholesterol, triglycerides
and three major fractions of lipoproteins, i.e. high density lipoproteins, low density lipoproteins and very low density lipoproteins.
All the values showed marked increase with the age. Except for serum triglycerides, values differ in males and females in
the age group of above 45 years. Compared to Northern Indian population low density lipoprotein and high density lipoprotein
values were higher, but values of triglycerides and very low density lipoproteins were lower. There is no significant difference
in total cholesterol values. Compared to Southern Indian population low density lipoprotein and very low density lipoprotein
values were higher but values of triglycerides, total cholesterol and high density lipoprotein were lower. All serum lipid
values were significantly lower than the Westem population. The range of values for both the sexes is presented for different
age groups. 相似文献
2.
A. Ray S. L. Dayalu Naik A. K. Bahadur S. T. Pasha R. S. Rautela B. K. Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(1):101-105
Serum levels of various lipid parameters, i.e., triglycerides, total cholesterol, alpha lipoprotein or high density lipoprotein
(HDL)-cholesterol and beta lipoprotein or low density lipoprotein (LDL)-cholesterol were measured in a total of 138 histologically
proven cases of breast cancer along with 146 control women. The mean levels of serum triglycerides, total cholesterol and
LDL-cholesterol were found to be significantly higher in breast cancer cases as compared to controls. However, lower mean
levels of serum HDL-cholesterol and sex-hormone binding glubulin (SHBG) were observed in breast cancer patients than the control
subjects. The results indicate a probable relation between serum lipids and the activity of sex-hormones. Moreover, the study
reflects an overall disturbance of lipid metabolism in the pathological process of breast cancer. 相似文献
3.
A. Dasgupta J. K. Agarwal S. S. Dubey 《Indian journal of clinical biochemistry : IJCB》1992,7(1):33-36
The aim of the present study was to evaluate the serum levels of lecithin cholesterol acyl transferase and lipoprotein cholesterol in hyperthyroid patients. The serum levels of total cholesterol and triacylglycerols were also determined in order to assess the lipid status of these patients. It was observed that serum content of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density liproprotein cholesterol (HDL-C) were significantly lower (P<0.001) in these patients whereas serum triacylglycerols (Tg.) and very low density lipoprotein cholesterol (VLDL-C) (P>0.05) did not show any significant change as compared to control values. However, the serum level of lecithin cholesterol acyl transferase (LCAT) was significantly higher (P<0.001) in these patients. It is concluded that an increased LCAT activity plays a significant role in regulating lipoprotein cholesterol levels in hyperthyroid patients. 相似文献
4.
Effects of three drugs, Gemfibrozil, Diltiazem and lsosorbide dinitrate (ISDN) on various lipid parameters were studied in patients with ischemic heart disease (IHD) with positive treadmill stress response. Gemfibrozil and diltiazem significantly lowered the levels of serum total lipids (TL), triglycerides (TG), phospholipids (PL), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), and incroased the levels of serum high density lipoprotein cholesterol (HDL-C) significantly. However, patients administered with ISDN showed a significant increase in all the lipid parameters except HDL-C, which showed a significant decrease. 相似文献
5.
Ananthakrishnan Ramani Sudhakar S. Nayak A. R. Aroor G. N. Kundaje 《Indian journal of clinical biochemistry : IJCB》1991,6(1):59-64
Both cigarette smoking and propranolol administration significantly alter plasma lipid profile. We examined the relationship
of cigarette smoking and propranolol administration with fasting serum total cholesterol, triglyceride, lipoprotein cholesterol
subfractions (high density, low density, and very low density), Apo-A, Apo-B and ratios obtained from these variables in 42
hypertensive patients. Significantly lower values of HDL cholesterol, Apo-A and HDL-C/total cholesterol and Apo-A/Apo-B ratios
were observed in smokers taking propranolol than non-smokers not taking propranolol. Smokers who were not on propranolol also
had significantly lower values as compared to non-smokers. These findings suggest that smoking may be the more significant
factor responsible for alteration in lipid profile. 相似文献
6.
The level of serum cholesterol (Ch), serum-high density lipoprotein cholesterol (HDLc), serum-low density lipoprotein cholesterol
(LDLc), serum very low density lipoprotein cholesterol (VLDLc), Triglyceride (Tg), Apolipoprotein A-1, B and ratio of Apolipoprotein
A1/B were observed in 151 survivors of myocardial infarction in different age groups. A significant increase was found in
the level of triglyceride, LDLc, apolipoprotein-B and a significant decrease in apolipoprotein-A1 and the ratio of apolipoprotein
A1/B. No significant alteration was found in serum cholesterol, HDLc except in the age group of 31–40 years and 41–50 years
and VLDLc. Thus, serum Apo A-1 and Apo-B may be considerably better markers for coronary artery disease than traditional lipid
parameters. 相似文献
7.
V. S. Choudhary M. D. Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》1989,4(1):31-35
20 male dogs weighing 20–25 kg were assigned an exercise schedule for 2 months. Blood samples were collected before exercise and again at the end of the exercise schedule, thus each dog served as its own control. Physical exercise caused a significant reduction in total lipids, total cholesterol and low density lipoprotein (LDL) cholesterol, whereas unesterified cholesterol (UC), high density lipoprotein (HDL) and very low density lipoprotein (VLDL) cholesterol remained unaffected. However, the ratio of HDL cholesterol to LDL cholesterol raised significantly from 0.36±0.01 to 0.58±0.01. Aerobic exercise also resulted in an increase in creatinine phosphokinase (CPK) level. The results show that aerobic exercise programme can significantly affect serum cholesterol and lipoprotein concentration. 相似文献
8.
Pushpa Durgawale Sangita Patil P. S. Shukla Ajit Sontakke Satish Kakade Sunil Yadav 《Indian journal of clinical biochemistry : IJCB》2009,24(1):30-35
Fasting samples of 914 subjects from healthy population were analyzed for total cholesterol, triglyceride and three major
fractions of lipoproteins i.e. high-density lipoprotein cholesterol, low lipoprotein cholesterol and very low-density lipoprotein
cholesterol. The values obtained were (in mg/dl) 165.7±30.2,88.36±31.2, 44.86±10.68, 101.66±29.8 and 18.11±7.35 respectively.
When these subjects were grouped according to the age and sex, no appropriate differences were observed between most of the
groups. Triglycerides were found to be low and HDL cholesterol was high in female when compared with male of similar age.
Beyond age 40 years cholesterol level and low density lipoprotein cholesterol was found to be gradually increased in case
of women. Minor difference was observed with dietary pattern. Present study suggests that clinical evaluation of patient should
be made on the basis of these reference values for Western Maharashtra population. 相似文献
9.
Vaneet Kaur Minni Verma Amandeep Kaur Shalini Gupta Kamaljit Singh 《Indian journal of clinical biochemistry : IJCB》2012,27(3):290-295
Overnight fasting samples of 1,031 apparently healthy people of Punjab visiting the hospital over a period of 3 years were tested for serum lipid profile. The mean ± SD of serum total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol in mg/dl were 182.2 ± 33.9, 122.4 ± 33.4, 44.1 ± 6.8, 113.9 ± 32.0, 24.6 ± 7.1 respectively. When these subjects were grouped according to age and sex, no appreciable difference was observed between most of the groups. Serum triglycerides were found to be low and HDL-C was high in females when compared with males of similar age and vice versa. With advancing age, total cholesterol and low density lipoprotein cholesterol levels were found to be higher in women. The present study suggests that the obtained lipid values should be taken into consideration during clinical evaluation. 相似文献
10.
目的:观察复方血栓通软胶囊联合阿托伐他汀钙片治疗老年高脂血症的临床疗效。方法:将64例符合纳入标准的高脂血症患者随机分为对照组和观察组,对照组应用阿托伐他汀钙片治疗,观察组应用复方血栓通软胶囊联合阿托伐他汀钙片治疗,两组治疗前后进行疗效比较。结果:治疗后观察组与对照组比较,血清总胆固醇、甘油三脂、低密度脂蛋白明显降低,高密度脂蛋白明显升高,差异均具有统计学意义(P0.05);观察组总有效率为,对照组总有效率为,两组比较差异有统计学意义(P0.05)。结论:复方血栓通软胶囊联合阿托伐他汀钙片治疗老年高脂血症能够迅速降低总胆固醇、甘油三脂、低密度脂蛋白,具有较好的临床疗效,值得广泛推广。 相似文献
11.
Effect of oral administration of 2 ml per day of suspension (in water) of alcoholic extract of whole fruit of Trichosanthes dioica (2%) (=100 g fresh wt.=7 g dry wt.=1/15 g of alcoholic extract) with the help of catheter alongwith basal diet for four weeks have been studied in the normal albino rabbits. It was observed that this extract lowered the blood sugar, total cholesterol, low density lipoprotein cholesterol and triglyceride levels, and increased the high density lipoprotein cholesterol, phospholipid and faecal sterol levels. Such effects are manifested from the very first week of feeding and are statistically significant. 相似文献
12.
Fasting samples of 1396 apparently healthy, middle class Bengali population of Kolkata, West Bengal were tested for total
cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density
lipoprotein cholesterol, over a period of three years. The values obtained were (in mg/dl) 190±33, 132±42, 53±10, 116±30 and
21±7 respectively. When these subjects were grouped according to the age and sex, no appreciable difference were observed
between most of the groups. Triglyceride was found to be low and HDL cholesterol was high in women below 30 years when compared
with men of similar age. Beyond 60 years, cholesterol level as well as low density lipoprotein cholesterol was found to be
gradually increased in case of women. Besides these changes, other minor differences were not statistically significant. It
is suggested that the lipid values of the present study should be taken as a base parameters and the clinical evaluation be
made on the basis of these finding. 相似文献
13.
12hrs fasting samples of 1485 apparently healthy, Assamese population in the age group of 20–80 yrs., mostly from the urban
area of Assam were tested for serum lipid profile that includes total cholesterol, triacylglycerol, high density lipoprotein
cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) over
a period of three years. The values (median and range in mg/dl) obtained were 170 (93–263); 110 (40–256); 40 (23–73); 103
(40–173) and 22 (8–51) respectively. After grouping these subjects according to the age and sex no significant difference
were observed between most of the groups. Median and upper range of total cholesterol, HDL-C and LDL-C were found to be higher
in women than in men in all the age groups. But triacylglycerol and VLDL-C concentrations were observed to be higher in the
men than women except in age group of 61–70 yrs. It can be suggested that lipid values obtained in this study can be used
as the reference value, based on which clinical correlation can be made. 相似文献
14.
This study was undertaken to evaluate the effects of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines
in humans. Twenty adult healthy subjects were supplemented with 1g/day fish oil concentrate capsules for 2 weeks. Fasting
blood samples were taken at baseline and again after 2 week intervention. Fish oil supplementation significantly lowered fasting
serum concentrations of total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (P <
0.01). Also high density lipoprotein increased significantly compared with baseline value (P < 0.01). Fish oil did not significantly
altere the fasting blood glucose concentration but significantly reduced the serum cytokines (P < 0.001). This study demonstrated
that eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) supplementation altered serum lipids, lipoprotein and cytokine
concentrations in normal human subjects even at the small dose of 660 mg of EPA plus DHA per day. It appears that EPA plus
DHA can be a safe and perhaps beneficial supplement to inflammatory diseases. 相似文献
15.
K. K. Reddy T. Ramachandraiah K. Soorya Kumari P. Reddanna K. Thyagaraju 《Indian journal of clinical biochemistry : IJCB》1992,7(2):125-133
The association of serum antioxidatns and lipids was studied in 350 urban individuals with an age range of 40–76 years, in comparison with a control rural sample of equal size. Glutathione Peroxidase (GPx) activity was found to be significantly higher in urban population when compared to rural population. Urban population were characterised by elevated levels of serum cholesterol (SC), low density lipoprotein cholesterol (LDLC) and triglycerides (TG) in comparison with rural population. In urban females both tocopherol (T) and GPx were negatively related with age. The serum lipid levels were found to be increased with age in urban population when compared to rural population. Further the correlation coefficients revealed that LDLC positively (.285:P<.05), and TG inversely (?.512:P<.05) related to ascorbic acid (AA), and an inverse association of SC (?.625:P<.05), high density lipoprotein cholesterol (HDLC) (?.369:P<.05) and LDLC (?.532:P<.05) with T in urban population. In rural population GPx shown a good positive correlation with lipid levels. The results of this study revealed that accumulation of lipids with unaltered antioxidants may be the consequence of urbanization. 相似文献
16.
P. K. Rai D. Jaiswal S. Mehta D. K. Rai B. Sharma Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2010,25(2):175-181
This study deals with the effects of freeze dried rhizome powder of Curcuma longa (C. longa) dissolved in milk on normal as
well as diabetic models. Diabetes of type II and type I was within 3 days of a single administration of doses of 45 and 65
mg kg−1 of streptozotocin respectively. Various parameters such as blood glucose levels, triglycerides, total cholesterol, high density
lipoprotein, very low density lipoprotein, low density lipoprotein, serum glutamic oxaloacetic transaminase, serum glutamic
pyruvate transaminase, alkaline phosphatase, creatinine, hemoglobin, urine protein and urine sugar in addition to body weight
were taken in to consideration and were analyzed after administration of variable doses of rhizome powder. The dose of 200
mg kg−1 was identified as the most effective dose as it increased HDL, Hb and bw (P<0.05) with significant decrease in the levels
of blood glucose, lipid profile and hepatoprotective enzymes (P<0.001). 相似文献
17.
D. Jain A. Ray A. K. Bahadur K. U. Chaturvedi R. Sood S. Sharma S. L. D. Naik B. K. Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(1):42-51
There are numerous growing evidences of resemblance between carcinomas of the breast and prostate. A total of 45 cases of
these two hormone-dependent cancers along with appropriate controls were subjected for status of epidermal growth factor receptors
as well as serum lipid profile. Paraffin embedded tissue sections from aforesald tumours were analysed by immunohistochemical
staining for epidermal growth factor receptor (EGF-R), c-erbB-2 oncoprotein, estrogen receptor (ER) and progesterone receptor
(PgR). Sera from same individuals were studied for serum lipid profile analysis. The study revealed that immunoexpression
of all receptor proteins (EGF-R). c-erbB-2 was significantly higher in breast carcinoma. In addition, mean levels of triglycerides,
total cholesterol, LDL-cholesterol were found to be significantly elevated while the level of HDL-cholesterol was observed
to be lower among patients with breast cancer as compared to matched controls. Further, ER-positive breast cancer cases have
significantly higher mean level of HDL-cholesterol when compared with ER-negative breast cancer patients. Contrary to this,
no alteration in different serum lipid fractions was noticed among the patients with prostate cancer. However, a positive
relationship was noticed between immunoexpressions of EGF-R and c-erbB-2 in prostate cancer. 相似文献
18.
Jayanta De Ananda Mukhopadhyay Pradip Kumar Saha 《Indian journal of clinical biochemistry : IJCB》2006,21(2):165-168
Four groups of subjects: normal healthy normotensive nonpregnant women (Group A), normal normotensive pregnant women (Group
B), women with preeclamptic toxaemia (Group C) and eclamptic women (Group D): with fifty subjects in each group, were investigated
for serum lipid profile in the third trimester of pregnancy. There was significant increase in serum triglyceride and VLDL
cholesterol leve as well as decrease in LDL cholesterol in normal pregnancy, while total cholesterol and HDL cholesterol levels
did not show any statistically significant alteration. The preeclampsia (Group C) was associated with a significant rise in
triglyceride and VLDL cholesterol and fall in HDL cholesterol concentration, while eclamptic women showed significant fall
in HDL cholesterol and rise in LDL cholesterol as compared to normal pregnant women. However, interestingly, elevation of
the ratios of total cholesterol: HDL cholesterol and triglyceride: HDL cholesterol as well as diminuition of the ratio of
HDL cholesterol: VLDL cholesterol showed statistical significance in pregnancy induced hypertension in both Groups C and D,
while eclamptic women showed significant elevation of LDL cholesterol: HDL cholesterol ratio in addition. 相似文献
19.
G. P. Das B. Mandal P. Ghosh C. R. Maity 《Indian journal of clinical biochemistry : IJCB》1993,8(1):39-43
Serum levels of cholesterol, triglyceride, free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol were studied
in 10 undernourished and 10 better nourished diabetic patients at different periods of insulin treatment and in non-diabetic
controls. Serum concentrations of cholesterol, triglyceride and FFA were significantly higher in untreated diabetic patients
than in control but the elevated lipid levels gradually shifted towards normal on insulin treatment. The HDL cholesterol,
on the other hand, was significantly lower in untreated diabetic subjects than those in controls and the HDL cholesterol also
gradually modified on insulin therapy. However, the improvement of all the lipid parameters on insulin treatment was somewhat
delayed in undernourished compared to those of better nourished diabetics. These results, therefore, suggest that malnutrition
interferes with the serum lipid improvement in diabetics on insulin treatment and may make them more prone to develop vascular
complications. 相似文献
20.
S. Mukhopadhyaya D. Sharma R. Shankar 《Indian journal of clinical biochemistry : IJCB》1995,10(2):93-97
The serum lipid classes in 75 pregnant women (25 in each trimester) and 25 matched controls were investigated. The lipid classes
studied were very low density lipoproteins (VLDLc), low density lipoproteins (LDLc), high density lipoproteins (HDLc), total
triacylglycerols (Tg), phospholipids (PL) and total cholesterol (Tc). It was found that there is increase in HDLc during first
trimester followed by decrease during second and third trimesters. All other lipid classed including Tc and PL showed a progressive
increase. Analysis of data showed that Tc/HDLc ratio has an increasing trend with parity. LDLc/HDLc also showed similar correlation.
The results of our study indicates that there is likely to be increased risk for CHD in multiparous women as predicted from
serum lipid parameters. 相似文献