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1.
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2.
Background: High-intensity interval training (HIIT) has been shown to improve cardiometabolic health during supervised lab-based studies but adherence, enjoyment, and health benefits of HIIT performed independently are yet to be understood. We compared adherence, enjoyment, and cardiometabolic outcomes after 8 weeks of HIIT or moderate-intensity continuous training (MICT), matched for energy expenditure, in overweight and obese young adults. Methods: 17 adults were randomized to HIIT or MICT. After completing 12 sessions of supervised training over 3 weeks, participants were asked to independently perform HIIT or MICT for 30 min, 4 times/week for 5 weeks. Cardiometabolic outcomes included cardiorespiratory fitness (VO2 peak), lipids, and inflammatory markers. Exercise enjoyment was measured by the validated Physical Activity Enjoyment Scale. Results: Exercise adherence (93.4?±?3.1% vs. 93.1?±?3.7%, respectively) and mean enjoyment across the intervention (100.1?±?4.3 vs. 100.3?±?4.4, respectively) were high, with no differences between HIIT and MICT (p?>?.05). Similarly, enjoyment levels did not change over time in either group (p?>?.05). After training, HIIT exhibited a greater decrease in low-density lipoprotein cholesterol than MICT (?0.66?mmol?L?1 vs. ?0.03?mmol?L?1, respectively) and a greater increase in VO2 peak than MICT (p?<?.05, +2.6?mL?kg?min?1 vs. +0.4?mL?kg?min?1, respectively). Interleukin-6 and C-reactive protein increased in HIIT (+0.5?pg?mL?1 and +?31.4?nmol?L?1, respectively) and decreased in MICT (?0.6?pg?mL?1 and ?6.7?nmol?L?1, respectively, p?<?.05). Conclusions: Our novel findings suggest that HIIT is enjoyable and has high unsupervised adherence rates in overweight and obese adults. However, HIIT may be associated with an increase in inflammation with short-term exercise in this population.  相似文献   

3.
High Intensity Interval Training (HIIT) can be performed with different effort to rest time-configurations, and this can largely influence training responses. The purpose of the study was to compare the acute physiological responses of two HIIT and one moderate intensity continuous training (MICT) protocol in young men. A randomised cross-over study with 10 men [age, 28.3?±?5.5years; weight, 77.3?±?9.3?kg; height, 1.8?±?0.1?m; peak oxygen consumption (VO2peak), 44?±?11?mL.kg?1.min?1]. Participants performed a cardiorespiratory test on a treadmill to assess VO2peak, velocity associated with VO2peak (vVO2peak), peak heart rate (HRpeak) and perceived exertion (RPE). Then participants performed three protocols equated by distance: Short HIIT (29 bouts of 30s at vVO2peak, interspersed by 30s of passive recovery, 29?min in total), Long HIIT (3 bouts of 4?min at 90% of vVO2peak, interspersed by 3?min of recovery at 60% of vVO2peak, 21?min in total) and MICT (21?min at 70% of vVO2peak). The protocols were performed in a randomised order with ≥48 h between them. VO2, HRpeak and RPE were compared. VO2peak in Long HIIT was significantly higher than Short HIIT and MICT (43?±?11 vs 32?±?8 and 37?±?8?mL.kg?1.min?1, respectively, P?P?P?2, HR and RPE than Short HIIT and MICT, suggesting a higher demand on the cardiorespiratory system. Short HIIT and MICT presented similar physiologic and perceptual responses, despite Short HIIT being performed at higher velocities.  相似文献   

4.
Abstract

Post exercise hypotension (PEH) is primarily attributed to post-exercise vasodilation via central and peripheral mechanisms. However, the specific contribution of metabolic cost during exercise, independent of force production, is less clear. This study aimed to use isolated concentric and eccentric exercise to examine the role of metabolic activity in eliciting PEH, independent of total work. Twelve participants (6 male) completed upper and lower body concentric (CONC), eccentric (ECC), and traditional (TRAD) exercise sessions matched for work (3?×?10 in TRAD and 3?×?20 in CONC and ECC; all at 65% 1RM). Blood pressure was collected at baseline and every 15?min after exercise for 120?min. Brachial blood flow and vascular conductance were also assessed at baseline, immediately after exercise, and every 30?min after exercise. ?O2 was lower during ECC compared to CONC and TRAD (?2.7?mL/Kg/min?±?0.4 and ?2.2?mL/Kg/min?±?0.4, respectively p?<?0.001). CONC augmented the PEH response (Peak ΔMAP ?3.3?mmHg?±?0.9 [mean?±?SE], p?=?0.006) through 75?min of recovery and ECC elicited a post-exercise hypertensive response through 120?min of recovery (Peak ΔMAP +4.5?mmHg?±?0.8, p?<?0.001). CONC and TRAD elicited greater increases in brachial blood flow post exercise than ECC (Peak Δ brachial flow +190.4?mL/min?±?32.3, +202.3?mL/min?±?39.2, and 69.6?mL/min?±?19.8, respectively, p?≤?0.005), while conductance increased immediately post exercise in all conditions and then decreased throughout recovery following ECC (?32.9?mL/min/mmHg?±?9.3, p?=?0.005). These data suggest that more metabolically demanding concentric exercise augments PEH compared to work-matched eccentric exercise.  相似文献   

5.
Abstract

Exercise is recognized as a frontline therapy for the prevention and treatment of type 2 diabetes (T2D) but the optimal type of exercise is not yet determined. We compared the effects of high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) for improvement of continuous glucose monitoring (CGM)-derived markers of glycaemic variability, and biomarkers of endothelial cell damage (CD31+ and CD62+ endothelial microparticles (EMPs)) within a population at elevated risk of developing T2D. Fifteen inactive overweight or obese women were randomized to 2 weeks (10-sessions) of progressive HIIT (n?=?8, 4–10X 1-min @ ～90% peak heart rate, 1-min rest periods) or MICT (n?=?7, 20–50?min of continuous activity at ～65% peak heart rate). Prior and three days post-training, fasting blood samples were collected. Both HIIT and MICT improved glycaemic variability as measured by CGM standard deviation (HIIT: 0.82?±?0.39 vs. 0.72?±?0.33?mmol/L; MICT: 0.82?±?0.19 vs. 0.62?±?0.16?mmol/L, pre vs. post) and mean amplitude of glycaemic excursions (MAGE; HIIT: 1.98?±?0.81 vs. 1.41?±?0.90; MICT; 1.98?±?0.43 vs. 1.65?±?0.48, pre vs. post) with no difference between groups. CD62+ EMPs were lower following HIIT (187.7?±?65 vs. 174.9?±?55, pre vs. post) and MICT (170?±?60 vs. 160.3?±?59, pre vs. post) with no difference between groups. There was no change in 24-h mean glucose or CD31+ EMPs. Two weeks of both HIIT or MICT similarly decreased glycaemic variability and CD62+ EMPs in overweight/obese women at elevated risk of T2D.  相似文献   

6.
Abstract

Internal training load refers to the degree of disturbance in psychophysiological homeostasis provoked by a training session and has been traditionally measured through session-RPE, which is the product of the session Rate of Perceived Exertion (RPE) and the duration. External training load refers to the actual physical work completed, and depends on session volume, intensity, frequency and density. Drafting, which is achieved by running closely behind another runner has been demonstrated to reduce the energy cost of running at a fixed speed and to improve performance. Therefore, it is hypothesised that psychophysiological responses might reflect different levels of internal load if training is performed individually or collectively. 16 elite middle-distance runners performed two high-intensity training sessions consisting of 4 repetitions of 500?m separated by 3?min of passive recovery. Sessions were performed individually and collectively. Times for each repetition, RPE, core affect (valence and felt arousal) and blood lactate concentrations [BLa] were measured after each repetition. Main time effect was significant and increased across repetitions for [BLa] and RPE (p?<?0.001), and decreased for valence (p?=?0.001). Main group effect was significant and values were higher when training individually for [BLa] (p?=?0.003) and RPE (p?=?0.001), and lower for valence (p?=?0.001). No differential responses were found between conditions in terms of repeat time or felt arousal. Findings demonstrate that elite middle-distance athletes running collectively display lower levels of internal training load compared to running alone, despite external training load being similar.  相似文献   

7.
Ratings of perceived exertion (RPE: 0–10) during resistance training with varying programming demands were examined. Blood lactate (BLa) and muscle activation (using surface electromyography: EMG) were measured as potential mediators of RPE responses. Participants performed three sets of single arm (preferred side) bicep curls at 70% of 1 repetition maximum over 4 trials: Trial (A) 3 sets?×?8 repetitions?×?120?s recovery between sets; (B) 3 sets?×?8 repetitions?×?240?s recovery; (C) 3 sets?×?maximum number of repetitions (MNR)?×?120?s recovery; (D) 3 sets?×?MNR?×?240?s recovery. Overall body (RPE-O) and active muscle (RPE-AM) perceptual responses were assessed following each set in each trial. Biceps brachii and brachioradialis muscle EMG was measured during each set for each trial. RPE-O and RPE-AM were not different between Trial A (3.5?±?1 and 6?±?1, respectively) and Trial B (3.5?±?1 and 5.5?±?1, respectively) (p?p?相似文献   

8.
This study compared knee angle-specific neuromuscular adaptations after two low-volume isometric leg press complex training programmes performed at different muscle lengths. Fifteen young males were divided into two groups and trained three times per week for 6 weeks. One group (n?=?8) performed 5–7 sets of 3 s maximum isometric leg press exercise, with 4?min recovery, with knee angle at 85°?±?2° (longer muscle-tendon unit length; L-MTU). The other group (n?=?7) performed the same isometric training at a knee angle of 145°?±?2° (180°?=?full extension; shorter muscle-tendon unit length; S-MTU). During the recovery after each set of isometric exercise, participants performed two CMJ every minute, as a form of complex training. Maximum isometric force (MIF) and rate of force development (RFD) were measured over a wide range of knee angles. Countermovement jump (CMJ) performance and maximum half-squat strength (1RM) were also assessed. Training at S-MTU induced a large increase of MIF (22–58%, p?p?p?=?0.001). In contrast, training at L-MTU, resulted in a moderate and similar (≈12.3%, p?=?0.028) improvement of force at all knee angles. CMJ performance and 1RM were equally increased in both groups after training by 10.4%?±?8.3% and 7.8%?±?4.7% (p?相似文献   

9.
The impact of perceived wellness on a range of external load parameters, rating of perceived exertion (RPE) and external load:RPE ratios, was explored during skill-based training in Australian footballers. Fifteen training sessions involving 36 participants were analysed. Each morning before any physical training, players completed a customised perceived wellness questionnaire (sleep quality, fatigue, stress, mood and muscle soreness). Microtechnology devices provided external load (average speed, high-speed running distance, player load and player load slow). Players provided RPE using the modified Borg category-ratio 10 RPE scale. Mixed-effect linear models revealed significant effects of wellness Z-score on player load and player load slow. Effects are reported with 95% confidence limits. A wellness Z-score of ?1 corresponded to a ?4.9 ± 3.1 and ?8.6 ± 3.9% reduction in player load and player load slow, respectively, compared to those without reduced wellness. Small significant effects were also seen in the average speed:RPE and player load slow:RPE models. A wellness Z-score of ?1 corresponded to a 0.43 ± 0.38 m·min?1 and ?0.02 ± 0.01 au·min?1 change in the average speed:RPE and player load slow:RPE ratios, respectively. Magnitude-based analysis revealed that the practical size of the effect of a pre-training perceived wellness Z-score of ?1 would have on player load slow was likely negative. The results of this study suggests that monitoring pre-training perceived wellness may provide coaches with information about the intensity of output that can be expected from individual players during a training session.  相似文献   

10.
This study aimed at comparing the effectiveness of three lifestyle intervention programmes in health clubs “exercise only” (E), “exercise plus nutritional counselling” (E?+?NC), and “exercise plus weight loss program” (E?+?WLP) on weight loss under real-life conditions. An observational multicenter study including 788 overweight/obese new customers of 95 health clubs in Germany was performed. Participants chose E (n?=?512, 38?±?14?year, BMI 30.4?±?4.7?kg/m2), E?+?NC (n?=?179, 42?±?14?year, BMI 31.7?±?4.5?kg/m2), or E?+?WLP (n?=?97, 40?±?11?year, BMI 31.6?±?5.1?kg/m2). Anthropometric data, energy expenditure, and energy intake were assessed at baseline and after 3 months. All groups significantly reduced body weight (E: ?1.5?±?2.9?kg, E?+?NC: ?3.4?±?3.6?kg, E?+?WLP: ?5.5?±?4.3?kg, p?p?p?相似文献   

11.
Running downhill, in comparison to running on the flat, appears to involve an exaggerated stretch-shortening cycle (SSC) due to greater impact loads and higher vertical velocity on landing, whilst also incurring a lower metabolic cost. Therefore, downhill running could facilitate higher volumes of training at higher speeds whilst performing an exaggerated SSC, potentially inducing favourable adaptations in running mechanics and running economy (RE). This investigation assessed the efficacy of a supplementary 8-week programme of downhill running as a means of enhancing RE in well-trained distance runners. Nineteen athletes completed supplementary downhill (?5% gradient; n?=?10) or flat (n?=?9) run training twice a week for 8 weeks within their habitual training. Participants trained at a standardised intensity based on the velocity of lactate turnpoint (vLTP), with training volume increased incrementally between weeks. Changes in energy cost of running (EC) and vLTP were assessed on both flat and downhill gradients, in addition to maximal oxygen uptake (?O2max). No changes in EC were observed during flat running following downhill (1.22?±?0.09 vs 1.20?±?0.07?Kcal?kg?1?km?1, P?=?.41) or flat run training (1.21?±?0.13 vs 1.19?±?0.12?Kcal?kg?1?km?1). Moreover, no changes in EC during downhill running were observed in either condition (P?>?.23). vLTP increased following both downhill (16.5?±?0.7 vs 16.9?±?0.6?km?h?1 , P?=?.05) and flat run training (16.9?±?0.7 vs 17.2?±?1.0?km?h?1, P?=?.05), though no differences in responses were observed between groups (P?=?.53). Therefore, a short programme of supplementary downhill run training does not appear to enhance RE in already well-trained individuals.  相似文献   

12.
Recently, there has been growing interest in high-intensity interval training (HIT) as a strategy to improve health. In this pilot study, we examined the feasibility of a 4-week low-volume HIT and its effects on cardiorespiratory fitness (CRF), blood pressure (BP) and enjoyment in overweight and obese youth. Twelve adolescents (body mass index (BMI): 34.8 ± 3.9 kg · m?2, 14.9 ± 1.5 years) participated in 12 sessions of HIT (10 × 60 s cycling bouts eliciting ~90% maximal heart rate, interspersed with 90 s recovery, 30 min/session, 3 sessions/week) over ~4 weeks. All the participants completed the study and exercise attendance averaged 92%. Despite no changes in body weight and total fat, HIT resulted in significant (P < 0.01) increases in CRF (pre: 20.1 versus post: 22.2 ml · kg?1 · min?1) and exercise time (pre: 425 versus post: 509 s) during peak oxygen uptake test, and a reduction in resting systolic BP (pre: 115.8 versus post: 107.6 mmHg). The majority of study participants (83%) enjoyed HIT and more than half of the participants (58%) reported that HIT is a more enjoyable form of exercise compared to other types of exercises. Low-volume HIT is a useful strategy to promote exercise participation and improve cardiovascular health in overweight and obese youth.  相似文献   

13.
Aim: The aim of this study was to examine the relationship between ventilatory adaptation and performance during altitude training at 2700?m. Methods: Seven elite cyclists (age: 21.2?±?1.1?yr, body mass: 69.9?±?5.6?kg, height 176.3?±?4.9?cm) participated in this study. A hypoxic ventilatory response (HVR) test and a submaximal exercise test were performed at sea level prior to the training camp and again after 15 d at altitude (ALT15). Ventilation (VE), end-tidal carbon-dioxide partial pressure (PETCO2) and oxyhaemoglobin saturation via pulse oximetry (SpO2) were measured at rest and during submaximal cycling at 250?W. A hill climb (HC) performance test was conducted at sea level and after 14 d at altitude (ALT14) using a road of similar length (5.5–6?km) and gradient (4.8–5.3%). Power output was measured using SRM cranks. Average HC power at ALT14 was normalised to sea level power (HC%). Multiple regression was used to identify significant predictors of performance at altitude. Results: At ALT15, there was a significant increase in resting VE (10.3?±?1.9 vs. 12.2?±?2.4?L·min?1) and HVR (0.34?±?0.24 vs. 0.71?±?0.49?L·min?1·%?1), while PETCO2 (38.4?±?2.3 vs. 32.1?±?3.3?mmHg) and SpO2 (97.9?±?0.7 vs. 94.0?±?1.7%) were reduced (P?VE at altitude as significant predictors of HC% (adjusted r2?=?0.913; P?=?0.003). Conclusions: Ventilatory acclimatisation occurred during a 2 wk altitude training camp in elite cyclists and a higher HVR was associated with better performance at altitude, relative to sea level. These results suggest that ventilatory acclimatisation is beneficial for cycling performance at altitude.  相似文献   

14.
Abstract

This study investigated the effects of upper-body repeated-sprint training in hypoxia vs. in normoxia on world-level male rugby union players’ repeated-sprint ability (RSA) during an international competition period. Thirty-six players belonging to an international rugby union male national team performed over a 2-week period four sessions of double poling repeated-sprints (consisting of 3 × eight 10-s sprints with 20-s passive recovery) either in normobaric hypoxia (RSH, simulated altitude 3000 m, n?=?18) or in normoxia (RSN, 300 m; n?=?18). At pre- and post-training intervention, RSA was evaluated using a double-poling repeated-sprint test (6 × 10-s maximal sprint with 20-s passive recovery) performed in normoxia. Significant interaction effects (P?<?0.05) between condition and time were found for RSA-related parameters. Compared to Pre-, peak power significantly improved at post- in RSH (423?±?52 vs. 465?±?69 W, P?=?0.002, η²=0.12) but not in RSN (395?±?65 vs. 397?±?57 W). Averaged mean power was also significantly enhanced from pre- to post-intervention in RSH (351?±?41 vs. 388?±?53 W, P?<?0.001, η²=0.15), while it remained unchanged in RSN (327?±?49 vs. 327?±?43 W). No significant change in sprint decrement (P?=?0.151, η²?=?0.02) was observed in RSH (?17?±?2% vs. ?16?±?3%) nor RSN (?17?±?2% vs. ?18?±?4%). This study showed that only four upper-body RSH sessions were beneficial in enhancing repeated power production in international rugby union players. Although the improvement from RSA to game behaviour remains unclear, this finding appears of practical relevance since only a short preparation window is available prior to international games.  相似文献   

15.
Parkour is a modern physical activity that consists of using the environment, mostly urban, as a playground of obstacles. The aims of this study were (i) to investigate age, anthropometric and training characteristics of Parkour practitioners, called ‘traceurs’ and (ii) to assess jump performances and muscular characteristics of traceurs, compared to those of gymnasts and power athletes. The mean age of the population of traceurs studied (n?=?130) was 19.4?±?4.3 years, women represented 12.4% of the total field and mean training volume was 8.1?±?0.5?hours/week. Vertical and long jump performances were analysed on smaller samples of participants (four groups, n?=?15 per group); and eccentric (?90°?s?1, ?30°?s?1), concentric (30°?s?1, 90°?s?1) and isometric knee extensors torques were evaluated by means of an isokinetic dynamometer. Traceurs showed greater (P?P?P?P?相似文献   

16.
There is limited research studying fluid and electrolyte balance in rugby union players, and a paucity of information regarding the test–retest reliability. This study describes the fluid balance of elite rugby union players across multiple squads and the reliability of fluid balance measures between two equivalent training sessions. Sixty-one elite rugby players completed a single fluid balance testing session during a game simulation training session. A subsample of 21 players completed a second fluid balance testing session during an equivalent training session. Players were weighed in minimal clothing before and after each training session. Each player was provided with their own drinks which were weighed before and after each training session. More players gained body weight (9 (14.8%)) during training than lost greater than 2% of their initial body mass (1 (1.6%)). Pre-training body mass and rate of fluid loss were significantly associated (r?=?0.318, p?=?.013). There was a significant correlation between rate of fluid loss in sessions 1 (1.74?±?0.32?L?h?1) and 2 (1.10?±?0.31?L.?h?1), (r?=?0.470, p?=?.032). This could be useful for nutritionists working with rugby squads to identify players with high sweat losses.  相似文献   

17.
β-hydroxy-β-methylbutyrate (calcium: HMB-Ca and free acid: HMB-FA) and α-hydroxyisocaproic acid (α-HICA) are leucine metabolites that have been proposed to improve body composition and strength when combined with resistance exercise training (RET). In this double-blind randomized controlled pragmatic trial, we evaluated the effects of off-the-shelf supplements: α-HICA, HMB-FA and HMB-Ca, on RET-induced changes in body composition and performance. Forty men were blocked randomized to receive α-HICA (n?=?10, fat-free mass [FFM]?=?62.0?±?7.1?kg), HMB-FA (n?=?11, FFM?=?62.7?±?10.5?kg), HMB-Ca (n?=?9, FFM?=?65.6?±?10.1?kg) or placebo (PLA; n?=?10, FFM?=?64.2?±?5.7?kg). The training protocol consisted of a whole-body resistance training routine, thrice weekly for 8 weeks. Body composition was assessed by dual-energy x-ray absorptiometry (DXA) and total body water (TBW) by whole-body bioimpedance spectroscopy (BIS), both at baseline and at the end of weeks 4 and 8. Time-dependent changes were observed for increase in trunk FFM (p?相似文献   

18.
ABSTRACT

High-intensity interval training (HIIT) has been proposed as a time-efficient exercise protocol to improve metabolic health, but direct comparisons with higher-volume moderate-intensity continuous training (MICT) under unsupervised settings are limited. This study compared low-volume HIIT and higher-volume MICT interventions on cardiometabolic and psychological responses in overweight/obese middle-aged men. Twenty-four participants (age: 48.1±5.2yr; BMI: 25.8±2.3kg·m?2) were randomly assigned to undertake either HIIT (10 X 1-min bouts of running at 80–90% HRmax separated by 1-min active recovery) or MICT (50-min continuous jogging/brisk walking at 65–70% HRmax) for 3 sessions/week for 8 weeks (2-week supervised + 6-week unsupervised training). Both groups showed similar cardiovascular fitness (VO2max) improvement (HIIT: 32.5±5.6 to 36.0±6.2; MICT: 34.3±6.0 to 38.2±5.1mL kg?1 min?1, p < 0.05) and %fat loss (HIIT: 24.5±3.4 to 23.2±3.5%; MICT: 23.0±4.3 to 21.5±4.1%, p< 0.05) over the 8-week intervention. Compared to baseline, MICT significantly decreased weight and waist circumference. No significant group differences were observed for blood pressure and cardiometabolic blood markers such as lipid profiles, fasting glucose and glycated haemoglobin. Both groups showed similar enjoyment levels and high unsupervised adherence rates (>90%). Our findings suggest that low-volume HIIT can elicit a similar improvement of cardiovascular fitness as traditional higher-volume MICT in overweight/obese middle-aged men.  相似文献   

19.
The goal of this randomized, double-blind, cross-over study was to assess the acute effects of caffeine ingestion on muscular strength and power, muscular endurance, rate of perceived exertion (RPE), and pain perception (PP) in resistance-trained men. Seventeen volunteers (mean?±?SD: age?=?26?±?6 years, stature?=?182?±?9?cm, body mass?=?84?±?9?kg, resistance training experience?=?7?±?3 years) consumed placebo or 6?mg?kg?1 of anhydrous caffeine 1?h before testing. Muscular power was assessed with seated medicine ball throw and vertical jump exercises, muscular strength with one-repetition maximum (1RM) barbell back squat and bench press exercises, and muscular endurance with repetitions of back squat and bench press exercises (load corresponding to 60% of 1RM) to momentary muscular failure. RPE and PP were assessed immediately after the completion of the back squat and bench press exercises. Compared to placebo, caffeine intake enhanced 1RM back squat performance (+2.8%; effect size [ES]?=?0.19; p?=?.016), which was accompanied by a reduced RPE (+7%; ES?=?0.53; p?=?.037), and seated medicine ball throw performance (+4.3%, ES?=?0.32; p?=?.009). Improvements in 1RM bench press were not noted although there were significant (p?=?.029) decreases in PP related to this exercise when participants ingested caffeine. The results point to an acute benefit of caffeine intake in enhancing lower-body strength, likely due to a decrease in RPE; upper-, but not lower-body power; and no effects on muscular endurance, in resistance-trained men. Individuals competing in events in which strength and power are important performance-related factors may consider taking 6?mg?kg?1 of caffeine pre-training/competition for performance enhancement.  相似文献   

20.
Irisin is a myokine that is thought to be secreted in response to exercise that may help to prevent obesity and maintain normal glucose metabolism. In this study we investigated the associations between irisin and glucose homeostasis in middle-aged, overweight and obese men (n?= 144) with impaired glucose regulation, and the impact of exercise training on these relationships. The participants underwent 12 weeks of resistance or aerobic (Nordic walking) exercise training three times per week, 60 minutes per session. Venous blood (n?=?105) and skeletal muscle samples (n?=?45) were obtained at baseline and post-intervention. Compared to controls, Nordic walking, but not resistance training, increased irisin levels in plasma (9.6?±?4.2%, P?=?0.014; 8.7?± 4.9%, P?=?0.087; respectively) compared to controls. When considering all subjects, baseline irisin correlated positively with atherogenic index of plasma (r?=?0.244, P?=?0.013) and 2-hour insulin levels (r?=?0.214, P?=?0.028), and negatively with age (r?=??0.262, P?=?0.007), adiponectin (r?=??0.240, P?=?0.014) and McAuley index (r?=??0.259, P?=?0.008). Training-induced FNDC5 mRNA changes were negatively correlated with HbA1c (r?=??0.527, P?=?0.030) in the resistance training group and with chemerin in the Nordic walking group (r?=??0.615, P?=?0.033). In conclusion, 12-weeks of Nordic walking was more effective than resistance training in elevating plasma irisin, in middle-aged men with impaired glucose tolerance. Thus, the change in irisin in response to exercise training varied by the type of exercise but showed limited association with improvements in glucose homeostasis.  相似文献   

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