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1.
非职业暴露后预防(nPEP)是指包括对性暴露后与静脉药物注射暴露后的预防H IV感染的措施.应该尽可能早的开始(暴露后72 h内),用多种药物联合治疗连续28 d.nPEP中心理咨询也是重要的组成部分.抗逆转录病毒治疗首选2个核苷类逆转录酶抑制剂.相对于职业暴露来说nPEP在预防H IV感染方面没有很好的效果.容易失败的原因主要有:①延时治疗;②非职业暴露者对PEP治疗依从性差;③反复多次发生暴露;④进行肛交是预防H IV感染所面临的一个严峻的问题;⑤不合理的药物组合. 相似文献
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陈敬成 《河北北方学院学报(医学版)》2006,23(5):61-62
目的：调查分析CO2治疗尖锐湿疣术后复发情况。方法：随访有完整资料的复发病人37例。结果：CO2治疗尖锐湿疣术后复发可能原因主要是治疗不彻底、感染、隐性感染或再感染。结论：为预防CO2治疗尖锐湿疣术后复发，激光治疗应选择适应证．且达到一定的范围和深度，对于感染部位同时治疗.尽量减少隐性（潜伏）感染导致的复发，避免再感染。 相似文献
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《赣南师范学院学报》2021,(3):53-59
血吸虫病严重危害人类健康.当前血吸虫病的治疗依赖于吡喹酮,长期、大规模使用吡喹酮存在耐药性风险,开发新型抗血吸虫药物具有重要意义.文章主要综述近十年来抗血吸虫药物的研究新进展,重点介绍吡喹酮衍生物、天然抗血吸虫药物、一些现有药物、金属有机配合物以及酶抑制剂等抗血吸虫活性研究,认为开发新的药物作用靶标是今后抗血吸虫药物研制的发展趋势. 相似文献
4.
目的：探讨泌尿系统感染性结石的病因、诊断及治疗护理。方法：通过对泌尿系统感染性结石的病因、诊断及治疗的探讨．对治疗泌尿系统感染性结石的诊断以及治疗采取有效的方法。结果：泌尿系感染性结石是由于细菌解体形成结石核心．通过X线平片检查和实验室检查诊断结石,对结石的治疗以外科治疗为主,以药物治疗为辅。结论：采用外科治疗碎石,用抗生素防止结石感染及复发。 相似文献
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禽流感的快速检测技术研究进展 总被引：1，自引：0，他引：1
禽流感是由A型流感病毒引起的一种禽类感染征或疾病综合症,快速诊断和及时监测是控制禽流感的首要步骤.介绍了几种禽流感快速检测技术,包括免疫荧光技术、酶联免疫吸附试验、免疫胶体金技术、分子生物学诊断技术和RT-LAMP检测技术等.并对禽流感快速诊断技术的发展趋势进行了评述. 相似文献
6.
李大鹏 《赤峰学院学报(自然科学版)》2013,(2):147-148
目的:乳腺叶状肿瘤临床酷似纤维腺瘤,分析其临床病理特点并与乳腺纤维腺瘤鉴别.方法:对比治疗的乳腺叶状肿瘤和纤维腺瘤患者,回顾性分析临床特点.结果:所有患者均经手术治疗,术后5年生存率100%,乳腺叶状肿瘤术后复发率14.28%,纤维腺瘤术后复发率2.50%,分叶状肿瘤的误诊率37.5%.结论:临床表现不易鉴别,诊断主要依靠病理组织检查.术前空芯针穿刺为最佳方法.治疗均以手术切除为主.叶状肿瘤临床具有恶性倾向,手术要求切缘净.主要并发症是局部复发,其原因为手术技术所致.局部切除后反复复发者应行乳房切除. 相似文献
7.
《赤峰学院学报(自然科学版)》2017,(12)
口腔颌面间隙感染是一种常见的病症,最为常见的感染部位为颌下间隙.口腔颌面部间隙感染患者一般采用综合治疗的方法,全身治疗措施包括原发感染灶的处理、抗菌药物的使用、支持疗法、对症疗法以及口腔护理方法等,本文对此进行了分析探讨. 相似文献
8.
口吃复发的研究进展述评 总被引：2，自引：0，他引：2
本文总结了口吃治疗后的长期效果或复发方面的研究。有数据基础的研究表明,有两种研究复发的方法,第一种方法试图分离复发的预测因素。虽然一些因素有一定的预测作用,如治疗前口吃的严重性,治疗结束时即时的焦虑水平,但是,很少有因素能独立、可靠地预测口吃复发。研究表明,几个因素结合起来能可靠地预测复发。这些因素包括口吃频率、言语速度、人格、控制点、言语方式以及参加抗复发活动等;第二种方法是评定抗复发策略的有效性,抗复发策略具有减少复发危险的潜在价值,具有重要的研究和治疗的意义。 相似文献
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Dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation in humans 总被引：2，自引：0，他引：2
Weng XC Zhou L Fu YY Zhu SM He HL Wu J 《Journal of Zhejiang University. Science. B》2005,6(9):869-872
INTRODUCTION Rocuronium bromide is a new steroidal nonde- polarizing neuromuscular blocking drug that has a faster onset of action than other nondepolarizing neuromuscular blocking drugs. The liver is the major route for its elimination. On the other hand, impaired liver function does not alter either atracurium’s elimination or plasma clearance (Ward and Neill, 1983; Pitter et al., 1990). The exclusion of the hepatic circulation and function during the anhepatic phase of orthotopic liv… 相似文献
12.
Weng Xiao-chuan Zhou Liang Fu Yin-yan Zhu Sheng-mei He Hui-liang Wu Jian 《浙江大学学报(A卷英文版)》2005,6(9):869-872
Objective: To compare the dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver
transplantation (OLT) in humans. Methods: Twenty male patients undergoing liver transplantation were randomly assigned to
two comparable groups of 10 patients each to receive a continuous infusion of rocuronium or atracurium under intravenous balanced
anesthesia. The response of adductor pollicis to train-of-four (TOF) stimulation of unlar nerve was monitored. The infusion
rates of rocuronium and atracurium were adjusted to maintain T1/Tc ratio of 2%–10%. The total dose of each drug given during
each of the three phases of OLT was recorded. Results: Rocuronium requirement, which were (0.468±0.167) mg/(kg·h) during the
paleohepatic phase, decreased significantly during the anhepatic phase to (0.303±0.134) mg/(kg·h) and returned to the initial
values at the neohepatic period ((0.429±0.130) mg/(kg·h)); whereas atracuruim requirements remained unchanged during orthotopic
liver transplantation. Conclusions: This study showed that the exclusion of the liver from the circulation results in the
significantly reduced requirement of rocuronium while the requirement of atracurium was not changed, which suggests that the
liver is of major importance in the clearance of rocuronium. A continuous infusion of atracurium with constant rate can provide
stable neuromuscular blockade during the three stages of OLT. 相似文献
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Objective
To compare biliary complications after biliary tract reconstruction with or without T-tube in orthotopic liver transplantation 相似文献14.
Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I: syngeneic
control (Wistar-to-Wistar); Group II: acute rejection (SD-to-Wistar); Group III: Thymic inoculation of SD rat LSA day 7 before
transplantation. The observation of common situation and survival time, rejection grades, NF-κB activity of splenocytes and
IL-2mRNA expression of grafted liver were used to analyze acute rejection severity and immune state of animals in different
groups. The common situation of group I was very well after transplantation and no signs of rejection were found. Recipients
of group II lost body weight progressively All dead within day 9 to day 13 posttransplantation; median survival time was 10.7
±0.51 days. It was an optimal acute rejection control. As for group III, 5 out of 6 recipients survived for a long time and
common situation was remarkably better than that of group II. Its rejection grades were significantly lower than that of group
II(P<0.05). NF-κB activity was only detected in group I at day 5 and day 7 after transplantation, whereas high activity of NF-κB
was detected at all time points in groupII and the low NF-κB activity detected in group III was significantly lower than that
of group II (P<0.05). No IL-2mRNA expression was detected at any time point in group I, whereas high level expression was detected at all
time points in group II and the low level expression only detected at day 3 in group III was significantly lower than that
of group II (P<0.05). Conclusion: LSA is an important transplantation antigen which is involved directly in the immunorejection of liver
transplantation. We report here for the first time that intrathymic inoculation of LSA can alleviate the rejection of liver
allotransplantation; and that grafts can survive for a long time thereby, thus leading to a novel way to achieve liver transplantation
immunotolerance.
Project (NO. 011106206) supported by the Science and Technology Bureau of Zhejiang Province Foundation 相似文献
15.
Objective: To assess the feasibility and outcome of orthotopic liver transplantation (OLT) with no veno-venous bypass(v-v
bypass) in adult patients. Methods: Between 1999 and 2001, 43 adult patients underwent OLT with v-v bypass, 33 with no v-v
bypass. The operation time, anhepatic time, amount of blood loss, amount of blood transfusion, ICU stay days of the two groups
were compared; renal function and gastrointestinal function in the two groups were examined. Results: There was no significant
difference in mean serum creatinine on day 3 and gas discharge time in patients with v-v bypass or not. With no v-v bypass,
the average operation time was 5.7±1.3 hours, anhepatic time was 64±13 minutes, median amount of blood loss in operation was
4000±820 mL, median amount of blood transfused intraoperatively was 4650±910 mL, median ICU stay was 5.7 days; all those were
lower or shorter than those with v-v bypass; and these differences between the two groups had statistical significances. Conclusion:
OLT with no v-v bypass is safe and can be performed in the majority of adult patients. The practice of liver transplantation
with no v-v bypass is associated with shorter total operation time, shorter anhepatic time, lower blood product usage, and
shorter ICU stay compared with standard technique of OLT with routine use of v-v bypass.
Project supported by Zhejiang Provincial Health Bureau (No.2000/ZD003) 相似文献
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Lipids changes in liver cancer 总被引：9，自引：1，他引：8
Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus （HBV） and hepatitis C virus （HCV）. HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer. 相似文献
18.
JIANG Jing-ting? XU Ning ZHANG Xiao-ying WU Chang-ping 《Journal of Zhejiang University. Science. B》2007,(6)
Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus (HBV) and hepatitis C virus (HCV). HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer. 相似文献
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Yang Guo Bo Chen Li-jun Chen Chun-feng Zhang Charlie Xiang 《Journal of Zhejiang University. Science. B》2016,17(11):831-841
Liver fibrosis is the end-stage of many chronic liver diseases and is a significant health threat. The only effective therapy is liver transplantation, which still has many problems, including the lack of donor sources, immunological rejection, and high surgery costs, among others. However, the use of cell therapy is becoming more prevalent, and mesenchymal stem cells (MSCs) seem to be a promising cell type for the treatment of liver fibrosis. MSCs have multiple differentiation abilities, allowing them to migrate directly into injured tissue and differentiate into hepatocyte-like cells. Additionally, MSCs can release various growth factors and cytokines to increase hepatocyte regeneration, regress liver fibrosis, and regulate inflammation and immune responses. In this review, we summarize the current uses of MSC therapies for liver fibrosis and suggest potential future applications. 相似文献