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1.
A. K. Pradhan A. K. Shukla M. V. R. Reddy N. Garg 《Indian journal of clinical biochemistry : IJCB》2004,19(1):83-87
Oxidative stress was assesed by estimating lipid peroxidation product (LPO) in the form of thiobarbituric acid reactive substances
(TBARS), enzymatic antioxidants in the form of superoxide dismutase (SOD), catalase and nonenzymatic antioxidant vitamins
e.g. vitamin C, β carotene and vitamin E in either serum or plasma or erythrocytes in 190 cases of age related cataract in
the age group of 50–80 years. 190 cases were grouped into three morphological types namely, 73 cases of cortical, 77 cases
of posterior subcapsular and 40 cases of nuclear cataract and values of LPO and antioxidants were compared with 78 cases of
age matched healthy control groups. Plasma TBARS levels were cataract cases when compared with control groups. There were
no significant differences in the erythrocyte levels of catalase and plasma levels of Vit E between cataract cases and control
groups. No significant changes of parameters were seen among three different morphological types of age related cataract.
The present study shows that the oxidative stress may play an important role in the age related cataract. 相似文献
2.
Das M Ghose M Borah NC Choudhury N 《Indian journal of clinical biochemistry : IJCB》2010,25(3):295-301
Till date no community based data on plasma homocysteine is available in North Eastern Region. Hence, the present study was
conducted to analyze and correlate the plasma homocysteine level with some life style factors like diet, alcohol intake, smoking
habit and body weight, in a cross-section of population. 12 h fasting samples of 970 apparently healthy, Assamese population
of both genders in the age group of 35–86 years, mostly from the urban area of Assam were tested for plasma total homocysteine
level over a period of 3 years. Out of 970 volunteers, hyperhomocysteinemia was detected in 533 (55%) individuals with a mean
value of 18.41 μmol/l. Of that hyperhomocysteinemia, 89.1% were in the range of moderately high and rest 10.9% were intermediate
high. Another finding was that males had a tendency towards greater value (mean = 20.36 μmol/l) than females (mean = 16.37 μmol/l).
It was observed that the relationship of homocysteine levels to gender and some of the life style factors were also significant. 相似文献
3.
Serge Herve Tiyong Ifoue C. Teugwa Mofor I. Gouado G. Teto T. Asonganyi P. H. Amvam Zollo 《Indian journal of clinical biochemistry : IJCB》2009,24(3):288-293
Oxidative stress is thought to be involved in the pathophysiology of malaria, especially in pregnancy where natural resistance
is markedly reduced. In the present study we investigated oxidative stress in 315 pregnant women out of which 159 had Plasmodium
falciparum malaria and 154 controls. We evaluated the level of lipid peroxidation products (MDA level) in the plasma, the
activity of erythrocyte antioxidant defense enzymes, superoxide dismutase (SOD, EC: 1.15.1.1) and catalase (Cat, EC: 1.11.1.6)
as well as the ability to resist oxidative stress by the FRAP (Ferric Reducing Ability of Plasma) assay. Total erythrocyte
protein levels were also examined. For the two groups of patients, several differences between the biochemical parameters
tested were found. Median parasitaemia in women with malaria was 25,392 parasites/μl of blood (Range1200–82000), while in
controls we had no parasites found in thin and thick smears. Levels of lipid peroxidation products (MDA) were significantly
higher in patients with parasitemia than in healthy asymptomatic volunteers (mean: 0.844 ± 0.290 and 0.384 ± 0.129 respectively,
p<0.001). This MDA level was higher in primigravidea and also correlates well with parasite density (p<0.001). Catalase activity
in erythrocytes of women with malaria did not differ statistically from that of controls. In contrast, SOD activity of patients
with malaria was found to be significantly higher than that of controls (mean: 0.7899 ± 0.2777 and 0.4263 ± 0.2629 respectively,
p<0.05). FRAP values declined, from parasitemic patients (1.4619 ± 0.6565) compare to controls (2.4396 ± 0.8883, p<0.05),
particularly in the first and third trimester of gestation (p<0.05 and p<0.01 respectively). Finally, total erythrocyte protein
concentrations of women with malaria did not differ from that of the controls. Our results suggest an imbalance between oxidants
and antioxidants in pregnant women suffering from malaria, a situation which could lead to severe damage for either the mother
or the fetus. Therefore, further research should be done to assess the potential benefits of antioxidant supplementation for
the pregnant women suffering from malaria. 相似文献
4.
Soma Gupta M. V. R. Reddy B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2004,19(1):138-141
Lipid peroxidation product, malonaldehyde (MDA) and antioxidants were estimated in plasma and erythrocytes of 34 cases of
oral submucous fibrosis (OSMF) of different grades with equal number of healthy controls to evaluate the association of reactive
oxygen species (ROS) and OSMF. While plasma MDA was found to be significantly higher in patients (3.3±0.4 nmole/ml, P<0.001)
as compared to controls (2.4±0.5 nmole/ml), plasma beta carotene and vitamin E levels were found to be decreased significantly
in patients (81.7±14.3 μg/100 ml, P<0.001; 9.3±0.9 mg/L, P<0.01 respectively) with respect to healthy controls (110±20.8 μg/100
ml and 10.1±1.2 mg/L). The decrease in beta-carotene and vitamin E was found to be more significant in OSMF grade II and III
than in grade I. After 6 weeks of oral administration of beta-carotene and vitamin E, patients showed increase in plasma level
of these two antioxidants along with decrease in MDA level associated with clinical improvement. 相似文献
5.
Short-chain acyl-CoA dehydrogenase (ACAD) deficiency is an extremely rare inherited mitochondrial disorder of fat metabolism.
This belongs to a group of diseases known as fatty acid oxidation disorders. Screening programmes have provided evidence that
all the fatty acid oxidation disorders combined are among the most common inborn errors of metabolism. Mitochondrial beta
oxidation of fatty acids is an essential energy producing pathway. It is a particularly important pathway during prolonged
periods of starvation and during periods of reduced caloric intake due to gastrointestinal illness or increased energy expenditure
during febrile illness. The most common presentation is an acute episode of life threatening coma and hypoglycemia induced
by a period of fasting due to defective hepatic ketogenesis. Here, the case of a 4 month old female patient who had seizures
since the third day of her birth and persistent hypoglycemia is described. She was born to parents of second degree consanguinity
after 10 years of infertility treatment. There was history of delayed cry after birth. Metabolic screening for TSH, galactosemia,
17-OHP, G6PD, cystic fibrosis, biotinidase were normal. Tandem mass spectrometric (TMS) screening for blood amino acids, organic
acids, fatty acids showed elevated butyryl carnitine (C4) as 3.40 μmol/L (normal <2.00 μmol/L), hexanoyl carnitine (C6) as
0.92 μmol/L (normal <0.72 μmol/L), C4/C3 as 2.93 μmol/L (normal <1.18 μmol/L). The child was started immediately on carnitor
syrup (carnitine) 1/2 ml twice daily. Limitation of fasting stress and dietary fat was advised. Baby responded well by gaining
weight and seizures were controlled. Until now, less than 25 patients have been reported worldwide. The limited number of
patients diagnosed until now is due to the rarity of the disorder resulting in under diagnosis. 相似文献
6.
K. T. Augusti Regi Jose G. R. Sajitha Paul Augustine 《Indian journal of clinical biochemistry : IJCB》2012,27(1):6-20
This review article on the beneficial uses of Allium antioxidants tries to give some answers to the recent doubts raised by
Singh et al. (Ind J Clin Biochem 25(3):225–243, 2010) against the claim of some researchers that Antioxidants (AOs) are miraculous molecules. Many people still believe that vitamins
like A, C and E are the only true AOs that play important role in the corrections of metabolic derangements in life style
diseases and hence all their faults are attributed to the failures of AOs as a class. This is quite unfair as there are many
other natural AOs that do equal or even better AO action than the vitamins. Such is the case with the Allium S-alkyl sulfoxide
aminoacids and their breakdown products viz, the various poly sulfides and their oxides e.g. allicin and ajoene type compounds
which trap electrons mainly. It is true that antioxidant vitamins and β-carotene a precursor of Vitamin A bring about problems
as prooxidant or as agents that block some metabolic pathways and gene expression. Again the argument that AOs cannot improve
the level of antioxidant enzymes like SOD, catalase and glutathione Px is also not universal. Actually allium AOs can even
spare the use of antioxidant vitamins in the body and enhance the action of antioxidant enzymes and supply of ATP and other
nutrients to the tissues as the former are good vasodialators and promoters of membrane permeability. The use of AOs should
be selective and moderate. Allium AOs satisfy the role of ideal AOs based on many of their invivo and invitro actions reported
by the author and others. Their metabolits can regenerate them and recycle them for a sufficient time in the body. They have
non antioxidant effects also such as antiplatelet, fibrinolytic, antiinflammatory, immunomodulatory, antiageing actions etc.
Plant derived AOs may be more beneficial and better tolerated in their partially purified forms rather than in their absolutely
purified forms as the accompanying principles have some protective and regulatory effects in general. This and other aspects
of allium AOs are discussed in the paper. 相似文献
7.
V. K. Verma V. Ramesh Satyendra Tewari R. K. Gupta Nakul Sinha C. M. Pandey 《Indian journal of clinical biochemistry : IJCB》2005,20(2):68-74
A study has been carried out on 250 CAD patients to see how the serum levels of three antioxidants i.e., Vitamin C, Bilirubin
and Ceruloplasmin are related to the CAD risk factors and characteristics in these patients. The number of severe category
CAD patients declined by 7–18% with increasing serum levels of the three antioxidants and, triple vessel disease declined
by 14–20%. A decline of 39% in Myocardial Infarction (MI) occurred with increasing serum Ceruloplasmin. Serum Ceruloplasmin
was significantly lower in the MI group compared to the non MI group CAD patients. There was a steady and a significant decline
in the mean values of serum levels of cholesterol, Triglyceride, VLDL cholesterol along with BMI with increasing serum level.
The study indicates that with increasing serum levels of the three antioxidants studied, the % MI along with % Triple vessel
disease and severity of CAD goes down suggesting that the modifiable risk factors have to be suitably modified in order to
maintain a reasonably high level of these antioxidants, as the risk factors are inversely related to the serum antioxidant
levels. 相似文献
8.
D. Vijayakumar K. Suresh S. Manoharan Ph.D. 《Indian journal of clinical biochemistry : IJCB》2006,21(1):105-105
The main objective of the study was to assess the oxidative stress in plasma and erythrocytes of rheumatoid arthritis patients
by measuring the levels of thiobarbituric acid reactive substances (TBARS), non-enzymatic antioxidants (vitamin E, C and reduced
glutathione) and enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx)]. This
study has been conducted on twenty-two adult female rheumatoid arthritis patients and an equal number of healthy subjects.
Elevated lipid peroxidation and multidirectional changes in the antioxidant defence system were noticed in patients with rheumatoid
arthritis. The enhanced lipid peroxidation accompanied by disturbance in antioxidant status indicates that rheumatoid arthritis
patients are more prone to free radical mediated oxidative damage. 相似文献
9.
K. K. Reddy T. P. K. Reddy B. V. Somasekharaiah K. Soorya Kumarl 《Indian journal of clinical biochemistry : IJCB》1998,13(1):20-26
Multiple mechanisms underlie the human aging process, but interest continues in the role that free radicals and antioxidants
may play. The concentrations of lymphocyte free radical generation (O2
−& H2O2), DNA damage and antioxidant enzyme levels (glutathione Stransferase, superoxide dismutase and catalase) were evaluated in
110 healthy individuals with an age range of 20–80 years. The antioxidant enzyme levels were significantly less in very old
age when compared to young. Moreover, the levels of free radical concentration and DNA damage were increased in the same age
group with respect to younger group. Cigarette smoking had a positive relation with free radicals and DNA damage, and inverse
relation with antioxidants. On the other hand, body mass was found to have positive relation with free radical generation
only. The data indicate that depletion of antioxidant enzyme levels would render the older people more susceptible to free
radical stress and DNA damage. 相似文献
10.
Santoshi R. Ghodake A. N. Suryakar R. D. Ankush K. Shaikh A. V. Katta 《Indian journal of clinical biochemistry : IJCB》2010,25(1):82-85
Nephrotic syndrome is the common chronic disorder characterized by alteration of permeability of the glomerular capillary
wall, resulting in its inability to restrict the urinary loss of proteins. Nephrotic syndrome is characterized by heavy proteinuria,
hypoalbuminemia, hyperlipidemia associated with peripheral edema. The molecular basis of glomerular permselectivity remains
largely unknown. In recent years it has been proposed that Nephrotic syndrome is a consequence of an imbalance between oxidant
and antioxidant activity. The present study was aimed to test that the reactive oxygen species are the mediators of excessive
protein permeability and other complications of Nephrotic syndrome. For this 30 adults with Nephrotic syndrome were studied.
The control group comprised 30 healthy adults matched for age. Serum levels of lipid peroxides, nitric oxide (NO⊙), α- tocopherol,
ascorbic acid, erythrocyte superoxide dismutase activity, serum albumin, uric acid, cholesterol and plasma total antioxidant
capacity were measured. Student’s ‘t’ test was applied for statistical analysis. There was a significant increase in lipid
peroxide (1.58 ± 0.42 in controls, 3.64 ±1.3 in patients) (P<0.001) levels in study group as compared with controls. α-tocopherol
(12.95 ± 1.04 in controls, 9.93 ± 1.43 in patients) (P<0.001), erythrocyte SOD activity(1.88 ± 0.9 in controls 1.07 ± 0.5
in patients) (P=0.01), serum albumin(4.06 ± 0.50 in controls, 3.04 ± 0.11 in patients) (P<0.001), and plasma total antioxidant
capacity (847.33 ± 126.83 in controls, 684.00±102.94 in patients) (P<0.001) were significantly decreased. There was non-significant
increase in uric acid (P>0.05), a non-significant decrease in NO⊙ (38.48 ± 15.47 in controls 37.47 ± 14.27 in patients) (P>0.05)
and ascorbic acid levels ascorbic acid,( 0.95 ± 0.31in controls 0.79 ± 0.30 in patients) (P>0.05) in study group as compared
with controls. Imbalance between oxidants and antioxidants may contribute to pathogenesis of proteinuria and related complications
in nephrotic syndrome. 相似文献
11.
A total of 41 healthy male pesticide sprayers exposed to different clases of pesticides for 3-5 years were compared with 21
controls matched for age and economic status with respect to free radical generation, lipid peroxidation, antioxidant status,
cholesterol, lipoprotein status and haematological profile. Plasma lipid peroxidation was estimated in the form of thiobarbituric
acid reactive substances (TBARS) produced. Significant increase in TBARS was observed in sprayers population when compared
with control subjects and the level of TBARS increased with increase in the duration of exposure. The levels of antioxidants
such as glutathione (GSH) were significantly depleted, whereas those of superoxide dismutase (SOD) were remarkably increased
than control population. Significant reduction in total cholesetrol, alteration in lipoprotein fractions and nonsignificant
changes in hematological parameters were observed. These results suggested that exposure to pesticidal residual drift augments
the free radical generation, and lipid peroxidation. Decline in non-enzymatic antioxidant and elevation of enzymatic antioxidant
were observed. Supplementation of α-tocopherol for 45 days resulted in the partial restoration of these biochemical changes
produced by pesticides. 相似文献
12.
P Renuka Devi S Krishna Kumari C Kokilavani 《Indian journal of clinical biochemistry : IJCB》2007,22(1):143-147
The effect of the oral administration ofVitex negundo leaf extract on the levels of enzymic and non-enzymic antioxidants were studied in the adjuvant induced arthritic (AIA) rats
The levels of antioxidant enzymes such as SOD, CAT, GPx, G6PD, GSH and Vit-C were estimated in various groups of the experimental
rats. It was observed that the antioxidant enzyme levels in the AIA were significantly low when compared to normal rats. A
significant decrease in enzymic antioxidant—SOD, CAT, GPx, G6PD and non-enzymic antioxidant—GSH, Vit-C were observed in the
liver of AIA rats compared to the normal rats. These results suggest that the leaf extract ofVitex negundo possesses antioxidant activity. 相似文献
13.
Caffeic acid is a well-known phenolic compound widely present in plant kingdom. The aim of this study was to investigate the
possible protective effect of caffeic acid (CA) against oxytetracycline (OXT) induced hepatotoxicity in male Albino Wistar
rats. A total of 30 rats weighing 150–170 g were randomly divided into five groups of six rats in each group. Oral administration
of OXT (200 mg/kg body weight/day) for 15 days produced hepatic damage as manifested by a significant increase in serum hepatic
markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase
(LDH), bilirubin and increased plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide). The present finding
shows that the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase
(GPx) were significantly decreased in OXT intoxicated rats. Upon oral administration of caffeic acid (40 mg/kg body weight/day)
there were decreased hepatic marker activities, bilirubin and lipid peroxidation and increased enzymatic antioxidants in OXT + Caffeic
acid group compared to Normal + OXT group(P < 0.05). Our study suggests that caffeic acid has antioxidant property and hepatoprotective ability against OXT induced toxicity. 相似文献
14.
Oxidative stress in Parkinson’s disease 总被引:1,自引:0,他引:1
Shashikant Nikam Padmaja Nikam S. K. Ahaley Ajit V. Sontakke 《Indian journal of clinical biochemistry : IJCB》2009,24(1):98-101
Oxidative stress contributes to the cascade, leading to dopamine cell degeneration in Parkinson’s disease. However, oxidative
stress is intimately linked to other components of the degenerative process, such as mitochondrial dysfunction, excitotoxicity,
nitric oxide toxicity and inflammation. It is therefore difficult to determine whether oxidative stress leads to or is a consequence
of, these events. Oxidative stress was assessed by estimating lipid peroxidation product in the form of thiobarbituric acid
reactive substances, nitric oxide in the form of nitrite & nitrate. Enzymatic antioxidants in the form of superoxide dismutase,
glutathione peroxidase, catalase, ceruloplasmin and non enzymatic antioxidant vitamins e.g. vitamin E and C in either serum
or plasma or erythrocyte in 40 patients of Parkinson’s disease in the age group 40–80 years. Trace elements e.g. copper, zinc
and selenium were also estimated. Plasma thiobarbituric acid reactive substances and nitric oxide levels were Significantly
high but superoxide dismutase, glutathione peroxidase, catalase, ceruloplasmin, vitamin-E, vitamin-C, copper, zinc and selenium
levels were significantly low in Parkinson’s disease when compared with control subjects. Present study showed that elevated
oxidative stress may be playing a role in dopaminergic neuronal loss in substentia nigra pars compacta and involved in pathogenesis
of the Parkinson’s disease. 相似文献
15.
Vishnu Kumar A. K. Khanna M. M. Khan Ranjana Singh Sushma Singh Ramesh Chander Farzana Mahdi J. K. Saxena Shweta Saxena V. K. Singh R. K. Singh 《Indian journal of clinical biochemistry : IJCB》2009,24(1):65-69
The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract
of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/
kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol,
phospholipid and free fatty acids. Furthermore, the root extract (100–400μg) inhibited the generation of superoxide anions
and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic,
lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia
and related diseases. 相似文献
16.
Ranjana Singh Rajesh K. Singh Anil K. Tripathi Nikhil Gupta Ajai Kumar Anil K. Singh Abbas A. Mahdi Rajendra Prasad Raj K. Singh 《Indian journal of clinical biochemistry : IJCB》2004,19(1):14-20
The circadian periodicity of plasma lipid peroxide levels and activities of superoxide dismutase (SOD), catalase (CAT) and
glutathione peroxidase (GPx) were studied in 50 clinically, bacteriologically and radiologically proven fresh cases of pulmonary
tuberculosis (age: 21–45 years) and 60 age-matched healthy volunteers with diurnal activity from 06∶00 to about 22∶00 and
nocturnal rest. A marked circadian variation in plasma lipid peroxide level was recorded in healthy subjects and pulmonary
tuberculosis patients with significant amplitude and acrophase around 16∶21 and 17∶12 respectively. The acrophase tended to
be delayed in tuberculosis patients. Furthermore, a statistically significant circadian rhythm was found in SOD, CAT and GPx
activities in normal volunteers and pulmonary tuberculopsis patients. SOD and CAT enzyme activity was noted to be maximum
at 06∶00 and minimum at 00∶00 in tuberculosis patients. The circadian acrophase for GPx activity was recorded at 16∶15 in
normals and around 22∶45 in patients. Moreover, the activity was found to be decreased at all sampling hours during 24-hours
sleep-awake period in patients in comparison to healthy counterparts. The MESOR and circadian amplitude also decreased markedly.
The decreased activity of measured antioxidant enzymes in pulmonary tuberculosis patients could probably be associated with
oxidative stress and/or decreased anti-oxidant defensive mechanism in such patients. 相似文献
17.
Gacche RN Shaikh RU Chapole SM Jadhav AD Jadhav SG 《Indian journal of clinical biochemistry : IJCB》2011,26(3):303-308
The study was designed to evaluate the antioxidant activity and effect of Cymbopogon martinii (Roxb.) Wats. (Poaceae) leaves on the activity of monoamine oxidase and kinetics of enzyme inhibition. Ethanol extract of
C. martinii and rat brain mitochondrial monoamine oxidase preparation ware used to study the kinetics of enzyme inhibition using double
reciprocal Lineweaver–Burk plot. The DPPH was used as a source of free radical to evaluate antioxidant potential. It is observed
that, the ethanolic extract of C. martinii inhibits the monoamine oxidase activity with competitive mode of inhibition. The V
max (0.01 mM/min) remained constant while, K
m varied from 21.00 ± 1.1, 43.33 ± 1.5 and 83.33 ± 1.4 mM for 100–500 μg/ml concentration of C. martinii. The K
i values were calculated to be 90.00 ± 0.87, 75.00 ± 0.69, 68.18 ± 0.68 μg for 100–500 μg/ml concentration of C. martini. It also shows a significant DPPH (1,1-diphenyl-2-picryl hydrazine) radical scavenging (IC50 = 0.34 ± 0.05 mg/ml) and reducing activity (IC50 = 0.70 ± 0.22 mg/ml). The C. martini can be considered as a possible source of MAO inhibitor used in the treatment of depression and other neurological disorders. 相似文献
18.
Seema Bhargava R. Parakh L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》2004,19(1):76-78
Homocysteine (Hcy) is a non-protein forming amino-acid, whose metabolism is at the intersection of two metabolic pathways:
remethylation and transsulfuration which are dependent on the vitamins folic acid, B12 and B6, and the enzymes methylenetetrahydrofolate reductase and cystathionine-β-synthetase. A deficiency of any of these vitamins
or enzymes results in hyperhomocysteinemia. This causes oxidative and other damage to blood vessels, thus affecting various
organ systems of the body. As part of our ongoing research on cardiovascular risk factors, we have studied the Hcy levels
in the plasma of normal controls and those suffering from vascular diseases. It was observed that Hcy is significantly higher
in patients of vascular diseases (21.59±1.28 μmol/L, mean±SEM), as compared to normal controls (11.33±0.18 μmol/L). This significance,
was more pronounced in cases of venous thrombosis (26.77±2.43 μmol/L) as opposed to cases of arterial block (17.27±0.84 μmol/L).
This signifies that Hcy estimation would be beneficial in obtaining a differential diagnosis in addition to being a modifiable
vascular risk factor. 相似文献
19.
20.
Rashmi Choudhary K. P. Mishra C. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2006,21(2):107-113
Recent reports on the involvement of calcineurin in cardiac hypertrophy and its susceptibility to free radicals, prompted
us to examine possible beneficial effects of dietary antioxidants in this regard. In continuation of initialin vitro studies revealing eugenol to be a potent calcineurin inhibitor, we investigated its ability to reverse isoproterenol-induced
cardiac hypertrophy in rats. Intraperitoneal administration of isoproterenol (1 mg/kg body wt/day for 10 days) induced cardiac
hypertrophy with increased heart weight and enhanced apoptosis of myocytes concomitant with accumulation of reactive oxygen
species, decreased glutathione contents, increased activities of calcineurin and protein kinase C in ventricular tissue. Administering
eugenol for 3 days (1 mg/kg body wt/twice a day), followed by combined administration of isoproterenol and eugenol resulted
in significant reversal of cardiac hypertrophy and restoration of above changes. These results suggest that eugenol, a natural
antioxidant of dietary origin, may offer potential benefits in the management of cardiac hypertrophy. 相似文献