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1.
K. R. Dave T. H. Patel S. S. Katyare 《Indian journal of clinical biochemistry : IJCB》2001,16(1):81-88
Erythrocyte membrane protein glycosylation increase by 3.4 fold in diabetes. Insulin or sulfonylurea treatment did not reduce
the extent of glycosylation. The serum protein glycosylation was comparable in all the groups including control. Erythrocyte
membrane Na+,K+-ATPase activity decreased in the diabetics; only insulin treatment partly restored the activity. Erythrocyte membrane acetylcholinesterase
activity decreased only in the sulfonylurea treated group. Serum butyrylcholinesterase activity was relatively low in the
diabetic and insulin treated diabetic groups. The Km and Vmax of the two components of Na+,K+-ATPase from erythrocyte membranes were differently affected in the diabetic and the two treatment groups. The Vmax of acetylcholinesterase
decreased only in the sulfonylurea treated group. Diabetic states resulted in decreased Vmax of components I and II of serum
butyrylcholinesterase. In insulin-treated diabetics, component II was absent. Sulfonylurea group resembled diabetics.In vitro incubation with insulin differentially affected the Na+,K+-ATPase and serum butyrylcholinesterase activities. 相似文献
2.
STZ诱导的糖尿病对骨密度和血清睾酮的影响(英文) 总被引:2,自引:0,他引:2
目的:探讨链脲霉素(STZ)诱导的糖尿病对大鼠骨代谢的影响及机制。材料与方法:雄性Wistar大鼠随机分成3组: 正常组(n = 6),糖尿病组(n = 5)和胰岛素治疗糖尿病组 (n = 5)。大鼠尾静脉一次性注射STZ(50 mg/kg 体重),选择空腹12 h血糖大于12 mmol/L的大鼠为本实验所需的糖尿病模型。治疗组大鼠每天在同一时间给予1.8-2.2U的胰岛素。实验周期为持续32天。采用双能X线骨吸收法(DEXA)测定股骨密度,ELISA法测定血清雄性激素睾酮水平,生化分析仪测定血清碱性磷酸酶、钙、磷浓度。结果:糖尿病大鼠的股骨密度和血清睾酮均显著低于正常组(P < 0.01),血清总碱性磷酸酶明显高于正常组和胰岛素治疗组(P < 0.01)。三组之间血钙和血磷的水平无明显差异。胰岛素治疗后糖尿病大鼠的骨密度、血清睾酮与总碱性磷酸酶得到明显的改善。结论:糖尿病严重影响骨密度,胰岛素缺乏及雄性激素降低是导致糖尿病性骨质疏松重要原因。胰岛素治疗能预防骨流失和提高血清睾酮浓度。 相似文献
3.
Present study aimed to evaluate the protective role of the aqueous extract of Phyllanthus niruri (P. niruri) against nimesulide-induced
hepatic disoder in mice by determining levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase
(GPT) and alkaline phosphatase (ALP) in serum and also by measuring the hepatic content of the antioxidant enzymes, superoxide
dismitase (SOD) and catalase (CAT); the free radical scavenger, reduced glutathione (GSH) and thiobarbituric acid reacting
substances (TBARS). Aqueous extract of P. niruri was administered either orally or intraperitoneally in different doses and
times as needed for the experiments. Intraperitoneal of the extract (100 mg/kg body weight for seven days) reduced nimesulide
(750 mg/kg body weight for 3 days) induced increased levels of GOT (37.0±1.8 units/ml in control group vs. 91.8±2.0 units/ml
in nimesulide treated group vs. 35.0±1.0 units/ml in extract treated group), GPT (30.0±2.1 units/ml in control group vs. 88.4±2.9
units/ml in nimesulide treated group vs. 34.1±1.8 units/ml in extract treated group), and ALP (7.86±0.47 KA units/ml in control
group vs. 23.80±0.60 KA units/ml in nimesulide treated group vs. 7.30±0.40 KA units/ml, in extract treated group) to almost
nomal. In addition, P. niruri restored the nimesulide induced alterations of hepatic SOD (550±20 units/mg total protein in
control group vs. 310±13 units/mg total protein in nimesulide treated group vs. 515±10 units/mg total protein in extract treated
group), CAT (99.5±2 units/mg total protein in control group vs. 25.0±1.5 units/mg total protein in nimesulide treated group
vs. 81.0±0.8 units/mg total protein in extract treated group), GSH (90±3 nmoles/mg total protein in control group vs. 17±4.2
nmoles/mg total protein in nimesulide treated group vs. 81±1 nmoles/mg total protein in extract treated group) and TBARS (measured
as MDA, 36.6±3.0 nmoles/g liver tissue in control group vs. 96.3±5.2 nmoles/g liver tissue in nimesulide treated group vs.
41.2±1.7 nmoles/g liver tissue in extract treated group) contents. Dose-dependent studies showed that the herb could protect
liver even if the nimesulide-induced injury is severe. Intraperitoneal administration of the extract showed better protective
effect than oral administration. Combining all, the data suggest that P. niruri possesses hepatoprotective activity against
nimesulide-induced liver toxicity and probably acts via an antioxidant defense mechanism. To the best of our knowledge, this
is the first report of the hepatoprotective action of P. niruri against nimesulide induced liver damage. 相似文献
4.
The effects of administration of glibenclamide, tolbutamide and insulin on serum lipoprotein fractions in alloxan diabetic rabbits were studied with a view to understand the role played by these antidiabetic drugs to influence serum levels of these fractions. The elevated levels of cholesterol in serum lipoprotein fractions—HDL, LDL and VLDL in alloxan diabetic rabbits were found to be decreased significantly on treatment with glibenclamide, tolbutamide and insulin. However, the LDL-cholesterol: HDL-cholesterol ratio which is considered to be an atherogenic index showed a statistically significant increase in tolbutamide treated group and a statistically significant decrease in insulin-treated group, whereas the glibenclamide treated group showed no change. 相似文献
5.
Effects of vanadate supplementation on high fat-diet and diabetes-induced metabolic changes in liver
Subbiah Pugazhenthi Joseph F. Angel Ramji L. Khandelwal 《Indian journal of clinical biochemistry : IJCB》1996,11(2):108-114
Normal and streptozotocin-induced diabetic rats were fed the control high starch-diet or a high fatdiet supplemented with or without sodium orthovanadate (1.5 mg/g diet) for six weeks. Plasma glucose, insulin and triacylglycerol levels and the activities of hepatic glycogen synthase, phosphorylase, glucose-6-phosphate dehydrogenase, malic enzyme, and ATP-citrate lyase were measured in these eight groups of rats. The high fat-diet increased the levels of insulin (P<0.05) and triacylglycerol (P<0.01) in plasma and decreased the activities (P<0.001) of phosphorylase (active from and total) and the lipogenic enzymes. Vanadate supplementation led to significant (P<0.001) decreases in the elevated insulin and triacylglycerol levels whereas the enzyme activities remained unaffected. Diabetes and fat diet in combination caused 3.7-fold increases in plasma glucose and triacylglycerol levels and vanadate decreased them by 58% and 74% respectively. Vanadate improved the activities of hepatic glycogen metabolizing and lipogenic enzymes in diabetic rats when they were fed on control starch-diet but not with high fat-diet. This study shows that vanadate normalizes hyperinsulinemia and hypertriglyceridemia but not the defective hepatic glycogen metabolism in high fat-fed rats. 相似文献
6.
Aniket V. Mali Sunita S. Bhise Surendra S. Katyare Mahabaleshwar V. Hegde 《Indian journal of clinical biochemistry : IJCB》2018,33(1):38-45
Recent studies have been noted that the erythrocytes from Type II diabetic patients show significantly altered structural and functional characteristics along with the changed intracellular concentrations of glycolytic intermediates. More recent studies from our laboratory have shown that the activities of enzymes of glycolytic pathway changed significantly in RBCs from Type II diabetic patients. In particular the levels of lactate dehydrogenase (LDH) increased significantly. Lactic acidosis is an established feature of diabetes and LDH plays a crucial role in conversion of pyruvate to lactate and reportedly, the levels of lactate are significantly high which is consistent with our observation on increased levels of LDH. Owing to this background, we examined the role of erythrocyte LDH in lactic acidosis by studying its kinetics properties in Type II diabetic patients. Km, Vmax and apparent catalytic efficiency were determined using pyruvate and NADH as the substrates. With pyruvate as the substrate the Km values were comparable but Vmax increased significantly in the diabetic group. With NADH as the substrate the enzyme activity of the diabetic group resolved in two components as against a single component in the controls. The Apparent Kcat and Kcat/Km values for pyruvate increased in the diabetic group. The Ki for pyruvate increased by two fold for the enzyme from diabetic group with a marginal decrease in Ki for NADH. The observed changes in catalytic attributes are conducive to enable the enzyme to carry the reaction in forward direction towards conversion of pyruvate to lactate leading to lactic acidosis. 相似文献
7.
Anjali C. Warrier Narasimha Y. Rao Devdutta S. Kulpati Tarun K. Mishra Bhaskar C. Kabi 《Indian journal of clinical biochemistry : IJCB》1995,10(1):9-13
There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white
blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus
(IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared
with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were
also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant
positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is
suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia
and lipid peroxidation in diabetes mellitus. 相似文献
8.
N. P. Suryawanshi A. K. Bhutey A. N. Nagdeote A. A. Jadhav G. S. Manoorkar 《Indian journal of clinical biochemistry : IJCB》2006,21(1):126-130
The study was designed to find out the correlation between lipid peroxidation, lipoprotein levels to severity and complication
of diabetes mellitus. Degree of lipid peroxidation was measured in terms of malondialdehyde (MDA) along with lipid profile
and blood glucose in diabetes mellitus. It is categorised into insulin dependent diabetes mellitus (IDDM), non insulin dependent
diabetes mellitus (NIDDM) and diabetes mellitus(DM) with complication.
Total 112 known diabetic patients and 52 non-diabetic controls were studied. These patients were grouped as per the concentration
of fasting blood glucose level i.e. controlled, poorly controlled, and uncontrolled group. There are significant increase
in the lipid peroxide (MDA) and lipid profile except HDL cholesterol which is decreased, has been found in all groups as compared
to controls In NIDDM group lipid peroxidation was markedly increased than IDDM group and it was higher in DM with complications.
Other finding observed was that the level of lipid peroxide increased as per the increase in concentration of blood glucose.
The increase lipid peroxidation in the hyperglycemic condition may be explained, as the superoxide dismutase enzyme which
is antioxidant becomes inactive due the formation of superoxide radical within the cell. Maximum lipid peroxidation leads
to the damage of the tissue and organs which results into complication in diabetic patients. High levels of total cholesterol
appear due to increased cholesterol synthesis. The triglyceride levels changes according to the glycemic, control. The increase
may be due to overproduction of VLDL-TG.
It is concluded that good metabolic control of hyperglycemia will prevent in alteration in peroxidation and the lipid metabolism,
which may help in good prognosis and preventing manifestation of vascular and secondary complication in diabetes mellitus. 相似文献
9.
Role of plasma amino acids and gaba in alcoholic and non-alcoholic fatty liver disease-a pilot study
S. Mukherjee K. Vaidyanathan D. M. Vasudevan Subir Kumar Das 《Indian journal of clinical biochemistry : IJCB》2010,25(1):37-42
Alcohol appears to affect brain function, primarily by interfering with the action of gamma-aminobutyric acid (GABA) and other
neurotransmitters. As alcohol is mainly metabolized in the liver, therefore we undertook this pilot study to monitor the patterns
of changes in plasma amino-acid concentrations due to alcoholic and nonalcohol fatty liver disease and their relation with
plasma GABA level. Plasma amino-acid concentrations were measured in 25 alcoholic liver disease (ALD) patients, 18 non-alcoholic
fatty liver disease (NAFLD) patients, and 24 age and sex matched control subjects by HPLC. GABA concentration was elevated,
while isoleucine and leucine levels reduced significantly in ALD patients compared to the control subjects. Methionine and
phenylalanine levels elevated and valine content reduced significantly in ALD patients compared to other two groups, and GABA
level was significantly correlated with methionine and phenylalanine. Plasma concentration of lysine was significantly reduced
in both groups of liver disease patients compared to the control group, but was not correlated with GABA level. Glycine and
tyrosine levels reduced significantly in NAFLD patients compared to other two groups and were significantly correlated with
GABA. Interestingly, though amino acids such as alanine, histidine, proline and serine were not affected by liver diseases,
but were significantly correlated with GABA level. This pilot study indicated that alcoholic liver disease presented a more
deranged plasma amino acid pattern than nonalcoholic, and the amino acid imbalances. More studies are necessary to identify
the role of any particular amino acid on brain function and on neurotransmitter(s). 相似文献
10.
Mahalingam Gayathri Krishnan Kannabiran 《Indian journal of clinical biochemistry : IJCB》2008,23(4):394-400
The aim of the present study was to evaluate the antidiabetic and ameliorative potential of aqueous extract of Ficus bengalensis
bark in streptozotocin induced diabetic rats. The effect of oral administration of aqueous extract of F. bengalensis bark
on blood glucose, serum electrolytes, serum glycolytic enzymes, liver microsomal protein, hepatic cytochrome P-450 dependent
monooxygenase enzymes and lipid peroxidation in liver and kidney of streptozotocin -induced diabetic rats was studied. Oral
administration of Ficus bengalensis to fed, fasted and glucose loaded diabetic rats significantly [F > 0.05 (ANOVA) and P<
0.05 (DMRT)] decreased the blood glucose level at 5 hrs and restored the levels of serum electrolytes, glycolytic enzymes
and hepatic cytochrome P-450 dependent enzyme systems and decreased the formation of liver and kidney lipid peroxides at the
end of 12 weeks. Further, the aqueous extract of Ficus bengalensis at a dose of 500mg/kg/day exhibits significant antidiabetic
and ameliorative activity as evidenced by histological studies in normal and Ficus bengalensis treated streptozotocin induced
diabetic rats. On the basis of our findings, it could be used as an antidiabetic and ameliorative agent for better management
of diabetes mellitus. 相似文献
11.
Najma Zaheer Baquer Dhananjay Gupta Jayadev Raju 《Indian journal of clinical biochemistry : IJCB》1998,13(2):63-80
Diabetes has been classified as a disease of glucose overproduction by tissues, mainly liver and glucose underutilization
by insulin requiring tissues like liver, adipose and muscle due to lack of insulin. There is, however, glucose over utilization
in tissues not dependent on insulin for glucose transport like kidney, nerve and brain. There are serious complications due
to this excess glucose in these tissues and their reversal is important for a good metabolic control and normalisation of
other parameters. Insulin, trace metals and some plant extracts have been used to see the reversal effects of the complications
of diabetes in liver and kidney in experimental diabetes. Almost complete reversal of the metabolic changes has been achieved
in the activities of key enzymes of metabolic pathways in liver and kidney and an effective glucose control has been achieved
suggesting a combination of therapies in the treatment of metabolic disturbance of the diabetic state. 相似文献
12.
Diabetes Mellitus in obese and non-obese Indian individuals.AIMS: Effect of Obesity and insulin resistance on diabetic control.SETTINGS AND DESIGN: 50 each groups Diabetic individuals obese and non-obese.METHODS AND MATERIAL: On selected 50 each group diabetic patient and normal, following blood investigations has been performed—Plasma Glucose,
Glycohemoglobin and Serum Insulin.STATISTICAL ANALYSIS USED: Individuals patient’s results were analyzed and compared with the normal controls.RESULTS AND CONCLUSION: The changes in glycosylated haemoglobin are mainly proportional to the post lunch glucose level (r=0.773) (p<0.01) and not
correlated to circulating insulin or the body mass index. However the levels were higher in obese diabetes (Type I and II
both) than in non-obese. Mechanism of resistance in insulin receptor interactions due to obesity is well known. However, obesity
does not seem to affect directly glycosylated haemoglobin. Under such circumstances, the reduction of weight for a diabetic
person can improve sugar control by minimizing insulin resistance and thereby can improve glycosylated haemoglobin levels. 相似文献
13.
Shrish Bhatnagar Farzana K. Beig Ashraf Malik 《Indian journal of clinical biochemistry : IJCB》2008,23(3):299-301
Adenosine deaminase and C-reactive protein in CSF were assessed in 72 cases of Tubercular meningitis, 24 cases of partially
treated pyogenic meningitis, 20 cases of Aseptic meningitis and 8 cases of febrile seizures. Mean Adenosine deaminase value
was 12.12±3.13 IU/L for Tubercular meningitis group. It was significantly higher (p<0.001) as compared to partially treated
pyogenic meningitis (5.39±2.70 IU/L) and aseptic meningitis (1.92±0.56 IU/L) groups. A combination of clinical criteria along
with biochemical test of Adenosine deaminase and C-reactive protein in CSF increased the sensitivity of diagnosing Tubercular
meningitis and differentiating it from other forms of meningitis at an early stage. 相似文献
14.
Dhanaraj Karthik Soundherrajan Ilavenil Balasubramanian Kaleeswaran Sivanesan Ravikumar 《Indian journal of clinical biochemistry : IJCB》2012,27(3):221-230
The uncontrolled hyperglycemia can lead to disturbances in the cell structure and functions of organs. This study was performed to analyze the “differential proteome” change in rat liver associated with diabetes mellitus in relation to effects of an anti-diabetic herb, Cynodon dactylon leaf extracts. Rats were intraperitoneally injected with alloxan (150 mg/kg/bw) and treated with C. dactylon leaf extracts (450 mg/kg/bw/day/orally). The liver proteins were subjected to proteome analysis using the advanced technologies i.e., 2D electrophoresis (2-DE) and mass spectrometry. Comparison of 2-DE protein distribution profiles among the livers from normal, alloxan-induced diabetic rats and alloxan-induced diabetic rats treated with C. dactylon leaves identified three proteins that were up-regulated in alloxan-induced diabetic rats i.e., nucleophosmin, l-xylulose reductase and carbonic anhydrase III which are known to be mainly involved in ribosome biogenesis, centrosome duplication, cell proliferation, tumor suppression, glucose metabolism, osmo-regulation, water–CO2 balance and acid–base balance. These results help us to understand the elucidation of molecular mechanism connected to liver function and insulin associated with diabetes mellitus. These identified proteins were primarily involved in cell proliferation and homoeostasis of liver tissues upon the treatment with C. dactylon leaf extracts. 相似文献
15.
Nasrin Ziamajidi Hamid Behrouj Roghayeh Abbasalipourkabir Fatemeh Lotfi 《Indian journal of clinical biochemistry : IJCB》2018,33(2):147-153
Diabetes mellitus (DM) is one of the most prevalent diseases in the world, which is strongly associated with liver dysfunction. Hyperglycemia, through an oxidative stress pathway, damages various tissues. Herbal medicine is a good candidate to ameliorate hyperglycemia and oxidative stress. In this study, the effects of aqueous Allium sativum (garlic) extract (AGE) on gene expression of inducible nitric oxide synthases (iNOS) and production of nitric oxide (NO) were evaluated in the liver tissue of diabetic rats. Four groups of rats contained normal control rats, garlic control rats (AGE), Streptozotocin (STZ) + nicotinamide-induced diabetic rats (DM), and diabetic rats treated with garlic (DM + AGE). Glucose levels and liver enzymes activities were determined by colorimetric assay in the serum. Gene expression of iNOS by real-time PCR, NO levels by Griess method, oxidative stress parameters by spectrophotometric method and histopathological examination by hematoxylin and eosin staining method were evaluated in the liver tissues. Glucose levels, activities of liver enzymes, oxidative stress markers, iNOS gene expression, and NO production increased significantly in diabetic rats in comparison with control rats, whereas after oral administration of garlic, these parameters decreased significantly, close to the normal levels. Hence, the beneficial effects of garlic on the liver injury of diabetes could be included in the hypoglycaemic and antioxidant properties of garlic via a decrease in gene expression of iNOS and subsequent NO production. 相似文献
16.
R. Baskar N. Saravanan P. Varalakshmi 《Indian journal of clinical biochemistry : IJCB》1995,10(2):98-102
The influence of Crataeva nurvala bark decoction was studied in calcium oxalate stone forming rats, in relation to oxalate
metabolism in liver. The activities of the major oxalate synthesizing enzymes in liver namely, glycollate oxidase (GAO) and
lactate dehydrogenase (LDH) were significantly increased in the calculogenic group. Bark decoction treatment lowered the liver
GAO activity considerably. Transport ATPases (Na+, K+ and Ca2+-ATPases) and alkaline phosphatase were enhanced in rats fed calculi producing diet, while the activities of acid phosphatase,
inorganic pyrophosphatase and aminotransferases were slightly reduced. Bark decoction administration produced a marginal decrease
in Na+, K+-ATPase and increase in aspartate aminotransferase activities, without significantly altering other enzyme activities. The
decrease in liver GAO activity seen during bark decoction treatment, with concomitant decrease in kidney oxalate level, may
prove beneficial as a prophylactic measure in preventing stone recurrence. 相似文献
17.
The microbicidal capacity of polymorphonuclear leucocytes of diabetic and control subjects was evaluated by estimating the release of lysosomal enzymes viz beta-glucuronidase, lysozyme, acid phosphatase, alkaline phosphatase, in response to a particulate stimulus-serum treated zymosan (STZ). The cells untreated and pretreated with cytochalasin B were exposed to STZ The total enzyme activities were estimated after cell lysis. The total enzyme activities were not altered in diabetic subjects as compared to control subjects. The release of lysosomal enzymes by cells pretreated with cytochalasin B was high as compared to untreated cells. The release of lysosomal enzymes from the cells isolated from diabetic patients, untreated and pretreated with cytochalasin B was reduced as compared to controls. The findings of the present study that the total lysosomal enzyme activities are normal while the release of these enzymes in response to stimulus is impaired in diabetics, suggest that the bactericidal capacity of these cells which involves phagocytosis is impaired in these patients. 相似文献
18.
G. P. Das B. Mandal P. Ghosh C. R. Maity 《Indian journal of clinical biochemistry : IJCB》1993,8(1):39-43
Serum levels of cholesterol, triglyceride, free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol were studied
in 10 undernourished and 10 better nourished diabetic patients at different periods of insulin treatment and in non-diabetic
controls. Serum concentrations of cholesterol, triglyceride and FFA were significantly higher in untreated diabetic patients
than in control but the elevated lipid levels gradually shifted towards normal on insulin treatment. The HDL cholesterol,
on the other hand, was significantly lower in untreated diabetic subjects than those in controls and the HDL cholesterol also
gradually modified on insulin therapy. However, the improvement of all the lipid parameters on insulin treatment was somewhat
delayed in undernourished compared to those of better nourished diabetics. These results, therefore, suggest that malnutrition
interferes with the serum lipid improvement in diabetics on insulin treatment and may make them more prone to develop vascular
complications. 相似文献
19.
Sona Valsaraj K. T. Augusti Varghese Chemmanam Regi Jose 《Indian journal of clinical biochemistry : IJCB》2009,24(2):175-178
In the present study the efficacies of therapy with insulin, sulphonylurea or insulin + metformin on NIDDM patients are compared.
One group which was on a definite dose of insulin therapy, but with uncontrolled diabetes was treated by doubling the insulin
dose, a second group whose diabetes was not controlled by glibenclamide was switched over to another sulphonylurea viz; glimepiride
and a third group whose diabetes was not controlled by insulin therapy was switched over to a combination therapy with insulin
+metformin. After recording their initial blood parameters all the groups were treated as above for 3 months, and the parameters
were again determined. The fasting blood sugar and serum lipids of the first group were controlled significantly, but the
values were far above normal range. However HDL Cholesterol and atherogenic index were near normal range. In glimepiride treated
group, none of the parameters showed any amelioration. In the combined therapy group, control of blood sugar and atherogenic
index was more or less the same as for group 1, but hyperlipidemia remained slightly above that of the same. From the findings
we can infer that in long term diabetes treatment higher doses of insulin and combined therapy with insulin and metformin
may be more beneficial than with low doses of insulin or sulfonyl urea alone 相似文献
20.
The objective of the present study is to evaluate the beneficial effect of tomatoes, which are rich source of Lycopene, relatively
a new carotenoid known to play an important role in human health and disease. In this study lipid peroxidation rate was measured
by estimating Malondialdehyde and the levels of serum enzymes involved in antioxidant activities like Super Oxide Dismutase,
Glutathione Peroxidase, Glutathione Reductase, Reduced Glutathione, in type-II diabetic group (n=40) and age matched control
group (n=50), and observed significantly lower levels of antioxidant enzymes and very high lipid peroxidation rate in type-II
diabetes when compared to control group (p<0.001). Short term supplementation with tomatoes (cooked) to diabetic group for
a period of 30 days, showed a significant improvement in antioxidant enzyme levels (p<0.001) and decreased lipid peroxidation
rate (p<0.001) suggesting the supplementation with tomato lycopene may serve as the best method of preventing the oxidative
stress in diabetic patients. 相似文献