共查询到20条相似文献，搜索用时 437 毫秒
1.
目的:探讨华蟾素对原发性肝癌骨转移继发骨侵蚀破坏患者疼痛缓解率的影响,观察华蟾素作用后患者血清骨桥蛋白(OPN)、基质金属蛋白酶-9(MMP-9)表达的变化。方法:选取2015年12月~2017年03月广西中医药大学附属瑞康医院收住的原发性肝癌骨转移继发骨侵蚀破坏患者60例,随机分为观察组35例和对照组25例,对照组采用射频消融、局部放疗联合唑来膦酸治疗,观察组加用华蟾素注射液。比较两组疼痛缓解率,检测两组治疗前、治疗后4、8、12w血清OPN、MMP-9水平,并分析相关性。结果:治疗后8、12w,观察组疼痛缓解率分别为82.86%、94.29%,对照的分别为48.00%、52.00%(P﹤0.05);两组治疗后4w、8w、12w与治疗前比较,OPN、MMP-9水平均降低(P﹤0.05),观察组治疗后OPN、MMP-9水平均显著低于对照组同期水平(P﹤0.05);观察组35例治疗后患者疼痛缓解率与外周血清OPN、MMP-9浓度水平呈显著负相关(r=-0.994、-0.999,P﹤0.05)。结论华蟾素注射液对于原发性肝癌骨转移继发骨侵蚀破坏患者有明显的镇痛作用,可以显著降低患者血清OPN、MMP-9的浓度水平,可能通过抑制OPN、MMP-9的表达发挥镇痛作用。 相似文献
2.
3.
4.
5.
6.
紫杉醇是一种具有独特结构和独特作用机制的抗肿瘤药物,该药是从红豆杉属植物紫杉中提取并开发利用的天然广谱抗癌新药。自1992年FDA批准上市以来,紫杉醇独特的抗肿瘤作用日益受到世界各国研究人员的重视,现已广泛应用于临床,并成为多种肿瘤的一线化疗药物。介绍了紫杉醇的抗肿瘤机制、临床应用、结构改进等研究进展情况。 相似文献
7.
目的探讨小鼠肝癌树突状细胞融合瘤苗抗肿瘤作用及其机制。方法用PEG法制备小鼠肝癌树突状细胞融合瘤苗;流式细胞仪检测融合细胞表型特征;RT-PCR法检测肿瘤组织中TNF-αmRNA、IFN-γmRNA表达:Western blot法检测肿瘤组织中Bcl-2、Bax、Caspase-3蛋白表达。结果小鼠肝癌树突状细胞融合瘤苗具备树突状细胞及肝癌细胞表型特征,能显著促进肿瘤组织中TNF-αmRNA、IFN-γm-RNA及Bcl-2、Bax、Caspase-3蛋白表达。结论小鼠肝癌树突状细胞融合瘤苗能有效地诱导抗肿瘤免疫反应,促进肿瘤细胞凋亡,在预防和治疗肝癌的复发及转移过程中有广阔的应用前景。 相似文献
8.
原发性肝细胞癌伴胆管癌栓(hepatocellular carcinoma with bile duct tumor thrombi,HCCBDT)是胆道系统最常见的继发性肿瘤,其主要以肝细胞癌向胆道系统转移所致梗阻性黄疸为特点,肝细胞肝癌合并胆管癌栓的发病率不到原发性肝细胞癌患者的10%[1],尸检发现其发生率为1.2%~9.0%[2]。虽然原发性肝细胞癌合并胆管癌栓发病率低,但由于我国人口基数较大,致使患者绝对数量也较大,发病人数每年超过10000人。以往通常认为肝癌出现黄疸症状已属肝癌晚期的表现,导致人们对肝细胞肝癌合并胆管癌栓多采取保守治疗或消极态度,缺乏根治的方法,致使很大一部分原发性肝细胞癌合并胆管癌栓病人丧失治疗机会,预后较差。近年来,随着外科领域的不断进步,发现原发性肝癌合并胆管癌栓其实并非肝癌的晚期表现。 相似文献
9.
10.
茯苓多糖为我国传统中药茯苓的主要有效成分,具有抗肿瘤、抗病毒等作用,结合实际,针对茯苓多糖的提取及应用进行了论述。 相似文献
11.
超抗原—SE抗肿瘤作用的研究现状 总被引：5，自引：0，他引：5
综述了SE抗肿瘤的作用机理、实验研究以及近年来的少量临床应用。葡萄球菌肠毒素（SE）是一种外源性超级抗原，仅需微量即能高效地刺激T细胞增殖，促使其产生大是和多种细胞因子及细胞毒，提高机体总体细胞免疫水平，使之获得抗肿瘤的有力，体外细胞水平和动物体内的研究结果表明：SE能够产生强大的杀伤和抑制肿瘤细胞效应，故是一种很有前途的新型肿瘤免疫治疗剂，目前已开始应用于肿瘤病人的治疗及对肿瘤病人在进行放化疗时保护机体白细胞降低以及防止其它毒副反应的发展。 相似文献
12.
Winston Costa Pereira Muddanna S. Rao D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(2):161-168
Immunization with a proper dose of an antigenic stimulus leads to cell proliferation and antibody response of circulating
lymphocytes. We have previously observed that Secondary immunized spleenocytes resist ceramide-mediated apoptosisin vitro. Our present study is aimed at investigating thein vivo effect of immunization on apoptosis. Mice were subjected to either Primary or Secondary dose with Tetanus Toxoid. Unimmunized
spleenocytes served as controls. Unimmunized, Primary and Secondary immunized mice were later exposed to chemotherapeutic
drugs such as Etoposide/Methotrexate/Vincristine to induce apoptosis. Apoptosis was studied by using the Feulgen reaction
on 5μ thin parafin sections of spleen. It was observed that Secondary immunized mice showed a lower percentage of apoptosis
as compared to Primary or Unimmunized mice that was subjected to either of the chemotherapeutic drugs. It was thus concluded
that Secondary immunization inhibits the process of chemotherapeutic drug induced apoptosis in vivo. 相似文献
13.
胃神经官能症是一种全身性疾病，乃是由于高级神经活动障碍而导致植物神经系统机能失调，临床主要表现为胃的分泌及运动机能紊乱，而出现呕吐或频繁暖气，患者多为中年妇性，运用柴胡疏肝汤加减治疗胃神经官能症56例均为1997年至1999年杭州市第一人民医院中医科门诊病例，治疗结果提法，只要谨守病机，在中医辨证论治的基础上灵活运用，即可取得满意的疗效。 相似文献
14.
天花粉蛋白研究新进展 总被引：3，自引：0，他引：3
天花粉蛋白是从葫芦科植物栝楼块根中分离纯化得到的单链核糖化失活蛋白，其一级结构、二级结构及空间结构皆已阐明。它的作用方式属于ＲＮＡ Ｎ－糖苷酶，专一水解真核细胞核糖体ｒＲＮＡ中Ａ４３２４位腺苷酸的Ｎ－Ｃ糖苷键，抑制真细胞核糖体功能。近来研究表明天花粉蛋白可以抗肿瘤、抗病毒，本文对其机理进行了探讨。利用体外无细胞翻译系统观察到天花粉蛋白对其自身核糖体存在毒性作用。 相似文献
15.
Bourret P 《Social studies of science》2005,35(1):41-68
Since the late 1980s, in France and in a number of other countries, cancer genetics testing has become a clinical reality, particularly for hereditary breast and ovarian cancer. BRCA tests allowing for the assessment of an increased cancer risk among patients and their healthy relatives are now being routinely performed as part of clinical practice. Based on fieldwork on French clinical cancer genetics and on the French Cancer Genetics Collaborative Network, this paper examines the configuration of entities, actors and activities mobilized by the performance of BRAC testing, and argues that the development of clinical molecular genetic practices is predicated upon the development of new forms of collaborative work that lead to a transformation of the content and organization of medical activities and judgements. The paper analyses three major collective configurations - local multidisciplinary collectives, data collectives and new clinical collectives - and argues that they not only provide the material conditions needed to carry out the relevant activities, but also articulate a series of distinctive bio-clinical interventions. These interventions provide an interface with research activities, produce the epidemiological measurements and tools that are a sine qua non for clinical work in this field, and, most importantly, establish the conventions that underlie practices, which define the criteria that turn tools and novel entities into operational components of clinical settings. It thus appears that in the field of clinical cancer genetics, bioclinical collectives, as a locus of expertise, have replaced the individual judgement of the practicing clinician. 相似文献
16.
小学语文教育即基础教育,也是一切学科教育的基础。因此,小学语文教育首当其冲的任务就是打好基础,努力提高小学生素质教育。受传统应试教育的影响,小学语文基础教育比较呆板,学生缺乏兴趣,长此以往,不仅不利于小学生听、说、读、写综合能力的发展,也为广大的小学语文老师开展教学工作带来极大的职业困扰。小学语文基础教育至关重要,小学生学习语文是一个长期累积的过程。是由量变到质变的过程,与此同时,也关系到其他学科的学习,因此,教师要在日常的教育教学过程中,不断地去研究如何提高小学语文基础教育质量,提高小学生的综合能力提升。本文结合实际的教学实践,分析了小学语文基础教育的重要性,并阐述了小学语文教育过程中存在的问题,并提出具有针对性的解决策略,以期为广大小学语文基础教育工作者提供些许参考。 相似文献
17.
全面推进素质教育是当前我国现代化建设的一项紧迫任务,小学教育在中国教育中占有举足轻重的地位,其中语文是学好其他课程的基本前提,是最重要的交际工具,在培养公民的人文素养和科学素养中起着重要的作用。笔者就如何开展小学语文教育阐述了自己的意见。 相似文献
18.
19.
科技查新工作中能够获得丰富的信息资源,要使这些信息资源得到充分的利用,必须对其进行深度挖掘。通过对科技查新工作中形成的各类信息资源进行归类和分析,形成查新信息资源的一次文献、二次文献及三次文献,并提出了利用科技查新工作中获取的信息资源开展定向服务的设想。 相似文献
20.
Gülsen Yilmaz Fatma Meriç Yilmaz Mehmet Senes Dogan Yucel 《Indian journal of clinical biochemistry : IJCB》2007,22(1):52-56
Serum tumor markers may be requested inappropriately by clinicians. In this retrospective study, we aimed to investigate the
appropriateness of TM requests in our hospital. Patients in the study were identified from the TM requests for 3 months between
June–August 2004, using the laboratory database. A total of 2249 patients (1351 men, 898 women) were included in the study
and there were 6570 TM requests. The number of requests were 1050 (16%) for Carbohydrate Antigen 19-9, 993 (15.1%) for Cancer
Antigen 125, 941 (14.3%) for Prostate Specific Antigen, 921 (14%) for free PSA, 925 (14.1%) for Cancer Antigen 15-3, 788 (12%)
for Alphafetoprotein, 730 (11.1%) for Carcinoembryonic Antigen and 222 (3.4%) for AFP/Human Chorionic Gonadotrophin. Our findings
support the idea that for the evidence-based use of TM requests the education of clinical staff is required. Clear clinical
guidelines including recommendations about the appropriate use of TM can be useful for this education process. Careful audit
studies are also useful to determine the impact of these guidelines on the practice of evidence-based laboratory medicine. 相似文献