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1.
《大众科技》2015,(12)
目的:系统评价胰升血糖素样肽-1(GLP-1)类似物治疗肥胖型2型糖尿病的临床疗效及应用价值。方法:检索1989~2015年国内发表的关于胰升血糖素样肽-1类似物治疗中国肥胖型2型糖尿病的临床疗效及应用价值的随机对照试验(RCT)。按既定的纳入与排除标准选择,资料处理采用Rev Man 5.3统计软件做Meta分析处理。结果:研究共纳入6个RCT,各实验的基线均可比。Meta分析结果表明:与单纯常规降糖治疗方案相比,胰升血糖素样肽-1类似物可以使肥胖型2型糖尿病的患者的体重、空腹血糖、糖化血红蛋白、总胆固醇、甘油三酯等降低并且差异有统计学意义,胰升血糖素样肽-1类似物治疗优于常规治疗。结论:胰升血糖素样肽-1类似物可通过降低血糖和减轻体重来治疗肥胖型2型糖尿病,可以指导临床。 相似文献
2.
目的:系统评价柴胡疏肝散治疗胆汁反流性胃炎(BRG)的有效性与安全性。方法:检索四大数据库中发表柴胡疏肝散治疗BRG的临床随机对照试验并运用Revman 5.2软件进行Meta分析,检索时限为建库至2016年7月。结果:所纳入7个研究中合计有392例胆汁反流性胃炎受试者,治疗干预予柴胡疏肝散加减,对照干预予常规西药。两者总有效率的Meta分析结果为柴胡疏肝散治疗BRG的临床有效率优于常规西药,差异有统计学意义[OR=5.73,95%Cl为(3.68,8.92),P0.000001]。总有效率漏斗图中可见散点分布不对称,由此说明文章存在偏倚,通过方法学评价而知纳入的RCT均属于高偏倚风险级别。结论:柴胡疏肝散在治疗BRG总有效率高于常规西药,但所纳入的RCT均属于高偏倚风险级别,RCT质量评价低,目前还没有足够证据支持推荐柴胡疏肝散用于治疗BRG。 相似文献
3.
4.
目的：系统评价香砂六君子汤治疗慢性萎缩性胃炎的疗效及安全性。方法：通过计算机检索万方数据库、CNKI、重庆维普中文科技期刊数据库（VIP）、pubmed、CBM、webofscience数据库的有关香砂六君子汤加减治疗慢性萎缩性胃炎的临床随机对照试验（RCT）,对最终纳入文献根据修改后Jadad质量评价表进行质量评价。运用Revman 5.3统计学软件进行文献风险评估及Meta分析。结果：Meta分析结果显示香砂六君子汤治疗慢性萎缩性胃炎在临床总有效率、胃粘膜炎症改善、Hp根除率、中医症状积分的改善方面具有良好的疗效,有效延缓慢性胃炎“炎-癌转化”进程。结论：研究表明香砂六君子汤治疗慢性萎缩性胃炎具有较好的临床疗效。但由于纳入研究的方法学质量普遍较低,影响结论的严谨性,仍需要高质量的随机双盲对照试验作进一步验证,为循证医学提供新的思路和方法。 相似文献
5.
目的评价扶正散结法中药辅助化疗治疗中晚期胃癌的疗效及安全性。方法通过检索数据库(The Cochrane Library,MEDLINE,EMBASE,CANCERLIT,CBM,CNKI,VIP等),查阅国内外重要学术会议论文汇编、中文类核心期刊等资料,将符合标准的扶正散结法中药(FZSJ)辅助化疗治疗中晚期胃癌的临床研究纳入本meta分析。使用RevMan 5.3软件进行Meta分析,采用Cochrane Handbook 5.3"偏倚风险评估"工具对文献质量进行评价。结果最终纳入20个随机对照研究,共计1735例患者。Meta分析结果显示:与单纯化疗比较,扶正散结法中药(FZSJ)辅助化疗可能提高患者近期有效率、1年及3年生存率、降低恶心呕吐及白细胞减少的毒副反应发生。结论扶正散结法中药辅助化疗治疗中晚期胃癌与单纯化疗比较,可能治疗效果更好,更安全,有一定的临床推广和运用价值。 相似文献
6.
建立反相高效液相色谱法测非布司他片中非布司他的含量。方法：采用奥泰公司C18色谱柱（220mm×4．6mm,5μm）,水-乙腈-乙酸（60：40：0．03）为流动相,检测波长为230nm,流速为1．0ml／min,柱温为30℃。非布司他在2～12mgmL-1范围内呈良好的线性关系（r=0．99995o非布司他平均回收率分别为99．5％。结论：本法简便、准确,可用于非布司他片中非布司他的含量测定。 相似文献
7.
《大众科技》2015,(12)
目的:系统评价呼吸功能训练对慢性阻塞性肺疾病(COPD)稳定期患者肺功能及运动耐力的影响。方法:计算机检索中国知网、维普数据库和万方数字化期刊全文数据库中关于呼吸功能训练对COPD患者的随机对照试验(RCT),按纳入与排除标准选择,包括呼吸功能训练结合常规药物治疗干预组和常规药物治疗对照组。提取资料后采用Rev Man5.0统计软件进行Meta分析。结果:共纳入11项RCT,合计696例患者。Meta分析结果显示,与对照组相比,呼吸功能训练明显改善了COPD稳定期患者用力肺活量水平(MD=0.15,95%CI:0.10-0.20,P0.00001)、第1秒用力呼气量水平(MD=0.26,95%CI:0.16-0.35,P0.00001)、第1秒用力呼气量与用力肺活量比值水平(MD=-2.34,95%CI:-2.92--2.75,P0.00001)、6分钟行走试验水平(MD=-14.07,95%CI:-22.98--5.16,P=0.002)。结论:呼吸功能训练能有效的改善COPD稳定期患者的肺功能和运动耐力水平,对COPD患者产生了积极的康复效果。 相似文献
8.
《科技风》2020,(24)
目的:评价单纯针灸治疗围绝经期失眠(PMI)的效果。方法:计算机全面检索至2019年8月中国知网、维普、万方、PubMed、Cochrane Library、EMbase数据库中内含针灸改善围绝经期失眠的随机对照试验(RCT)的发表文献。经两名研究人员独立筛选文献、提取资料并评价偏倚风险后,运用Rev Man5.3软件进行Meta分析。结果:最终用于评价分析的文献共12篇,涉及患者1178例,质量评价总体文献质量偏低。Meta结果分析显示针灸组的总有效率高于西药组及安慰针灸组,差异有统计学意义。结论:现有证据支持单纯针灸治疗围绝经期失眠优于常规西药治疗及假针刺治疗。 相似文献
9.
《西藏科技》2021,(5)
目的探讨西藏地区冠心病患者中不同性别尿酸水平与其冠脉狭窄程度的相关性分析。方法回顾性分析2013年1月至2018年12月在西藏自治区人民医院心血管内科接受冠脉造影的冠心病患者321例为研究对象。依据性别将所有研究对象分为男性组(269例)与女性组(52例),再依据其各自血尿酸水平分组:男性血尿酸420umol/L,女性血尿酸360umol/L,将男性研究对象分为高尿酸组(154例)和非高尿酸组(115例),女性研究对象分为高尿酸组(37例)和非高尿酸组(15例),并且分别比较各组冠状动脉狭窄程度。结果在269例男性患者中,高尿酸患者组冠状动脉狭窄评分高于其非高尿酸血症患者(P0.05),而在52例女性患者中,高尿酸患者组与非高尿酸血症患者相比较其冠脉狭窄评分无统计学意义(P0.05)。结论西藏地区男性冠心病患者血尿酸水平与其冠状动脉狭窄程度密切相关。 相似文献
10.
《西藏科技》2018,(12)
目的了解高原人群血红蛋白浓度对血尿酸水平及高尿酸血症患病率的影响。方法连续录入2015年度西藏自治区人民医院体检中心常规体检人群共计10328人次,排除18岁以下及80岁以上、明确贫血、严重肝肾功异常、严重心肺疾病及肿瘤患者及资料不齐全等情况,最终纳入共计5644人。所有患者采集血压、血样饱和度、体重指数、脉率、血常规、肝功、肾功、血脂、血糖、尿酸等常规体检项目。比较不同血红蛋白浓度组血尿酸水平的变化及不同性别慢性高原病患者高尿酸血症的患病率。结果根据血红蛋白水平分为以下五组,1组HB140g/L;2组140g/L≤HB160g/L;3组160g/L≤HB180g/L;4组180g/L≤HB200g/L;5组HB≥200g/L。血尿酸水平分别为:1组为278.04±83.16umol/L;2组为293.87±72.50umol/L;3组为351.84±85.82umol/L;4组为398.48±83.13umol/L;5组为434.93±89.69/L。随着血红蛋白浓度的升高血尿酸水平也进行性升高,而且所有组间差异均有统计学意义(p=0.00);女性CMS患者高尿酸血症的患病率为非CMS人群的3倍(36.2%与12.1%,p=0.00);男性CMS患者高尿酸血症的患病率也显著高于非CMS人群(64.22%与36.1%,p=0.00)。同时,男性CMS患者高尿酸血症患病率显著高于女性CMS患者(64.2%与36.2%,p=0.00);男性非CMS人群高尿酸血症患病率也显著高于女性非CMS患者(36.09%与11.98%,p=0.00)。结论高原地区人群血尿酸水平及高尿酸血症患病率显著高于平原地区,这一现象与慢性高原缺氧导致血红蛋白浓度的升高密切相关。 相似文献
11.
Serum CRP and uric acid levels were estimated in twenty-five patients with psoriasis (group III) before and after 12 weeks
of treatment. Results were compared with a group of 25 normal subjects (group I) and a group of 25 patients of various skin
diseases other than psoriatic lesion (group II). Mean value for CRP was found to be increased by more than 20 folds in patients
with psoriasis, which was subsequently reduced to nearly 50% of the initial value after 12 weeks of treatment. These patients
also showed hyperuricemia. Nearly 25% of these patients also exhibited arthritis. It is thus suggested that both CRP and uric
acid levels should be monitored in patients with psoriasis. 相似文献
12.
Pasalic D Marinkovic N Feher-Turkovic L 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):63-75
With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms. 相似文献
13.
目的:对比身痛逐瘀汤加减与非甾体类抗炎药治疗腰椎间盘突出症的临床疗效。方法:检索维普资讯中文科技期刊数据库、CNKI中国期刊全文数据库,万方医学网数据库等。将符合纳入标准的7篇文献、774位患者的临床疗效进行Meta-分析。Meta-分析的软件为Cochrane协作网免费提供的Revman5.2专用软件。结果:提示身痛逐瘀汤治疗腰椎间盘突出症比非甾体类抗炎药治疗腰椎间盘突出症临床疗效好。结论:纳入资料Meta-分析后,同等基础条件下,治疗组中加入身痛逐瘀汤加减,对照组中加入单一或多种非甾体类抗炎药,治疗组可以显著提高治疗腰椎间盘突出症的有效率。 相似文献
14.
Pallab Basu Sabyasachi Som Nabendu Choudhuri Harendranath Das 《Indian journal of clinical biochemistry : IJCB》2008,23(4):361-364
A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to
see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis
by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls.
A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was found
that the ratios were significantly higher in cases than controls (3.1± 1.3 vs 0.96± 0.54; P < 0.001) and among asphyxia patients,
a significant negative linear correlation was found between the uric acid to creatinine ratio and the Apgar score (r = −0.857,
P < 0.001). So urinary uric acid to creatinine ratio can be used as an additional non-invasive dispace, easy and at the same
time early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and severity grading of
asphyxia by Apgar score. 相似文献
15.
Kiran Chaudhari S. Khanzode S. Khanzode G. Dakhale A. Saoji S. Sarode 《Indian journal of clinical biochemistry : IJCB》2010,25(1):77-81
Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective
Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined.
This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale
for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects
before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly
diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more
significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant
and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= −0.864,
P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid
and improves Hamilton Rating Scale for Depression score in major depressive disorder. 相似文献
16.
目的:观察马来酸氟吡汀治疗外伤性疼痛的有效性及其安全性。方法:选取符合纳入标准的外伤性疼痛患者40例,随机分为观察组和对照组各20例,其中观察组服用马来酸氟吡汀治疗,对照组服用洛芬待因缓释片治疗。对比两组的有效性,并观察不良反应情况。结果:观察组治疗后视觉模拟评分法(VAS)显著低于对照组(t=2.778,P=0.012);且观察组临床疗效高于对照组(u=10.951,P=0.012));观察组的不良反应少,且程度轻微,但与对照组相比,差异无统计学意义(χ2=2.133,P=0.144)。结论:马来酸氟吡汀治疗外伤性疼痛有较好临床疗效好,安全性高。 相似文献
17.
目的:评价枇杷清肺饮加减对比抗菌类药物治疗寻常型痤疮的临床疗效。方法:检索维普资讯中文科技期刊数据库、CNKI中国期刊全文数据库,万方医学网数据库、Pubmed数据库。将符合纳入标准的5篇文献、495位患者的临床疗效进行Meta-分析。Meta-分析的软件为Cochrane协作网免费提供的Revman5.2专用软件。结果:对纳入的随机对照试验的有效数据进行异质性检验,X2=6.27,P=0.18,大于显著性检验水准0.05,故进行固定效应模型分析,结果 5篇文献的疗效评价及效应量OR=4.92,95%的CI为[2.72,8.92],效应合并值的假设检验:Z=5.25,P0.00001,提示枇杷清肺饮汤加减比抗菌类药物治疗寻常型痤疮的有效率高。对纳入的随机对照试验的治愈数据进行异质性检验,X2=5.78,P=0.22,大于显著性检验水准0.05,故进行固定效应模型分析,结果纳入文献的疗效评价及效应量OR=2.79,95%的CI为[1.87,4.17],效应合并值的假设检验:Z=5.01,P0.00001,提示枇杷清肺饮汤加减比抗菌类药物治疗寻常型痤疮的治愈率高。结论:现有资料的Meta-分析,治疗组及对照组在同等的治疗方案下,治疗组中加入枇杷清肺饮加减,对照组中加入单一一种抗菌类药物,治疗组可以显著提高治疗寻常型痤疮的有效率及治愈率。 相似文献
18.
Mridula Mahajan Sukhraj Kaur Shruti Mahajan Ravi Kant 《Indian journal of clinical biochemistry : IJCB》2009,24(2):205-207
Uric acid an endogenous aqueous antioxidant in normal humans is present in much higher concentrations than vitamin C and has
been known to cover 2/3rd of the free radical scavenging capacity in plasma. In the present study average uric acid levels of patients of rheumatoid
arthritis were found to be close to the normal individuals. A unique feature was observed after classifying the patients on
the basis of the duration of suffering, the patients having longer duration of disease had least uric acid levels as compared
to those suffering from relatively lesser period, similar trend was observed in the ascorbic acid estimations. The decline
in uric acid values with progression of the disease was much more than what was observed in case of ascorbic acid suggesting
the significant role of uric acid in scavenging of free radicals. Too much lowering of Uric Acid should be checked and vitamin
C should be supplemented in diet for maintaining the balance between pro oxidant and antioxidant forces to check pro oxidant
insult in rheumatoid arthritis. 相似文献
19.
Urinary abnormalities were evaluated in 100 renal stone patients with first episode of renal stone having age 22 to 45 years
from both sex and compared to 100 normal healthy control group having same age group from both sex. Twenty-four hours urinary
oxalate, calcium, uric acid, sodium, magnesium, phosphorus and citrate were estimated. The urinary pH was also determined.
In stone formers urinary oxalate, calcium, sodium and uric acid excretions were significantly higher when compared with control
group. Whereas citrate, phosphate and magnesium excretion were significantly lower in stone formers when compared with control.
The pH of urine in stone formers was lower than the controls. High dietary intake of purine rich diet causes elevated excretion
of uric acid, which leads to calcium oxalate crystal formation and precipitation. Other risk factors such as urinary oxalate,
calcium also related to formation of renal calculi.
Hypocitraturia is the main cause of renal calculi along with hypomagnesiuria and hypophosphaturia in the patient of Marathwada
region. On the basis of urinary abnormalities further stone formation in the patient can be prevented by dietary modifications. 相似文献
20.
Putative Role of Cardio Metabolic Risk Among Poorly Controlled Asthmatics in South Indian Population
Murugaiyan Sathish Babu K. P. Sreesoorya Surendra K. Menon Subiman Saha A. R. Srinivasan S. Arul Vijaya Vani R. Reeta V. Kuzhandai Velu 《Indian journal of clinical biochemistry : IJCB》2017,32(2):225-229
Mortality and morbidity attributed to asthma remains to be the biggest nightmare worldwide. Hence, the study was aimed to compare the cardio metabolic risk factors as assessed by Body mass index (BMI), waist hip ratio (WHR), serum triacylglycerol and uric acid in well controlled and poorly controlled asthmatics and to correlate these parameters with the severity of asthma. A case control study was conducted on 90 subjects who were segregated into well controlled asthmatics (n = 30) and poorly controlled asthmatics (n = 30) who were diagnosed based on Global initiative for Asthma management guidelines and healthy volunteers (n = 30). Centrifuged fasting venous blood samples were used for biochemical analysis, pulmonary function test, BMI, and waist hip ratio (WHR) were measured. The statistical analysis was done using SPSS version 17. There was a significant increase in BMI, WHR, lipid profile, serum uric acid and decrease in forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC in poorly controlled asthmatics. There was a significant association between FEV1 and serum uric acid, BMI and Triacylgycerol in poorly controlled asthmatics. Poorly controlled asthmatics have greater risk of developing cardiometabolic problems. Serum uric acid can be used as one of the severity markers in asthma to assess cardio metabolic risk. 相似文献