共查询到20条相似文献，搜索用时 31 毫秒
1.
Hajar Eftekhari Maryam Pilehchian Langroudi Ali Banihashemi Mandana Azizi Reza Youssefi Kamangar Haleh Akhavan-Niaki 《Indian journal of clinical biochemistry : IJCB》2018,33(2):231-234
α-Thalassemia (α-thal) is considered as the most common inherited hemoglobin disorder worldwide. The present study describes the first observation of a combination of rare α-chain variants, and β-globin gene cluster deletion. A 21-year-old woman with thalassemia trait, marked microcytosis, mild anemia, and normal range of Hb F was referred to Amirkola genetic center in the North of Iran for routine molecular test of thalassemia in the context of carrier detection and prevention of thalassemia major birth. Nucleotide sequencing revealed a novel compound heterozygosity status for two non-deletional mutations on HBA2, Hb O Indonesia (α116(GH4)Glu → Lys), and Hb Matsue–Oki (α75 (EF4) Asp → Asn), together with heterozygosity for the sicilian (δβ)0-thal mutation. This finding highlights the necessity of deep molecular investigation of thalassemia in regions where thalassemia is abundant, and present highly heterogeneous population. 相似文献
2.
Despite a substantial body of research investigating the market significance of inventions by independent inventors, relatively little attention has been devoted to understanding their technological significance. A recent study conducted by [Dahlin, K., Taylor, M., Fichman, M., 2004. Today's Edisons or weekend hobbyists: technical impact and success of inventions by independent inventors. Res. Policy 33, 1167-1183] on the tennis racket industry shows that independent inventors are a heterogeneous group which includes both “heroes” who contribute substantially to technological progress and “hobbyists” who make only a marginal contribution. What is not asked - and therefore not explained - is why this distinction arises. In this paper, we focus on the type of prior technological knowledge (in terms of technological specialization and diversity) applied by independent inventors and their corporate counterparts as a factor explaining differences in technological impact. Our empirical setting is the field of medical equipment technology. We find that independent inventors are more sensitive to the negative effects of technological diversity than their corporate counterparts. Furthermore, our study reveals that technological specialization pays off more for independent inventors than for their corporate counterparts. Therefore, those independent inventors who apply low degrees of diversity and high degrees of specialization are capable of reaching the same level as or even outperforming their corporate counterparts, thus becoming “heroes”. Based on our findings, we discuss implications for research and corporate practice. 相似文献
3.
What determines knowledge sourcing from host locations of overseas R&D operations? We investigate factors that influence the extent to which overseas R&D laboratories source knowledge from host locations. Drawing on both the capabilities perspective and the embeddedness perspective, we have developed a conceptual model and then examined it empirically focusing on overseas R&D labs of Japanese multinationals. Statistical findings from negative binomial regressions show that both technological capabilities of the lab and external embeddedness in the local scientific and engineering communities matter. 相似文献
4.
Nabarun Mandal Debojyoti Bhattacharjee Jayanta Kumar Rout Anindya Dasgupta Gorachand Bhattacharya Chandan Sarkar Prasanta Kumar Gangopadhyaya 《Indian journal of clinical biochemistry : IJCB》2016,31(4):468-472
Wilson’s disease is a disease of abnormal copper metabolism in which free serum copper level is raised. The objective of the study was to determine, whether in Wilson disease, l-cysteine/l-cystine influx into RBC was decreased or not and the specific amino acid transporter affected by copper in normal human RBC. For l-cysteine/l-cystine influx, ten untreated cases, ten treated cases and ten age and sex matched healthy controls were recruited. To study the effect of copper on l-cysteine/l-cystine influx in RBC, 15 healthy subjects were selected. RBC GSH and l-cysteine/l-cystine influx were estimated by Beautler’s and Yildiz’s method respectively. In untreated cases, l-cysteine/l-cystine influx and erythrocyte GSH level were decreased showing that elevated level of free copper in serum or media decreased l-cysteine/l-cystine influx in human RBC. Copper treatment inhibited L amino acid transporter in normal RBC specifically. 相似文献
5.
This paper studies the impact of R&D spending on output as well as forecasting the impact of a regionally enhanced R&D tax credit on the ‘user cost’ (or price) of R&D expenditure and subsequently the demand for R&D. The example we use of a ‘disadvantaged’ region is Northern Ireland (partly because it has the lowest levels of R&D spending in the UK, and partly because the necessary data is available for this region). We find that in the long run, R&D spending has a mostly positive impact on output across various manufacturing industries. In addition, plants with a zero R&D stock experience significant one-off negative productivity effects. As to the adjustment of R&D in response to changes in the ‘user cost’, our results suggest a rather slow adjustment over time, and a long-run own-price elasticity of around −1.4 for Northern Ireland. We also find that to have a major impact on R&D spending in the Province, the R&D tax credit would need to be increased substantially; this would be expensive in terms of the net exchequer cost. 相似文献
6.
7.
Most of the literature on university–industry (U–I) linkages assumes that these linkages are beneficial per se. We question this assumption, suggesting that not all such linkages are equally helpful. In this paper, we explore the factors driving the formation of ‘valuable U–I linkages’, conceived as those linkages between universities and firms that have a higher potential to diffuse knowledge to other firms in their regional economy. Our empirical strategy combines case-study methodology with econometric techniques using data from two wine clusters in Chile and in Italy. The firm's knowledge base is found to be a key driver of ‘valuable’ U–I linkages. We conclude that selectivity should be encouraged among policy makers endeavouring to promote U–I linkages. 相似文献
8.
9.
《国家科学评论(英文版)》2015,(1)
<正>The current science and technology(ST)system in China has drawn both criticism and recommendations from the local and international academic community.Reform of China’s ST system has recently become a hot topic for government leaders and the Chinese scientiic community.‘Deepening reforms of 相似文献
10.
This article aimed to identify the effect of university-industry (U-I) collaborations on the innovative performance of firms operating in the advanced materials field, and by doing so, it proposed an original classification of the research organization partners. The main contribution resides in the estimation of the role played by collaborations with differently experienced scientists. In contrast with previous studies, whose empirical setting was the life science industry, in the advanced materials industry the most effective collaborations are not with “Star scientists”, but with “Pasteur scientists”. The latter concept was empirically tested first by the authors of this article, to deepen the present understanding of industrial heterogeneity in innovation processes and to offer new insights for the formulation of corporate innovation strategies. The results of the estimation of a negative binomial regression model applied to a sample of 455 firms active in the photocatalysis in Japan confirm the idea that engaging in research collaborations, measured as co-invention, with “Pasteur scientists” increases firms’ R&D productivity, measured as number of registered patents. In contrast, we found that firms’ collaborations with “Star scientists” exert little impact on their innovative output. 相似文献
11.
Graves’ disease (GD) is an organ-specific heterogenous autoimmune disorder associated with T-lymphocyte abnormality affecting
the thyroid, eyes and skin. GD is a multifactorial disease that develops as a result of complex interaction between genetic
susceptibility genes and environmental factors. It has been suggested that the Cytotoxic T lymphocytes associated molecule-4
(CTLA-4) is a genetic susceptibility candidate for GD. The present study was focused on A/G polymorphism at position 49 in
exon-1 of the CTLA-4 gene in 80 GD patients (GP) and 80 sex and age matched healthy individuals among South Indian (Madurai)
population. Serum concentrations of thyroid hormone (T4, T3 and TSH) were determined by using automated analyzer. The genomic DNA was isolated from the patient and control groups and
genotyping was performed using the polymerase chain reaction followed by restriction enzyme analysis using Bbv1. Significant difference (P < 0.001) was observed in the level of T3, T4 and TSH in GD patients and healthy individuals. The results revealed the CTLA-4 gene G/G genotype to be 32 (40%) in patients
and 26 (32.50%) in healthy individuals, A/G genotype to be 37 (46.25%) in patients and 25 (31.25%) in healthy individuals
and A/A genotype to be 11 (13.75%) in patients and 29 (36.25%) in healthy individuals. The calculated odds ratio (OR) in individuals
with mutant genotype (GG/AG) reveal 3.6 fold risk for GD (95% confidence interval = 1.6–7.8). The mutant “G” allele frequency
was observed to be 0.63 in GD patients and 0.48 in healthy individuals. Thus the present study demonstrates an association
between the CTLA-4 gene polymorphism and Graves’ disease. 相似文献
12.
B. Antony M. Benny T. N. B. Kaimal 《Indian journal of clinical biochemistry : IJCB》2008,23(4):378-381
Emblica officinalis Gaertn., commonly known as the Indian gooseberry or “Amla”, has been used as health food for centuries
in India and other Asian countries. The biological effects of amla have been attributed to the antioxidant properties of the
low-molecular weight hydrolysable tannins present in the fruit. Amlamax™ is a purified, standardized, dried extract of amla
containing about 35% galloellagi tannins along with other hydrolysable tannins. Our earlier studies on rabbits showed significant
reduction in total cholesterol and triglycerides as well as increase in HDL. The present study extends these results to human
volunteers. Two doses of the extract were evaluated — 500 mg and 1000 mg per day for 6 months. Blood samples were collected
at the 3rd and 6th months showed reduction in total and LDL cholesterols and enhancement of beneficial HDL cholesterol. In
addition, blood CRP levels, a marker for inflammation, were also significantly reduced. Since dyslipidemia and inflammation
are the two major components of cardiovascular diseases, the present results must be considered encouraging and indicate the
potential of Amlamax™ in the management of heart diseases. 相似文献
13.
一个女孩
听啊,听啊,在废墟中,在瓦砾下,传来阵阵清脆读书声。一个压在废墟下的女孩,打着手电筒在忘情读书。她忘记了危险,忘记了伤痛,忘记了饥饿,用读书声驱赶着恐惧,与死神抗争,同时也召唤着生的希望。废墟下是黑暗的,但你心中有阳光,因为知识会带来勇气,文化会带来光明。临危不惧,从容镇静,在你身上,显示了广大灾民的不屈精神,体现着我们民族的光辉未来。你是最优秀的“读书种子”,你也是最出色的抗震勇士,向你致敬,为你祝福! 相似文献
14.
稍息、立正、跨立、齐步走、正步走……一样的动作,一样的要求,一样的口号将我的思绪带回到初中军训的时光。三年前的军训见证了我的成长：从初一的懵懂到初二的张扬再到初三的沉稳。经历鲜花簇拥时的快乐,也有身处荆棘时的痛苦,但无论处境如何,总有父母的双手为我导航,总有朋友的身影与我并肩,总有老师的目光陪我前行。 相似文献
15.
翻译活动是个极其复杂的过程,其中,作者、译者和读者的身份不同,然而彼此联系紧密。斌从信息交流的角度讨论翻译活动中这三类不同的主体,揭示其重要的地位和作用,对有关评判译作标准的问题抒一己之见。 相似文献
16.
17.
李小莹 《科技成果管理与研究》2007,(5)
2006年9月13日.欧盟创新峰会在比利时布鲁塞尔召开,会议讨论通过了《欧盟全面创新战略》报告,并提出了10项鼓励创新的措施;2006年11月26日,欧洲第一届再创新(Re-innovating)会议在西班牙巴伦西亚召开,会议讨论了传统产业的创新问题,旨在增强欧洲工业的基础创新能力.…… 相似文献
18.
Rani James G. Ramesh Lakshmi Krishnamoorthy Rahul Bhagat Shilpa Chadaga Vijayalaxmi Deshmane Girija Ramaswamy 《Indian journal of clinical biochemistry : IJCB》2014,29(1):21-28
Vascular endothelial growth factor (VEGF) plays an important role in the development of Breast Cancer. The aim of this study was to investigate the association of polymorphisms in the VEGF gene on prognosis of Breast Cancer patients. This study comprised 200 patients with histologically confirmed cases of Breast cancer and 200 controls. Genotyping of the VEGF gene polymorphisms at +405G>C,−1154G>A, were performed by PCR-RFLP analysis. Preoperative plasma VEGF levels were determined by ELISA. Amongst both cases and controls, the genotypic distribution of the individual SNPs were all in Hardy–Weinberg equilibrium. Mean VEGF level was significantly elevated in cases compared to controls (t = 8.248; P < 0.001). No significant association was found between +405G>C,−1154G>A VEGF polymorphism and Breast Cancer. Logistic regression analysis revealed that 405GG & 1154GG were associated with higher levels of VEGF. 相似文献
19.
《科技成果管理与研究》编辑部 《科技成果管理与研究》2007,(8)
诺贝尔奖这一代表世界创造力与创新能力的最高奖项,从1901年至今已经走过了107年,它见证了科技创新的原动力,浓缩了20世纪以来科技发展的历程.…… 相似文献
20.
宋代大儒张载说过,文人的责任是“为天地立心,为生民请命,为往圣继绝学,为万世开太平”。高校教师作为现代“文人”,主要是通过“教书育人,管理育人,服务育人”来培养社会主义的建设者和接班人来达到这个责任的。 相似文献