共查询到19条相似文献，搜索用时 500 毫秒
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目的 旨在观察三羧氨基喹啉 (L inomide)对人舌鳞状细胞癌裸鼠移植瘤生长的抑制效应 ,以明确 L inomide的抑瘤作用 ,为 L inomide用于人口腔鳞癌的治疗以及后续的进一步研究提供理论和实验依据 .方法 将人舌鳞癌细胞系 Tca8113接种至 BAL B/ C(nu/ nu)裸鼠 ,建立人舌癌裸鼠移植瘤模型 ,设立对照组、5 0 mg/ (kg· d)及 10 0 mg/ (kg· d) L inomide腹腔注射组 ,观察L inomide对肿瘤生长的抑制作用 .结果 与对照组相比 ,给予 Linomide治疗组的裸鼠皮下肿瘤体积明显缩小 (P<0 .0 1) ,肿瘤的生长明显受到抑制 ,10 0 mg/ (kg· d)组的瘤块体积要小于 5 0 mg/(kg· d)组的荷瘤裸鼠 (P<0 .0 1) ,说明 Linomide能抑制人舌癌裸鼠移植瘤的生长 ,且抑制程度与L inomide的剂量相关 .给予 L inomide治疗的荷瘤裸鼠其平均瘤重低于对照组 (P<0 .0 1) ,10 0mg/ (kg· d)组的荷瘤裸鼠的平均瘤重与 5 0 mg/ (kg· d)组的裸鼠比较 ,其瘤重的降低更为明显 (P<0 .0 1) .给药组裸鼠的存活时间与对照组相比明显延长 (P<0 .0 1) ,10 0 mg/ (kg· d)组的荷瘤裸鼠存活时间要长于 5 0 mg/ (kg· d)组的裸鼠 (P<0 .0 1) .结论 L inomide对人舌鳞状细胞癌裸鼠移植瘤有明显的抑瘤效应 . 相似文献
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3月18日是全国爱肝日。四川省肿瘤医院肝胆外科主任医师彭俊平提醒,肝癌已成为癌症致人死亡的“二号杀手”,大部分肝癌患者发病时已进入晚期,但肝癌并不可怕,只要做好病因预防、三早预防和积极综合特异性治疗这“三级预防”工作,就可有效避免肝癌发生或降低肝癌复发率。 相似文献
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3月18日是全国爱肝日。四川省肿瘤医院肝胆外科主任医师彭俊平提醒,肝癌已成为癌症致人死亡的"二号杀手",大部分肝癌患者发病时已进入晚期,但肝癌并不可怕,只要做好病因预防、三早预防和积极综合特异性治疗这"三级预防"工作,就可有效避免肝癌发生或降低肝癌复发率。 相似文献
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肝癌是死亡率仅次于胃癌、食道癌的第三大常见恶性肿瘤。而且由于该病恶性程度高、早期症状不明显、病情进展快等特点,在治疗上不仅难度大,疗效也差,一般发病后患者生存时间仅为6个月,故被人称之为“癌中之王”。据相关数据显示,我国新病例占了全球所有肝癌病例的一半以上（55%）,每年约有11万人死于肝癌。肝癌患者有个很明显的特征就是发病率男性明显高于女性,多年来科学家们都希望了解其中的原因,但是一直以来未能发现明确的分子机制。 相似文献
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肝癌是死亡率最高的癌症之一,全世界每年约有100万人死于该症,因而,肝癌又有"癌中王"之称.迄今为止,手术切除仍是首选方法. 相似文献
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探讨TCTE3 mRNA在人肝癌细胞株中的表达水平及意义。采用实时荧光定量PCR技术分别检测TCTE3基因在常规培养或缺氧诱导（CoCl2为诱导剂）的人肝癌细胞株中的表达情况。TCTE3 mRNA在常规培养的人正常肝细胞株L02,肝癌细胞株Bel-7402、SMMC-7721、HepG2和QGY-7701中不表达或极低表达;但经缺氧诱导后,SMMC-7721细胞中的TCTE3 mRNA表达量逐渐升高,4h达到最大,随后逐渐降低,与HIF1a mRNA表达的曲线变化有一定相似之处,只是这种变化的时间要早于HIF1a基因。在缺氧状态下肝癌细胞TCTE3 mRNA表达增加,且这种上调表达可能对HIF1a mRNA的表达有一定的促进作用。 相似文献
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研究了基于WSR方法论的人力资源开发,构建了人力资源开发系统的物理因素、事理因素、人理因素的三维体系和绩效函数模型,针对开发主体的多元性,重点对人理因素的开发主体及其关系进行了分析。 相似文献
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Krishnan Gokuladhas Subramaniyan Jayakumar Balan Rajan Ramasamy Elamaran Chengalvarayan Subramani Pramila Mani Gopikrishnan Sasivarman Tamilarasi Thiruvengadam Devaki 《Indian journal of clinical biochemistry : IJCB》2016,31(2):171-184
Liver cancer is the fifth most common cancer and is still one of the leading causes of death world wide, due to food additives, alcohol, fungal toxins, air, toxic industrial chemicals, and water pollutants. Chemopreventive drugs play a potential role in liver cancer treatment. Obviously in the production of anticancer drugs, the factors like poor solubility, bioavailability, biocompatibility, limited chemical stability, large amount of dose etc., plays a major role. Against this backdrop, the idea of designing the chemopreventive nature of bio flavanoid hesperetin (HP) drug conjugated with pegylated gold nanoparticles to increasing the solubility, improve bioavailability and enhance the targeting capabilities of the drug during diethylnitrosamine (DEN) induced liver cancer in male wistar albino rats. The dose fixation studies and the toxicity of pure HP and HP conjugated gold nanoparticles (Au-mPEG(5000)-S-HP) were analysed. After concluded the dose fixation and toxicity studies the experimental design were segregated in six groups for the anticancer analysis of DEN induced HCC for 16 weeks. After the experimental period the body weight, relative liver weight, number of nodules and size of nodules, the levels of tumor markers like CEA, AFP and the level of lipid peroxidation, lipid hydroperoxides and the activities of antioxidant enzymes were assessed. The administration of DEN to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma glutamyl transpeptidase. The levels of lipid peroxides elevated (in both serum and tissue) with subsequent decrease in the final body weight and tissue antioxidants like superoxide dismutase, catalase, reduced glutathione, glutathione peroxidise, and glutathione reductase. HP supplementation (20 mg/kg b.wt) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer and the HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) treated animals shows the better treatment than the pure HP due to the solubility of drug, bioavailability and the target drug delivery of the biodegradable polymer. Histological observations were also carried out, which added supports to the chemopreventive action of the pure HP and HP loaded gold nanoparticles (Au-mPEG(5000)-S-HP) against DEN induction during liver cancer progression. These findings suggest that HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) shows better efficacy than the pure HP against lipid peroxidation, hepatic cell damage and protects the antioxidant system in DEN induced hepatocellular carcinogenesis. 相似文献
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Emad F. Eskander Ahmed A. Abd-Rabou Shaymaa M. M. Yahya Ashraf El Sherbini Mervat S. Mohamed Olfat G. Shaker 《Indian journal of clinical biochemistry : IJCB》2014,29(1):3-7
Viral infection with hepatitis C virus (HCV) has a high propensity in becoming chronic and it is the major cause of hepatocellular carcinoma (HCC) worldwide. This review was basically established to illustrate the putative role of the P53 gene Arg72Pro polymorphism on various cancer models and viral infections, focusing on HCV and HCC incidences. Authors studied the 72 G/C single base substitution of P53 gene at codon 72 using various polymorphic techniques. Intriguingly, authors investigated that the P53 codon 72 plays a crucial role as risk factor in several cancer models. Others found that there is no association between codon 72 genotypes and HCV disease severity or liver cancer. Moreover, the lack of a significant relationship between this polymorphism and risk of HCC shows that it does not predispose towards hepatocarcinogenesis and the frequent loss of the proline allele in HCV-associated carcinogenesis of the liver plays some critical role in hepatocarcinogenesis. Amazingly, there is a significant correlation between male homozygotes for P53 72Pro with HCV type 1b infection. However, there was no significant difference between the P53 polymorphism and HCV genotypes 2a and 2b. It was concluded that the P53 gene polymorphism at codon 72 has been investigated as potential risk factor in several cancer models and HCV infections. 相似文献
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Red-cell glutathione (GSH) contents and enzyme activities of glutathione peroxidase (GSH-Px) as well as glutathione reductase (GSSG-R) were assayed in 30 normal subjects, 60 cirrhotic patients and 60 cancer patients. The mean GSH level and GSSG-R activity studied showed increased values in all diseased groups compared to normal values with significant elevations only in liver metastases group. Reduced enzyme activity of GSH-Px has been noted in both the cirrhotic groups but the decrease was significant only in alcoholic cirrhotic group. Decreased red-cell GSH-Px activities below the normal range were found in all the cancer patients with remarkable reduction in liver metastases than in hepatocellular carcinoma. 相似文献
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基于Nooteboom模型构建网络中企业间创新合作的博弈模型,确定企业合作伙伴数的临界值,结合复杂网络模型仿真企业网络的动态演化,研究企业网络结构与合作度的变化规律。结果表明,企业合作的临界伙伴数由合作收益、成本及风险决定。当企业合作伙伴数小于临界值时,合作是最优策略,且随着合作度增加,合作网络的特征路径长度缩短,集聚度下降网络出现均匀而致密的结构;在合作的伙伴数等于临界值时,网络中的合作度最大,结构趋于稳定。 相似文献
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The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich
regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased
expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group,
is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The
results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable
in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and
the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer. 相似文献
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Mohamed Ahmed Abdelmoaty Ahmed Mohamed Bogdady Mervat Mohamed Attia Nayel Abdelhamed Zaky 《Indian journal of clinical biochemistry : IJCB》2009,24(4):398-403
Hemodynamic disorders of liver cirrhosis complicated with portal hypertension are associated with an increased angiogenesis in animal model of portal hypertension and cirrhosis which were linked to increased expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO). The aim of study was to evaluate the serum concentration of VEGF and total nitric oxide (NO) in liver cirrhosis and the possible association with the degree of liver insufficiency. VEGF and NO were measured in serum of 64 patients with liver cirrhosis by ELISA and spectrophotometry respectively. The significant increase of serum VEGF was observed in liver cirrhosis compared to healthy individuals as well as serum NO (106.1 ± 66.7 vs. 41.5 ± 6 pg/mL, P < 0.05; 113.5 ± 65.8 vs. 20.8 ± 3.8 μmol/l, P< 0.001, respectively). Serum VEGF and NO showed significant associations with biochemical indices of liver function and with Child-pugh score where they were increased respectively to the degree of liver insufficiency. A significant association of raised serum NO in early stage of portal hypertension reflect its benefit in early expect of portal hypertension but, high serum VEGF in late stage may reflect its prognostic value in liver cirrhosis. 相似文献