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1.
短裙竹荪多糖清除O^—.2及对人工细胞膜自由基氧化的影响 总被引：3，自引：0，他引：3
短裙竹荪「Ｄｉｃｔｙｏｐｈｏｒａ ｄｕｐｌｉｃａｔａ（Ｂｏｓｅ）Ｆｉｓｈｅｒ」经热水抽提,乙醇沉淀,Ｓｅｖａｇ法去蛋白,乙醇分级分离,再经ＤＥＡＥ－纤维素柱层析得多糖组分ＰＳ。在体外产生Ｏ＾－．２的反应体系中,竹荪多糖组分ＰＳ在较低浓度下（〈２００ｍｇ／Ｌ）具有清除Ｏ＾－．２的作用,而在较高浓度下（〉２００ｍｇ／Ｌ）作用不明显。同时用荧光法研究了竹荪多糖组分ＰＳ对人红细胞膜脂质过氧化的影响,结果表 相似文献
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ＤＥＶＥＬＯＰＭＥＮＴＯＦＡＶＡＣＵＵＭＳＰＡＲＫＤＩＳＣＨＡＲＧＥＳＯＵＲＣＥＤＥＶＥＬＯＰＭＥＮＴＯＦＡＶＡＣＵＵＭＳＰＡＲＫＤＩＳＣＨＡＲＧＥＳＯＵＲＣＥ￥ＧｕｏＹｕ－ｂｉｎ；ＬｉＦｕ－ｔｉａｎ（ＣｈａｎｇｃｈｕｎＩｎａｔｉｔｉｄｅｏｆＯｐｔｉ... 相似文献
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慢性肺心病患者血清TNF-α及IL-8改变及意义 总被引：3，自引：0，他引：3
探讨了慢性肺心病（ＣＰＨＤ）急性加重期及经治疗缓解后血清白细胞介素－８（ＩＬ－８）和肿瘤坏死因子－α（ＴＮＦ－α）水平的变化．用双抗体夹心ＥＬＩＳＡ法检测了３０例ＣＰＨＤ患者急性加重期及治疗缓解后血清ＩＬ－８和ＴＮＦ－α,并与相应年龄的健康对照组比较．结果发现ＣＰＨＤ患者急性加重期血清ＩＬ－８及ＴＮＦ－α水平显著高于正常对照组（Ｐ＜０．０５）,且治疗缓解后血清ＴＮＦ－α水平显著降低（Ｐ＜０．０５）,而血清ＩＬ－８水平则基本不变（Ｐ＞０．０５）．说明ＩＬ－８、ＴＮＦ－α参与了ＣＰＨＤ的发生和发展,这为探求治疗新途径提供了依据． 相似文献
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ＣＲＹＳＴＡＬＳＴＲＵＣＴＵＲＥＳＯＦＣＨＡＲＧＥＴＲＡＮＳＦＥＲＳＡＬＴＳ（ＴＴＭＴＴＦ）_２Ｃｕ_２Ｃｌ_６ＡＮＤＣ_（４０）Ｈ_（７２）Ｎ_６Ｓｅ_４ＮｉＣｈｅｎＸｕｅ－ａｎ；ＹａｎｇＸｕｅ－ｙｏｎｇ；ＷｕＰｅｉ－ｊｉ；ＺｈｕＤａｏ－ｂｅｎ；ＦｕＨｅ?.. 相似文献
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ＡＮＯＴＥＯＮＦＩＲＳＴＰＡＳＳＡＧＥＴＩＭＥＳＦＯＲＧＩ／Ｍ／１ＴＹＰＥＭＡＲＫＯＶＰＲＯＣＥＳＳＥＳ￥Ｘｕｅ－Ｍｉｎｇ；Ｙｕａｎ（ＩｎｓｔｉｔｕｔｅｏｆＡｕｔｏｍａｔｉｏｎ，ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉｅｎｃｅｓ，Ｂｅｉｊｉｎｇ，１００... 相似文献
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为观察ＦＤＰ（１．６－二磷酸果糖）治疗高原心脏病的疗效，我们对２８例确诊为高原心脏病患者进行了ＦＤＰ治疗前后的ＤＣＧ检测；并与心脏彩色多普勒超声检查、心脏Ｘ线检查相对照，结果表明：ＤＣＧ检测结果与其一致，且明显优于之。 相似文献
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ＤＥＴＥＲＭＩＮＡＴＩＯＮＯＦＣＹＡＮＩＤＥＢＹＡＳＰＥＣＴＲＯＰＨＯＴＯＭＥＴＲＩＣＲＥＶＥＲＳＥＤＦＬＯＷＩＮＪＥＣＴＩＯＮＭＥＴＨＯＤ￥ＪｉｎｇｆｕＬｉｕａｎｄＨｕｉｃｈａｎｇＭａ（ＲｅｓｅｔｒｃｈＣｅｎｔｅｒｆｏｒＥｃｏ－Ｅｎｖｉｒｏｎｍｅｎ... 相似文献
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用化学还原法制备了非晶态合金催化剂Ｎｉ－Ｂ、Ｃｏ－Ｂ和Ｃｏ－Ｎｉ－Ｂ合金的非晶性质由Ｘ射线衍射（ＸＲＤ）及透射电子显微镜（ＴＥＭ）鉴定，组成用电感耦合等离子发射光谱（ＩＣＰ）分析，在高高真空程序升温脱附质谱（ＴＰＤ－ＭＳ）装置上研究了ＣＯ、Ｈ２在三种催化剂上的吸附及ＣＯ和Ｈ２的表面反应（ＴＰＳＲ），发现ＣＯ和Ｈ２在三种催化剂 分别有二种和一种吸附态，吸附强度和二种吸附态的数目在不同合金上有较大差异 相似文献
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应用Ｓｏｕｔｈｅｒｎ印迹杂交法、高压琼脂糖凝胶电泳和标准的微量淋巴细胞毒试验对中国汉族人４４例正常无相关个体进行了Ｃ４基因限制性片段长度多态性（ＲＦＬＰ）、Ｃ４蛋白分型及ＨＬＡ－ＤＲ分型的测定，结果发现Ｃ４ＲＦＬＰ Ａ、Ｂ二种格局在Ｃ４Ｂ＊Ｑ０的表现型上有显著差异（Ｐ〈０．０５）；ＲＦＬＰ Ａ型格局与ＤＲ４相关（Ｐ〈０．０５）。 相似文献
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目的:研究帕金森病(PD)非运动症状(NMS)发生和分布特点及其美多巴治疗后的变化,为早期诊断、病情进展和预后评估及治疗提供依据.方法:对PD组和对照组行NMS问卷调查,给予美多巴治疗3个月,依据统一帕金森病评分量表、简易精神状态检查、汉密尔顿抑郁量表、匹兹堡睡眠质量指数、便秘问题量表评估对照.结果:PD组出现记忆下降、便秘、情绪下降、感觉下降等与对照组相比具有显著差异(P＜0.05),而头晕、失眠、泌尿系症状两组间无显著差异(P＞0.05).其中以记忆下降发生率最高,其次为便秘、注意力下降、汗多、流涎;美多巴对改善NMS亦有一定的疗效.结论:(1)NMS存在于PD各期,其中以记忆下降发生率最高;(2)美多巴对改善NMS亦有一定疗效. 相似文献
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开展吉林市医学院校大学生丙型病毒性肝炎防治知识调查,为提高医学生对丙肝的防护知识、诊断及治疗能力提供基础资料及科学依据.方法 采用整群分层抽样的方法,对吉林市2所医学院校在校大学生进行问卷调查.结果医学生丙型肝炎防护知识总体知晓率,15项问题中有3项知晓率低于50％,有8项各年级知晓率有统计学差异（P＜0.01）,7项问题不同院系学生知晓率有统计学差异（P＜0.01）,2项问题知晓率农村和城市学生有差异,但无统计学意义（P＞0.05）.结论医学院校不同院系学生对丙肝相关知识的知晓率存在差异,应针对不同年级、不同专业进行相应的丙型肝炎相关知识培训及健康教育干预. 相似文献
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为探讨rDNA在重楼属Paris L.中的分布规律，利用荧光原位杂交（FISH）对4种重楼属植物
的18-26S rDNA进行了定位。所有植物均为二倍体，基因组由A、B、C、D和
E5条染色体构成。（1）滇重楼P.polyphylla var.yunnanensis:2n=10=6m+4t，C和D染色体的
短臂上各有1个18-26S rDNA位点;（2）长柱重楼P.forrestii:2n=10=6m+4t，B染色体的长臂
、C和D染色体的短臂上各有1个位点;（3）五指莲P.axialis:2n=10=6m（2sat）+4t（2sat）
+1-2B，C和D染色体的短臂上各有1个位点;在有1个B染色体的细胞中，B染色体没有信号点，
而有2个B染色体的细胞中，只有1个B染色体上有信号点，表明B染色体上有基因存在且其分裂
不均等;（4）大理重楼P.daliensis:2n=10=4m+2sm+2st+2t，C染色体的短臂上有1个位点。1
8-26S rDNA位点不仅出现在染色体的次缢痕上，也出现在非次缢痕位点。另外，4个种中C染
色体短臂末端均有18-26S rDNA。 相似文献
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Mohit Kumar Gangania Jyoti Batra Suman Kushwaha Rachna Agarwal 《Indian journal of clinical biochemistry : IJCB》2017,32(3):353-356
Parkinson’s disease (PD) is an old age disorder of basal ganglia which involves oligomerization of α-synuclein protein and formation of intercellular inclusions known as “Lewy bodies” in substantia nigra and caudate nuclei in brain which is progressive in nature. It is second most prevalent neurodegenerative disorder characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes in posture (instability). Both excess and deficiency in levels of transition metals (especially iron, copper) can be detrimental to the central nervous system. Abnormalities in iron (Fe) and copper (Cu) metabolism have been reported to produce oxidative stress which is one of the major cause in pathogenesis of PD. In the present study 35 PD patients and 33 controls of Northern Indian population were included and serum levels of Fe, Cu and ceruloplasmin (Cp) were measured. Serum Fe (p < 0.01) and Cu (p < 0.01) levels were found to be significantly decreased in PD, whereas there was no significant change in Cp levels in PD patients as compared to controls. These results suggest the existence of a defect in iron which over the time, may hasten the entry of iron into the brain and decrease iron in the extracellular compartment in PD patients. 相似文献
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Glucose-6-phosphate dehydrogenase (G6PD), a cytoplasmic enzyme, plays a protective role during oxidative stress in eucaryotic
cells, since they provide coenzymes and substrates to the primary antioxidant enzymes. The redistribution of G6PD in the hippocampus
was studied post-ischemia (PI). There was a characteristic localisation of G6PD in pyramidal cell layers of the rat hippocampus.
In hippocampus CA1 cells were stained weakly whereas CA3 cells showed strong histochemical staining. Ischemia induced up-regulation
of G6PD in the hippocampus was in a specific manner. First, the activity increased in the whole hippocampus (at 4 hours PI)
which persisted 6 hrs PI in CA1 area. However G6PD activity decreased in the CA3 area & dentate gyrus. At 10 & 24 hrs PI,
activity decreased in CA1 area but normalised in CA3 area & dentate gyrus compared to controls. This suggests that the sensitive
CA1 neurons are transiently capable of generating an anti-oxidative arsenal to cope with the oxidative stress in the first
few hours PI. We can conclude that the brain contains inducible endogenous mechanisms that are capable of enhancing the ability
of neurons to withstand lethal ischemic challenge.
(Presently working in Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi) 相似文献
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Mads Nybo Bente Jespersen Michael Aarup Charlotte Ejersted Anne Pernille Hermann Kim Brixen 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2013,23(3):342-350
Introduction:
The aim of the study was to identify biomarkers of alteration in bone mineral density (BMD) in patients on haemodialysis (HD) and peritoneal dialysis (PD).Materials and methods:
In a cross-sectional, longitudinal study dual-energy X-ray absorptiometry scans were performed in 146 HD-patients and 28 PD-patients. Follow-up after 14 months (mean) was conducted in 73 patients. As potential biomarkers we investigated parathyroid hormone (PTH), 25-hydroxy vitamin-D, ionised calcium, albumin, phosphate, and total alkaline phosphatases (t-ALP).Results:
Both groups of dialysis patients had lower BMD in the femoral neck (BMDneck) (P < 0.001) and forearm (BMDforearm) (P < 0.001) compared to healthy controls, but comparable BMD in the lumbar spine (BMDspine). BMD did not differ between dialysis types, but patients ever-treated with glucocorticoids had significantly lower BMD, while patients with polycystic kidney disease had higher BMD. BMD correlated with body weight, actual age, age at initiation of dialysis, duration of dialysis and levels of PTH and t-ALP. However, t-ALP only remained associated with low BMDspine after adjusting for other factors (P = 0.001). In the follow-up study all patients had decreased BMD in all three locations, but only for the lumbar spine there was a significant association between BMD and the bone markers t-ALP (P = 0.009) and PTH (P = 0.013).Conclusions:
Both HD and PD patients have low BMD, and increased concentrations of t-ALP is associated BMDspine after adjustment, while PTH and t-ALP is associated with decrease in BMDspine over time. This substantiates the use of these biomarkers in both types of dialysis patients. 相似文献18.
复杂产品(系统)创新存在技术能力学习路径选择问题。通过借鉴Lyapounov函数有关复杂产品(系统)的稳定性描述,对产品开发与技术能力的协同机理、产品开发与技术引进的关系等进行了研究,提出产品开发需求是复杂产品(系统)创新的基础、技术引进必须服务产品开发这个中心、产品序列升级过程就是技术能力成长过程;通过对我国核电工程的协同分析,指出现阶段需把握好产品开发与组织适应性、技术先进性及知识管理的平衡关系,并在自主创新的基础上保持技术能力提高途径的多样性。 相似文献
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P. R. Krishnaswamy Anjali Rao W. Murali H. Sudarshan Ballal 《Indian journal of clinical biochemistry : IJCB》2006,21(2):173-176
Serum paraoxonase (PON1) and antibodies to oxidized-LDL (anti ox-LDL) were measured in chronic renal failure subjects on renal
replacement therapy such as hemodialysis (HD) peritoneal dialysis (PD) and transplantation (Txp). Paraoxonase activity was
significantly lower in HD and PD group (P<0.001) than in control subjects. In transplant patients, paraoxonase activity was
not significantly different from that of controls. Antibodies to ox-LDL was significantly higher in HD, PD and Transplant
patients (P<0.0001) compared to control subjects. High titers of antibodies were observed in the HD group compared to the
PD and Transplant subjects. A decrease in paraoxonase activity and high titers of Antibodies to ox-LDL in the dialysis group
suggest a decreased cardio protective effect of HDL and enhanced risk of premature cardiovascular complications. Whereas in
case of transplant subjects, there seems to be restoration of PON1 activity, but elevated levels of anti-oxLDL could still
be a potential atherogenic factor. Hence, we propose that estimation of these two parameters can be used as a useful index
to measure the cardiac risk in the above patient category 相似文献
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在分析心理距离理论基础上,对心理距离的影响因素进行了细分,将心理距离视为由文化距离、商业环境距离与地理距离构成,给出了心理距离测量指标体系,并对测量方式进行了研究,构建了心理距离指数。利用澳大利亚出口市场目标国选择数据,探索了心理距离指数对目标国市场选择的影响,从而检验了心理距离指数的有效性,并进一步验证了目标市场选择过程中的心理相似性。 相似文献