一种高速喷射与机械钻井相结合的钻井方法     

Butle.  T 康勇 《图书与石油科技信息》1990,4(2):72-76

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Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells     

Liang J  Li T  Zhang YL  Guo ZL  Xu LH 《Journal of Zhejiang University. Science. B》2011,12(12):951-960

Due to their toxicity, the increased distribution of microcystins (MCs) has become an important worldwide problem. MCs have been recognized as inhibitors of protein phosphatase 2A (PP2A) through their binding to the PP2A catalytic subunit. However, the exact mechanism of MC toxicity has not been elucidated, especially concerning the cellular response and its autoregulation. To further dissect the role of PP2A in MC-induced toxicity, the present study was undertaken to determine the response of PP2A in human amniotic epithelial (FL) cells treated with microcystin-LR (MCLR), one of the MC congeners. The results show that a low-dose treatment of MCLR in FL cells for 6 h induced an increase in PP2A activity, and a high-dose treatment of MCLR for 24 h decreased the activity of PP2A, as expected. The increased mRNA and protein levels of the PP2A C subunit may explain the increased activity of PP2A. Furthermore, MCLR altered microtubule post-translational modifications through PP2A. These results further clarify the underlying mechanism how MCLR affects PP2A and may be helpful for elucidating the complex toxicity of MCLR.  相似文献   

A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats     

He XL  Yin HL  Wu J  Zhang K  Liu Y  Yuan T  Rao HL  Li L  Yang G  Zhang XM 《Journal of Zhejiang University. Science. B》2011,12(1):32-39

Radiation therapy has been widely applied in cancer treatment. However, it often causes thrombocytopenia (deficiency of white blood cells) as an adverse effect. Recombinant human interleukin-6 (rhIL-6) has been found to be a very effective way against this thrombocytopenia, but IL-6 has low stability in blood, which reduces its efficacy. To increases the stability and half-life of rhIL-6, it was modified by polyethylene glycol (PEG). The pharmacokinetics and the tissue distribution of PEG-rhIL-6 labeled with ¹²⁵I were examined after subcutaneous injection in rats. The pharmacokinetic pattern of PEG-rhIL-6 was defined with linear-kinetics, and we fitted a one-compartment model with half-lives of 10.44–11.37 h (absorption, t _{1/2K a}) and 19.77–21.53 h (elimination, t _1/2Ke), and peak concentrations at 20.51–21.96 h (t _peak) in rats. Half-lives and t _peak of PEG-rhIL-6 were longer than those of rhIL-6 previously reported. In the present study, for deposition of PEG-rhIL-6 in rats, the tissue distribution examination showed that blood was the major organ involved, rather than liver. However, as to the elimination of PEG-rhIL-6, the major organ was the kidney. The excretion fraction of the injection dose recovered from urine was 23.32% at 192 h after subcutaneous administration. Less than 6% of PEG-rhIL-6 was eliminated via the feces at 192 h. These results indicate that PEG-rhIL-6 is a good candidate drug formulation for patients with cancer.  相似文献   

拯救生命的给予     

T.J. Maciak  Joyce 《英语辅导》2015,(2):18-20

大多数的人总是倾向于临渴挖井而非居安思危,总觉得那些不幸之事不会降临到自己身上,但是大家有没有想过,也许有一天躺在病床上苦苦等待别人救助的会变成我们自己或者我们亲友?我是那些幸运儿之一,现在轮到我去帮助别人了。我最近进行了一次奇妙的旅行,刚从南非的德班回来,我在那里参加了第19届世界移植运动会。自1996年起,我就一直有参加这个移植运动会。无论怎么看,我  相似文献   

我就会怒火中烧     

T·德杰塞士 《小学教学设计》2013,(9):1

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反思教育援助部门方法及其对技术援助的意义：埃及社会发展基金会     

萨米尔&#;T．伊沙克  杨红 《教育展望》2001,30(4):79-88

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情报学对图书馆学理论和实践的重要性     

高尔文  T 周俊 《四川图书馆学报》1990,(2):75-77

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联机检索与传统咨询服务的结合     

Roose  T 宋小兰 《情报杂志》1989,8(1):56-58

利用联机数据库进行情报资料检索怎样才能与传统的咨询服务结合起来呢?在回答这个问题之前,我们应当先弄清楚它们结合的真正含义。作者认为,这是指创造一种条件,即通过电子计算机网络利用其数据库,就象读者通过传统检索工具利用馆藏的印刷型和缩微型资料一样方便、迅速。  相似文献   

3G运营:新商业模式与新生活     

Tomi  T.  Ahonen  王丽娜 《深圳特区科技》2004,(12)

早在19世纪初期,美国的一位政治哲学家John C.Calhoun曾经说过:“旧事物的衰败与新事物的形成是一个转换过程,其中肯定会出现不确定、混乱、错误与盲从现象.“……  相似文献   

The use of colours on the the seventeenth century royal warship Vasa     

Tångeberg P 《Endeavour》2000,24(4):147-151

The seventeenth-century Swedish Royal warship Vasa was painted and decorated with almost 500 figure sculptures and many carved ornaments. It is probably the most extensive sculptural work in wood to have been preserved from this period in European history. The ship's decorations are of particular importance given the scarcity of knowledge of how sculptures in general, and large ships in particular, were painted in Northern Europe during this period. About 20 different pigments have been characterized and it has been possible to reconstruct the appearance of many of the sculptures and to extend this knowledge to the ship's original appearance.  相似文献