Using Logistic Regression and the Mantel-Haenszel With Multiple Ability Estimates to Detect Differential Item Functioning     

Kathleen M. Mazor  Anil Kanjee  Brian E. Clauser 《Journal of Educational Measurement》1995,32(2):131-144

Logistic regression has recently been advanced as a viable procedure for detecting differential item functioning (DIF). One of the advantages of this procedure is the considerable flexibility it offers in the specification of the regression equation. This article describes incorporating two ability estimates into a single regression analysis, with the result that substantially fewer items exhibit DIF. A comparable analysis is conducted using the Mantel-Haenszel with similar results. It is argued that by simultaneously conditioning on two relevant ability estimates, more accurate matching of examinees in the reference and focal groups is obtained, and thus multidimensional item impact is not mistakenly identified as DIF.  相似文献   

Hypolipidemic effect of water extract ofFicus bengalensis in alloxan induced diabetes mellitus in rabbits     

Rimi Shukla  Kiran Anand  K. M. Prabhu  P. Suryanarayana Murthy 《Indian journal of clinical biochemistry : IJCB》1995,10(2):119-121

Hypolipidemic effect of the water extract of the bark ofFicus bengalensis was investigated in alloxan induced diabetes mellitus in rabbits. Treatment for one month (50 mg/kg body weight/day) brought down the level of total serum cholesterol (TC) in subdiabetic and diabetic rabbits (five in each group) from 82±11 mg% and 118±10.6 mg% to 42.7±3.1 mg% and 51.7±4.7 mg% respectively. Low density lipoprotein cholesterol and very low density lipoprotein cholesterol values came down from 34±10 mg% and 95±24 mg% to 16±3 mg% and 29±4 mg% in subdiabetic and diabetic rabbits. Triacylglycerol level before treatment was 121±21.6 mg% and 416±70 mg% in subdiabetic and diabetic rabbits. Treatment brought it down to 45±5 mg% and 81±27.5 mg%. Glycosylated hemoglobin was brought down from 2.1±0.3% to 1.5±0.1% in subdiabetic group and from 4.28±0.5% to 2±0.3% in diabetic group, indicating that treatment with water extract effectively controlled blood sugar. After treatment with water extract serum lipid values were nearly equal to those in healthy controls (normal) in subdiabetic rabbits, while in diabetic group, the values were only slightly above those of normal.  相似文献   

A sensitive and economical modified method for estimation of cerebrospinal fluid proteins     

Pushpa Durgawale  Sudhir Kanase  Pramod S. Shukla  Shubhangi Sontakke 《Indian journal of clinical biochemistry : IJCB》2005,20(2):174-177

Cerebrospinal fluid protein estimation is a routine diagnostic tool for various diseases. The proposed modified bromocresol green (BCG) method is applicable to automated as well as manual measurements. Protein concentrations and absorbance at 600 nm are linearly related throughout a wide range of concentrations from 10 mg % to 2000 mg %. Ninety C.S.F. samples were analyzed and results obtained by both the modified BCG method and routine pyrogallol red method were compared. An excellent co-relation was observed (n=90, g=0.996, P<0.001).  相似文献   

Effect of antioxidants and antibiotics on levels of seminal oxidative stress in leukocytospermic infertile men     

Sunil B. Yadav  Adinath N. Suryakar  Anil D. Huddedar  Pramod S. Shukla 《Indian journal of clinical biochemistry : IJCB》2006,21(1):152-156

Defective sperm function is the most common cause of infertility. A prospective study was carried out to correlate the concentration of nitrite (the stable metabolite of nitric oxide) in seminal plasma with leukocytospermia, and sperm membrane integrity. Total Fifty-seven normozoospermic subjects with and without leukocytospermia visiting the Infertility clinic at KH and MRC, Karad, were included in the present study. Semen samples were checked for sperm concentration, total sperm count, sperm motility, seminal leukocyte concentration and sperm membrane integrity as Hypoosmotic Swelling Test. Similarly the concentration of nitrite in seminal plasma was measured by Griess reaction and total antioxidant power measured as ferric reducing ability of plasma. The concentration of nitrite in seminal plasma was found to be raised with significantly increased leukocyte concentration in semen. Also significantly lowered levels of total antioxidant power along with defective sperm function was observed. Our results suggest that supplementary treatment of antioxidants with antibiotic for leukocytospermic infertile male patients may improve the sperm membrane integrity.  相似文献   

Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease     

K. Kaur  G. Bedi  M. Kaur  Anil Vij  Inderpreet Kaur 《Indian journal of clinical biochemistry : IJCB》2008,23(1):33-37

Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Traditional risk factors account for only half of the morbidity and mortality from coronary artery disease. There is substantial evidence that oxidative stress plays the major role in the atherosclerotic process. The present study was undertaken to evaluate the level of lipid peroxidation (by measuring malondialdehyde) and antioxidant enzymes (ceruloplasmin, glutathione, superoxide dismutase) in coronary artery disease. Serum malondialdehyde levels and serum ceruloplasmin levels were significantly raised in all the subgroups of study group as compared to control group (p<0.001). Whole blood glutathione levels and hemolysate superoxide dismutase activity was significantly decreased in all the subgroups of study group as compared to control group (p<0.001). Above results suggests that the patients of coronary artery disease show increased oxidative stress and decreased levels of antioxidant enzymes. So it is recommended that the management protocol for coronary artery disease patients should include antioxidant supplementation along with simultaneous lowering of lipid peroxidation.  相似文献   

Sex hormone binding globulin in breast cancer     

Dayalu Naik S L  Suresh Hedau  Anil Kumar Bahadur  Renuka Saha  Sudershan Kaur  Amitabha Ray 《Indian journal of clinical biochemistry : IJCB》2008,23(3):250-254

The present study was undertaken to determine the significance of sex hormone binding globulin, the major and specific binding protein for testosterone and estradiol, in breast cancer. Among breast cancer patients, lower serum levels of Sex hormone binding globulin and higher levels of testosterone were observed. Sex hormone binding globulin showed an inverse relationship with testosterone and total cholesterol, and a direct relation with HDL-cholesterol. By the western blot analyses, Sex hormone binding globulin was detected in all biological samples that we examined. In the breast tumor tissue sections, immuno-staining for Sex hormone binding globulin was confined in cell cytoplasm and 29% cases were positive, which showed no association with the investigated prognostic markers of breast cancer such as ER and HER-2/neu over-expression. In this study, decreased circulating levels of Sex hormone binding globulin in breast cancer patients possibly indicate higher bioavailable estrogens.  相似文献   

Calcium antagonist prevents calcium flux induced necrosis and apoptosis in ischemic reperfusion of rat liver     

Pronobesh Chattopadhyay  Nevneet Verma  Anurag Verma  Gunjan Shukla  Arun Kumar Wahi 《Indian journal of clinical biochemistry : IJCB》2008,23(4):356-360

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Application of Tucatinib and Trastuzumab: Dual Anti HER2 Therapy Against HER2 Positive Breast Cancer     

Sumanpreet Kaur  Rajasri Bhattacharyya  Dibyajyoti Banerjee  Jaya Shukla 《Indian journal of clinical biochemistry : IJCB》2021,36(1):124

Synergism in action of tucatinib and trastumab is reported in breast cancer management. However, its molecular basis is yet to be determined. In this context we attempted to provide an explanation at the molecular level by performing in silico experimentation and coupling its result with already available published observations. Our study will provide basis for planning further experimental study for unravelling the truth.  相似文献   

The Development of Simile Comprehension: From Similarity to Scalar Implicature     

Madeleine Long  Vishakha Shukla  Paula Rubio-Fernandez 《Child development》2021,92(4):1439-1457

Similes require two different pragmatic skills: appreciating the intended similarity and deriving a scalar implicature (e.g., “Lucy is like a parrot” normally implies that Lucy is not a parrot), but previous studies overlooked this second skill. In Experiment 1, preschoolers (N = 48; ages 3–5) understood “X is like a Y” as an expression of similarity. In Experiment 2 (N = 99; ages 3–6, 13) and Experiment 3 (N = 201; ages 3–5 and adults), participants received metaphors (“Lucy is a parrot”) or similes (“Lucy is like a parrot”) as clues to select one of three images (a parrot, a girl or a parrot-looking girl). An early developmental trend revealed that 3-year-olds started deriving the implicature “X is not a Y,” whereas 5-year-olds performed like adults.  相似文献   

Peter Debye and electrochemistry     

A. K. Shukla  T. Prem Kumar 《Resonance》2010,15(12):1068-1073

Debye won the 1936 Nobel Prize in Chemistry for his contributions to molecular structure, dipole moment relationship and for diffraction of X-rays and electrons. Electrochemists, however, remember him for the Debye-Hückel limiting law that describes the behavior of strong electrolytes. In explaining the non-ideal behavior of strong electrolytes, his mathematical treatment assumes that each ion is surrounded by an ionic cloud of oppositely charged ions, which retards the movement of ions in the medium. The theory not only provides a method for calculation of activity coefficients, but has also helped, among other things, in our understanding of diffusion in ionic media, change in the rate of ionic reactions upon addition of salts, and biochemical reactions.  相似文献