Narratives, choices, alienation, and identity: learning from an elementary science teacher     

Bhaskar Upadhyay 《Cultural Studies of Science Education》2009,4(3):601-610

As we contemplate on teacher identity research, there is a need to place a teacher’s narratives or story-lines at the center of that work. In this forum, in response to the insightful commentary from Stephen Ritchie and Maria Iñez Mafra Goulart and Eduardo Soares, I place a greater emphasis on understanding Daisy’s narratives from an existing social identity framework. Narratives tell us intricate and complex actions that a teacher has taken both personally and professionally. Additionally, narratives help us see implicit nature of identity explicitly. Therefore, a greater focus has to be placed on interactions and utterances of a teacher to make sense of who they are and what they do as expressed by their own words (identity and action). Finally, I join with Ritchie and Goulart and Soares to advocate that identity research needs to include participants as co-researchers and co-authors as identities are very personal and complex to be fully understood by the outsiders (researchers).  相似文献   

Membrane potentials of hypertensive,diabetic and arthritic polymorphonuclear leukocytes     

I. Rahman  A. Upadhyay  V. Tule  N. Nath 《Indian journal of clinical biochemistry : IJCB》1993,8(1):29-32

We studied the membrane potentials of normal, essential hypertensive, diabetes mellitus and rheumatoid arthritic polymorphonuclear leukocytes (PMNL). It was found that diabetic PMNL were grossly hyperpolarized as compared to normal. On the other hand hypertensive and arthritic PMNL elicited a significant depolarization. The PMNL obtained from treated hypertensive patients showed considerable recovery where as partial recovery was evidenced in membrane potentials in diabetic and arthritic PMNL. The implications are discussed.  相似文献   

Assay of tubercular antibody, circulating free and immune complexed antigen in the diagnosis of pulmonary tuberculosis     

Swati Banerjee  E Raji Nair  Satish Kumar  M. V. R. Reddy  Bhaskar C. Harinath 《Indian journal of clinical biochemistry : IJCB》2001,16(2):203-206

Analysis of tubercular antibody, circulating free and immune complexed antigen (CIC-Ag) was done in confimed pulmonary tuberculosis sera by ELISA, using ES-31 antigen and affinity purified anti ES-31 antibody. Twenty three of 25 (92%) tuberculosis sera were positive for IgG antibody to ES-31 antigen. Using anti ES-31 antibody, free tubercular antigen could be detected in 20 of 25 (80%) cases whereas circulating immune complexed antigen (CIC-Ag) in 18 of 25 (72%) cases by sandwich ELISA. Of the two sera showing absence of antibody, one showed presence of free and CIC-Ag whereas the other showed the presence of free antigen. Thus antigen assay may be used as an adjunct tool for confirmation of pulmonary tuberculosis.  相似文献   

Evaluation of adenosine deaminase activity and lipid peroxidation levels in diabetes mellitus     

Anjali C. Warrier  Narasimha Y. Rao  Devdutta S. Kulpati  Tarun K. Mishra  Bhaskar C. Kabi 《Indian journal of clinical biochemistry : IJCB》1995,10(1):9-13

There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus (IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia and lipid peroxidation in diabetes mellitus.  相似文献   

Photodynamic Therapy (PDT)     

Bhaskar?G?MaiyaEmail author  G.?Hariprasad  L.?Giribabu 《Resonance》2000,5(8):13-21

In this concluding article, three emerging aspects related to PDT are presented: (i) new approaches to PDT of cancer, (ii) PDT diagnostics, and (iii) new clinical applications.  相似文献   

Using first-order cognitive analysis to understand problem solving behavior: An example from accounting     

Jesse F. Dillard  R. Bhaskar  Ray G. Stephens 《Instructional Science》1982,11(1):71-92

We report a study of human problem solving in the accounting domain. This study has three characteristics. First, it is explicitly intended to aid in the development of instructional materials. Second, it uses a powerful task analyzing scheme as the basis for its conclusions. Third, we use a technique called First-Order Cognitive Analysis that combines the advantages of task analysis to overcome some of the traditional methodological problems posed to protocol analysis. Our representational scheme, KO, seems to be largely valid as a basis for reasoning about cognition, although only three subjects were studied.  相似文献   

Skill acquisition in the bookkeeping task     

R. Bhaskar  Jesse F. Dillard  Ray G. Stephens 《Instructional Science》1983,11(4):329-356

Skill acquisition in a domain is the acquisition of appropriate problem solving schemes, as determined by experts. This paper extends previous research in the accounting domain by investigating skill acquisition. It does so by a series of protocol analyses of a single subject as she progressed through an intermediate accounting course. These findings are compared with the behavior of a skilled subject. Our results suggest that the strategy transformation of unit-building is utilized in the bookkeeping task environment.  相似文献   

EGFR Mutation Analysis in Non-small Cell Lung Carcinoma Patients: A Liquid Biopsy Approach     

Jigna Joshi  Apexa Raval  Urja Desai  Vinal Upadhyay  Mansi Bhavsar  Kanisha Shah  Rakesh Rawal  Harsha Panchal  Franky Shah 《Indian journal of clinical biochemistry : IJCB》2021,36(1):51

In the era of the targeted therapy identification of EGFR mutation detection in lung cancer is extremely helpful to predict the treatment efficacy of EGFR tyrosine kinase inhibitors (TKIs). Unfortunately, the inadequacy and quality of the biopsy samples are the major obstacles in molecular testing of EGFR mutation in lung cancer. To address this issue, the present study intended to use liquid biopsy as the non-invasive method for EGFR mutation detection. A total of 31 patients with an advanced stage of lung cancer were enrolled in the study from which cell-free DNA (cfDNA) and FFPE tissue DNA was extracted. Extracted DNA samples were analyzed for further EGFR exon specific mutation analysis by ARMS-PCR. Data were analyzed statistically using SPSS software. In cfDNA samples, the prevalence of wild type EGFR was 48% while the prevalence of TKI resistant and TKI sensitive mutations were 3%. Conversely, in tissue DNA samples, the prevalence of wild type, TKI sensitive and TKI resistant mutations were 48%, 19%, and 3%, respectively. The overall concordance of EGFR mutation between cfDNA and tissue DNA was 83%. McNemar’s test revealed that there was no significant difference between EGFR expression of cfDNA and tissue DNA samples. Additionally, the significant-high incidence of TKI resistant mutations was observed in tobacco habituates, indicating the role of carcinogens present in the tobacco in developing resistant mutations. In conclusion, our data suggest that evaluation of EGFR mutation from cfDNA samples is practicable as a non-invasive tool in patients with advanced-stage of lung cancer.  相似文献   

Transportation infrastructure settlement and heave distress: challenges and solutions     

Anand J. Puppala  Bhaskar C. S. Chittoori 《浙江大学学报(A卷英文版)》2012,13(11):850-857

Transportation agencies spend millions of dollars annually to repair civil transportation infrastructure including pavements, earth structures and approach slabs distressed by soft compressible soils and expansive soils. Several research studies performed at the University of Texas at Arlington (UTA) focused on stabilizing these problematic soils so that they will provide better and more stable support to the transportation infrastructure. This paper focuses on a summary of two major distresses and mechanisms, and remedial measures for addressing these distress problems. A combined lime-cement stabilization method is fully evaluated in providing better support of pavement infrastructure, and these results are described here. Another major transportation infrastructure problem involving bridge approach slabs requires different treatment methods, and these results are briefly described. As a part of the recently completed research study assessments, both shallow and deep soil treatment methods for stabilizing soils are fully evaluated for their effectiveness in arresting the distress posed to the pavements and bridge approach slabs. These results along with a few future research needs are presented in this paper.  相似文献   

A novel design method for optimal IIR system identification using opposition based harmony search algorithm     

P. Upadhyay  R. Kar  D. Mandal  S.P. Ghoshal  V. Mukherjee 《Journal of The Franklin Institute》2014

In this paper a population based evolutionary optimization methodology called Opposition based Harmony Search Algorithm (OHS) is applied for the optimization of system coefficients of adaptive infinite impulse response (IIR) system identification problem. The original Harmony Search (HS) algorithm is chosen as the parent one and opposition based approach is applied to it with an intention to exhibit accelerated near global convergence profile. During the initialization, for choosing the randomly generated population/solution opposite solutions are also considered and the fitter one is selected as apriori guess for having faster convergence profile. Each solution in Harmony Memory (HM) is generated on the basis of memory consideration rule, a pitch adjustment rule and a re-initialization process which gives the optimum result corresponding to the least error fitness in multidimensional search space. Incorporation of different control parameters in basic HS algorithm results in balancing of exploration and exploitation of search space. The proposed OHS based system identification approach has alleviated from inherent drawbacks of premature convergence and stagnation, unlike Genetic Algorithm (GA), Particle Swarm Optimization (PSO) and Differential Evolution (DE). The simulation results obtained for some well known benchmark examples justify the efficacy of the proposed OHS based system identification approach over GA, PSO and DE in terms of convergence speed, identifying the system plant coefficients and mean square error (MSE) fitness values produced for both same order and reduced order models of adaptive IIR filters.  相似文献