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排序方式: 共有133条查询结果,搜索用时 15 毫秒
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Grizzi F Franceschini B Fiamengo B Russo C Dioguardi N 《Journal of Zhejiang University. Science. B》2007,8(4):217-220
Hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions. Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue, and discuss why this parameter might provide additional information regarding cancer behavior. The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation, and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. 相似文献
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For more than 150 years, the United States Government Printing Office (GPO), along with its Federal Depository Library Program (FDLP), has supported an informed citizenry and democracy by ensuring access and preservation to a broad swath of federal government information. This collaborative national public information program between local libraries and the national government, if it is to survive beyond its second century of service, must overcome profound challenges within a rapidly evolving complex of e-government policies and principles. The FDLP can (and must) find a way to serve its traditional values – permanent and public access to government information – that allows for growth and change within the demands of a dynamic electronic environment between the governors and the governed. 相似文献
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Lupo C Minganti C Cortis C Perroni F Capranica L Tessitore A 《Journal of sports sciences》2012,30(9):889-897
This study aimed to compare specific technical and tactical indicators of the team and centre forward role of Euro League, and Italian Serie A1, Serie A2, and Serie B men's water polo club competitions. A notational analysis was performed on 21 water polo matches to evaluate the occurrence of technical and tactical team and centre forward indicators, highlighting differences among championships according to chi-square analyses. Differences emerged for Counterattack (P < 0.001) and Power-Play (P < 0.001) possessions, Even (P < 0.001; Euro League: 3 ± 1, Serie A1: 3 ± 2, Serie A2: 3 ± 2, Serie B: 6 ± 4) and Power-Play (P = 0.001) goals, and exclusions and penalties (P = 0.008) of the team during Even possessions. Relatively to the role analyses, effects emerged for perimeter players playing events (P = 0.049), as well as for centre forwards' goals (P = 0.007) and exclusions and penalties (P < 0.001; Euro League: 8 ± 1, Serie A1: 6 ± 2, Serie A2: 6 ± 2, Serie B: 3 ± 2) occurring at the end of Even possessions. Therefore, in Euro League, and Italian Serie A1 and Serie A2, teams perform a high occurrence of Power-Play possessions following up an exclusion, especially achieved by the centre forward during Even possessions, while, in Italian Serie B, goals were mostly scored during Even possessions, with a relevant contribution from the centre forward role. 相似文献
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A framework for discussing (through the concepts of ‘model’ and ‘field of experience’) the nature of the relationships between
contexts and the formation of mathematical knowledge is proposed, and some educational, cultural and cognitive problems of
situated teaching-learning are tackled within it. This framework is supported and illustrated with references to the curricular
innovation and educational research carried out by the Genoa group, of which the authors are members.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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According to the literature, in recent years, developing experiential learning has fulfilled the requirement of a deep understanding of lean philosophy by engineering students, demonstrating the advantages and disadvantages of some of the key principles of lean manufacturing. On the other hand, the literature evidences how some kinds of game-based experiential learning overlook daily difficulties, which play a central role in manufacturing systems. To fill the need of a game overcoming such lack of vision, an innovative game direct in-field, named Kart Factory, has been developed. Actual production shifts are simulated, while keeping all the elements peculiar to a real production set (i.e. complexity, effort, safety). The working environment is a real pedal car assembly department, the products to be assembled have relevant size and weight (i.e. up to 35 kg approximately), and the provided tools are real production equipment (e.g. keys, screwdrivers, trans-pallets, etc.). Due to the need to maximise the impact on students, a labour-intensive process characterises the production department. The whole training process is based on three educational principles: Experience Value Principle, Error Value Principle, and Team Value Principle. As the ‘learn by doing’ and ‘learn by failing’ are favoured, the theory follows the practice, while crating the willingness to ‘do’ instead of just designing or planning. The gathered data prove the Kart Factory's effectiveness in reaching a good knowledge of lean concepts, notwithstanding the students’ initial knowledge level. 相似文献
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Saskia Damen Marleen J. Janssen Wied A. J. J. M. Ruijssenaars Carlo Schuengel 《International Journal of Disability, Development & Education》2015,62(2):215-243
Trevarthen’s theory of innate intersubjectivity is relevant to understanding communication problems in children with sensory disabilities. Trevarthen and Aitken used the term “intersubjectivity” to describe “the ability of humans to detect and change each other’s minds and behavior”. When children lack auditory and/or visual means of interaction, they may not be able to fully develop intersubjectivity, which impedes the development of more complex interpersonal communication. This article presents a review of 31 studies about intersubjectivity in children with sensory disabilities. The results indicate that the intersubjective development of children with sensory disabilities is often delayed. The studies also describe similar strategies for mediating intersubjectivity in children with sensory disabilities and in typical children, but say that specific adaptations may be needed. From an intersubjectivity perspective, symbolic communication delays in children with sensory disabilities may be improved through specific, purposeful forms of social interaction. 相似文献
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Manjima Dhar Jessica Wong Armin Karimi James Che Corinne Renier Melissa Matsumoto Melanie Triboulet Edward B. Garon Jonathan W. Goldman Matthew B. Rettig Stefanie S. Jeffrey Rajan P. Kulkarni Elodie Sollier Dino Di Carlo 《Biomicrofluidics》2015,9(6)
Circulating tumor cells (CTCs) are important biomarkers for monitoring tumor dynamics and efficacy of cancer therapy. Several technologies have been demonstrated to isolate CTCs with high efficiency but achieve a low purity from a large background of blood cells. We have previously shown the ability to enrich CTCs with high purity from large volumes of blood through selective capture in microvortices using the Vortex Chip. The device consists of a narrow channel followed by a series of expansion regions called reservoirs. Fast flow in the narrow entry channel gives rise to inertial forces, which direct larger cells into trapping vortices in the reservoirs where they remain circulating in orbits. By studying the entry and stability of particles following entry into reservoirs, we discover that channel cross sectional area plays an important role in controlling the size of trapped particles, not just the orbital trajectories. Using these design modifications, we demonstrate a new device that is able to capture a wider size range of CTCs from clinical samples, uncovering further heterogeneity. This simple biophysical method opens doors for a range of downstream interventions, including genetic analysis, cell culture, and ultimately personalized cancer therapy. 相似文献