Timothy Richard’s vision: Education and reform in China, 1880–1910     

Limin Bai 《Frontiers of Education in China》2016,11(1):117-118

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CIDE gene expression in adipose tissue,liver, and skeletal muscle from obese and lean pigs     

Yue-qin Qiu  Xue-fen Yang  Xian-yong Ma  Yun-xia Xiong  Zhi-mei Tian  Qiu-li Fan  Li Wang  Zong-yong Jiang 《Journal of Zhejiang University. Science. B》2017,18(6):492-500

The expression of the cell death-inducing DNA fragmentation factor α-like effector (CIDE) family including Cidea, Cideb, and Cidec was significantly increased in mouse and human models of obesity. However, there was less information on these genes’ expression in pigs. Here, we hypothesized that different fat accumulation between lean (Duroc×Landrace×Yorkshire gilts, DLY) and obese (Lantang) pigs was attributed to porcine CIDE-modulating lipid metabolism. Our data showed that Cidea and Cidec were expressed at a high level in adipose tissue, and at a relatively high level in skeletal muscle, whereas Cideb was mainly expressed in the liver in both breeds of pig. Lantang pigs had higher white adipose and skeletal muscle Cidea and Cidec mRNA abundance, and hepatic and muscle Cideb mRNA than DLY pigs. Lipid metabolism-related genes including sterol regulatory element binding protein 1c (SREBP-1c), hepatocyte nuclear factor-4α (HNF-4α), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), fatty acid synthase (FASN), diacylglycerol O-acyltransferase 1 (DGAT1), and DGAT2 showed a higher expression level in adipose tissue from obese pigs than in that from lean pigs. Lantang pigs exhibited higher mRNA abundance for liver SREBP-1c, HNF-4α, and PGC-1α, and higher skeletal muscle SREBP-1c, HNF-4α, PGC-1α, and DGAT2 expression, as compared with DLY pigs. However, the perlipin2 mRNA levels in adipose tissues, liver, and skeletal muscle were significantly lower in obese pigs than in their lean counterparts. Furthermore, plasma non-esterified fatty acid (NEFA), glucose, and triacylglycerol (TAG) levels were greater in obese pigs than in lean pigs. Finally, data from correlation analysis further found that CIDE mRNA expression was positively correlated with back fat thickness (BFT), abdominal fat mass (AFM), and the levels of NEFA, TAG, and glucose in the two breeds. Collectively, these data revealed that the porcine CIDEs possibly modulated lipid metabolism and contributed to the development of fat deposition and obesity in Lantang pigs.  相似文献   

Conversion of CO<Subscript>2</Subscript> to useful substances with composite iron,nickel, and copper catalysts     

Takashi Sagawa 《浙江大学学报(A卷英文版)》2018,19(1):80-85

Composite materials of Fe/Al₂O₃, which consist of small particles of iron supported by thermally stable alumina even at 500–700 °C, have been widely used in the water-gas shift reaction for natural gas reforming. Therefore, Fe/Al₂O₃ is one of the promising candidates for re-transformation of exhausted CO₂ into fuels such as alcohols and hydrocarbons. The development of a CO₂ reforming system using the composite materials of Fe/Al₂O₃ through CO₂ reduction to CO, dissociation of water into hydrogen, and methanol synthesis has been investigated. It was found that dry and steam (i.e. wet) reforming of CO₂ produced almost the same amount of CO. At a temperature above 500 °C, maximal and saturated yields of CO and H₂ from CO₂ and water were obtained. However, this CO₂ reforming system requires higher-pressure conditions from several tens to hundreds standard atmospheric pressure in order to achieve high yield and selectivity for methanol production. In this study we developed the modified CO₂ reforming system by the utilization of Ni and/or Cu instead of Fe in order to obtain other types of useful products such as CO, CH₄, and carbon, more efficiently and selectively under atmospheric pressure. When Ni or Cu was used, conversion of CO₂ was reduced to 76%, while 9% of methane was detected in the case of Ni. On the other hand, though the CO₂ conversion reduced half of the Fe, the selectivity of CO from CO₂ increased to 95% in the case of Cu.  相似文献   

Conversations with Innovators in Learning and Technology: E. Jane Davidson     

Fredrick W. BakerIII 《TechTrends》2017,61(5):411-414

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Numerical investigation of cavitating flow behind the cone of a poppet valve in water hydraulic system   总被引：2，自引：0，他引：2  

高红  傅新  杨华勇  Tsukiji Tetsuhiro 《浙江大学学报(A卷英文版)》2002,3(4):395-400

Computational Fluid Dynamics (CFD) simulations of cavitating flow through water hydraulic poppet valves were performed using advanced RNGk-epsilon turbulence model. The flow was turbulent, incompressible and unsteady, for Reynolds numbers greater than 43000. The working fluid was water, and the structure of the valve was simplified as a two dimensional axisymmetric geometrical model. Flow field visualization was numerically achieved. The effects of inlet velocity, outlet pressure, opening size as well as poppet angle on cavitation intensity in the poppet valve were numerically investigated. Experimental flow visualization was conducted to capture cavitation images near the orifice in the poppet valve with 30° poppet angle using high speed video camera. The binary cavitating flow field distribution obtained from digital processing of the original cavitation image showed a good agreement with the numerical result. Project supported by the National Natural Science Foundation of China (No. 59835160) and Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry of China (No. 50175097)  相似文献   

Operationalizing and validating disciplinary literacy in secondary education     

Hiller A. Spires  Shea N. Kerkhoff  Abbey C. K. Graham  Isaac Thompson  John K. Lee 《Reading and writing》2018,31(6):1401-1434

The goal of this study was to define the construct and establish the validity of disciplinary literacy, which has recently gained attention from the implementation of the Common Core State Standards (National Governors Association Center for Best Practices & Council of Chief State School Officers in Common Core State Standards for English language arts & literacy in history/social studies, science, and technical subjects [PDF]. Authors, Washington, DC, 2010). After defining disciplinary literacy in the four core disciplines of English language arts, science, history and social studies, and mathematics, scales were developed and administered to a snowball sample of professionals nationwide, with 857 respondents. The data showed evidence of disciplinary literacy as a multidimensional construct with three related factors: source literacy, analytic literacy, and expressive literacy. Based on EFA and CFA results, we can conclude that there are at least three types of literacy in operation among the four core disciplines. The three factors of literacy varied significantly by the four core disciplines of English/language arts (ELA), science, history and social studies, and mathematics, supporting the notion that each discipline uses literacy uniquely. This is the first study of its kind to attempt to define, quantify, and validate the construct of disciplinary literacy.  相似文献   

Classifications of college students’ protean and boundaryless orientation to work     

Jay W. Rojewski  Christopher Pisarik  Hyojung Han 《International Journal for Educational and Vocational Guidance》2017,17(3):329-346

Increasingly, individuals navigate their own careers in self-directed (protean) and boundaryless contexts. These concepts have been applied to adult employees but have seen limited application with young adults. Therefore, 205 college students were assessed on the Protean and Boundaryless Career Attitudes scales (Briscoe, Hall, and DeMuth, 2006); i.e., self-directed career management, values-driven, boundaryless mindset, and organizational mobility preferences. Scale items were reworded to focus on college experience. Cluster analysis organized respondents into five distinct protean-boundaryless career types. Three types were similar to those hypothesized for adults, while two types were unique to our sample.  相似文献   

Filtration of micro-particles within multi-fiber arrays by adhesive DEM-CFD simulation     

Ran Tao  Meng-meng Yang  Shui-qing Li 《浙江大学学报(A卷英文版)》2018,19(1):34-44

A 3D multi-time scale discrete element method-computational fluid dynamic (DEM-CFD) coupling approach was applied to investigate the filtration of micron-sized particles by different types of fiber arrays. Both the pressure drop and the filtration efficiency were examined to indicate the filtration performance of the fiber arrays. Fibers that were uniformly arrayed in a parallel or staggered manner were compared. Results showed that the staggered array showed a better performance than the parallel array in terms of both pressure drop and filtration efficiency. Further, we compared the performance of different staggered arrays, i.e. a regular case, one densified in the front layers and another densified in the back layers. The front densified array was found to enter the clogging and cake filtration stage in the shortest time, leading to the highest filtration efficiency, but the highest pressure drop. The back densified array still achieved a much higher filtration efficiency, despite a much lower pressure drop comparable to that of the regular array. The results suggest that the two kinds of densified arrays may be suited for different purposes, e.g. baghouse filters or breathing masks.  相似文献   

A novel multi-objective optimization method for the pressurized reservoir in hydraulic robotics     

Xiao-ping Ouyang  Bo-qian Fan  Hua-yong Yang  Shuo Ding 《浙江大学学报(A卷英文版)》2016,17(6):454-467

The pressurized reservoir is a closed hydraulic tank which plays a significant role in enhancing the capabilities of hydraulic driven robotics. The spring pressurized reservoir adopted in this paper requires comprehensive performance, such as weight, size, fluid volume, and pressure, which is hard to balance. A novel interactive multi-objective optimization approach, the feasible space tightening method, is proposed, which is efficient in solving complicated engineering design problems where multiple objectives are determined by multiple design variables. This method provides sufficient information to the designer by visualizing the performance trends within the feasible space as well as its relationship with the design variables. A step towards the final solution could be made by raising the threshold on performance indicators interactively, so that the feasible space is reduced and the remaining solutions are more preferred by the designer. With the help of this new method, the preferred solution of a spring pressurized reservoir is found. Practicability and efficiency are demonstrated in the optimal design process, where the solution is determined within four rounds of interaction between the designer and the optimization program. Tests on the designed prototype show good results.  相似文献   

Florida and Puerto Rico Secondary Science Teachers’ Knowledge and Teaching of Climate Change Science     

Benjamin C. Herman  Allan Feldman  Vanessa Vernaza-Hernandez 《International Journal of Science and Mathematics Education》2017,15(3):451-471

Misconceptions about climate change science are pervasive among the US public. This study investigated the possibility that these misconceptions may be reflective of science teachers’ knowledge and teaching of climate change science. Florida and Puerto Rico secondary science teachers who claim to teach extensively about climate change were surveyed in regard to their conceptions of climate change science and the climate change-related topics they teach. Results show that many teachers hold naïve views about climate change (e.g. that ozone layer depletion is a primary cause of climate change) and climate change science (e.g. that it must be based on controlled experiments for it to be valid). In addition, teachers in both groups neglect crucial topics such as how evidence for climate change is developed and the social, political, and economic dimensions of climate change. Our results suggest the need for teachers to understand how to teach climate change and the nature of climate change science using authentic contexts that promote effective socioscientific decision-making and climate change mitigation.  相似文献