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91.
During the decision-making process, especially in multi-disciplinary complex cases, assessment technique is needed to assist policy-makers in making the right decision. Many of such assessment techniques have been developed for policy-makers, but the inevitable subjectivity of policy-makers often becomes the main obstacle in making the right or proper policy. Interlink decision-making index (IDMI) is a newly proposed assessment method with the advantages of being simple to use and having less human interference over other methods, as it does not require a weighting process of each selection criterion. This paper implements IDMI to assist with decision-making in national or regional low-carbon development, using China as a case study. The Chinese government has annotmced its carbon emission reduction target along with other development targets by 2020. Many policy settings can be chosen in order to achieve those targets. The problem is how to determine the best setting and the means by which decision-makers can avoid subjectivity and extremes. A number of policy setting options are generated carefully by a system dynamic model under different policy scenarios. The IDMI demonstrates a perfect way to assist in selecting the "best" among all the options that can achieve the goals within the acceptable range. 相似文献
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Eric R. Muoz Jaclyn B. Caccese Brittany E. Wilson Kyle T. Shuler Fernando V. Santos Carolina T. Cabn John J. Jeka Dianne Langford Matthew B. Hudson 《运动与健康科学(英文)》2021,10(2):122
BackgroundConsidering the potential cumulative effects of repetitive head impact (HI) exposure, we need sensitive biomarkers to track short- and long-term effects. Circulating small extracellular vesicles (sEVs) (<200 nm) traffic biological molecules throughout the body and may have diagnostic value as biomarkers for disease. The purpose of this study was to identify the microRNA (miRNA) profile in circulating sEVs derived from human plasma following repetitive HI exposure.MethodsHealthy adult (aged 18–35 years) soccer players were randomly assigned to one of 3 groups: the HI group performed 10 standing headers, the leg impact group performed 10 soccer ball trapping maneuvers over 10 min, and the control group did not participate in any soccer drills. Plasma was collected before testing and 24 h afterward, and sEVs were isolated and characterized via nanoparticle tracking analysis. Next-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs, and candidate microRNAs were analyzed via quantitative polymerase chain reaction. In silico target prediction was performed using TargetScan (Version 7.0; targetscan.org) and miRWalk (http://mirwalk.umm.uni-heidelberg.de/) programs, and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney (HEK) 293T/17 cells.ResultsPlasma sEV concentration and size were not affected across time and group following repetitive HI exposure. After 24 h, the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p, miR-423-5p, and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p, miR-144-5p, miR-221-5p, and miR-22-3p. Analysis of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA levels. To our knowledge, miR-7844-5p is a previously unknown miRNA. We identified 8 miR-7844-5p mRNA targets: protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), LIM and senescent cell antigen-like domains 1 (LIMS1), autophagy-related 12 (ATG12), microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), integrin subunit alpha-1 (ITGA1), mitogen-activated protein kinase 1 (MAPK1), glycogen synthase kinase 3β (GSK3β), and mitogen-activated protein kinase 8 (MAPK8).ConclusionCollectively, these data indicate repetitive HI exposure alters plasma sEV miRNA content, but not sEV size or number. Furthermore, for the first time we demonstrate that previously unknown miR-7844-5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease. 相似文献
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This study tested competing predictions about the implications of Internet use for traditional inequities in social support availability. Using survey data collected as part of the Pew Internet and American Life Project, inequities in social support availability stemming from demographic and network-related factors were examined among non-users, Internet users, and Internet users who also participated in a social network site (SNS). The results offered evidence consistent with the social compensation perspective. Traditional inequities in support availability related to age, race, and total network size persisted among respondents who did not use the Internet, but were less evident or absent among Internet users and/or Internet users who participated in an SNS. Using the Internet to connect with others appeared to be an important mechanism through which inequality in support availability was mitigated. 相似文献
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Henderson J. Bryan Zillmer Nicole Holton April Weiner Steven Greenwald Eric Goss Megan Lopez M. Lisette Morales Christina Pearson P. David McNeill Katherine L. 《Journal of Science Education and Technology》2021,30(6):803-815
Journal of Science Education and Technology - We present lessons learned from an ongoing attempt to conceptualize, develop, and refine a way for teachers to gather formative assessment evidence... 相似文献
98.
The current study investigated the efficacy of a self-managed activity schedule to teach 2 participants how to effectively order food items from a local community bakery. 2 participants who were on the autism spectrum were taught to follow a task analysis that was displayed on an iPhone. We used a multiple baseline design across participants to evaluate the effectiveness of the teaching procedure. Results showed that the participants were able to order items, and this skill generalized to a novel bakery. The task analysis and iPhone were immediately withdrawn at a 2 to 5 week follow-up, and both participants were still able to effectively perform the steps of the task analysis without the use of prompts. 相似文献
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Stuart W. Twemlow Bridget K. Biggs Timothy D. Nelson Eric M. Vernberg Peter Fonagy Stephen W. Twemlow 《Psychology in the schools》2008,45(10):947-959
This study evaluated the Gentle Warrior Program, a traditional martial arts–based intervention to reduce aggression in children, as it was implemented in three elementary schools. The sample consisted of 254 children in grades 3, 4, and 5 who participated in the Gentle Warrior Program as part of a larger school violence intervention. Results indicated that boys who participated in more Gentle Warrior sessions reported a lower frequency of aggression and greater frequency of helpful bystanding (i.e., helpful behavior toward victims of bullying) over time, relative to boys with less frequent participation. The effect of participation on aggression was partially mediated by empathy. The effect of participation on helpful bystanding was fully mediated by changes in student empathy. No significant results were found for girls. Results of the study provide preliminary support for the use of martial arts–based interventions to address bullying in schools for boys, by teaching empathy, self‐control, and peaceful strategies to resolve conflicts. © 2008 Wiley Periodicals, Inc. 相似文献