Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic set points     

Kelsey H.Collins  Graham Z.MacDonald  David A.Hart  Ruth A.Seerattan  Jaqueline L.Rios  Raylene A.Reimer  Walter Herzog 《运动与健康科学(英文)》2020,9(2):132-139,197

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators.Of note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of obesity.We wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic disturbances.Based on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage scores.Methods:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult group.The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group.Although knee joint damage scores were low in all 3 groups,we found,contrary to our hypothesis,that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups.Furthermore,we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.Conclusion:These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group.Interestingly,when assessing various serum proinflammatory markers,no significant differences were detected between the HTS Adult and HFS Weanling groups.Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated,these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced.Moreover,increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet.  相似文献   

‘The influence of overseas coaching and management on the occupational subculture of English professional soccer: views from the dugout’     

Graham Smith 《Soccer & Society》2019,20(1):61-85

It is generally acknowledged that expatriate British players and coaches were instrumental in soccer’s radiant global diffusion and that different technical and tactical emphases developed according to particular geographical locations and cultural milieu. As the twentieth century unfolded, the trend reversed with increased inward flows of elite foreign playing and coaching labour challenging the distinctive and erstwhile dominant occupational culture of the English game. This paper explores the dynamics and tensions of subcultural modification and adaptation at the British: migrant coaching talent interface. Owing to issues associated with access, the occupational subculture of elite-level football is impenetrable to most researchers. Previous employment in professional soccer allowed this author to overcome such impediments, permitting access to a range of high-status national and international players and coaches (n = 25) affecting and affected by occupational subcultural change. This enabled a distinctive research platform combining insider knowledge and grounded experience with academic orthodoxy. The paper is built upon primary data collected in semi-structured interviews and critical analysis of emerging themes. In doing so, it offers a fresh dimension to understanding the impact of globalization on elite professional English soccer. Key findings indicated the opinion of British coaches on the impact of this foreign influx polarized. Although many demonstrated an enlightened standpoint, adopting innovative practices introduced by overseas coaching talent, these views were counter-balanced by evidence of a myopic arrogance bordering on xenophobic resistance to change in what now has to be considered the global rather than the ‘English’ game.  相似文献   

A Football Man: the contribution of Eric Dunning to the acceptance of soccer as an area for serious academic study     

Graham Curry 《Soccer & Society》2019,20(6):891-895

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Acute effects of different warm-up protocols on highly skilled golfers’ drive performance     

Ben L. Langdown  Jack E.T. Wells  Sean Graham  Matt W. Bridge 《Journal of sports sciences》2019,37(6):656-664

Previous research has highlighted the positive effect that different warm-up protocols have on golf performance (e.g. Sorbie et al., 2016; Tilley & Macfarlane, 2012) with the design of warm-ups and programmes targeting and improving golf performance through the activation and development of specific muscle groups. This study aimed to examine the acute effects of two warm-up protocols on golf drive performance in comparison to a control condition. Using a randomised counterbalanced design over three testing sessions, twenty-three highly skilled golfers completed the control, dynamic and resistance-band warm-up conditions. Following each condition, a GC2 launch monitor was used to record ball velocity and other launch parameters of ten shots hit with the participants’ own driver. A repeated-measures ANOVA found significant increases in ball velocity (η_p² = .217) between the control and both the dynamic and resistance-band warm-up conditions but no difference between these latter two, and a reduction in launch angle between control and dynamic conditions. The use of either a dynamic stretching or resistance-band warm-up can have acute benefits on ball velocity but golfers should liaise with a PGA Professional golf coach to effectively integrate this into their golf driving performance.  相似文献   

Vain games of no value? A social history of association football in Britain during its first long century     

Graham Curry 《Sport in History》2017,37(2):251-254

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Youth exercise intention and past exercise behavior: examining the moderating influences of sex and meeting exercise recommendations     

Downs DS  Graham GM  Yang S  Bargainnier S  Vasil J 《Research quarterly for exercise and sport》2006,77(1):91-99

The study purposes were to examine: (a) the determinants of exercise intention and past exercise behavior (PEB) using the theories of reasoned action and planned behavior, and (b) the moderating influences of sex and exercise group (meeting or not meeting exercise guidelines). Participants (n = 676 adolescents) completed self-reported measures of their exercise attitude, subjective norm, perceived behavioral control (PBC), intention, and PEB. We found that attitude, subjective norm, and PBC explained 55% of the variance in intention, and intention and PBC explained 51% of the variance in PEB. While we found sex and exercise group differences across the study measures, we did not find evidence of significant moderation. Thus, the theory constructs predicted intention and PEB similarly across sex and exercise groups.  相似文献   

A television programme on finite differences     

Alexander Graham  Graham A. Read 《Educational Studies in Mathematics》1971,3(2):206-219

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Laptops in the Scottish Primary School: Interim Report     

Graham Turnbull  Tom Gilmour 《Educational Media International》2013,50(2):63-66

Abstract

The following paper should be seen as an addition to that provided in the Proceedings of the 7th ICTE.’ For reasons of brevity, it does not deal to any large extent with the background to the project, but details the progress of a study into the effects of introducing laptops into primary (elementary) school. The project has provided every pupil in one class with a laptop computer and has tracked the use being made of it as a curriculum tool for writing. The second phase of the project is under way, with a completion date of April 1991.  相似文献   

Junior Pinpoint: A Child's Guide to Data Handling     

Alan Graham 《Teaching Statistics》1995,17(2):75-75

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Information overload within the health care system: a literature review     

Hall A  Walton G 《Health information and libraries journal》2004,21(2):102-108

There is a widespread view held by health clinicians that their work effectiveness is impaired by 'information overload.' Building upon a previous work by Wilson, a review of the literature was undertaken to look for the evidence of this. It was found that the literature, particularly in the context of the clinical environment, was limited. This review explores the diverse overarching theories of information overload, effects of the phenomenon that are perceived to occur and proposed solutions to this problem. Many of the papers noted an information explosion but only three authors explicitly attempted to measure both the quantity and the complexity of this information. It was also found that the typology of the information studied was severely limited with most studies exploring information such as guidelines, access to journals, research findings and other knowledge intensive areas. Solutions proposed seem to concentrate on technological means rather than exploring the use of humans either in management of information or as a step in the filtering process.  相似文献