Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic set points     

Kelsey H.Collins  Graham Z.MacDonald  David A.Hart  Ruth A.Seerattan  Jaqueline L.Rios  Raylene A.Reimer  Walter Herzog 《运动与健康科学(英文)》2020,9(2):132-139,197

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators.Of note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of obesity.We wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic disturbances.Based on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage scores.Methods:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult group.The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group.Although knee joint damage scores were low in all 3 groups,we found,contrary to our hypothesis,that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups.Furthermore,we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.Conclusion:These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group.Interestingly,when assessing various serum proinflammatory markers,no significant differences were detected between the HTS Adult and HFS Weanling groups.Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated,these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced.Moreover,increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet.  相似文献   

A Football Man: the contribution of Eric Dunning to the acceptance of soccer as an area for serious academic study     

Graham Curry 《Soccer & Society》2019,20(6):891-895

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Meeting in the Middle: The Role of Mutual Biracial Friends in Cross-Race Friendships     

Leslie Echols  Sandra Graham 《Child development》2020,91(2):401-416

Social network analysis was used to examine the role of having a mutual biracial friend on cross-race friendship nominations among monoracial sixth-grade students (M_age = 10.56 years) in two racially diverse middle schools (n = 385; n = 351). Monoracial youth were most likely to choose same-race peers as friends but more likely to choose biracial than different-race peers as friends, suggesting that racial homophily may operate in an incremental way to influence friendships. Monoracial different-race youth were also more likely to be friends if they had a mutual biracial friend. The findings shed light on the unique role that biracial youth play in diverse friendship networks. Implications for including biracial youth in studies of cross-race friendship are discussed.  相似文献   

How Haptics and Drawing Enhance the Learning of Anatomy     

Stephen Reid  Leonard Shapiro  Graham Louw 《Anatomical sciences education》2019,12(2):164-172

Students’ engagement with two-dimensional (2D) representations as opposed to three-dimensional (3D) representations of anatomy such as in dissection, is significant in terms of the depth of their comprehension. This qualitative study aimed to understand how students learned anatomy using observational and drawing activities that included touch, called haptics. Five volunteer second year medical students at the University of Cape Town participated in a six-day educational intervention in which a novel “haptico-visual observation and drawing” (HVOD) method was employed. Data were collected through individual interviews as well as a focus group discussion. The HVOD method was successfully applied by all the participants, who reported an improvement of their cognitive understanding and memorization of the 3D form of the anatomical part. All the five participants described the development of a “mental picture” of the object as being central to “deep learning.” The use of the haptic senses coupled with the simultaneous act of drawing enrolled sources of information that were reported by the participants to have enabled better memorization. We postulate that the more sources of information about an object, the greater degree of complexity could be appreciated, and therefore the more clearly it could be captured and memorized. The inclusion of haptics has implications for cadaveric dissection versus non-cadaveric forms of learning. This study was limited by its sample size as well as the bias and position of the researchers, but the sample of five produced a sufficient amount of data to generate a conceptual model and hypothesis.  相似文献   

Fateful aspects of aspiration among graduates in New York and Los Angeles     

John Loewenthal  Patrick Alexander  Graham Butt 《International Studies in Sociology of Education》2019,28(3-4):345-361

ABSTRACT

This article presents ethnographic research on the aspirations of graduates from a private university in New York City, some of whom move to Los Angeles. Findings depict financial and family pressures exerting a governing force upon the graduates’ futures, often beyond their control. Focusing on the narratives of four individuals, we introduce the language of fate as a means of conceptualising the potential repercussions of aspiration and Higher Education. The premise of both is an increased determinacy over one’s future, yet in the high-stakes U.S. context here examined, this financial investment and articulation of family hope may generate fated (seemingly inescapable) and/or fateful (ominous) outcomes. The dynamic of ‘cruel optimism’ illustrates some of the paradoxical consequences of Higher Education, whereby people may be punished by their aspirations. We discuss what factors affect differing outlooks on the future and imply alternative dimensions to adversity beyond the remit of ‘inequality’.  相似文献   

Acute effects of different warm-up protocols on highly skilled golfers’ drive performance     

Ben L. Langdown  Jack E.T. Wells  Sean Graham  Matt W. Bridge 《Journal of sports sciences》2019,37(6):656-664

Previous research has highlighted the positive effect that different warm-up protocols have on golf performance (e.g. Sorbie et al., 2016; Tilley & Macfarlane, 2012) with the design of warm-ups and programmes targeting and improving golf performance through the activation and development of specific muscle groups. This study aimed to examine the acute effects of two warm-up protocols on golf drive performance in comparison to a control condition. Using a randomised counterbalanced design over three testing sessions, twenty-three highly skilled golfers completed the control, dynamic and resistance-band warm-up conditions. Following each condition, a GC2 launch monitor was used to record ball velocity and other launch parameters of ten shots hit with the participants’ own driver. A repeated-measures ANOVA found significant increases in ball velocity (η_p² = .217) between the control and both the dynamic and resistance-band warm-up conditions but no difference between these latter two, and a reduction in launch angle between control and dynamic conditions. The use of either a dynamic stretching or resistance-band warm-up can have acute benefits on ball velocity but golfers should liaise with a PGA Professional golf coach to effectively integrate this into their golf driving performance.  相似文献   

Rating Pakistani medical journals using the principles of citation analysis     

Ullah M  Butt IF 《Health information and libraries journal》2008,25(1):50-54

OBJECTIVE: To quantify the impact of Pakistani Medical Journals using the principles of citation analysis. METHODS: References of articles published in 2006 in three selected Pakistani medical journals were collected and examined. The number of citations for each Pakistani medical journal was totalled. The first ranking of journals was based on the total number of citations; second ranking was based on impact factor 2006 and third ranking was based on the 5-year impact factor. Self-citations were excluded in all the three ratings. RESULTS: A total of 9079 citations in 567 articles were examined. Forty-nine separate Pakistani medical journals were cited. The Journal of the Pakistan Medical Association remains on the top in all three rankings, while Journal of College of Physicians and Surgeons-Pakistan attains second position in the ranking based on the total number of citations. The Pakistan Journal of Medical Sciences moves to second position in the ranking based on the impact factor 2006. The Journal of Ayub Medical College, Abbottabad moves to second position in the ranking based on the 5-year impact factor. CONCLUSION: This study examined the citation pattern of Pakistani medical journals. The impact factor, despite its limitations, is a valid indicator of quality for journals.  相似文献   

Guide on the Side and LibWizard Tutorials Side-By-Side: How Do the Two Platforms for Split-Screen Online Tutorials Compare?     

Graham Sherriff 《Journal of Web Librarianship》2017,11(2):124-142

Split-screen tutorials are an appealing and effective way for libraries to create online learning objects where learners interact with real-time Web content. Many libraries are using the University of Arizona's award-winning, open source platform, Guide on the Side. In 2016, Springshare released a proprietary alternative, LibWizard Tutorials. This article reviews the advantages and limitations of this kind of tutorial. It also examines the differences between each platform's distinctive characteristics. These platforms create similar split-screen tutorials, but have differences that affect diverse aspects of installation, administration, authoring and editing, student learning, data management, and accessibility. Libraries now have the opportunity to consider and compare alternative platforms, and decide which one is best suited to their needs, priorities, and resources.  相似文献   

Autonomy of Artistic Expression for Adult Learners with Disabilities     

Graham C. Young 《The International Journal of Art & Design Education》2008,27(2):116-123

When an art tutor adopts the role of assistant to a disabled artist it is difficult not to move from helping with the physical handling of materials on the one hand into the actual creative process on the other, thus influencing how the artwork looks. Ecas is an Edinburgh‐based charity which promotes opportunities for physically disabled people to be self‐fulfilled and to participate in all aspects of society. They run, among other things, traditional art classes and computer classes. The use of computer technology (CT) in art seemed to offer the chance for self‐fulfilment for disabled artists by increasing control over artistic choices and providing for self expression with only minimal assistance required from others. Ecas decided to fund a research project in the form of a ten‐week pilot course and the data collected during the trial confirmed these possibilities and it was clear that adult learners with disabilities could benefit from CT in order to have greater autonomy in the creation of their art than before. In particular the program Corel Painter IX.5 and various graphics tablets proved to be a powerful arsenal for self‐expression without having to wait for a tutor to tape paper to a board, replenish paint, change brushes attached to a head pointer or any one of the many and varied problems disabled students had with traditional art materials.  相似文献   

Philosophy of Education: An Anthology - Edited by Randall Curren     

Graham  Haydon 《British Journal of Educational Studies》2008,56(2):232-233

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