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781.
The use of experimentation as a policy change tool is described and assessed, based on the experience of the Experimental Technology Incentives Program (ETIP). ETIP conducted innovation-related policy experiments with U.S. government agencies in the areas of regulation, procurement, venture capital, R&D funding, and technology commercialization. A case study of a policy experiment with new analytical and institutional procedures for monitoring the impacts of venture capital market regulations is used to show how the policy experiment can provide an iterative and low-risk, low-cost approach to policy change. Equally important, instututionalization of the procedures for monitoring existing policies and the provision of decision-relevant information are shown to be important benefits from policy experimentation in the context of the overall policy change process. The reasons behind ETIP's termination after 10 years of operation are themselves important lessons for institutions involved in the development and management of industry growth policies.  相似文献   
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783.
Isolated mitochondria display a wide range of sizes plausibly resulting from the coexistence of subpopulations, some of which may be associated with disease or aging. Strategies to separate subpopulations are needed to study the importance of these organelles in cellular functions. Here, insulator-based dielectrophoresis (iDEP) was exploited to provide a new dimension of organelle separation. The dielectrophoretic properties of isolated Fischer 344 (F344) rat semimembranosus muscle mitochondria and C57BL/6 mouse hepatic mitochondria in low conductivity buffer (0.025–0.030 S/m) at physiological pH (7.2–7.4) were studied using polydimethylsiloxane (PDMS) microfluidic devices. First, direct current (DC) and alternating current (AC) of 0–50 kHz with potentials of 0–3000 V applied over a channel length of 1 cm were separately employed to generate inhomogeneous electric fields and establish that mitochondria exhibit negative DEP (nDEP). DEP trapping potential thresholds at 0–50 kHz were also determined to be weakly dependent on applied frequency and were generally above 200 V. Second, we demonstrated a separation scheme using DC potentials <100 V to perform the first size-based iDEP sorting of mitochondria. Samples of isolated mitochondria with heterogeneous sizes (150 nm–2 μm diameters) were successfully separated into sub-micron fractions, indicating the ability to isolate mitochondria into populations based on their size.  相似文献   
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785.
The purpose of this study was to examine relationships between functional movement screen scores, maturation and physical performance in young soccer players. Thirty males (11–16 years) were assessed for maturation, functional movement screen scores and a range of physical performance tests (squat jump, reactive strength index protocol and reactive agility cut). Older players significantly outperformed younger participants in all tests (P < 0.05; effect sizes = 1.25–3.40). Deep overhead squat, in-line lunge, active straight leg raise and rotary stability test were significantly correlated to all performance tests. In-line lunge performance explained the greatest variance in reactive strength index (adjusted R2 = 47%) and reactive agility cut (adjusted R2 = 38%) performance, whilst maturation was the strongest predictor of squat jump performance (adjusted R2 = 46%). This study demonstrated that variation of physical performance in youth soccer players could be explained by a combination of both functional movement screen scores and maturation.  相似文献   
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788.
The self-regulation of learning behavior is an important key competence for university students. In this presented study, we aimed at fostering students’ self-regulation of learning by means of a standardized learning journal. In two of four courses that were included in the study, students had to keep a structured learning diary and/or received further intervention on self-regulated learning through a weekly course. Students who received these interventions were compared to students who received no treatment whatsoever in their self-regulation and learning achievement. The study reports pre–post measures as well as process analyses. Results revealed that keeping a structured learning diary without any further intervention did not improve students’ self-regulation. Those students who only kept learning diaries even showed a decrease in their motivation. Students who kept the learning diary and at the same time received further information on self-regulation showed increases in their strategy use and their self-efficacy. However, no improvements were found for students’ academic performance. It can be concluded that in order for students to profit in keeping a structured learning diary, they should be informed on the benefits of self-monitoring to increase their motivation.  相似文献   
789.
Over the last 2 decades, Irish schooling and society have gone through a period of significant structural and policy-driven change. To meet the emerging needs of the knowledge/learning society, schools and teachers are challenged to develop their capacities as "active learning communities". This places greater demands on teachers and schools to reflect on their classroom practices, to utilise a wider repertoire of pedagogic styles more suited to the needs of the 21st century learners and so that meaningfully collaborate with their fellow professionals. Teaching and Learning for the 21st Century (TL21) was a 4-year (2003-2007) multi-pronged research and development project involving the Education Department at the National University of Ireland, Maynooth (NUIM) and 15 post-primary schools. The project sought to address a number of key aims in terms of developing schools as professional learning communities, including addressing the isolation and insulation which teachers can, and do experience in their day-to-day professional lives and prioritize quality in teaching and learning as a key challenge for school development planning. This paper attempts to succinctly frame the key developments and findings which emerged over the duration of this process.  相似文献   
790.
Rounding is a necessary step in many mathematical processes. We are taught early in our education about significant figures and how to properly round a number. So when we are given a data set and asked to find a regression line, we are inclined to offer the line with rounded coefficients to reflect our model. However, the effects are not as insignificant as they might seem at first. In this paper, we investigate some consequences of rounding the coefficients in a least squares linear regression with respect to the calculated value of R2, and consider ways to minimize the amount of error that can arise.  相似文献   
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